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Results: 1167
DIA label-free proteomic analysis of murine bone-marrow-derived macrophages.
Christa P Baker, Iain R Phair, Alejandro J Brenes, Abdelmadjid Atrih, Dylan G Ryan, Roland Bruderer, Albena T Dinkova-Kostova, Douglas J Lamont, J Simon C Arthur, Andrew JM Howden
Oct 28, 2022
Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We provide a complete step-by-step protocol describing sample preparation...
Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism.
Dylan Gerard Ryan, Ming Yang, Hiran Prag, Giovanny Rodriguez Blanco, Efterpi Nikitopoulou, Marc Segarra-Mondejar, Christopher A Powell, Tim Young, Nils Burger, Jan Lj Miljkovic, Michal Minczuk, Mike Murphy, Alex Von Kriegsheim, Christian Frezza
Jan 10, 2022
The Tricarboxylic Acid (TCA) Cycle is arguably the most critical metabolic cycle in physiology and exists as an essential interface coordinating cellular metabolism, bioenergetics, and redox homeostasis. Despite decades of...
Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism.
Dylan Gerard Ryan, Ming Yang, Hiran A Prag, Giovanny Rodriguez Blanco, Efterpi Nikitopoulou, Marc Segarra-Mondejar, Christopher A Powell, Tim Young, Nils Burger, Jan Lj Miljkovic, Michal Minczuk, Michael P Murphy, Alex Von Kriegsheim, Christian Frezza
Jan 28, 2022
The Tricarboxylic Acid (TCA) Cycle is arguably the most critical metabolic cycle in physiology and exists as an essential interface coordinating cellular metabolism, bioenergetics, and redox homeostasis. Despite decades of...
IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity.
Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to...
A new Gaussian Process based model for non-linear wave loading on vertical cylinders
Tianning Tang, Gerard Ryan, Haoyu Ding, Xi Chen, Jun Zang, Paul H. Taylor, Thomas A.A. Adcock
Mar 31, 2024
We aim to establish a fast and accurate model for fast prediction of nonlinear loading on vertical cylinders such as are typically used for fixed offshore wind turbines. We follow a ‘Stokes-type’ force model and approximate...
The Grizzly, February 7, 1995
Marc Ellman, Mark Leiser, Jayson Blocksidge, Michelle Ryan, Phil Caiazzo, Amy K. Davenport, Tarik Qasim, Nicole D'orsaneo, Michael A. Pizzi, Doug Plitt, Fred Klee, Joel Schofer, Ellen Cosgrove, Charlie Weingroff
Jan 01, 0001
Faculty and Administrators Focus on Sophomore Concerns Survey of Ursinus Freshmen Voice of Ursinus Rings Clear Border Dispute Between Ecuador and Peru Tabby Buckingham Dies at 16 Ursinus Students Attend March for Life ...
Ursinus College Collegeville Pennsylvania newspaper gymnastics Basketball Swimming Bridget Cauley Ellen Cosgrove campus security WVOU radio station Abortion Tabby Buckingham Michelle Ryan CIRP Sophomore Week cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
TCA cycle signalling and the evolution of eukaryotes.
A major question remaining in the field of evolutionary biology is how prokaryotic organisms made the leap to complex eukaryotic life. The prevailing theory depicts the origin of eukaryotic cell complexity as emerging from the...
A new Gaussian Process based model for non-linear wave loading on vertical cylinders
Tianning Tang, Gerard Ryan, Haoyu Ding, Xi Chen, Jun Zang, Paul H. Taylor, Thomas A.A. Adcock
Mar 31, 2024
We aim to establish a fast and accurate model for fast prediction of nonlinear loading on vertical cylinders such as are typically used for fixed offshore wind turbines. We follow a ‘Stokes-type’ force model and approximate...
A meta-analysis of techniques to promote motivation for health behaviour change from a self-determination theory perspective
A systematic review and meta-analysis was conducted of the techniques used to promote psychological need satisfaction and motivation within health interventions based on self-determination theory (SDT; Ryan & Deci, 2017)....
Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases.
Alvin Djajadikerta, Swati Keshri, Mariana Pavel, Ryan Prestil, Laura Ryan, David C Rubinsztein
Dec 11, 2019
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lysosomes for degradation. Genetic studies have revealed extensive links between autophagy and neurodegenerative disease, and...
Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses.
Mimmi LE Lundahl, Morgane Mitermite, Dylan Gerard Ryan, Sarah Case, Niamh C Williams, Ming Yang, Roisin I Lynch, Eimear Lagan, Filipa M Lebre, Aoife L Gorman, Bojan Stojkovic, Adrian P Bracken, Christian Frezza, Frederick J Sheedy, Eoin M Scanlan, Luke AJ O'Neill, Stephen V Gordon, Ed C Lavelle
Oct 29, 2022
HRas and Myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes.
