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Results: 32
An Energy Harvester for Low-Frequency Electrical Signals
Xin Wang, Peter Wilson, Ricardo Leite, Guiyou Chen, Helena Freitas, Kamal Asadi, Edsger Smits, Ilias Katsouras, Paulo Rocha
Jun 05, 2020
Generating electricity from low-frequency mechanical agitations produced by ocean waves, plants, or human motion is emerging as a key, environmentally friendly technology in combating harmful emissions caused by burning...
An Energy Harvester for Low-Frequency Electrical Signals
Xin Wang, Peter Wilson, Ricardo Leite, Guiyou Chen, Helena Freitas, Kamal Asadi, Edsger Smits, Ilias Katsouras, Paulo Rocha
Jun 05, 2020
Generating electricity from low-frequency mechanical agitations produced by ocean waves, plants, or human motion is emerging as a key, environmentally friendly technology in combating harmful emissions caused by burning...
Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5.
Andrzej Harris, Manuel Wagner, Dijun Du, Stefanie Raschka, Lea-Marie Nentwig, Holger Gohlke, Sander HJ Smits, Ben F Luisi, Lutz Schmitt
Nov 05, 2021
Fungal Endophyte Alternaria tenuissima Can Affect Growth and Selenium Accumulation in Its Hyperaccumulator Host Astragalus bisulcatus
Stormy D. Lindblom, Ami L. Wangeline, Jose R. Valdez Barillas, Berthal Devilbiss, Sirine C. Fakra, Elizabeth A. H. Pilon-Smits
Aug 01, 2018
Endophytes can enhance plant stress tolerance by promoting growth and affecting elemental accumulation, which may be useful in phytoremediation. In earlier studies, up to 35% elemental selenium (Se0 ) was found in Se...
Published by: Digital Commons @ Texas A&M University-San Antonio
Fungal Endophyte Alternaria tenuissima Can Affect Growth and Selenium Accumulation in Its Hyperaccumulator Host Astragalus bisulcatus
Stormy D. Lindblom, Ami L. Wangeline, Jose R. Valdez Barillas, Berthal Devilbiss, Sirine C. Fakra, Elizabeth A. H. Pilon-Smits
Aug 01, 2018
Endophytes can enhance plant stress tolerance by promoting growth and affecting elemental accumulation, which may be useful in phytoremediation. In earlier studies, up to 35% elemental selenium (Se0 ) was found in Se...
Published by: Digital Commons @ Texas A&M University-San Antonio
Identity Determinants of the Translocation Signal for a Type 1 Secretion System
The toxin hemolysin A was first identified in uropathogenic E. coli strains and shown to be secreted in a one-step mechanism by a dedicated secretion machinery. This machinery, which belongs to...
Olivia Spitz, Isabelle N Erenburg, Kerstin Kanonenberg, Sandra Peherstorfer, Michael HH Lenders, Jens Reiners, Miao Ma, Ben F Luisi, Sander HJ Smits, Lutz Schmitt
Feb 24, 2022
Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5
Andrzej Harris, Manuel Wagner, Dijun Du, Stefanie Raschka, Lea-Marie Nentwig, Holger Gohlke, Sander H. J. Smits, Ben F. Luisi, Lutz Schmitt
Sep 08, 2021
Abstract: Pdr5, a member of the extensive ABC transporter superfamily, is representative of a clinically relevant subgroup involved in pleiotropic drug resistance. Pdr5 and its homologues drive drug efflux through uncoupled...
Fungal Endophyte Alternaria tenuissima Can Affect Growth and Selenium Accumulation in Its Hyperaccumulator Host Astragalus bisulcatus
Stormy D. Lindblom, Ami L. Wangeline, Jose R. Valdez Barillas, Berthal Devilbiss, Sirine C. Fakra, Elizabeth A. H. Pilon-Smits
Aug 01, 2018
Endophytes can enhance plant stress tolerance by promoting growth and affecting elemental accumulation, which may be useful in phytoremediation. In earlier studies, up to 35% elemental selenium (Se0 ) was found in Se...
Published by: Digital Commons @ Texas A&M University-San Antonio
Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5.
