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Results: 58
Rapid genome editing by CRISPR-Cas9-POLD3 fusion
Ganna Reint, Zhuokun Li, Kornel Labun, Salla Keskitalo, Inkeri Soppa, Katariina Mamia, Eero Tolo, Monika Szymanska, Leonardo A Meza-Zepeda, Susanne Lorenz, Artur Cieslar-Pobuda, Xian Hu, Diana L Bordin, Judith Staerk, Eivind Valen, Bernhard Schmierer, Markku Varjosalo, Jussi Taipale, Emma Haapaniemi
Jan 28, 2022
Rapid genome editing by CRISPR-Cas9-POLD3 fusion.
Ganna Reint, Zhuokun Li, Kornel Labun, Salla Keskitalo, Inkeri Soppa, Katariina Mamia, Eero Tolo, Monika Szymanska, Leonardo A Meza-Zepeda, Susanne Lorenz, Artur Cieslar-Pobuda, Xian Hu, Diana L Bordin, Judith Staerk, Eivind Valen, Bernhard Schmierer, Markku Varjosalo, Jussi Taipale, Emma Haapaniemi
Jan 28, 2022
Domain decomposition preconditioning for high-frequency Helmholtz problems with absorption
In this paper we give new results on domain decomposition preconditioners for GMRES when computing piecewise-linear finite-element approximations} of the Helmholtz equation $-\Delta u - (k^2+ \ri \eps)u = f$, with absorption...
Domain decomposition preconditioning for high-frequency Helmholtz problems with absorption
In this paper we give new results on domain decomposition preconditioners for GMRES when computing piecewise-linear finite-element approximations} of the Helmholtz equation $-\Delta u - (k^2+ \ri \eps)u = f$, with absorption...
Petascale solvers for anisotropic PDEs in atmospheric modelling on GPU clusters
Memory bound applications such as solvers for large sparse systems of equations remain a challenge for GPUs. Fast solvers should be based on numerically efficient algorithms and implemented such that global memory access is...
Placing strategy discourse in context
There has been increasing interest in the discursive aspects of strategy over the last two decades. In this paper we review the existing literature, focusing on six major bodies of discursive scholarship: post‐structural...
Petascale solvers for anisotropic PDEs in atmospheric modelling on GPU clusters
Memory bound applications such as solvers for large sparse systems of equations remain a challenge for GPUs. Fast solvers should be based on numerically efficient algorithms and implemented such that global memory access is...
Placing strategy discourse in context
There has been increasing interest in the discursive aspects of strategy over the last two decades. In this paper we review the existing literature, focusing on six major bodies of discursive scholarship: post‐structural...
Longitudinal associations of physical activity, sedentary time, and cardiorespiratory fitness with arterial health in children - the PANIC study.
Marika Korhonen, Juuso Väistö, Aapo Veijalainen, Marja Leppänen, Ulf Ekelund, Jari A Laukkanen, Soren Brage, Niina Lintu, Eero A Haapala, Timo A Lakka
May 03, 2021
We investigated the longitudinal associations of physical activity (PA), sedentary time (ST), and cardiorespiratory fitness (CRF) with arterial health among children. In our primary analyses, we investigated 245 children (girls...
An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women.
Tiina Karppanen, Tea Kaartokallio, Miira M Klemetti, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Anne Cathrine Staff, Hannele Laivuori
Sep 29, 2016
BACKGROUND: Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3' UTR polymorphism of the Regulator of...
Candidate gene study Preeclampsia Pregnancy Regulator of G-protein signaling 2 3' Untranslated Regions Adult Alleles Biomarkers Body Mass Index Case-Control Studies Female Gene Expression Regulation Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Models Biological Odds Ratio Overweight Polymorphism Single Nucleotide pre-eclampsia Pregnancy RGS Proteins Risk Factors
Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children
Eero A Haapala, Petri Wiklund, Niina Lintu, Tuomo Tompuri, Juuso Väistö, Taija Finni, Ina M Tarkka, Titta Kemppainen, Alan R Barker, Ulf Ekelund, Soren Brage, Timo A Lakka
Dec 03, 2019
Adiposity, physical activity and neuromuscular performance in children.
Eero A Haapala, Juuso Väistö, Niina Lintu, Tuomo Tompuri, Soren Brage, Kate Westgate, Ulf Ekelund, Eeva-Kaarina Lampinen, Arja Sääkslahti, Virpi Lindi, Timo A Lakka
Jan 13, 2016
Adiposity DXA children physical activity Physical Fitness Absorptiometry Photon Adipose Tissue Adiposity Body Mass Index Child Exercise Exercise Test Hand Strength Humans Male Motor Skills Movement Muscle Strength Muscle Skeletal obesity Physical Fitness Postural Balance Running Surveys and Questionnaires
Associations of physical activity, sedentary time, and cardiorespiratory fitness with heart rate variability in 6- to 9-year-old children
Aapo Veijalainen, Eero A. Haapala, Juuso Väistö, Marja H. Leppänen, Niina Lintu, Tuomo Tompuri, Santeri Seppälä, Ulf Ekelund, Mika P. Tarvainen, Kate Westgate, Søren Brage, Timo A. Lakka
Sep 17, 2020
Abstract: Purpose: To study the associations of physical activity (PA), sedentary time (ST), and cardiorespiratory fitness (CRF) with heart rate variability (HRV) in children. Methods: The participants were a population sample...
Associations of Objectively Measured Physical Activity and Sedentary Time With Arterial Stiffness in Pre-Pubertal Children.
