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Results: 97
The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.
Eleonora Khabirova, Aileen Moloney, Stefan J Marciniak, Julie Williams, David A Lomas, Stephen G Oliver, Giorgio Favrin, David B Sattelle, Damian C Crowther
May 18, 2018
The human Aβ peptide causes progressive paralysis when expressed in the muscles of the nematode worm, C. elegans. We have exploited this model of Aβ toxicity by carrying out an RNAi screen to identify genes whose reduced...
Precise identification of cancer cells from allelic imbalances in single cell transcriptomes.
Mi K Trinh, Clarissa N Pacyna, Gerda Kildisiute, Christine Thevanesan, Alice Piapi, Kirsty Ambridge, Nathaniel D Anderson, Eleonora Khabirova, Elena Prigmore, Karin Straathof, Sam Behjati, Matthew D Young
Sep 07, 2022
A fundamental step of tumour single cell mRNA analysis is separating cancer and non-cancer cells. We show that the common approach to separation, using shifts in average expression, can lead to erroneous biological conclusions....
Precise identification of cancer cells from allelic imbalances in single cell transcriptomes.
Mi K Trinh, Clarissa N Pacyna, Gerda Kildisiute, Christine Thevanesan, Alice Piapi, Kirsty Ambridge, Nathaniel D Anderson, Eleonora Khabirova, Elena Prigmore, Karin Straathof, Sam Behjati, Matthew D Young
Oct 10, 2022
A fundamental step of tumour single cell mRNA analysis is separating cancer and non-cancer cells. We show that the common approach to separation, using shifts in average expression, can lead to erroneous biological conclusions....
Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.
Eleonora Khabirova, Laura Jardine, Tim HH Coorens, Simone Webb, Taryn D Treger, Justin Engelbert, Tarryn Porter, Elena Prigmore, Grace Collord, Alice Piapi, Sarah Teichmann, Sarah Inglott, Owen Williams, Olaf Heidenreich, Matthew D Young, Karin Straathof, Simon Bomken, Jack Bartram, Muzlifah Haniffa, Sam Behjati
Apr 19, 2022
Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours.
Lars Custers, Eleonora Khabirova, Tim HH Coorens, Thomas RW Oliver, Camilla Calandrini, Matthew D Young, Felipe A Vieira Braga, Peter Ellis, Lira Mamanova, Heidi Segers, Arie Maat, Marcel Kool, Eelco W Hoving, Marry M van den Heuvel-Eibrink, James Nicholson, Karin Straathof, Liz Hook, Ronald R de Krijger, Claire Trayers, Kieren Allinson, Sam Behjati, Jarno Drost
Apr 26, 2021
Malignant rhabdoid tumour (MRT) is an often lethal childhood cancer that, like many paediatric tumours, is thought to arise from aberrant fetal development. The embryonic root and differentiation pathways underpinning MRT are...
Cell Differentiation DNA Methylation Drug Screening Assays Antitumor Gene Expression Profiling Gene Expression Regulation Neoplastic Histone Deacetylase Inhibitors Humans Mutation Neural Crest Phylogeny Rhabdoid Tumor SMARCB1 Protein Single-Cell Analysis TOR Serine-Threonine Kinases Tissue Culture Techniques
Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.
Eleonora Khabirova, Laura Jardine, Tim HH Coorens, Simone Webb, Taryn D Treger, Justin Engelbert, Tarryn Porter, Elena Prigmore, Grace Collord, Alice Piapi, Sarah A Teichmann, Sarah Inglott, Owen Williams, Olaf Heidenreich, Matthew D Young, Karin Straathof, Simon Bomken, Jack Bartram, Muzlifah Haniffa, Sam Behjati
Apr 20, 2022
The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies
Eleonora Market
Jan 01, 0001
Activation-induced cytidine deaminase (AID) is indispensable for somatic hypermutation (SHM) and class switch recombination (CSR) in B cells. SHM alters the affinity of an antibody for its corresponding antigen by introducing...
Published by: Rockefeller University
Does Patient Health Behaviour respond to Doctor Effort?
Incentive pay systems have been introduced in public sectors such as education and health care. In these sectors the output (education or health respectively) depends on the actions of different agents and it is unclear what the...
Health behaviours Health care incentives Pay-for-performance /dk/atira/pure/subjectarea/asjc/2000/2002 name=Economics and Econometrics /dk/atira/pure/subjectarea/asjc/1400/1407 name=Organizational Behavior and Human Resource Management /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Can payers use prices to improve quality? Evidence from English hospitals
In most activity-based financing systems, payers set prices reactively based on historical averages of hospital reported costs. If hospitals respond to prices, payers might set prices proactively to affect the volume of...
