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Results: 36
A focus group study of women's views and experiences of maternity care as delivered collaboratively by midwives and health visitors in England.
BACKGROUND: Research suggests that collaboratively delivered maternity care can positively impact health outcomes. However, women's perspectives on models of care involving interprofessional collaboration between midwives and...
Health visitor Interprofessional collaboration Maternal Health Midwife Postnatal Pregnancy Qualitative enquiry thematic analysis Women’s experiences Adult communication Continuity of Patient Care Delivery of Health Care England Female Focus Groups Humans Interprofessional Relations Maternal Health Services Midwifery Nurses community health Patient Care Team patient satisfaction Professional Role qualitative research
Processing of positive newborn screening results
Jane Chudleigh, Holly Chinnery, Pru Holder, Rachel S Carling, Kevin Southern, Ellinor Olander, Louise Moody, Stephen Morris, Fiona Ulph, Mandy Bryon, Alan Simpson
Dec 22, 2020
OBJECTIVE: To explore current communication practices for positive newborn screening results from the newborn bloodspot screening (NBS) laboratory to clinicians to highlight differences, understand how the pathways are...
Midwives' and health visitors' collaborative relationships
OBJECTIVES: Interprofessional collaboration between midwives and health visitors working in maternal and child health services is widely encouraged. This systematic review aimed to identify existing and potential areas for...
Process evaluation of co-designed interventions to improve communication of positive newborn bloodspot screening results.
Jane Chudleigh, Pru Holder, Louise Moody, Alan Simpson, Kevin Southern, Stephen Morris, Francesco Fusco, Fiona Ulph, Mandy Bryon, James R Bonham, Ellinor Olander
Sep 28, 2021
Objective
To implement and evaluate co-designed interventions to improve communication of positive newborn bloodspot screening results and make recommendations for future research and practice.Design
A process...
Public Health Paediatrics qualitative research Humans Neonatal Screening communication Parents Infant Newborn Health Personnel State Medicine
Published by: BMJ Open
Co-designing Improved Communication of Newborn Bloodspot Screening Results to Parents
Jane Chudleigh, Lynette Shakespeare, Pru Holder, Holly Chinnery, Gemma Hack, Tanya Gill, Rachel Gould, Kevin W Southern, Ellinor K Olander, Stephen Morris, James R Bonham, Alan Simpson, Louise Moody
Sep 02, 2022
BACKGROUND: Each year in England, almost 10,000 parents are informed of their child's positive newborn bloodspot screening (NBS) results. This occurs approximately 2 to 8 weeks after birth depending on the condition....
Process evaluation of co-designed interventions to improve communication of positive newborn bloodspot screening results.
Jane Chudleigh, Pru Holder, Louise Moody, Alan Simpson, Kevin Southern, Stephen Morris, Francesco Fusco, Fiona Ulph, Mandy Bryon, James R Bonham, Ellinor Olander
Sep 05, 2021
OBJECTIVE: To implement and evaluate co-designed interventions to improve communication of positive newborn bloodspot screening results and make recommendations for future research and practice. DESIGN: A process evaluation...
Delivering Positive Newborn Screening Results
Francesco Fusco, Jane Chudleigh, Pru Holder, James R Bonham, Kevin W Southern, Alan Simpson, Louise Moody, Ellinor K Olander, Holly Chinnery, Stephen Morris
Mar 15, 2022
Although the communication pathways of Newborn Bloodspot Screening (NBS) are a delicate task, these pathways vary across different conditions and are often not evidence-based. The ReSPoND interventions were co-designed by...
Process evaluation of co-designed interventions to improve communication of positive newborn bloodspot screening results.
Jane Chudleigh, Pru Holder, Louise Moody, Alan Simpson, Kevin Southern, Stephen Morris, Francesco Fusco, Fiona Ulph, Mandy Bryon, James R Bonham, Ellinor Olander
Jul 08, 2022
OBJECTIVE: To implement and evaluate co-designed interventions to improve communication of positive newborn bloodspot screening results and make recommendations for future research and practice. DESIGN: A process evaluation...
