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Survey of the Library, 1950
Elenor Pasmik
Jan 01, 0001
Survey of the library of the Rockefeller Institute for Medical Research, 1950
Presented to the School of Library Service of Columbia University in partial requirement for the Degree of Master of Science by Elenor Emilia...
Published by: Rockefeller University
Clinical and cost-effectiveness of cognitive behaviour therapy for health anxiety in medical patients
Clinical and cost-effectiveness of cognitive behaviour therapy for health anxiety in medical patients
Anterior expansion and posterior addition to the notochord mechanically coordinate zebrafish embryo axis elongation.
How force generated by the morphogenesis of one tissue impacts the morphogenesis of other tissues to achieve an elongated embryo axis is not well understood. The notochord runs along the length of the somitic compartment and is...
Measuring the effects of fractionated radiation therapy in a 3D prostate cancer model system using SERS nanosensors.
Victoria L Camus, Grant D Stewart, William H Nailon, Duncan B McLaren, Colin J Campbell
Sep 05, 2016
Quantification of very low-abundant proteins in bacteria using the HaloTag and epi-fluorescence microscopy.
Alessia Lepore, Hannah Taylor, Dirk Landgraf, Burak Okumus, Sebastián Jaramillo-Riveri, Lorna McLaren, Somenath Bakshi, Johan Paulsson, M El Karoui
Aug 19, 2019
Cell biology is increasingly dependent on quantitative methods resulting in the need for microscopic labelling technologies that are highly sensitive and specific. Whilst the use of fluorescent proteins has led to major...
Targeted SERS nanosensors measure physicochemical gradients and free energy changes in live 3D tumor spheroids.
Lauren E Jamieson, Victoria L Camus, Pierre O Bagnaninchi, Kate M Fisher, Grant D Stewart, William H Nailon, Duncan B McLaren, David J Harrison, Colin J Campbell
Oct 26, 2016
Insights into the influence of solvent polarity on the crystallization of poly(ethylene oxide) spin-coated thin films via <i>in situ</i> grazing incidence wide-angle X-ray scattering
Daniel T W Toolan, Anna Isakova, Richard Hodgkinson, Nik Reeves-McLaren, Oliver S. Hammond, Karen J. Edler, Wuge H. Briscoe, Thomas Arnold, Tim Gough, Paul D. Topham, Jonathan R. Howse
Jun 28, 2016
Controlling polymer thin-film morphology and crystallinity is crucial for a wide range of applications, particularly in thin-film organic electronic devices. In this work, the crystallization behavior of a model polymer...
Predicting radiotherapy-induced xerostomia in head and neck cancer patients using day-to-day kinetics of radiomics features.
Thomas Berger, David J Noble, Leila EA Shelley, Thomas McMullan, Amy Bates, Simon Thomas, Linda J Carruthers, George Beckett, Aileen Duffton, Claire Paterson, Raj Jena, Duncan B McLaren, Neil G Burnet, William H Nailon
Dec 18, 2022
BACKGROUND AND PURPOSE: The images acquired during radiotherapy for image-guidance purposes could be used to monitor patient-specific response to irradiation and improve treatment personalisation. We investigated whether the...
Flexible and scalable diagnostic filtering of genomic variants using G2P with Ensembl VEP.
Anja Thormann, Mihail Halachev, William McLaren, David J Moore, Victoria Svinti, Archie Campbell, Shona M Kerr, Marc Tischkowitz, Sarah E Hunt, Malcolm G Dunlop, Matthew E Hurles, Caroline F Wright, Helen V Firth, Fiona Cunningham, David R FitzPatrick
Feb 07, 2020
We aimed to develop an efficient, flexible and scalable approach to diagnostic genome-wide sequence analysis of genetically heterogeneous clinical presentations. Here we present G2P ( www.ebi.ac.uk/gene2phenotype ) as an online...
Insights into the influence of solvent polarity on the crystallization of poly(ethylene oxide) spin-coated thin films via <i>in situ</i> grazing incidence wide-angle X-ray scattering
Daniel T W Toolan, Anna Isakova, Richard Hodgkinson, Nik Reeves-McLaren, Oliver S. Hammond, Karen J. Edler, Wuge H. Briscoe, Thomas Arnold, Tim Gough, Paul D. Topham, Jonathan R. Howse
Jun 28, 2016
Controlling polymer thin-film morphology and crystallinity is crucial for a wide range of applications, particularly in thin-film organic electronic devices. In this work, the crystallization behavior of a model polymer...