Andrzej Harris, Manuel Wagner, Dijun Du, Stefanie Raschka, Lea-Marie Nentwig, Holger Gohlke, Sander H J Smits, Ben F Luisi, Lutz Schmitt
Oct 08, 2021
Pdr5, a member of the extensive ABC transporter superfamily, is representative of a clinically relevant subgroup involved in pleiotropic drug resistance. Pdr5 and its homologues drive drug efflux through uncoupled hydrolysis of...
Vanadates Rhodamines ATP-Binding Cassette Transporters Saccharomyces cerevisiae Proteins Adenosine Triphosphate detergents Cryoelectron Microscopy Drug Resistance Fungal Catalytic Domain Protein Conformation Hydrolysis Mutation Genetic Pleiotropy Protein Domains
Published by: Nature Communications
Getting to the Root of Selenium Hyperaccumulation—Localization and Speciation of Root Selenium and Its Effects on Nematodes
Christine N. Prins, Laura J. Hantzis, Jose R. Valdez Barillas, Jennifer J. Cappa, Sirine C. Fakra, Cecilia Milano de Tomasel, Diana H. Wall, Elizabeth A. H. Pilon-Smits
Jul 01, 2019
Elemental hyperaccumulation protects plants from many aboveground herbivores. Little is known about effects of hyperaccumulation on belowground herbivores or their ecological interactions. To examine effects of plant selenium...
Published by: Digital Commons @ Texas A&M University-San Antonio
Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization.
Laura Formentini, Fulvio Santacatterina, Cristina Núñez de Arenas, Konstantinos Stamatakis, David López-Martínez, Angela Logan, Manuel Fresno, Ron Smits, Michael P Murphy, José M Cuezva
Aug 17, 2017
Mitochondria are signaling hubs in cellular physiology that play a role in inflammatory diseases. We found that partial inhibition of the mitochondrial ATP synthase in the intestine of transgenic mice triggers an...
ATP synthase Cytokines innate immunity Animals Cells Cultured Colitis Ulcerative Immunity Innate Intestines Macrophage Activation MACROPHAGES Mice Mice Inbred C57BL Mitochondria Mitochondrial Proton-Translocating ATPases NF-kappa B Phenotype Proto-Oncogene Proteins c-akt Reactive Oxygen Species STAT3 Transcription Factor Signal Transduction TOR Serine-Threonine Kinases
High-level integration of murine intestinal transcriptomics data highlights the importance of the complement system in mucosal homeostasis.
Nirupama Benis, Jerry M Wells, Mari A Smits, Soumya Kanti Kar, Bart van der Hee, Vitor AP Martins dos Santos, Maria Suarez-Diez, Dirkjan Schokker
Mar 02, 2020
BACKGROUND: The mammalian intestine is a complex biological system that exhibits functional plasticity in its response to diverse stimuli to maintain homeostasis. To improve our understanding of this plasticity, we performed a...
Complement Pathway Data integration Homeostasis Intestine pathway analysis transcriptomics Animals Complement Activation Complement System Proteins Computational Biology Gene Expression Profiling Homeostasis Intestinal Mucosa Mice Models Biological Molecular Sequence Annotation Signal Transduction Transcriptome
Getting to the Root of Selenium Hyperaccumulation—Localization and Speciation of Root Selenium and Its Effects on Nematodes
Christine N. Prins, Laura J. Hantzis, Jose R. Valdez Barillas, Jennifer J. Cappa, Sirine C. Fakra, Cecilia Milano de Tomasel, Diana H. Wall, Elizabeth A. H. Pilon-Smits
Jul 01, 2019
Elemental hyperaccumulation protects plants from many aboveground herbivores. Little is known about effects of hyperaccumulation on belowground herbivores or their ecological interactions. To examine effects of plant selenium...
Published by: Digital Commons @ Texas A&M University-San Antonio
Increased Frequency of CD4+ Follicular Helper T and CD8+ Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis.
Dornatien Chuo Anang, Tamara H Ramwadhdoebe, Janine S Hähnlein, Bo van Kuijk, Noortje Smits, Krijn P van Lienden, Mario Maas, Daniëlle M Gerlag, Paul P Tak, Niek de Vries, Lisa GM van Baarsen
Mar 28, 2022
Follicular T helper cells (Tfh cells) provide key B-cell help and are essential in germinal center formation and (auto) antibody generation. To gain more insight into their role during the earliest phase of rheumatoid arthritis...