Qualitative exploration of health professionals' experiences of communicating positive newborn bloodspot screening results for nine conditions in England.
Jane Chudleigh, Holly Chinnery, Jim R Bonham, Ellinor Olander, Louise Moody, Alan Simpson, Stephen Morris, Fiona Ulph, Mandy Bryon, Kevin Southern
Oct 06, 2020
OBJECTIVE: To explore health professionals' experiences of communicating positive newborn bloodspot screening (NBS) results, highlight differences, share good practice and make recommendations for future research. DESIGN...
Delivering Positive Newborn Screening Results
Francesco Fusco, Jane Chudleigh, Pru Holder, James R Bonham, Kevin W Southern, Alan Simpson, Louise Moody, Ellinor K Olander, Holly Chinnery, Stephen Morris
Apr 24, 2022
Although the communication pathways of Newborn Bloodspot Screening (NBS) are a delicate task, these pathways vary across different conditions and are often not evidence-based. The ReSPoND interventions were co-designed by...
Process evaluation of co-designed interventions to improve communication of positive newborn bloodspot screening results
Jane Chudleigh, Pru Holder, Louise Moody, Alan Simpson, Kevin Southern, Stephen Morris, Francesco Fusco, Fiona Ulph, Mandy Bryon, James R Bonham, Ellinor Olander
Sep 01, 2021
Objective: To implement and evaluate co-designed interventions to improve communication of positive newborn bloodspot screening results and make recommendations for future research and practice. Design: A process evaluation...
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics
Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson
Jan 23, 2021
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics
Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson
Oct 08, 2020
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
Julia Ast, Anastasia Arvaniti, Nicholas HF Fine, Daniela Nasteska, Fiona B Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J Jones, Maria A Lucey, Shugo Sasaki, Daniel I Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D'Agostino, Frank Reimann, Francis C Lynn, Christopher A Reissaus, Amelia K Linnemann, Elisa D'Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J Hodson
Jan 29, 2020
The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in metabolism. Presently, its visualization is limited to genetic manipulation, antibody detection or the use of probes that...
Amino Acid Sequence Animals Brain Cell Line Fluorescent Dyes Glucagon-Like Peptide-1 Receptor HEK293 Cells Human Embryonic Stem Cells Humans Islets of Langerhans Mice Mice Knockout Microscopy Fluorescence Multiphoton Models Molecular Molecular Structure Peptide Fragments Signal Transduction Tissue Distribution
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
Julia Ast, Anastasia Arvaniti, Nicholas H F Fine, Daniela Nasteska, Fiona B Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J Jones, Maria A Lucey, Shugo Sasaki, Daniel I Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D'Agostino, Frank Reimann, Francis C Lynn, Christopher A Reissaus, Amelia K Linnemann, Elisa D'Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J Hodson
Feb 25, 2020
Published by: Nature Communications
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.
Molly Went, Amit Sud, Asta Försti, Britt-Marie Halvarsson, Niels Weinhold, Scott Kimber, Mark van Duin, Gudmar Thorleifsson, Amy Holroyd, David C Johnson, Ni Li, Giulia Orlando, Philip J Law, Mina Ali, Bowang Chen, Jonathan S Mitchell, Daniel F Gudbjartsson, Rowan Kuiper, Owen W Stephens, Uta Bertsch, Peter Broderick, Chiara Campo, Obul R Bandapalli, Hermann Einsele, Walter A Gregory, Urban Gullberg, Jens Hillengass, Per Hoffmann, Graham H Jackson, Karl-Heinz Jöckel, Ellinor Johnsson, Sigurður Y Kristinsson, Ulf-Henrik Mellqvist, Hareth Nahi, Douglas Easton, Paul Pharoah, Alison Dunning, Julian Peto, Federico Canzian, Anthony Swerdlow, Rosalind A Eeles, Zsofia Kote-Jarai, Kenneth Muir, Nora Pashayan, Jolanta Nickel, Markus M Nöthen, Thorunn Rafnar, Fiona M Ross, Miguel Inacio da Silva Filho, Hauke Thomsen, Ingemar Turesson, Annette Vangsted, Niels Frost Andersen, Anders Waage, Brian A Walker, Anna-Karin Wihlborg, Annemiek Broyl, Faith E Davies, Unnur Thorsteinsdottir, Christian Langer, Markus Hansson, Hartmut Goldschmidt, Martin Kaiser, Pieter Sonneveld, Kari Stefansson, Gareth J Morgan, Kari Hemminki, Björn Nilsson, Richard S Houlston, PRACTICAL Consortium
Sep 20, 2018
Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and...