Disease-associated XMRV sequences are consistent with laboratory contamination.
Stéphane Hué, Eleanor R Gray, Astrid Gall, Aris Katzourakis, Choon Ping Tan, Charlotte J Houldcroft, Stuart McLaren, Deenan Pillay, Andrew Futreal, Jeremy A Garson, Oliver G Pybus, Paul Kellam, Greg J Towers
Oct 03, 2018
BACKGROUND: Xenotropic murine leukaemia viruses (MLV-X) are endogenous gammaretroviruses that infect cells from many species, including humans. Xenotropic murine leukaemia virus-related virus (XMRV) is a retrovirus that has been...
FlyMine
Rachel Lyne, Richard Smith, Kim Rutherford, Matthew Wakeling, Andrew Varley, Francois Guillier, Hilde Janssens, Wenyan Ji, Peter Mclaren, Philip North, Debashis Rana, Tom Riley, Julie Sullivan, Xavier Watkins, Mark Woodbridge, Kathryn Lilley, Steve Russell, Michael Ashburner, Kenji Mizuguchi, Gos Micklem
Mar 27, 2020
FlyMine is a data warehouse that addresses one of the important challenges of modern biology: how to integrate and make use of the diversity and volume of current biological data. Its main focus is genomic and proteomics data...
Published by: Genome Biol
Genetic map of regional sulcal morphology in the human brain from UK biobank data.
Benjamin B Sun, Stephanie J Loomis, Fabrizio Pizzagalli, Natalia Shatokhina, Jodie N Painter, Christopher N Foley, Biogen Biobank Team, Megan E Jensen, Donald G McLaren, Sai Spandana Chintapalli, Alyssa H Zhu, Daniel Dixon, Tasfiya Islam, Iyad Ba Gari, Heiko Runz, Sarah E Medland, Paul M Thompson, Neda Jahanshad, Christopher D Whelan
Nov 16, 2022
Genetic associations with macroscopic brain structure can provide insights into brain function and disease. However, specific associations with measures of local brain folding are largely under-explored. Here, we conducted...
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.
Niccolo Bolli, Hervé Avet-Loiseau, David C Wedge, Peter Van Loo, Ludmil B Alexandrov, Inigo Martincorena, Kevin J Dawson, Francesco Iorio, Serena Nik-Zainal, Graham R Bignell, Jonathan W Hinton, Yilong Li, Jose MC Tubio, Stuart McLaren, Sarah O' Meara, Adam P Butler, Jon W Teague, Laura Mudie, Elizabeth Anderson, Naim Rashid, Yu-Tzu Tai, Masood A Shammas, Adam S Sperling, Mariateresa Fulciniti, Paul G Richardson, Giovanni Parmigiani, Florence Magrangeas, Stephane Minvielle, Philippe Moreau, Michel Attal, Thierry Facon, P Andrew Futreal, Kenneth C Anderson, Peter J Campbell, Nikhil C Munshi
Nov 29, 2018
Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number profiling and cytogenetics to analyse 84 myeloma samples....
Adult Aged Antigens Nuclear Cohort Studies DNA Copy Number Variations Early Growth Response Protein 1 evolution Molecular Exome GTP Phosphohydrolases Genetic Heterogeneity Humans Lymphotoxin-beta Membrane Proteins Middle Aged multiple myeloma Mutation Mutation Missense Nerve Tissue Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins B-raf Proto-Oncogene Proteins p21(ras) Receptors Immunologic Sequence Analysis DNA Transcription Factors Tumor Suppressor Protein p53 ras Proteins
Genetic map of regional sulcal morphology in the human brain from UK biobank data.
Benjamin B Sun, Stephanie J Loomis, Fabrizio Pizzagalli, Natalia Shatokhina, Jodie N Painter, Christopher N Foley, Biogen Biobank Team, Megan E Jensen, Donald G McLaren, Sai Spandana Chintapalli, Alyssa H Zhu, Daniel Dixon, Tasfiya Islam, Iyad Ba Gari, Heiko Runz, Sarah E Medland, Paul M Thompson, Neda Jahanshad, Christopher D Whelan
Oct 14, 2022
Genetic associations with macroscopic brain structure can provide insights into brain function and disease. However, specific associations with measures of local brain folding are largely under-explored. Here, we conducted...
