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Results: 146
Identification of host transcriptional networks showing concentration-dependent regulation by HPV16 E6 and E7 proteins in basal cervical squamous epithelial cells.
Progranulin plasma levels predict the presence of GRN mutations in asymptomatic subjects and do not correlate with brain atrophy
Daniela Galimberti, Giorgio G Fumagalli, Chiara Fenoglio, Sara MG Cioffi, Andrea Arighi, Maria Serpente, Barbara Borroni, Alessandro Padovani, Fabrizio Tagliavini, Mario Masellis, Maria Carmela Tartaglia, John van Swieten, Lieke Meeter, Caroline Graff, Alexandre de Mendonça, Martina Bocchetta, Jonathan D Rohrer, Elio Scarpini, Genetic FTD Initiative (GENFI)
May 14, 2018
We investigated whether progranulin plasma levels are predictors of the presence of progranulin gene (GRN) null mutations or of the development of symptoms in asymptomatic at risk members participating in the Genetic...
biomarker brain atrophy frontotemporal dementia (FTD) Plasma levels Progranulin (GRN) Proximity marker Adult Aged Aged 80 and over Atrophy Cohort Studies Female frontotemporal dementia Genetic Association Studies Genetic Testing Gray Matter Heterozygote Humans Intercellular Signaling Peptides and Proteins Male Membrane Proteins Middle Aged Multicenter Studies as Topic Mutation Nerve Tissue Proteins Progranulins Sensitivity and Specificity Young Adult
HPV16 oncogene expression levels during early cervical carcinogenesis are determined by the balance of epigenetic chromatin modifications at the integrated virus genome.
Cell Line Tumor Chromatin Chromatin Assembly and Disassembly Cyclin-Dependent Kinase 9 Epigenesis Genetic Female Gene Expression Regulation Neoplastic Gene Expression Regulation Viral Genome Viral Human papillomavirus 16 Humans Oncogene Proteins Viral Papillomavirus E7 Proteins Repressor Proteins Uterine Cervical Neoplasms Virus Integration
Virus transcript levels and cell growth rates after naturally occurring HPV16 integration events in basal cervical keratinocytes.
Cervical carcinogenesis is characterized by a clonal selection process in which the high-risk human papillomavirus (HRHPV) genome usually changes from the extra-chromosomal (episomal) state seen in productive infections to DNA...
E6/E7 human papillomavirus integration selection Cell Line Cell Proliferation Cell Shape Cell Transformation Viral Cervix Uteri Chromatin Assembly and Disassembly DNA Replication DNA Viral Female Gene Dosage Gene Expression Regulation Viral Genotype Human papillomavirus 16 Humans Keratinocytes Oncogene Proteins Viral Papillomavirus E7 Proteins Papillomavirus Infections Phenotype RNA Messenger RNA Viral Repressor Proteins Time Factors Up-Regulation Uterine Cervical Neoplasms Virus Integration Virus Replication
Tissue transglutaminase mediates the pro-malignant effects of oncostatin M receptor over-expression in cervical squamous cell carcinoma.
Maria M Caffarel, Anasuya Chattopadhyay, Angela M Araujo, Julien Bauer, Cinzia G Scarpini, Nicholas Coleman
Aug 19, 2020
Oncostatin M receptor (OSMR) is commonly over-expressed in advanced cervical squamous cell carcinoma (SCC), producing a significantly worse clinical outcome. Cervical SCC cells that over-express OSMR show enhanced responsiveness...
cell migration Fibronectin integrin-α5β1 invasion oncostatin M receptor squamous cell carcinoma tissue transglutaminase Blotting Western Carcinoma Squamous Cell Female Fibronectins Fluorescent Antibody Technique GTP-Binding Proteins Humans Immunohistochemistry Immunoprecipitation Integrin alpha5beta1 Microscopy Confocal Neoplasm Invasiveness Oligonucleotide Array Sequence Analysis Protein Glutamine gamma Glutamyltransferase 2 Real-Time Polymerase Chain Reaction Receptors Oncostatin M Signal Transduction Tissue Array Analysis Transglutaminases Up-Regulation Uterine Cervical Neoplasms
Lipoprotein lipase is frequently overexpressed or translocated in cervical squamous cell carcinoma and promotes invasiveness through the non-catalytic C terminus.
BACKGROUND: We studied the biological significance of genes involved in a novel t(8;12)(p21.3;p13.31) reciprocal translocation identified in cervical squamous cell carcinoma (SCC) cells. METHODS: The rearranged genes were...
A high-throughput computational framework for identifying significant copy number aberrations from array comparative genomic hybridisation data.
Ian Roberts, Stephanie A Carter, Cinzia Scarpini, Konstantina Karagavriilidou, Jenny CJ Barna, Mark Calleja, Nicholas Coleman
Aug 19, 2020
Published by: Advances in bioinformatics
Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales.