Eero A Haapala, Juuso Väistö, Aapo Veijalainen, Niina Lintu, Petri Wiklund, Kate Westgate, Ulf Ekelund, Virpi Lindi, Soren Brage, Timo A Lakka
Jan 17, 2017
Cross-Sectional Associations of Objectively-Measured Physical Activity and Sedentary Time with Body Composition and Cardiorespiratory Fitness in Mid-Childhood
Paul J Collings, Kate Westgate, Juuso Väistö, Katrien Wijndaele, Andrew J Atkin, Eero A Haapala, Niina Lintu, Tomi Laitinen, Ulf Ekelund, Soren Brage, Timo A Lakka
Sep 19, 2016
Associations of physical activity, sedentary time, and cardiorespiratory fitness with heart rate variability in 6- to 9-year-old children
Aapo Veijalainen, Eero A Haapala, Juuso Väistö, Marja H Leppänen, Niina Lintu, Tuomo Tompuri, Santeri Seppälä, Ulf Ekelund, Mika P Tarvainen, Kate Westgate, Søren Brage, Timo A Lakka
Sep 13, 2019
Longitudinal and cross-sectional associations of adherence to 24-hour movement guidelines with cardiometabolic risk.
Marja H Leppänen, Eero A Haapala, Juuso Väistö, Ulf Ekelund, Søren Brage, Tuomas O Kilpeläinen, Timo A Lakka
Nov 12, 2021
This study aimed to examine (1) adherence to 24 h movement guidelines over a 2 years follow-up in children aged 6-8 years and (2) association of this adherence with cardiometabolic risk factors. Physical activity and sleep were...
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children
Timo A Lakka, Niina Lintu, Juuso Väistö, Anna Viitasalo, Taisa Sallinen, Eero A Haapala, Tuomo T Tompuri, Sonja Soininen, Panu Karjalainen, Theresia M Schnurr, Santtu Mikkonen, Mustafa Atalay, Tuomas O Kilpeläinen, Tomi Laitinen, David E Laaksonen, Kai Savonen, Soren Brage, Ursula Schwab, Jarmo Jääskeläinen, Virpi Lindi, Aino-Maija Eloranta
Oct 29, 2020
AIMS/HYPOTHESIS: We studied for the first time the long-term effects of a combined physical activity and dietary intervention on insulin resistance and fasting plasma glucose in a general population of predominantly...
The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children
Annie M Constable, Josie E Porter, Danielle Benger, Dimitris Vlachopoulos, Alan R Barker, Sarah A Moore, Sonja Soininen, Eero A Haapala, Kate Westgate, Soren Brage, Ricardo R Agostinete, Romulo A Fernandes, Timo A Lakka
Jun 07, 2021
PURPOSE: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of...
Longitudinal associations of physical activity and sedentary time with cardiometabolic risk factors in children.
Juuso Väistö, Eero A Haapala, Anna Viitasalo, Theresia M Schnurr, Tuomas O Kilpeläinen, Panu Karjalainen, Kate Westgate, Hanna-Maaria Lakka, David E Laaksonen, Ulf Ekelund, Søren Brage, Timo A Lakka
Nov 22, 2018
BACKGROUND: There are few prospective studies on the associations of changes in objectively measured vigorous physical activity (VPA∆ ), moderate-to-vigorous physical activity (MVPA∆ ), light physical activity (LPA∆ ), and...
Physical activity volume and intensity distribution in relation to bone, lean and fat mass in children.
Annie M Skinner, Dimitris Vlachopoulos, Alan R Barker, Sarah A Moore, Alex V Rowlands, Sonja Soininen, Eero A Haapala, Juuso Väistö, Kate Westgate, Soren Brage, Timo A Lakka
Nov 17, 2022
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children
Timo A. Lakka, Niina Lintu, Juuso Väistö, Anna Viitasalo, Taisa Sallinen, Eero A. Haapala, Tuomo T. Tompuri, Sonja Soininen, Panu Karjalainen, Theresia M. Schnurr, Santtu Mikkonen, Mustafa Atalay, Tuomas O. Kilpeläinen, Tomi Laitinen, David E. Laaksonen, Kai Savonen, Soren Brage, Ursula Schwab, Jarmo Jääskeläinen, Virpi Lindi, Aino-Maija Eloranta
Aug 26, 2021
The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children
Annie M Constable, Josie E Porter, Danielle Benger, Dimitris Vlachopoulos, Alan R Barker, Sarah A Moore, Sonja Soininen, Eero A Haapala, Kate Westgate, Soren Brage, Ricardo R Agostinete, Romulo A Fernandes, Timo A Lakka
Jul 07, 2021
Purpose
Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The...
Satellite Observations for Detecting and Forecasting Sea-Ice Conditions
The detection, monitoring, and forecasting of sea-ice conditions, including their extremes, is very important for ship navigation and offshore activities, and for monitoring of sea-ice processes and trends. We summarize...
Marko Mäkynen, Jari Haapala, Giuseppe Aulicino, Beena Balan-Sarojini, Magdalena Balmaseda, Alexandru Gegiuc, Fanny Girard-Ardhuin, Stefan Hendricks, Georg Heygster, Larysa Istomina, Lars Kaleschke, Juha Karvonen, Thomas Krumpen, Mikko Lensu, Michael Mayer, Flavio Parmiggiani, Robert Ricker, Eero Rinne, Amelie Schmitt, Markku Similä, Steffen Tietsche, Rasmus Tonboe, Peter Wadhams, Mai Winstrup, Hao Zuo
Apr 11, 2020
The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children
Annie M. Constable, Josie E. Porter, Danielle Benger, Dimitris Vlachopoulos, Alan R. Barker, Sarah A. Moore, Sonja Soininen, Eero A. Haapala, Kate Westgate, Soren Brage, Ricardo R. Agostinete, Romulo A. Fernandes, Timo A. Lakka
May 20, 2021
Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of...
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