Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo.
Maximilian Kleinert,
Lykke Sylow,
Daniel J Fazakerley,
James R Krycer,
Kristen C Thomas,
Anne-Julie Oxbøll,
Andreas B Jordy,
Thomas E Jensen,
Guang Yang,
Peter Schjerling,
Bente Kiens,
David E James,
Markus A Ruegg,
Erik A Richter
Aug 28, 2020
The effect of acute inhibition of both mTORC1 and mTORC2 on metabolism is unknown. A single injection of the mTOR kinase inhibitor, AZD8055, induced a transient, yet marked increase in fat oxidation and insulin resistance in...