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Parents' views about healthcare professionals having real-time remote access to their young child's diabetes data
Parents' experiences of using remote monitoring technology to manage type 1 diabetes in very young children during a clinical trial
Ruth I Hart, Barbara Kimbell, David Rankin, Janet M Allen, Charlotte K Boughton, Fiona Campbell, Carine de Beaufort, Elke Fröhlich-Reiterer, Julia Ware, Sabine E Hofer, Thomas M Kapellen, Birgit Rami-Merhar, Ajay Thankamony, Roman Hovorka, Julia Lawton, KidsAP Consortium
Mar 31, 2022
Closed-loop system Parents qualitative research remote monitoring sensor-augmented pump therapy type 1 diabetes young children Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Clinical Trials as Topic Diabetes mellitus Type 1 Humans Infant Insulin Insulin Infusion Systems Parents Remote Sensing Technology
Psychological Well-Being of Parents of Very Young Children With Type 1 Diabetes – Baseline Assessment
Carine de Beaufort, Ineke M. Pit-ten Cate, Ulrike Schierloh, Nathan Cohen, Charlotte K. Boughton, Martin Tauschmann, Janet M. Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Alena G. Thiele, Daniela Abt, Kerstin Faninger, Julia K. Mader, Sonja Slegtenhorst, Nicole Ashcroft, Malgorzata E. Wilinska, Judy Sibayan, Craig Kollman, Sabine E. Hofer, Elke Fröhlich-Reiterer, Thomas M. Kapellen, Carlo L. Acerini, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka
Aug 27, 2021
Background: Type 1 diabetes in young children is a heavy parental burden. As part of pilot phase of the KIDSAP01 study, we conducted a baseline assessment in parents to study the association between hypoglycemia fear, parental...
Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children
Martin Tauschmann, Janet M Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Ulrike Schierloh, Alena G Thiele, Daniela Abt, Harald Kojzar, Julia K Mader, Sonja Slegtenhorst, Nicole Barber, Malgorzata E Wilinska, Charlotte Boughton, Gianluca Musolino, Judy Sibayan, Nathan Cohen, Craig Kollman, Sabine E Hofer, Elke Fröhlich-Reiterer, Thomas M Kapellen, Carlo L Acerini, Carine de Beaufort, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka, KidsAP Consortium
Jan 29, 2019
Young Children Have Higher Variability of Insulin Requirements
Klemen Dovc, Charlotte Boughton, Martin Tauschmann, Hood Thabit, Lia Bally, Janet M Allen, Carlo L Acerini, Sabine Arnolds, Carine de Beaufort, Richard M Bergenstal, Fiona Campbell, Amy Criego, David B Dunger, Daniella Elleri, Mark L Evans, Elke Fröhlich-Reiterer, Sabine Hofer, Thomas Kapellen, Lalantha Leelarathna, Thomas R Pieber, Birgit Rami-Merhar, Viral N Shah, Judy Sibayan, Malgorzata E Wilinska, Roman Hovorka, AP@Home, and KidsAP Consortia APCam11
Apr 30, 2019
OBJECTIVE: To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We retrospectively analyzed data from hybrid closed-loop studies involving young...
Adolescent Adult Age Factors Aged Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Cross-Over Studies Diabetes mellitus Type 1 Dose-Response Relationship Drug Female Humans Hypoglycemic Agents Individuality Infant Insulin Insulin Infusion Systems Male Middle Aged Multicenter Studies as Topic Randomized Controlled Trials as Topic Retrospective Studies Young Adult
Reduced burden of diabetes and improved quality of life
Gianluca Musolino, Klemen Dovc, Charlotte K Boughton, Martin Tauschmann, Janet M Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Ulrike Schierloh, Alena G Thiele, Daniela Abt, Harald Kojzar, Julia K Mader, Sonja Slegtenhorst, Nicole Ashcroft, Malgorzata E Wilinska, Judy Sibayan, Nathan Cohen, Craig Kollman, Sabine E Hofer, Elke Fröhlich-Reiterer, Thomas M Kapellen, Carlo L Acerini, Carine de Beaufort, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka, KidsAP Consortium
May 29, 2019
OBJECTIVE: To evaluate the experiences of families with very young children aged 1 to 7 years (inclusive) with type 1 diabetes using day-and-night hybrid closed-loop insulin delivery. METHODS: Parents/caregivers of 20 children...
Artificial Pancreas closed-loop insulin delivery type 1 diabetes very young children Blood Glucose Blood Glucose Self-Monitoring Caregivers Child Child Preschool Circadian Rhythm Cost of Illness Cross-Over Studies Diabetes mellitus Type 1 Family Female Humans Infant Insulin Insulin Infusion Systems Male Parents Quality of life Surveys and Questionnaires
User Engagement With the CamAPS FX Hybrid Closed-Loop App According to Age and User Characteristics.
