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Results: 41
Prodromal symptoms and remission following first episode psychosis.
Laoise Renwick, John Lyne, Brian O Donoghue, Liz Owens, Roisin Doyle, Michele Hill, Emma McCarthy, Mark Pilling, Eadbhard O'Callaghan, Mary Clarke
Jun 08, 2018
Duration of prodrome Duration of untreated psychosis first-episode psychosis Prodromal Symptoms Adult Chi-Square Distribution Female Humans Male Middle Aged Predictive Value of Tests principal component analysis Prodromal Symptoms Psychiatric Status Rating Scales Psychotic Disorders Retrospective Studies
The Canine POMC Gene, Obesity in Labrador Retrievers and Susceptibility to Diabetes Mellitus.
BACKGROUND: Diabetes mellitus (DM) in dogs is a common endocrinopathy with a complex genetic architecture. Disease susceptibility in several breeds is associated with polymorphisms in immune response genes, but in the Labrador...
Silicon central pattern generators for cardiac diseases
Alain Nogaret, Erin L. O'Callaghan, Renata M. Lataro, Helio C. Salgado, C. Daniel Meliza, Edward Duncan, Henry D. I. Abarbanel, Julian F. R. Paton
Feb 15, 2015
Cardiac rhythm management devices provide therapies for both arrhythmias and resynchronisation but not heart failure, which affects millions of patients worldwide. This paper reviews recent advances in biophysics and...
Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.
Michael E Reschen, Da Lin, Anil Chalisey, Elizabeth J Soilleux, Christopher A O'Callaghan
Dec 17, 2018
BACKGROUND AND AIMS: Coronary artery disease (CAD) risk is associated with non-coding genetic variants at the phosphatase and actin regulating protein 1(PHACTR1) gene locus. The PHACTR1 gene encodes an actin-binding protein with...
Atherosclerosis Expression quantitative trait locus (eQTL) Functional genomics genetic disease Genetic polymorphism Genomics Low-density lipoprotein (LDL) Myocardial Infarction Oxidized low density lipoprotein (oxLDL) PHACTR1 Adult Aged Alleles Atherosclerosis Coronary Artery Disease Coronary Vessels Endothelial Cells Gene Expression Regulation Gene-Environment Interaction Genotype Humans Inflammation Lipopolysaccharides MACROPHAGES Microfilament Proteins Middle Aged Muscle Smooth Vascular Polymorphism Single Nucleotide Tumor Necrosis Factor-alpha Young Adult
Cerebellar atrophy in Parkinson's disease and its implication for network connectivity.
Claire O'Callaghan, Michael Hornberger, Joshua H Balsters, Glenda M Halliday, Simon JG Lewis, James M Shine
Dec 01, 2017
Pathophysiological and atrophic changes in the cerebellum are documented in Parkinson's disease. Without compensatory activity, such abnormalities could potentially have more widespread effects on both motor and non-motor...
Cerebellar atrophy in neurodegeneration-a meta-analysis.
Helena M Gellersen, Christine C Guo, Claire O'Callaghan, Rachel H Tan, Saber Sami, Michael Hornberger
Dec 01, 2017
INTRODUCTION: The cerebellum has strong cortical and subcortical connectivity, but is rarely taken into account for clinical diagnosis in many neurodegenerative conditions, particularly in the absence of clinical ataxia. The...
Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.
Michael E Reschen, Kyle J Gaulton, Da Lin, Elizabeth J Soilleux, Andrew J Morris, Susan S Smyth, Christopher A O'Callaghan
Dec 17, 2018
Genome-wide association studies (GWAS) have identified over 40 loci that affect risk of coronary artery disease (CAD) and the causal mechanisms at the majority of loci are unknown. Recent studies have suggested that many causal...
Novel Smartphone Interventions Improve Cognitive Flexibility and Obsessive-Compulsive Disorder Symptoms in Individuals with Contamination Fears.
Baland Jalal, Annette Brühl, Claire O'Callaghan, Thomas Piercy, Rudolf N Cardinal, Vilayanur S Ramachandran, Barbara J Sahakian
Nov 02, 2018
One type of obsessive-compulsive disorder (OCD) is characterized by contamination fears and compulsive cleansing. Few effective treatments are available for this debilitating condition. Compulsive symptoms, such as excessive...
Silicon central pattern generators for cardiac diseases
Alain Nogaret, Erin L. O'Callaghan, Renata M. Lataro, Helio C. Salgado, C. Daniel Meliza, Edward Duncan, Henry D. I. Abarbanel, Julian F. R. Paton
Feb 15, 2015
Cardiac rhythm management devices provide therapies for both arrhythmias and resynchronisation but not heart failure, which affects millions of patients worldwide. This paper reviews recent advances in biophysics and...