Nitrate radicals and biogenic volatile organic compounds
N Lee Ng, SS Brown, AT Archibald, E Atlas, RC Cohen, JN Crowley, DA Day, NM Donahue, JL Fry, H Fuchs, RJ Griffin, MI Guzman, H Herrmann, A Hodzic, Y Iinuma, A Kiendler-Scharr, BH Lee, DJ Luecken, J Mao, R McLaren, A Mutzel, HD Osthoff, B Ouyang, B Picquet-Varrault, U Platt, HOT Pye, Y Rudich, RH Schwantes, M Shiraiwa, J Stutz, JA Thornton, A Tilgner, BJ Williams, RA Zaveri
Mar 27, 2017
Eligibility for clinical trials in primary Sjögren's syndrome
Clare Oni, Sheryl Mitchell, Katherine James, Wan-Fai Ng, Bridget Griffiths, Victoria Hindmarsh, Elizabeth Price, Colin T Pease, Paul Emery, Peter Lanyon, Adrian Jones, Michele Bombardieri, Nurhan Sutcliffe, Costantino Pitzalis, John Hunter, Monica Gupta, John McLaren, Annie Cooper, Marian Regan, Ian Giles, David Isenberg, Vadivelu Saravanan, David Coady, Bhaskar DasGupta, Neil McHugh, Steven Young-Min, Robert Moots, Nagui Gendi, Mohammed Akil, Francesca Barone, Ben Fisher, Saaeha Rauz, Andrea Richards, Simon J Bowman
Mar 01, 2016
OBJECTIVE: To identify numbers of participants in the UK Primary Sjögren's Syndrome Registry (UKPSSR) who would fulfil eligibility criteria for previous/current or potential clinical trials in primary SS (pSS) in order to...
Eligibility for clinical trials in primary Sjögren's syndrome
Clare Oni, Sheryl Mitchell, Katherine James, Wan-Fai Ng, Bridget Griffiths, Victoria Hindmarsh, Elizabeth Price, Colin T Pease, Paul Emery, Peter Lanyon, Adrian Jones, Michele Bombardieri, Nurhan Sutcliffe, Costantino Pitzalis, John Hunter, Monica Gupta, John McLaren, Annie Cooper, Marian Regan, Ian Giles, David Isenberg, Vadivelu Saravanan, David Coady, Bhaskar DasGupta, Neil McHugh, Steven Young-Min, Robert Moots, Nagui Gendi, Mohammed Akil, Francesca Barone, Ben Fisher, Saaeha Rauz, Andrea Richards, Simon J Bowman
Mar 01, 2016
OBJECTIVE: To identify numbers of participants in the UK Primary Sjögren's Syndrome Registry (UKPSSR) who would fulfil eligibility criteria for previous/current or potential clinical trials in primary SS (pSS) in order to...
Evaluating the Impact of Functional Genetic Variation on HIV-1 Control.
Paul J McLaren, Sara L Pulit, Deepti Gurdasani, Istvan Bartha, Patrick R Shea, Cristina Pomilla, Namrata Gupta, Effrossyni Gkrania-Klotsas, Elizabeth H Young, Norbert Bannert, Julia Del Amo, M John Gill, Jill Gilmour, Paul Kellam, Anthony D Kelleher, Anders Sönnerborg, Robert Zangerle, Frank A Post, Martin Fisher, David W Haas, Bruce D Walker, Kholoud Porter, David B Goldstein, Manjinder S Sandhu, Paul IW de Bakker, Jacques Fellay
Apr 05, 2019
Background: Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. Methods: We sought to...
HIV host dependency factors HIV-1 control HIV-1 progression Exome Sequencing host genetics of infection Adult Female Genetic Predisposition to Disease genetic variation Genotype HIV Infections HIV-1 Host-Pathogen Interactions Humans Male Middle Aged Polymorphism Single Nucleotide Viral Load Whole exome sequencing
A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.