Autonomous self-healing structural composites with bio-inspired design
Strong and tough natural composites such as bone, silk or nacre are often built from stiff blocks bound together using thin interfacial soft layers that can also provide sacrificial bonds for self-repair. Here we show that it is...
The effect of cash transfers on mental health – New evidence from South Africa
BACKGROUND: Mental health and poverty are strongly interlinked. There is a gap in the literature on the effects of poverty alleviation programmes on mental health. We aim to fill this gap by studying the effect of an...
Cash transfer fixed effects Instrumental variable estimation Mental Health Poverty South Africa /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/sustainabledevelopmentgoals/no_poverty name=SDG 1 - No Poverty /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
Lars Custers, Eleonora Khabirova, Tim H. H. Coorens, Thomas R. W. Oliver, Camilla Calandrini, Matthew D. Young, Felipe A. Vieira Braga, Peter Ellis, Lira Mamanova, Heidi Segers, Arie Maat, Marcel Kool, Eelco W. Hoving, Marry M. van den Heuvel-Eibrink, James Nicholson, Karin Straathof, Liz Hook, Ronald R. de Krijger, Claire Trayers, Kieren Allinson, Sam Behjati, Jarno Drost
Mar 03, 2021
Abstract: Malignant rhabdoid tumour (MRT) is an often lethal childhood cancer that, like many paediatric tumours, is thought to arise from aberrant fetal development. The embryonic root and differentiation pathways underpinning...
Can payers use prices to improve quality? Evidence from English hospitals
In most activity-based financing systems, payers set prices reactively based on historical averages of hospital reported costs. If hospitals respond to prices, payers might set prices proactively to affect the volume of...
Estimating the late-life effects of social and emotional skills in childhood using mid-life mediators
Social and emotional skills are known to affect health and non-health outcomes, but there is limited evidence on whether these skills in childhood affect late life outcomes because of a shortage of long-running datasets...
Protecting Adolescents in Low- And Middle-Income Countries from Interpersonal Violence (PRO YOUTH TRIAL)
Background: Interpersonal violence can significantly reduce adolescents' opportunities for becoming happy and healthy adults. Central America is the most violent region in the world and it is estimated that adolescents are...
adolescence Family skills training programmes interpersonal violence low- and middle-income countries Panama Prevention Strengthening Families Programme 10-14 (SFP 10-14) /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/2700/2736 name=Pharmacology (medical) /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
Joint analysis of gravitational-wave and electromagnetic data of mergers
Giulia Gianfagna, Luigi Piro, Francesco Pannarale, Hendrik Van Eerten, Fulvio Ricci, Geoffrey Ryan, Eleonora Troja
Aug 01, 2023
On 2017 August 17, Advanced LIGO and Virgo observed GW170817, the first gravitational-wave (GW) signal from a binary neutron star merger. It was followed by a short-duration gamma-ray burst, GRB 170817A, and by a non-thermal...
The effect of cash transfers on mental health – New evidence from South Africa
BACKGROUND: Mental health and poverty are strongly interlinked. There is a gap in the literature on the effects of poverty alleviation programmes on mental health. We aim to fill this gap by studying the effect of an...
Cash transfer fixed effects Instrumental variable estimation Mental Health Poverty South Africa /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/sustainabledevelopmentgoals/no_poverty name=SDG 1 - No Poverty /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Does Patient Health Behaviour respond to Doctor Effort?
Incentive pay systems have been introduced in public sectors such as education and health care. In these sectors the output (education or health respectively) depends on the actions of different agents and it is unclear what the...
Health behaviours Health care incentives Pay-for-performance /dk/atira/pure/subjectarea/asjc/2000/2002 name=Economics and Econometrics /dk/atira/pure/subjectarea/asjc/1400/1407 name=Organizational Behavior and Human Resource Management /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
The effects in-utero exposure to influenza on mental health and mortality risk throughout the life-course.
Studies examining the later-life health consequences of in-utero exposure to influenza have typically estimated effects on physical health conditions, with little evidence of effects on mental health outcomes or mortality....
Protecting Adolescents in Low- And Middle-Income Countries from Interpersonal Violence (PRO YOUTH TRIAL)
Background: Interpersonal violence can significantly reduce adolescents' opportunities for becoming happy and healthy adults. Central America is the most violent region in the world and it is estimated that adolescents are...
adolescence Family skills training programmes interpersonal violence low- and middle-income countries Panama Prevention Strengthening Families Programme 10-14 (SFP 10-14) /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/2700/2736 name=Pharmacology (medical) /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
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