Natalie S Chen, Charlotte K Boughton, Sara Hartnell, Julia Fuchs, Janet M Allen, Malgorzata E Willinska, Ajay Thankamony, Carine de Beaufort, Fiona M Campbell, Elke Fröhlich-Reiterer, Sabine E Hofer, Thomas M Kapellen, Birgit Rami-Merhar, Atrayee Ghatak, Tabitha L Randell, Rachel EJ Besser, Daniela Elleri, Nicola Trevelyan, Louise Denvir, Nikki Davis, Eleanor Gurnell, Robert Lindsay, Damian Morris, Eleanor M Scott, Lia Bally, Hood Thabit, Lalantha Leelarathna, Mark L Evans, Helen R Murphy, Julia K Mader, Roman Hovorka, AP@home04, CLOuD, DAN05, DAN06, and KidsAP consortia AiDAPT
Apr 12, 2021
CamAPS FX (CamDiab, Cambridge, UK) is a hybrid closed-loop app hosting the Cambridge closed-loop algorithm on an Android smartphone, and is approved in the EU for use in children ≥1 year, and adults (including during pregnancy)...
Psychological Well-Being of Parents of Very Young Children With Type 1 Diabetes - Baseline Assessment.
Carine de Beaufort, Ineke M Pit-Ten Cate, Ulrike Schierloh, Nathan Cohen, Charlotte K Boughton, Martin Tauschmann, Janet M Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Alena G Thiele, Daniela Abt, Kerstin Faninger, Julia K Mader, Sonja Slegtenhorst, Nicole Ashcroft, Malgorzata E Wilinska, Judy Sibayan, Craig Kollman, Sabine E Hofer, Elke Fröhlich-Reiterer, Thomas M Kapellen, Carlo L Acerini, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka
Jul 27, 2021
BACKGROUND: Type 1 diabetes in young children is a heavy parental burden. As part of pilot phase of the KIDSAP01 study, we conducted a baseline assessment in parents to study the association between hypoglycemia fear, parental...
Child Behavior hypoglycemia fear parental well-being Sleepiness type 1 diabetes very young children Adult Age of Onset Anxiety Child Child Behavior Child Preschool Diabetes mellitus Type 1 Europe Fear Female Humans Hypoglycemia Infant Insulin Insulin Infusion Systems Male Parents Surveys and Questionnaires
Hyperoxia Reprogrammes Microvascular Endothelial Cell Response to Hypoxia in an Organ-Specific Manner.
Organ function relies on microvascular networks to maintain homeostatic equilibrium, which varies widely in different organs and during different physiological challenges. The endothelium role in this critical process can only...
Hyperoxia Reprogrammes Microvascular Endothelial Cell Response to Hypoxia in an Organ-Specific Manner.
Organ function relies on microvascular networks to maintain homeostatic equilibrium, which varies widely in different organs and during different physiological challenges. The endothelium role in this critical process can only...
Assessing the efficacy, safety and utility of closed-loop insulin delivery compared with sensor-augmented pump therapy in very young children with type 1 diabetes (KidsAP02 study)
Julia Fuchs, Janet M Allen, Charlotte K Boughton, Malgorzata E Wilinska, Ajay Thankamony, Carine de Beaufort, Fiona Campbell, James Yong, Elke Froehlich-Reiterer, Julia K Mader, Sabine E Hofer, Thomas M Kapellen, Birgit Rami-Merhar, Martin Tauschmann, Korey Hood, Barbara Kimbell, Julia Lawton, Stephane Roze, Judy Sibayan, Nathan Cohen, Roman Hovorka, KidsAP Consortium
Jan 12, 2021
INTRODUCTION: Diabetes management in very young children remains challenging. Glycaemic targets are achieved at the expense of high parental diabetes management burden and frequent hypoglycaemia, impacting quality of life for...
DIABETES & ENDOCRINOLOGY general diabetes paediatric endocrinology Paediatrics Austria Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Cross-Over Studies Diabetes mellitus Type 1 Humans Hypoglycemic Agents Infant Insulin Insulin Infusion Systems Luxembourg Multicenter Studies as Topic Quality of life Randomized Controlled Trials as Topic Treatment Outcome
Acute and chronic hypoxia differentially predispose lungs for metastases
Moritz Reiterer, Renato Colaço, Pardis Emrouznejad, Anders Jensen, Helene Rundqvist, Randall S. Johnson, Cristina Branco
Jul 14, 2020
Abstract: Oscillations in oxygen levels affect malignant cell growth, survival, and metastasis, but also somatic cell behaviour. In this work, we studied the effect of the differential expression of the two primary hypoxia...