High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta.
Caroline Daelemans, Matthew E Ritchie, Guillaume Smits, Sayeda Abu-Amero, Ian M Sudbery, Matthew S Forrest, Susana Campino, Taane G Clark, Philip Stanier, Dominic Kwiatkowski, Panos Deloukas, Emmanouil T Dermitzakis, Simon Tavaré, Gudrun E Moore, Ian Dunham
Jun 14, 2011
The Nucleosome Remodeling and Deacetylase Complex NuRD is built from preformed catalytically active sub-modules
W. Zhang, A. Aubert, J. M. Gomez de Segura, M. Karuppasamy, S. Basu, A. Murthy, A. Diamante, T. A. Drury, J. Balmer, J. Cramard, A. A. Watson, D. Lando, S. F. Lee, M. Palayret, S. Kloet, A. Smits, M. Deery, M. Vermeulen, B. Hendrich, D. Klenerman, C. Schaffitzel, I. Berger, E. D. Laue
Apr 28, 2016
Getting to the Root of Selenium Hyperaccumulation—Localization and Speciation of Root Selenium and Its Effects on Nematodes
Christine N. Prins, Laura J. Hantzis, Jose R. Valdez Barillas, Jennifer J. Cappa, Sirine C. Fakra, Cecilia Milano de Tomasel, Diana H. Wall, Elizabeth A. H. Pilon-Smits
Jul 01, 2019
Elemental hyperaccumulation protects plants from many aboveground herbivores. Little is known about effects of hyperaccumulation on belowground herbivores or their ecological interactions. To examine effects of plant selenium...
Published by: Digital Commons @ Texas A&M University-San Antonio
Increased Frequency of CD4+ Follicular Helper T and CD8+ Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis.
Dornatien Chuo Anang, Tamara H Ramwadhdoebe, Janine S Hähnlein, Bo van Kuijk, Noortje Smits, Krijn P van Lienden, Mario Maas, Daniëlle M Gerlag, Paul P Tak, Niek de Vries, Lisa GM van Baarsen
May 13, 2022
Follicular T helper cells (Tfh cells) provide key B-cell help and are essential in germinal center formation and (auto) antibody generation. To gain more insight into their role during the earliest phase of rheumatoid arthritis...
Validated imaging biomarkers as decision-making tools in clinical trials and routine practice
Nandita M deSouza, Eric Achten, Angel Alberich-Bayarri, Fabian Bamberg, Ronald Boellaard, Olivier Clément, Laure Fournier, Ferdia Gallagher, Xavier Golay, Claus Peter Heussel, Edward F Jackson, Rashindra Manniesing, Marius E Mayerhofer, Emanuele Neri, James O'Connor, Kader Karli Oguz, Anders Persson, Marion Smits, Edwin JR van Beek, Christoph J Zech, European Society of Radiology
Oct 11, 2019
Observer-driven pattern recognition is the standard for interpretation of medical images. To achieve global parity in interpretation, semi-quantitative scoring systems have been developed based on observer assessments; these are...
The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules
W Zhang, A Aubert, JM Gomez de Segura, M Karuppasamy, S Basu, A Murthy, A Diamante, TA Drury, J Balmer, J Cramard, AA Watson, D Lando, SF Lee, M Palayret, S Kloet, A Smits, M Deery, M Vermeulen, B Hendrich, D Klenerman, C Schaffitzel, I Berger, ED Laue
Apr 20, 2017
Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset.
Nancy J Newman, Patrick Yu-Wai-Man, Valerio Carelli, Mark L Moster, Valerie Biousse, Catherine Vignal-Clermont, Robert C Sergott, Thomas Klopstock, Alfredo A Sadun, Piero Barboni, Adam A DeBusk, Jean François Girmens, Günther Rudolph, Rustum Karanjia, Magali Taiel, Laure Blouin, Gerard Smits, Barrett Katz, José-Alain Sahel, LHON Study Group
Apr 15, 2021
PURPOSE: To evaluate the efficacy of a single intravitreal injection of rAAV2/2-ND4 in subjects with visual loss from Leber hereditary optic neuropathy (LHON). DESIGN: RESCUE is a multicenter, randomized, double-masked...