Fair play
Claire O'Callaghan, Maxime Bertoux, Muireann Irish, James M Shine, Stephanie Wong, Leonidas Spiliopoulos, John R Hodges, Michael Hornberger
Dec 01, 2017
Adherence to social norms is compromised in a variety of neuropsychiatric conditions. Functional neuroimaging studies have investigated social norm compliance in healthy individuals, leading to the identification of a network of...
behavioural variant frontotemporal dementia Empathy fairness prosocial Punishment social norm compliance Aged Atrophy Case-Control Studies Cerebral Cortex Corpus Striatum Decision Making Empathy Female frontotemporal dementia Gray Matter Humans Magnetic Resonance Imaging Male Middle Aged Neuroimaging Neuropsychological Tests Social Norms
Enhancing respiratory sinus arrhythmia increases cardiac output in rats with left ventricular dysfunction
Erin O'Callaghan, Renata M. Lataro, Eva Roloff, Ashok Chauhan, Helio C. Salgado, Edward R. Duncan, Alain Nogaret, Julian F R Paton
Feb 01, 2020
Key points: Respiratory sinus arrhythmia is physiological pacing of the heart that disappears in cardiovascular disease and is associated with poor cardiac prognosis. In heart failure, cardiac pacing has little, if any...
GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition.
Alexander G Murley, Matthew A Rouse, P Simon Jones, Rong Ye, Frank H Hezemans, Claire O'Callaghan, Polytimi Frangou, Zoe Kourtzi, Catarina Rua, T Adrian Carpenter, Christopher T Rodgers, James B Rowe
Jul 28, 2020
GABA frontotemporal dementia Glutamate Impulsivity progressive supranuclear palsy Aged Aged 80 and over Female Frontotemporal Lobar Degeneration Glutamates Humans INHIBITION Psychological Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Neuropsychological Tests Neurotransmitter Agents Reaction Time Supranuclear Palsy Progressive Visual Cortex gamma-Aminobutyric Acid
Enhancing respiratory sinus arrhythmia increases cardiac output in rats with left ventricular dysfunction
Erin O'Callaghan, Renata M. Lataro, Eva Roloff, Ashok Chauhan, Helio C. Salgado, Edward R. Duncan, Alain Nogaret, Julian F R Paton
Feb 01, 2020
Key points: Respiratory sinus arrhythmia is physiological pacing of the heart that disappears in cardiovascular disease and is associated with poor cardiac prognosis. In heart failure, cardiac pacing has little, if any...
An in vivo probabilistic atlas of the human locus coeruleus at ultra-high field.
Rong Ye, Catarina Rua, Claire O'Callaghan, P Simon Jones, Frank H Hezemans, Sanne S Kaalund, Kamen A Tsvetanov, Christopher T Rodgers, Guy Williams, Luca Passamonti, James B Rowe
Oct 20, 2020
Early and profound pathological changes are evident in the locus coeruleus (LC) in dementia and Parkinson's disease, with effects on arousal, attention, cognitive and motor control. The LC can be identified in vivo using...
Cognitive training for freezing of gait in Parkinson's disease
Courtney C Walton, Loren Mowszowski, Moran Gilat, Julie M Hall, Claire O'Callaghan, Alana J Muller, Matthew Georgiades, Jennifer YY Szeto, Kaylena A Ehgoetz Martens, James M Shine, Sharon L Naismith, Simon JG Lewis
Sep 05, 2018
The pathophysiological mechanism of freezing of gait (FoG) has been linked to executive dysfunction. Cognitive training (CT) is a non-pharmacological intervention which has been shown to improve executive functioning in...
1103 Clinical Sciences Clinical Clinical Medicine and Science aging Mind and Body Neurosciences Neurodegenerative Clinical Research Brain Disorders Parkinson's Disease Behavioral and Social Science Acquired Cognitive Impairment Mental Health Clinical Trials and Supportive Activities Neurological 6.6 Psychological and behavioural
Fronto-striatal circuits for cognitive flexibility in far from onset Huntington's disease
Christelle Langley, Sarah Gregory, Katie Osborne-Crowley, Claire O'Callaghan, Paul Zeun, Jessica Lowe, Eileanoir B Johnson, Marina Papoutsi, Rachael I Scahill, Geraint Rees, Sarah J Tabrizi, Trevor W Robbins, Barbara Jacquelyn Sahakian
Nov 03, 2020
OBJECTIVES: Cognitive flexibility, which is key for adaptive decision-making, engages prefrontal cortex (PFC)-striatal circuitry and is impaired in both manifest and premanifest Huntington's disease (pre-HD). The aim of this...
Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.
Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS)
Finbar J K O'Callaghan, Stuart W. Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L. Johnson, Colin R. Kennedy, Marcus Likeman, Andrew L. Lux, Mark Mackay, Andrew A. Mallick, Richard W. Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M. Verity, John P. Osborne
Jan 01, 2017
Background: Infantile spasms constitutes a severe infantile epilepsy syndrome that is difficult to treat and has a high morbidity. Hormonal therapies or vigabatrin are the most commonly used treatments. We aimed to assess...
Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.
Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson's disease.
Claire O'Callaghan, Frank H Hezemans, Rong Ye, Catarina Rua, P Simon Jones, Alexander G Murley, Negin Holland, Ralf Regenthal, Kamen A Tsvetanov, Noham Wolpe, Roger A Barker, Caroline H Williams-Gray, Trevor W Robbins, Luca Passamonti, James B Rowe
Mar 24, 2021
Parkinson’s disease atomoxetine Locus Coeruleus neuromelanin imaging Noradrenaline Adrenergic Uptake Inhibitors Aged Atomoxetine Hydrochloride Double-Blind Method Female Humans INHIBITION Psychological Locus Coeruleus Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Parkinson Disease Reaction Time
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