Bayes Theorem Chromatin Chromatin Immunoprecipitation Female Gene Expression Regulation Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Male multiple myeloma Polymorphism Single Nucleotide Promoter Regions Genetic Quality Control Quantitative Trait Loci risk White People
A RAC-GEF network critical for early intestinal tumourigenesis.
KA Pickering, K Gilroy, JW Cassidy, SK Fey, AK Najumudeen, LB Zeiger, DF Vincent, DM Gay, J Johansson, RP Fordham, B Miller, W Clark, A Hedley, EB Unal, C Kiel, E McGhee, LM Machesky, C Nixon, AE Johnsson, M Bain, D Strathdee, SR van Hoof, JP Medema, KI Anderson, SM Brachmann, VM Stucke, A Malliri, M Drysdale, M Turner, L Serrano, K Myant, AD Campbell, OJ Sansom
Feb 08, 2021
RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon homeostasis, we...
Intestines Animals Mice Knockout rac1 GTP-Binding Protein Guanine Nucleotide Exchange Factors Adenomatous Polyposis Coli Protein Signal Transduction Organ Specificity Up-Regulation Homeostasis Phenotype Mutation Proto-Oncogene Proteins p21(ras) Proto-Oncogene Proteins c-vav Wnt Signaling Pathway Carcinogenesis T-Lymphoma Invasion and Metastasis-inducing Protein 1
A RAC-GEF network critical for early intestinal tumourigenesis
K. A. Pickering, K. Gilroy, J. W. Cassidy, S. K. Fey, A. K. Najumudeen, L. B. Zeiger, D. F. Vincent, D. M. Gay, J. Johansson, R. P. Fordham, B. Miller, W. Clark, A. Hedley, E. B. Unal, C. Kiel, E. McGhee, L. M. Machesky, C. Nixon, A. E. Johnsson, M. Bain, D. Strathdee, S. R. van Hoof, J. P. Medema, K. I. Anderson, S. M. Brachmann, V. M. Stucke, A. Malliri, M. Drysdale, M. Turner, L. Serrano, K. Myant, A. D. Campbell, O. J. Sansom
Jan 04, 2021
Abstract: RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon...
Association analyses based on false discovery rate implicate new loci for coronary artery disease
CP Nelson, A Goel, AS Butterworth, S Kanoni, TR Webb, E Marouli, L Zeng, I Ntalla, FY Lai, JC Hopewell, O Giannakopoulou, T Jiang, SE Hamby, E Di Angelantonio, TL Assimes, EP Bottinger, JC Chambers, R Clarke, CNA Palmer, RM Cubbon, P Ellinor, R Ermel, E Evangelou, PW Franks, C Grace, D Gu, AD Hingorani, JMM Howson, E Ingelsson, A Kastrati, T Kessler, T Kyriakou, T Lehtimäki, X Lu, Y Lu, W März, R McPherson, A Metspalu, M Pujades-Rodriguez, A Ruusalepp, EE Schadt, AF Schmidt, MJ Sweeting, PA Zalloua, K AlGhalayini, BD Keavney, JS Kooner, RJF Loos, RS Patel, MK Rutter, M Tomaszewski, I Tzoulaki, E Zeggini, J Erdmann, G Dedoussis, JLM Björkegren, EPIC-CVD Consortium, CARDIoGRAMplusC4D, UK Biobank CardioMetabolic Consortium CHD working group, H Schunkert, M Farrall, J Danesh, NJ Samani, H Watkins, P Deloukas
Aug 21, 2017
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.
