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Interview with David Boone - OH 677
This interview was conducted by Dr. George Garrison with Brother David Boone for his Emmett Scott High School history project. Emmett Scott High School was the segregated high school for African-Americans, which was named after...
Published by: Winthrop University
Evaluation of a worldwide EQA scheme for complex clonality analysis of clinical lymphoproliferative cases demonstrates a learning effect.
Cleo Keppens, Elke Boone, Paula Gameiro, Véronique Tack, Elisabeth Moreau, Elizabeth Hodges, Paul Evans, Monika Brüggemann, Ian Carter, Dido Lenze, Maria Eugenia Sarasquete, Markus Möbs, Hongxiang Liu, Elisabeth MC Dequeker, Patricia JTA Groenen
Aug 14, 2021
Clonality analysis of immunoglobulin (IG) or T-cell receptor (TR) gene rearrangements is routine practice to assist diagnosis of lymphoid malignancies. Participation in external quality assessment (EQA) aids laboratories in...
Clonality analysis external quality assessment IG rearrangements TCR rearrangements Gene Rearrangement Genes Immunoglobulin Genes T-Cell Receptor Humans Laboratory Proficiency Testing Lymphoproliferative Disorders Molecular Diagnostic Techniques Observer Variation Polymerase Chain Reaction Predictive Value of Tests Quality Assurance Health Care Quality Control Reproducibility of Results
Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe.
The Genetics of Pneumothorax.
Philip M Boone, Rachel M Scott, Stefan J Marciniak, Elizabeth P Henske, Benjamin A Raby
Feb 11, 2019
A genetic influence on spontaneous pneumothoraces-those occurring without a traumatic or iatrogenic cause-is supported by several lines of evidence: 1) pneumothorax can cluster in families (i.e., familial spontaneous...
The integrated stress response regulates BMP signalling through effects on translation.
Elke Malzer, Caia S Dominicus, Joseph Chambers, Jennifer Dickens, Souradip Mookerjee, Stefan Marciniak
May 24, 2018
Background: Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family of stress sensing kinases to trigger the integrated stress response (ISR), which has pro-survival and...
Low-Cost Hyperspectral Imaging with A Smartphone.
Mary B Stuart, Andrew JS McGonigle, Matthew Davies, Matthew J Hobbs, Nicholas A Boone, Leigh R Stanger, Chengxi Zhu, Tom D Pering, Jon R Willmott
Aug 11, 2021
Recent advances in smartphone technologies have opened the door to the development of accessible, highly portable sensing tools capable of accurate and reliable data collection in a range of environmental settings. In this...
Pulmonary endoplasmic reticulum stress-scars, smoke, and suffocation.
Protein misfolding within the endoplasmic reticulum (ER stress) can be a cause or consequence of pulmonary disease. Mutation of proteins restricted to the alveolar type II pneumocyte can lead to inherited forms of pulmonary...
Mitochondrial and nuclear disease panel (Mito-aND-Panel)
Angela Abicht, Florentine Scharf, Stephanie Kleinle, Ulrike Schön, Elke Holinski-Feder, Rita Horvath, Anna Benet-Pagès, Isabel Diebold
Mar 07, 2019
BACKGROUND: The diagnosis of mitochondrial disorders is challenging because of the clinical variability and genetic heterogeneity of these conditions. Next-Generation Sequencing (NGS) technology offers a robust high-throughput...
NUMTs heteroplasmy detection high-throughput sequencing mitochondrial and nuclear disease panel mitochondrial disorders mtDNA-server Costs and Cost Analysis DNA Mitochondrial Genetic Testing High-Throughput Nucleotide Sequencing Humans Mitochondrial Diseases Sensitivity and Specificity Sequence Analysis DNA
Familial pneumothorax
Rachel M Scott, Elizabeth P Henske, Benjamin Raby, Philip M Boone, Rosemary A Rusk, Stefan J Marciniak
May 18, 2018
One in 10 patients suffering from primary spontaneous pneumothoraces has a family history of the disorder. Such familial pneumothoraces can occur in isolation, but can also be the presentation of serious genetic disorders with...