Giorgio G Fumagalli, Paola Basilico, Andrea Arighi, Martina Bocchetta, Katrina M Dick, David M Cash, Sophie Harding, Matteo Mercurio, Chiara Fenoglio, Anna M Pietroboni, Laura Ghezzi, John van Swieten, Barbara Borroni, Alexandre de Mendonça, Mario Masellis, Maria C Tartaglia, James B Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B Frisoni, Robert Laforce, Elizabeth Finger, Sandro Sorbi, Elio Scarpini, Jonathan D Rohrer, Daniela Galimberti, Genetic FTD Initiative (GENFI)
Sep 08, 2018
BACKGROUND: In patients with frontotemporal dementia, it has been shown that brain atrophy occurs earliest in the anterior cingulate, insula and frontal lobes. We used visual rating scales to investigate whether identifying...
Chronic Hepatitis B Virus Infection
Phaedra M Tachtatzis, Aileen Marshall, Aloysious Arvinthan, Suman Verma, Sue Penrhyn-Lowe, Marianna Mela, Cinzia Scarpini, Susan E Davies, Nicholas Coleman, Graeme JM Alexander
Aug 19, 2020
BACKGROUND: Chronic Hepatitis B virus (HBV) infection can lead to the development of chronic hepatitis, cirrhosis and hepatocellular carcinoma. We hypothesized that HBV might accelerate hepatocyte ageing and investigated the...
Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis
Ian J. Groves, Emma L. A. Drane, Marco Michalski, Jack M. Monahan, Cinzia G. Scarpini, Stephen P. Smith, Giovanni Bussotti, Csilla Várnai, Stefan Schoenfelder, Peter Fraser, Anton J. Enright, Nicholas Coleman
Sep 14, 2021
Development of cervical cancer is directly associated with integration of human papillomavirus (HPV) genomes into host chromosomes and subsequent modulation of HPV oncogene expression, which correlates with multi-layered...
Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival.
Justyna A Kucia-Tran, Valtteri Tulkki, Stephen Smith, Cinzia G Scarpini, Katherine Hughes, Angela M Araujo, Ka Yin Matthew Yan, Jan Botthof, Eduardo Pérez-Gómez, Miguel Quintanilla, Kate Cuschieri, Maria M Caffarel, Nicholas Coleman
Jun 23, 2016
STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle.
Ethan L Morgan, Christopher W Wasson, Lucy Hanson, David Kealy, Ieisha Pentland, Victoria McGuire, Cinzia Scarpini, Nicholas Coleman, J Simon C Arthur, Joanna L Parish, Sally Roberts, Andrew Macdonald
Jul 16, 2018
Human papillomaviruses (HPV) activate a number of host factors to control their differentiation-dependent life cycles. The transcription factor signal transducer and activator of transcription (STAT)-3 is important for cell...
Case-Control Studies Cell Differentiation Cells Cultured DNA-Binding Proteins Female Genome Viral Host-Pathogen Interactions Human papillomavirus 18 Humans Keratinocytes Oncogene Proteins Viral Papillomavirus Infections Phosphorylation STAT3 Transcription Factor Squamous Intraepithelial Lesions of the Cervix Uterine Cervical Neoplasms Virus Replication
Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma.
Justyna A Kucia-Tran, Valtteri Tulkki, Cinzia G Scarpini, Stephen Smith, Maja Wallberg, Marta Paez-Ribes, Angela M Araujo, Jan Botthoff, Maria Feeney, Katherine Hughes, Maria M Caffarel, Nicholas Coleman
Feb 13, 2018
The oncostatin M (OSM) receptor (OSMR) shows frequent gene copy number gains and overexpression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes. In SCC cells that overexpress OSMR, the...
STAT3 cervix head and neck metastasis neutralizing antibodies oncostatin M receptor squamous cell carcinoma Animals Antineoplastic Agents Immunological Autocrine Communication Cell Line Tumor Female Gene Expression Regulation Neoplastic Head and Neck Neoplasms Humans Janus Kinase 2 Lung Neoplasms Mice Inbred NOD Mice SCID Oncostatin M Oncostatin M Receptor beta Subunit Phosphorylation STAT3 Transcription Factor Signal Transduction Squamous Cell Carcinoma of Head and Neck Suppressor of Cytokine Signaling 3 Protein Up-Regulation Uterine Cervical Neoplasms Xenograft Model Antitumor Assays
Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis.
Ian J Groves, Emma LA Drane, Marco Michalski, Jack M Monahan, Cinzia G Scarpini, Stephen P Smith, Giovanni Bussotti, Csilla Várnai, Stefan Schoenfelder, Peter Fraser, Anton J Enright, Nicholas Coleman
Oct 26, 2021
Lack of correlation between predicted and actual off-target effects of short-interfering RNAs targeting the human papillomavirus type 16 E7 oncogene.
JE Hanning, HK Saini, MJ Murray, S van Dongen, MPA Davis, EM Barker, DM Ward, CG Scarpini, AJ Enright, MR Pett, N Coleman
Nov 16, 2017
BACKGROUND: When designing therapeutic short-interfering RNAs (siRNAs), off-target effects (OTEs) are usually predicted by computational quantification of messenger RNAs (mRNAs) that contain matches to the siRNA seed sequence in...
Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis.
