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Results: 5
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Jan Felix, Eaazhisai Kandiah, Steven De Munck, Yehudi Bloch, Gydo CP van Zundert, Kris Pauwels, Ann Dansercoer, Katka Novanska, Randy J Read, Alexandre MJJ Bonvin, Bjorn Vergauwen, Kenneth Verstraete, Irina Gutsche, Savvas N Savvides
Jul 06, 2020
Subversion of the host immune system by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting effective immune responses. The widespread mammalian pathogen parapox Orf virus deploys GIF...
Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID.
Kapil Gupta, Aleksandra A Watson, Tiago Baptista, Elisabeth Scheer, Anna L Chambers, Christine Koehler, Juan Zou, Ima Obong-Ebong, Eaazhisai Kandiah, Arturo Temblador, Adam Round, Eric Forest, Petr Man, Christoph Bieniossek, Ernest D Laue, Edward A Lemke, Juri Rappsilber, Carol V Robinson, Didier Devys, Làszlò Tora, Imre Berger
Jan 24, 2018
General transcription factor TFIID is a key component of RNA polymerase II transcription initiation. Human TFIID is a megadalton-sized complex comprising TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). TBP binds...
S. cerevisiae TBP associated factors TFIID Biochemistry biophysics core promoter DNA Gene regulation histone fold domain human structural biology Transcription Factors Crystallography X-Ray DNA Histone Acetyltransferases Humans Mass Spectrometry Promoter Regions Genetic Protein Binding Protein Conformation Protein Interaction Mapping TATA-Binding Protein Associated Factors TATA-Box Binding Protein Transcription Factor TFIID
Associations of hippocampal subfields in the progression of cognitive decline related to Parkinson's disease.
Heidi Foo, Elijah Mak, Russell Jude Chander, Aloysius Ng, Wing Lok Au, Yih Yian Sitoh, Louis CS Tan, Nagaendran Kandiah
Mar 07, 2019
OBJECTIVE: Hippocampal atrophy has been associated with mild cognitive impairment (MCI) in Parkinson's disease (PD). However, literature on how hippocampal atrophy affects the pathophysiology of cognitive impairment in PD has...
CA cornu ammonis COGNITIVE IMPAIRMENT HATA hippocampal-amygdaloid transition region Hippocampal atrophy Parkinson's Disease Volumetry Aged Aged 80 and over Cognition Disorders Female Functional Laterality Hippocampus Humans Image Processing Computer-Assisted Longitudinal Studies Magnetic Resonance Imaging Male Mental Status Schedule Middle Aged Neuropsychological Tests Parkinson Disease
DTI Profiles for Rapid Description of Cohorts at the Clinical-Research Interface.
Christine Lock, Janell Kwok, Sumeet Kumar, Azlina Ahmad-Annuar, Vairavan Narayanan, Adeline SL Ng, Yi Jayne Tan, Nagaendran Kandiah, Eng-King Tan, Zofia Czosnyka, Marek Czosnyka, John D Pickard, Nicole C Keong
Feb 22, 2019
Normal pressure hydrocephalus (NPH) is a syndrome comprising gait disturbance, cognitive decline and urinary incontinence that is an unique model of reversible brain injury, but it presents as a challenging spectrum of disease...
Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.
Vincent CT Mok, Sarah Pendlebury, Adrian Wong, Suvarna Alladi, Lisa Au, Philip M Bath, Geert Jan Biessels, Christopher Chen, Charlotte Cordonnier, Martin Dichgans, Jacqueline Dominguez, Philip B Gorelick, SangYun Kim, Timothy Kwok, Steven M Greenberg, Jianping Jia, Rajesh Kalaria, Miia Kivipelto, Kandiah Naegandran, Linda CW Lam, Bonnie Yin Ka Lam, Allen TC Lee, Hugh S Markus, John O'Brien, Ming-Chyi Pai, Leonardo Pantoni, Perminder Sachdev, Ingmar Skoog, Eric E Smith, Velandai Srikanth, Guk-Hee Suh, Joanna Wardlaw, Ho Ko, Sandra E Black, Philip Scheltens
Jun 18, 2020
We have provided an overview on the profound impact of COVID-19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health-care settings...