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.
Sally E Thomas, Elke Malzer, Adriana Ordóñez, Lucy E Dalton, Emily FA van T Wout, Elizabeth Liniker, Damian C Crowther, David A Lomas, Stefan J Marciniak
Feb 12, 2019
Cell cycle checkpoints ensure that proliferation occurs only under permissive conditions, but their role in linking nutrient availability to cell division is incompletely understood. Protein folding within the endoplasmic...
Animals Cell Cycle Cell Line Cell Line Tumor Cell Proliferation Cell Separation Drosophila melanogaster Endoplasmic Reticulum Flow Cytometry Gene Expression Regulation Genes p53 HEK293 Cells HeLa Cells Humans Plasmids Protein Biosynthesis Protein Phosphatase 1 RNA Interference Tumor Suppressor Protein p53
Addressing the need for standardization of test methods for self-healing concrete
Tim Van Mullem, Giovanni Anglani, Marta Dudek, Hanne Vanoutrive, Girts Bumanis, Chrysoula Litina, Arkadiusz Kwiecień, Abir Al-Tabbaa, Diana Bajare, Teresa Stryszewska, Robby Caspeele, Kim Van Tittelboom, Tulliani Jean-Marc, Elke Gruyaert, Paola Antonaci, Nele De Belie
Jul 21, 2021
Development and commercialization of self-healing concrete is hampered due to a lack of standardized test methods. Six inter-laboratory testing programs are being executed by the EU COST action SARCOS, each focusing on test...
Objectively Measured Physical Activity and Body Fatness
Esther Winters-VAN Eekelen, Jeroen HPM VAN DER Velde, Sebastiaan C Boone, Kate Westgate, Søren Brage, Hildo J Lamb, Frits R Rosendaal, Renée de Mutsert
Jun 07, 2021
PURPOSE: It remains unclear to what extent habitual physical activity and sedentary time (ST) are associated with visceral fat and liver fat. We studied the substitution of ST with time spent physically active and total body fat...
The Grizzly, October 24, 2002
Anne Antanavage, '04, Kelly Gray, Quinn Dinsmore, Blake Forrest, Cassie Stewart, Amy Beyer, Jessica Moore, Dean Edwards, Lauren Springer, Cara Nageli, Eileen Algeo, Jacqueline Jacobs, Fallon Szarko, Lisa Minardi, Kate Juliano, Johanna Nash, Noelle Bolletino, Jerel Smith, Dana Mazzenga, Nina Simoncavage, Lauren Denis, Sean Brennan, Meghan Jarrett
Jan 01, 0001
Cloudy Weather Fails to Dampen Spirits for Homecoming 2002 You Break it! You Buy it! President Bush Warns of War as Situation in Iraq Intensifies Psychology Department Welcomes Dr. DaCosta Ursinus Awarded Gold Star for...
Ursinus College Collegeville Pennsylvania newspaper Alcohol field hockey Football Rugby Laura Borsdorf Daniel Boone Homestead Lantern poetry Walter Annenberg campus sculptures vandalism DEEP Kneia DaCosta Homecoming career planning George Heckert Faith Lockner Michael Papenberg cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Dual-energy computed tomography in acute ischemic stroke
Stephanie Mangesius, Tanja Janjic, Ruth Steiger, Lukas Haider, Rafael Rehwald, Michael Knoflach, Gerlig Widmann, Elke Gizewski, Astrid Grams
May 20, 2021
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
Joseph E Chambers, Lucy E Dalton, Hanna J Clarke, Elke Malzer, Caia S Dominicus, Vruti Patel, Greg Moorhead, David Ron, Stefan J Marciniak
May 26, 2015
CReP D. melanogaster GADD34 PPP1R15A PPP1R15B actin Biochemistry Cell Biology human integrated stress response MOUSE Actins Amino Acid Sequence Animals Conserved Sequence Depsipeptides Drosophila melanogaster Eukaryotic Initiation Factor-2 HEK293 Cells Humans Mice Molecular Sequence Data Phosphorylation Protein Binding Protein Phosphatase 1 Stress Physiological
New Concepts in Alpha-1 Antitrypsin Deficiency Disease Mechanisms.
