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Results: 32
Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids.
Alexandre B Leitão, Xueni Bian, Jonathan P Day, Simone Pitton, Eşref Demir, Francis M Jiggins
Sep 24, 2019
It is common to find abundant genetic variation in host resistance and parasite infectivity within populations, with the outcome of infection frequently depending on genotype-specific interactions. Underlying these effects are...
Chemical inhibition of NAT10 corrects defects of laminopathic cells.
Delphine Larrieu, Sébastien Britton, Mukerrem Demir, Raphaël Rodriguez, Stephen P Jackson
Aug 02, 2019
A simulation-based decision support tool for informing the management of patients with Parkinson’s disease
We describe a decision support toolkit that was developed with the aim of assisting those responsible with the management and treatment of Parkinson’s disease (PD) in the UK. Having created a baseline model and established its...
Dual band, Miniaturized Permittivity Measurement Sensor with Negative-Order SIW Resonator
A novel dual band, highly sensitive Substrate Integrated Waveguide (SIW) sensor for permittivity measurements is presented. A pair of modified Complementary Split Ring Resonators (CSRRs) is etched on SIW surface. CSRRs are...
Compact Size, and Highly Sensitive, Microwave Sensor for Non-Invasive Measurement of Blood Glucose Level
None-invasive blood glucose measurement enables effective diagnosis and treatment of diabetic patients. The existing microwave sensors suffer from low sensitivity and large size. This article presents a highly sensitive and...
Branch line coupler compact size high sensitivity Microwave sensor transmission zeros /dk/atira/pure/subjectarea/asjc/3100/3105 name=Instrumentation /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Familial partial lipodystrophy linked to a novel peroxisome proliferator activator receptor -γ (PPARG) mutation, H449L
T Demir, H Onay, DB Savage, E Temeloglu, AK Uzum, P Kadioglu, C Altay, S Ozen, L Demir, U Cavdar, B Akinci
Sep 04, 2017
AIMS: To describe the phenotype associated with a novel heterozygous missense PPARG mutation discovered in a Turkish family and to compare the fat distribution and metabolic characteristics of subjects with the peroxisome...
Dual band, Miniaturized Permittivity Measurement Sensor with Negative-Order SIW Resonator
A novel dual band, highly sensitive Substrate Integrated Waveguide (SIW) sensor for permittivity measurements is presented. A pair of modified Complementary Split Ring Resonators (CSRRs) is etched on SIW surface. CSRRs are...
A simulation-based decision support tool for informing the management of patients with Parkinson’s disease
We describe a decision support toolkit that was developed with the aim of assisting those responsible with the management and treatment of Parkinson’s disease (PD) in the UK. Having created a baseline model and established its...
Compact Size, and Highly Sensitive, Microwave Sensor for Non-Invasive Measurement of Blood Glucose Level
None-invasive blood glucose measurement enables effective diagnosis and treatment of diabetic patients. The existing microwave sensors suffer from low sensitivity and large size. This article presents a highly sensitive and...
Branch line coupler compact size high sensitivity Microwave sensor transmission zeros /dk/atira/pure/subjectarea/asjc/3100/3105 name=Instrumentation /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
A stochastic programming approach for chemotherapy appointment scheduling
Chemotherapy appointment scheduling is a challenging problem due to the uncertainty in premedication and infusion durations. In this paper, we formulate a two‐stage stochastic mixed integer programming model for the chemotherapy...
appointment scheduling Chemotherapy progressive hedging scheduling stochastic programming /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research
A stochastic programming approach for chemotherapy appointment scheduling
Chemotherapy appointment scheduling is a challenging problem due to the uncertainty in premedication and infusion durations. In this paper, we formulate a two‐stage stochastic mixed integer programming model for the chemotherapy...
appointment scheduling Chemotherapy progressive hedging scheduling stochastic programming /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research
MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance.
Israel Salguero, Rimma Belotserkovskaya, Julia Coates, Matylda Sczaniecka-Clift, Mukerrem Demir, Satpal Jhujh, Marcus D Wilson, Stephen P Jackson
Dec 16, 2019
Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to promote the...
A Blockchain-Based System for Aid Delivery
Climate-related catastrophes leave people in dire need of aid. A major obstacle in providing help to people is the lack of trust in the aid process. Charity organizations want to ensure that funds and materials reach the...
Published by: IGI Global Scientific Publishing
Antenatal iron supplementation, FGF23, and bone metabolism in Kenyan women and their offspring
Vickie S Braithwaite, Martin N Mwangi, Kerry S Jones, Ayşe Y Demir, Ann Prentice, Andrew M Prentice, Pauline EA Andang'o, Hans Verhoef
Mar 22, 2021
BACKGROUND: Fibroblast growth factor-23 (FGF23) regulates body phosphate homeostasis primarily by increasing phosphaturia. It also acts as a vitamin D-regulating hormone. Maternal iron deficiency is associated with perturbed...
CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing.
Ting-Wei Will Chiang, Carlos le Sage, Delphine Larrieu, Mukerrem Demir, Stephen P Jackson
Apr 13, 2016
Alleles Base Sequence CRISPR-Cas Systems Cell Line Deoxyribonuclease I Drug Discovery Gene Editing Gene Knockout Techniques Gene Order Gene Targeting Genetic Loci Genetic Vectors Genomics Genotype High-Throughput Screening Assays Humans Mutagenesis Phenotype RNA Guide Kinetoplastida Vascular Endothelial Growth Factor A
MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
Israel Salguero, Rimma Belotserkovskaya, Julia Coates, Matylda Sczaniecka-Clift, Mukerrem Demir, Satpal Jhujh, Marcus D. Wilson, Stephen P. Jackson
Nov 14, 2020
Abstract: Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to...
MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance.
Israel Salguero, Rimma Belotserkovskaya, Julia Coates, Matylda Sczaniecka-Clift, Mukerrem Demir, Satpal Jhujh, Marcus D Wilson, Stephen P Jackson
Oct 09, 2019
Logistics planning of cash transfer to Syrian refugees in Turkey
Ramez Kian, Güneş Erdoğan, Sander de Leeuw, Sibel Salman, Bahar Kara, Ehsan Sabet, Muhittin Demir
Feb 01, 2022
This paper addresses a humanitarian logistics problem connected with the Syrian refugee crisis. The ongoing conflict in Syria has caused displacement of millions of people. Cash-based interventions play an important role in...
Cash-based interventions Humanitarian logistics Location-routing Syrian refugee crisis /dk/atira/pure/subjectarea/asjc/1700/1700 name=General Computer Science /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research /dk/atira/pure/subjectarea/asjc/1800/1802 name=Information Systems and Management /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
Logistics planning of cash transfer to Syrian refugees in Turkey
Ramez Kian, Güneş Erdoğan, Sander de Leeuw, Sibel Salman, Bahar Kara, Ehsan Sabet, Muhittin Demir
Feb 01, 2022
This paper addresses a humanitarian logistics problem connected with the Syrian refugee crisis. The ongoing conflict in Syria has caused displacement of millions of people. Cash-based interventions play an important role in...
Cash-based interventions Humanitarian logistics Location-routing Syrian refugee crisis /dk/atira/pure/subjectarea/asjc/1700/1700 name=General Computer Science /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research /dk/atira/pure/subjectarea/asjc/1800/1802 name=Information Systems and Management /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
Christine K Schmidt, Yaron Galanty, Matylda Sczaniecka-Clift, Julia Coates, Satpal Jhujh, Mukerrem Demir, Matthew Cornwell, Petra Beli, Stephen P Jackson
Sep 22, 2015
Carrier Proteins Cell Cycle Cell Line Tumor Cell Survival DNA Breaks Double-Stranded Endodeoxyribonucleases Green Fluorescent Proteins HEK293 Cells Humans Immunoblotting Microscopy Confocal Nuclear Proteins RNA Interference Recombinational DNA Repair Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Ubiquitination
CtIP tetramer assembly is required for DNA-end resection and repair.
Owen R Davies, Josep V Forment, Meidai Sun, Rimma Belotserkovskaya, Julia Coates, Yaron Galanty, Mukerrem Demir, Christopher R Morton, Neil J Rzechorzek, Stephen P Jackson, Luca Pellegrini
Mar 09, 2015
Anemia in Patients With Resistance to Thyroid Hormone α
ALM van Gucht, ME Meima, C Moran, M Agostini, A Tylki-Szymanska, M-W Krajewska, K Chrzanowska, A Efthymiadou, D Chrysis, K Demir, WE Visser, TJ Visser, K Chatterjee, TB van Dijk, RP Peeters
Oct 04, 2017
Adolescent Adult Anemia Case-Control Studies Cells Cultured Child Child Preschool Erythrocytes Erythropoiesis Female Gene Expression Regulation Humans Incidence Male Middle Aged Mutation Prognosis Reference Values Role Stem Cells Thyroid Hormone Receptors alpha Thyroid Hormone Resistance Syndrome Young Adult
Mycophenolate Mofetil Versus Cyclophosphamide for Remission Induction in Childhood Polyarteritis Nodosa
Paul A Brogan, Barbara Arch, Helen Hickey, Jordi Anton, Este Iglesias, Eileen Baildam, Kamran Mahmood, Gavin Cleary, Elena Moraitis, Charalampia Papadopoulou, Michael W Beresford, Phil Riley, Selcan Demir, Seza Ozen, Giovanna Culeddu, Dyfrig A Hughes, Pavla Dolezalova, Lisa V Hampson, John Whitehead, David Jayne, Nicola Ruperto, Catrin Tudur-Smith, Despina Eleftheriou
Apr 19, 2021
OBJECTIVE: Cyclophosphamide (CYC) is used in clinical practice off-label for the induction of remission in childhood polyarteritis nodosa (PAN). Mycophenolate mofetil (MMF) might offer a less toxic alternative. This study was...
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
Gabriel Balmus, Delphine Larrieu, Ana C Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J Geisler, Christopher J Lelliott, Jacqueline K White, Natasha A Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J Adams, Stephen P Jackson
Feb 09, 2018
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic disease characterized by segmental premature aging, with cardiovascular disease being the main cause of death. Cells from HGPS patients accumulate...
Mycophenolate Mofetil Versus Cyclophosphamide for Remission Induction in Childhood Polyarteritis Nodosa
Paul A. Brogan, Barbara Arch, Helen Hickey, Jordi Anton, Este Iglesias, Eileen Baildam, Kamran Mahmood, Gavin Cleary, Elena Moraitis, Charalampia Papadopoulou, Michael W. Beresford, Phil Riley, Selcan Demir, Seza Ozen, Giovanna Culeddu, Dyfrig A. Hughes, Pavla Dolezalova, Lisa V. Hampson, John Whitehead, David Jayne, Nicola Ruperto, Catrin Tudur‐Smith, Despina Eleftheriou
Aug 02, 2021
Published by: Arthritis & Rheumatology
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