Aleksandra Boikova, Megan J Bywater, Gregory A Quaife-Ryan, Jasmin Straube, Lucy Thompson, Camilla Ascanelli, Trevor D Littlewood, Gerard I Evan, James E Hudson, Catherine H Wilson
Dec 08, 2022
AIM: Adult mammalian cardiomyocytes are incapable of significant proliferation, limiting regeneration after myocardial injury. Overexpression of the transcription factor Myc has been shown to drive proliferation in the adult...
A meta-analysis of techniques to promote motivation for health behaviour change from a self-determination theory perspective
A systematic review and meta-analysis was conducted of the techniques used to promote psychological need satisfaction and motivation within health interventions based on self-determination theory (SDT; Ryan & Deci, 2017)....
Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses.
Mimmi LE Lundahl, Morgane Mitermite, Dylan Gerard Ryan, Sarah Case, Niamh C Williams, Ming Yang, Roisin I Lynch, Eimear Lagan, Filipa M Lebre, Aoife L Gorman, Bojan Stojkovic, Adrian P Bracken, Christian Frezza, Frederick J Sheedy, Eoin M Scanlan, Luke AJ O'Neill, Stephen V Gordon, Ed C Lavelle
Oct 12, 2022
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Coupling Krebs cycle metabolites to signalling in immunity and cancer.
Dylan G Ryan, Michael P Murphy, Christian Frezza, Hiran A Prag, Edward T Chouchani, Luke A O'Neill, Evanna L Mills
Feb 12, 2019
Metabolic reprogramming has become a key focus for both immunologists and cancer biologists, with exciting advances providing new insights into underlying mechanisms of disease. Metabolites traditionally associated with...
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana SH Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R Zecchini, Sabrina H Rossi, Charlie Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent Gnanapragasam, Anne Y Warren, Grant D Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Jan 22, 2023
Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and...
A Hybridized Deep Learning Strategy for Course Recommendation
Recommender systems have been actively used in many areas like e-commerce, movie and video suggestions, and have proven to be highly useful for its users. But the use of recommender systems in online learning platforms is often...
Published by: IGI Global Scientific Publishing
Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
Megan J. Bywater, Deborah L. Burkhart, Jasmin Straube, Arianna Sabò, Vera Pendino, James E. Hudson, Gregory A. Quaife-Ryan, Enzo R. Porrello, James Rae, Robert G. Parton, Theresia R. Kress, Bruno Amati, Trevor D. Littlewood, Gerard I. Evan, Catherine H. Wilson
Apr 14, 2021
Abstract: It is unclear why some tissues are refractory to the mitogenic effects of the oncogene Myc. Here we show that Myc activation induces rapid transcriptional responses followed by proliferation in some, but not all...
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana SH Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R Zecchini, Sabrina H Rossi, Charlie Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent Gnanapragasam, Anne Y Warren, Grant D Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Dec 20, 2022
Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and...
Respected Winthrop Student Veteran Passes Away
Winthrop University
Jan 01, 0001
Cpl. Ryan Holdaway transferred to Winthrop's College of Business Administration. He was a respected member of the veterans community. Respected Winthrop University student Cpl.
Published by: Winthrop University
The 1919 eclipse results that verified general relativity and their later detractors
Einstein became world famous on 7 November 1919, following press publication of a meeting held in London on 6 November 1919 where the results were announced of two British expeditions led by Eddington, Dyson and Davidson...
The Sage Page Fall 2017
Winthrop University Honors Association
Jan 01, 0001
Inside this issue:
Welcome by Dr. Lyon Meet the Officers Letter from WUHA! President Photo Story: Awesome Honors Events Alumni Story 2017 Seniors How the Honors Program Helped me Earn Five Scholarships Being Honors and Greek...
Published by: Winthrop University
The Lantern Vol. 56, No. 2, Spring 1990
Neil Schafer, Anthony McCurdy, Dawna Grieco, Deborah Kriebel, Laura Sassaman, Patricia L. Benes, Andrea Lynn, Janet Mast, Carolyn Elder, Kathy Barrett, Diane Orleman, Tim Driscoll, Jennifer Blay, Jerry VanKanan, Vince Leskusky, Dennis Moir, Katrina Steffy, Melissa Pollack, Orena Herold
Jan 01, 0001
Brasil Plastic Flowers Be a Pepper Grunge Handling the Responsibility Returning to the Forest How Nice Nooze Emma Restoration Chestnuts Frozen Moments Once Upon A Clipped Wings Gerard Manley...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
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