Ian J Groves, Emma L A Drane, Marco Michalski, Jack M Monahan, Cinzia G Scarpini, Stephen P Smith, Giovanni Bussotti, Csilla Várnai, Stefan Schoenfelder, Peter Fraser, Anton J Enright, Nicholas Coleman
Sep 25, 2021
Development of cervical cancer is directly associated with integration of human papillomavirus (HPV) genomes into host chromosomes and subsequent modulation of HPV oncogene expression, which correlates with multi-layered...
Published by: PLoS pathogens
A Multi-institutional Pooled Analysis Demonstrates That Circulating miR-371a-3p Alone is Sufficient for Testicular Malignant Germ Cell Tumor Diagnosis.
Jin Piao, John T Lafin, Cinzia G Scarpini, Michelle M Nuño, Isabella Syring, Klaus-Peter Dieckmann, Gazanfer Belge, Jörg Ellinger, James F Amatruda, Aditya Bagrodia, Nicholas Coleman, Mark D Krailo, A Lindsay Frazier, Matthew J Murray
Sep 01, 2021
Small non-coding RNA sequencing reveals global dysregulation of piwi-interacting RNA (piRNA) expression in gonadal malignant germ cell tumours.
Sean Laidlaw, Luz Alonso-Crisostomo, Shivani Bailey, Harpreet K Saini, Attila Molnár, James C Nicholson, Anton J Enright, Cinzia G Scarpini, Raheleh Rahbari, Nicholas Coleman, Matthew J Murray, on behalf the Children's Cancer and Leukaemia Group
Oct 26, 2022
Diagnosis of bladder cancer by immunocytochemical detection of minichromosome maintenance protein-2 in cells retrieved from urine.
K Saeb-Parsy, A Wilson, C Scarpini, M Corcoran, S Chilcott, M McKean, B Thottakam, B Rai, G Nabi, D Rana, M Perera, K Stewart, RA Laskey, DE Neal, N Coleman
Aug 19, 2020
BACKGROUND: We tested the accuracy of immunocytochemistry (ICC) for minichromosome maintenance protein-2 (MCM-2) in diagnosing bladder cancer, using cells retrieved from urine. METHODS: Adequate samples were obtained from 497...
Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis—A Multicenter European Prospective Cohort Study (EPIC)
Yunxia Lu, Raul Zamora-Ros, Simon Chan, Amanda J Cross, Heather Ward, Paula Jakszyn, Robert Luben, Jorrit L Opstelten, Bas Oldenburg, Göran Hallmans, Pontus Karling, Olof Grip, Timothy Key, Manuela M Bergmann, Heiner Boeing, Kim Overvad, Domenico Palli, Giovanna Masala, Kay-Tee Khaw, Antoine Racine, Franck Carbonnel, Marie-Christine Boutron-Ruault, Vibeke Andersen, Anja Olsen, Anne Tjonneland, Rudolf Kaaks, Rosario Tumino, Antonia Trichopoulou, Augustin Scalbert, Elio Riboli, Andrew R Hart
Mar 26, 2018
Exploring causality of the association between smoking and Parkinson's disease.
Valentina Gallo, Paolo Vineis, Mariagrazia Cancellieri, Paolo Chiodini, Roger A Barker, Carol Brayne, Neil Pearce, Roel Vermeulen, Salvatore Panico, Bas Bueno-de-Mesquita, Nicola Vanacore, Lars Forsgren, Silvia Ramat, Eva Ardanaz, Larraitz Arriola, Jesper Peterson, Oskar Hansson, Diana Gavrila, Carlotta Sacerdote, Sabina Sieri, Tilman Kühn, Verena A Katzke, Yvonne T van der Schouw, Andreas Kyrozis, Giovanna Masala, Amalia Mattiello, Robert Perneczky, Lefkos Middleton, Rodolfo Saracci, Elio Riboli
Dec 11, 2018
Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.
Lourdes Ortiz-Fernández, Elio G Carmona, Martin Kerick, Paul Lyons, Francisco David Carmona, Raquel López Mejías, Chiea Chuen Khor, Peter C Grayson, Enrico Tombetti, Lindi Jiang, Haner Direskeneli, Guher Saruhan-Direskeneli, José-Luis Callejas-Rubio, Augusto Vaglio, Carlo Salvarani, Jose Hernández-Rodríguez, Maria Cinta Cid, Ann W Morgan, Peter A Merkel, David Burgner, Kenneth GC Smith, Miguel Angel Gonzalez-Gay, Amr H Sawalha, Javier Martin, Ana Marquez
Feb 21, 2023
Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes
Josefin E Löfvenborg, Sofia Carlsson, Tomas Andersson, Christiane S Hampe, Albert Koulman, María Dolores Chirlaque Lopez, Paula Jakszyn, Verena A Katzke, Tilman Kühn, Cecilie Kyrø, Giovanna Masala, Peter M Nilsson, Kim Overvad, Salvatore Panico, Maria-Jose Sánchez, Yvonne van der Schouw, Matthias B Schulze, Anne Tjønneland, Elisabete Weiderpass, Elio Riboli, Nita G Forouhi, Stephen J Sharp, Olov Rolandsson, Nicholas J Wareham
Jan 15, 2021
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