The integrated stress response regulates BMP signalling through effects on translation.
Elke Malzer, Caia S Dominicus, Joseph Chambers, Jennifer Dickens, Souradip Mookerjee, Stefan Marciniak
May 24, 2018
Background: Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family of stress sensing kinases to trigger the integrated stress response (ISR), which has pro-survival and...
Acute and chronic hypoxia differentially predispose lungs for metastases.
Moritz Reiterer, Renato Colaço, Pardis Emrouznejad, Anders Jensen, Helene Rundqvist, Randall S Johnson, Cristina Branco
Aug 29, 2019
Oscillations in oxygen levels affect malignant cell growth, survival, and metastasis, but also somatic cell behaviour. In this work, we studied the effect of the differential expression of the two primary hypoxia inducible...
Animals Basic Helix-Loop-Helix Transcription Factors Cell Hypoxia Cell Survival Disease Susceptibility Endothelial Cells Endothelium Vascular Female Genotype Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Lung Male Mice Mice Inbred C57BL Neoplasm Metastasis Oxygen Primary Cell Culture Signal Transduction Vascular Endothelial Growth Factor A
Pulmonary endoplasmic reticulum stress-scars, smoke, and suffocation.
Protein misfolding within the endoplasmic reticulum (ER stress) can be a cause or consequence of pulmonary disease. Mutation of proteins restricted to the alveolar type II pneumocyte can lead to inherited forms of pulmonary...
Inferring modulators of genetic interactions with epistatic nested effects models
Maps of genetic interactions can dissect functional redundancies in cellular networks. Gene expression profiles as high-dimensional molecular readouts of combinatorial perturbations provide a detailed view of genetic...
LC Comandar, M Lucamarini, B Fröhlich, JF Dynes, AW Sharpe, SWB Tam, ZL Yuan, RV Penty, AJ Shields
Mar 02, 2016
The role of structural order in heterogeneous ice nucleation.
Gabriele C Sosso, Prerna Sudera, Anna T Backes, Thomas F Whale, Janine Fröhlich-Nowoisky, Mischa Bonn, Angelos Michaelides, Ellen HG Backus
Jul 03, 2022
The freezing of water into ice is a key process that is still not fully understood. It generally requires an impurity of some description to initiate the heterogeneous nucleation of the ice crystals. The molecular structure, as...
Mitochondrial and nuclear disease panel (Mito-aND-Panel)
Angela Abicht, Florentine Scharf, Stephanie Kleinle, Ulrike Schön, Elke Holinski-Feder, Rita Horvath, Anna Benet-Pagès, Isabel Diebold
Mar 07, 2019
BACKGROUND: The diagnosis of mitochondrial disorders is challenging because of the clinical variability and genetic heterogeneity of these conditions. Next-Generation Sequencing (NGS) technology offers a robust high-throughput...
NUMTs heteroplasmy detection high-throughput sequencing mitochondrial and nuclear disease panel mitochondrial disorders mtDNA-server Costs and Cost Analysis DNA Mitochondrial Genetic Testing High-Throughput Nucleotide Sequencing Humans Mitochondrial Diseases Sensitivity and Specificity Sequence Analysis DNA
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.
Sally E Thomas, Elke Malzer, Adriana Ordóñez, Lucy E Dalton, Emily FA van T Wout, Elizabeth Liniker, Damian C Crowther, David A Lomas, Stefan J Marciniak
Feb 12, 2019
Cell cycle checkpoints ensure that proliferation occurs only under permissive conditions, but their role in linking nutrient availability to cell division is incompletely understood. Protein folding within the endoplasmic...
Animals Cell Cycle Cell Line Cell Line Tumor Cell Proliferation Cell Separation Drosophila melanogaster Endoplasmic Reticulum Flow Cytometry Gene Expression Regulation Genes p53 HEK293 Cells HeLa Cells Humans Plasmids Protein Biosynthesis Protein Phosphatase 1 RNA Interference Tumor Suppressor Protein p53
Addressing the need for standardization of test methods for self-healing concrete
Tim Van Mullem, Giovanni Anglani, Marta Dudek, Hanne Vanoutrive, Girts Bumanis, Chrysoula Litina, Arkadiusz Kwiecień, Abir Al-Tabbaa, Diana Bajare, Teresa Stryszewska, Robby Caspeele, Kim Van Tittelboom, Tulliani Jean-Marc, Elke Gruyaert, Paola Antonaci, Nele De Belie
Jul 21, 2021
Development and commercialization of self-healing concrete is hampered due to a lack of standardized test methods. Six inter-laboratory testing programs are being executed by the EU COST action SARCOS, each focusing on test...
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