Humphrey visual field perimetry Leber hereditary optic neuropathy Phase 3 randomized double-masked clinical trial Quality of life best-corrected visual acuity bilateral visual improvement Contrast Sensitivity EFFICACY intravitreal gene therapy retinal anatomic measures Safety Adolescent Adult Aged DNA Mitochondrial Dependovirus Double-Blind Method Electroretinography Female Follow-Up Studies Genetic Therapy Genetic Vectors Humans Intravitreal Injections Male Middle Aged Mutation Optic Atrophy Hereditary Leber Quality of life Time Factors Treatment Outcome Visual Acuity Visual Field Tests Visual Fields Young Adult
Community-led comparative genomic and phenotypic analysis of the aquaculture pathogen Pseudomonas baetica a390T sequenced by Ion semiconductor and Nanopore technologies.
Ainsley Beaton, Cédric Lood, Edward Cunningham-Oakes, Alison MacFadyen, Alex J Mullins, Walid El Bestawy, João Botelho, Sylvie Chevalier, Shannon Coleman, Chloe Dalzell, Stephen K Dolan, Alberto Faccenda, Maarten GK Ghequire, Steven Higgins, Alexander Kutschera, Jordan Murray, Martha Redway, Talal Salih, Ana C da Silva, Brian A Smith, Nathan Smits, Ryan Thomson, Stuart Woodcock, Martin Welch, Pierre Cornelis, Rob Lavigne, Vera van Noort, Nicholas P Tucker
Sep 20, 2018
Pseudomonas baetica strain a390T is the type strain of this recently described species and here we present its high-contiguity draft genome. To celebrate the 16th International Conference on Pseudomonas, the genome of P. baetica...
Development of an intervention to expedite cancer diagnosis through primary care
Marian Andrei Stanciu, Rebecca-Jane Law, Sadia Nafees, Maggie Hendry, Seow Tien Yeo, Julia Hiscock, Ruth Lewis, Rhiannon T Edwards, Nefyn H Williams, Katherine Brain, Paul Brocklehurst, Andrew Carson-Stevens, Sunil Dolwani, Jon Emery, William Hamilton, Zoe Hoare, Georgios Lyratzopoulos, Greg Rubin, Stephanie Smits, Peter Vedsted, Fiona Walter, Clare Wilkinson, Richard D Neal, WICKED Team on behalf of
Jan 08, 2019
BACKGROUND: GPs can play an important role in achieving earlier cancer diagnosis to improve patient outcomes, for example through prompt use of the urgent suspected cancer referral pathway. Barriers to early diagnosis include...
What is influencing the phenotype of the common homozygous polymerase-γ mutation p.Ala467Thr?
Vivienne CM Neeve, David C Samuels, Laurence A Bindoff, Bianca van den Bosch, Gert Van Goethem, Hubert Smeets, Anne Lombès, Claude Jardel, Michio Hirano, Salvatore DiMauro, Maaike De Vries, Jan Smeitink, Bart W Smits, Ireneus FM de Coo, Carsten Saft, Thomas Klopstock, Bianca-Cortina Keiling, Birgit Czermin, Angela Abicht, Hanns Lochmüller, Gavin Hudson, Grainne G Gorman, Doug M Turnbull, Robert W Taylor, Elke Holinski-Feder, Patrick F Chinnery, Rita Horvath
Mar 07, 2019
Polymerase-γ (POLG) is a major human disease gene and may account for up to 25% of all mitochondrial diseases in the UK and in Italy. To date, >150 different pathogenic mutations have been described in POLG. Some mutations...
Adolescent Adult Age of Onset Alanine Child Cohort Studies DNA Mutational Analysis DNA Polymerase gamma DNA-Directed DNA Polymerase Diffuse Cerebral Sclerosis of Schilder Europe Family Health Female Genetic Predisposition to Disease Homozygote Humans Male Middle Aged Mitochondrial Diseases Muscle Skeletal Mutation Ophthalmoplegia Chronic Progressive External Statistics as Topic statistics Nonparametric Threonine Young Adult
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