Alejandra Bruna, Oscar M Rueda, Wendy Greenwood, Ankita Sati Batra, Maurizio Callari, Rajbir Nath Batra, Katherine Pogrebniak, Jose Sandoval, John W Cassidy, Ana Tufegdzic-Vidakovic, Stephen-John Sammut, Linda Jones, Elena Provenzano, Richard Baird, Peter Eirew, James Hadfield, Matthew Eldridge, Anne McLaren-Douglas, Andrew Barthorpe, Howard Lightfoot, Mark J O'Connor, Joe Gray, Javier Cortes, Jose Baselga, Elisabetta Marangoni, Alana L Welm, Samuel Aparicio, Violeta Serra, Mathew J Garnett, Carlos Caldas
Oct 21, 2016
Subclonal diversification of primary breast cancer revealed by multiregion sequencing.
Lucy R Yates, Moritz Gerstung, Stian Knappskog, Christine Desmedt, Gunes Gundem, Peter Van Loo, Turid Aas, Ludmil B Alexandrov, Denis Larsimont, Helen Davies, Yilong Li, Young Seok Ju, Manasa Ramakrishna, Hans Kristian Haugland, Peer Kaare Lilleng, Serena Nik-Zainal, Stuart McLaren, Adam Butler, Sancha Martin, Dominic Glodzik, Andrew Menzies, Keiran Raine, Jonathan Hinton, David Jones, Laura J Mudie, Bing Jiang, Delphine Vincent, April Greene-Colozzi, Pierre-Yves Adnet, Aquila Fatima, Marion Maetens, Michail Ignatiadis, Michael R Stratton, Christos Sotiriou, Andrea L Richardson, Per Eystein Lønning, David C Wedge, Peter J Campbell
Nov 01, 2018
The sequencing of cancer genomes may enable tailoring of therapeutics to the underlying biological abnormalities driving a particular patient's tumor. However, sequencing-based strategies rely heavily on representative sampling...
Mutational processes molding the genomes of 21 breast cancers.
Serena Nik-Zainal, Ludmil B Alexandrov, David C Wedge, Peter Van Loo, Christopher D Greenman, Keiran Raine, David Jones, Jonathan Hinton, John Marshall, Lucy A Stebbings, Andrew Menzies, Sancha Martin, Kenric Leung, Lina Chen, Catherine Leroy, Manasa Ramakrishna, Richard Rance, King Wai Lau, Laura J Mudie, Ignacio Varela, David J McBride, Graham R Bignell, Susanna L Cooke, Adam Shlien, John Gamble, Ian Whitmore, Mark Maddison, Patrick S Tarpey, Helen R Davies, Elli Papaemmanuil, Philip J Stephens, Stuart McLaren, Adam P Butler, Jon W Teague, Göran Jönsson, Judy E Garber, Daniel Silver, Penelope Miron, Aquila Fatima, Sandrine Boyault, Anita Langerød, Andrew Tutt, John WM Martens, Samuel AJR Aparicio, Åke Borg, Anne Vincent Salomon, GIlles Thomas, Anne-Lise Børresen-Dale, Andrea L Richardson, Michael S Neuberger, P Andrew Futreal, Peter J Campbell, Michael R Stratton, Breast Cancer Working Group of the International Cancer Genome Consortium
Aug 27, 2020
All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the DNA damage and repair processes to which cancer cells and their precursors have been exposed. To explore these mechanisms further, we...
The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.
Jennifer Yen, Richard M White, David C Wedge, Peter Van Loo, Jeroen de Ridder, Amy Capper, Jennifer Richardson, David Jones, Keiran Raine, Ian R Watson, Chang-Jiun Wu, Jiqiu Cheng, Iñigo Martincorena, Serena Nik-Zainal, Laura Mudie, Yves Moreau, John Marshall, Manasa Ramakrishna, Patrick Tarpey, Adam Shlien, Ian Whitmore, Steve Gamble, Calli Latimer, Erin Langdon, Charles Kaufman, Mike Dovey, Alison Taylor, Andy Menzies, Stuart McLaren, Sarah O'Meara, Adam Butler, Jon Teague, James Lister, Lynda Chin, Peter Campbell, David J Adams, Leonard I Zon, E Elizabeth Patton, Derek L Stemple, P Andy Futreal
Nov 29, 2018
BACKGROUND: Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. Even...
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