Stefan J Marciniak, Adriana Ordóñez, Jennifer A Dickens, Joseph E Chambers, Vruti Patel, Caia S Dominicus, Elke Malzer
Jun 04, 2019
Alpha-1 antitrypsin deficiency is predominantly caused by point mutations that alter the protein's folding. These mutations fall into two broad categories: those that destabilize the protein dramatically and lead to its...
endoplasmic reticulum overload endoplasmic reticulum overload response Endoplasmic reticulum stress serpin Unfolded Protein Response Endoplasmic Reticulum Endoplasmic reticulum stress Humans Mutation NF-kappa B Signal Transduction Unfolded Protein Response alpha 1-Antitrypsin alpha 1-Antitrypsin Deficiency
Mitochondrial dysfunction in liver failure requiring transplantation.
Maria Lane, Veronika Boczonadi, Sahar Bachtari, Aurora Gomez-Duran, Thorsten Langer, Alexandra Griffiths, Stephanie Kleinle, Christine Dineiger, Angela Abicht, Elke Holinski-Feder, Ulrike Schara, Patrick Gerner, Rita Horvath
Mar 07, 2019
Liver failure is a heterogeneous condition which may be fatal and the primary cause is frequently unknown. We investigated mitochondrial oxidative phosphorylation in patients undergoing liver transplantation. We studied 45...
Liver Mitochondria Humans Liver Neoplasms Biliary Atresia Liver Failure Liver Cirrhosis Mitochondrial Diseases Electron Transport Complex IV DNA Mitochondrial Liver Transplantation Electron Transport Oxidative Phosphorylation Adolescent Adult Middle Aged Child Child Preschool Infant Female Male Young Adult
The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin.
Jennifer A Dickens, Adriana Ordóñez, Joseph E Chambers, Alison J Beckett, Vruti Patel, Elke Malzer, Caia S Dominicus, Jayson Bradley, Andrew A Peden, Ian A Prior, David A Lomas, Stefan J Marciniak
Nov 16, 2016
Parents' views about healthcare professionals having real-time remote access to their young child's diabetes data
Barbara Kimbell, David Rankin, Ruth I Hart, Janet M Allen, Charlotte K Boughton, Fiona Campbell, Elke Fröhlich-Reiterer, Sabine E Hofer, Thomas M Kapellen, Birgit Rami-Merhar, Ulrike Schierloh, Ajay Thankamony, Julia Ware, Roman Hovorka, Julia Lawton, KidsAP Consortium
May 26, 2022
Respiratory chain deficiency in nonmitochondrial disease.
Angela Pyle, Helen J Nightingale, Helen Griffin, Angela Abicht, Janbernd Kirschner, Ivo Baric, Mario Cuk, Konstantinos Douroudis, Lea Feder, Markus Kratz, Birgit Czermin, Stephanie Kleinle, Mauro Santibanez-Koref, Veronika Karcagi, Elke Holinski-Feder, Patrick F Chinnery, Rita Horvath
Mar 07, 2019
OBJECTIVE: In this study, we report 5 patients with heterogeneous phenotypes and biochemical evidence of respiratory chain (RC) deficiency; however, the molecular diagnosis is not mitochondrial disease. METHODS: The reported...
Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.
Maik Pietzner, Beatrice Engelmann, Tim Kacprowski, Janine Golchert, Anna-Luise Dirk, Elke Hammer, K Alexander Iwen, Matthias Nauck, Henri Wallaschofski, Dagmar Führer, Thomas F Münte, Nele Friedrich, Uwe Völker, Georg Homuth, Georg Brabant
Nov 16, 2020
BACKGROUND: Determinations of thyrotropin (TSH) and free thyroxine (FT4) represent the gold standard in evaluation of thyroid function. To screen for novel peripheral biomarkers of thyroid function and to characterize...
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