Max Nobis, David Herrmann, Sean C Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C Lucas, Nadine Reischmann, Claire Vennin, James RW Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M Law, David Gallego-Ortega, Christopher J Ormandy, Stacey N Walters, Shane T Grey, Jacqueline Bailey, Tatyana Chtanova, Julian MW Quinn, Paul A Baldock, Peter I Croucher, Juliane P Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C Hardeman, Peter W Gunning, Gonzalo Del Monte-Nieto, Richard P Harvey, Michael S Samuel, Marina Pajic, Ewan J McGhee, Anna-Karin E Johnsson, Owen J Sansom, Heidi CE Welch, Jennifer P Morton, Douglas Strathdee, Kurt I Anderson, Paul Timpson
Jun 27, 2019
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated...
FLIM-FRET actin Biosensors Breast Cancer Cell Biology development immunology intravital imaging pancreatic cancer small GTPase RhoA Animals Antineoplastic Agents Biosensing Techniques Bone and Bones Cell Movement Dasatinib Erlotinib Hydrochloride Female Fluorescence Resonance Energy Transfer Gene Expression Regulation Intestine Small Intravital Microscopy Mammary Glands Animal Mammary Neoplasms Experimental Mechanotransduction Cellular Mice Mice Transgenic Neutrophils Osteocytes Pancreatic Neoplasms Time-Lapse Imaging rho GTP-Binding Proteins rhoA GTP-Binding Protein
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.
Krishna G Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N Wolford, Deepak S Atri, Elle M Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas A Marston, Frederick K Kamanu, Ida Surakka, Loreto Muñoz Venegas, Paul Sherliker, Satoshi Koyama, Kazuyoshi Ishigaki, Bjørn O Åsvold, Michael R Brown, Ben Brumpton, Paul S de Vries, Olga Giannakopoulou, Panagiota Giardoglou, Daniel F Gudbjartsson, Ulrich Güldener, Syed M Ijlal Haider, Anna Helgadottir, Maysson Ibrahim, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Tomasz Konopka, Ling Li, Lijiang Ma, Thomas Meitinger, Sören Mucha, Matthias Munz, Federico Murgia, Jonas B Nielsen, Markus M Nöthen, Shichao Pang, Tobias Reinberger, Gavin Schnitzler, Damian Smedley, Gudmar Thorleifsson, Moritz von Scheidt, Jacob C Ulirsch, Biobank Japan, EPIC-CVD, David O Arnar, Noël P Burtt, Maria C Costanzo, Jason Flannick, Kaoru Ito, Dong-Keun Jang, Yoichiro Kamatani, Amit V Khera, Issei Komuro, Iftikhar J Kullo, Luca A Lotta, Christopher P Nelson, Robert Roberts, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Thomas R Webb, Aris Baras, Johan LM Björkegren, Eric Boerwinkle, George Dedoussis, Hilma Holm, Kristian Hveem, Olle Melander, Alanna C Morrison, Marju Orho-Melander, Loukianos S Rallidis, Arno Ruusalepp, Marc S Sabatine, Kari Stefansson, Pierre Zalloua, Patrick T Ellinor, Martin Farrall, John Danesh, Christian T Ruff, Hilary K Finucane, Jemma C Hopewell, Robert Clarke, Rajat M Gupta, Jeanette Erdmann, Nilesh J Samani, Heribert Schunkert, Hugh Watkins, Cristen J Willer, Panos Deloukas, Sekar Kathiresan, Adam S Butterworth, CARDIoGRAMplusC4D Consortium
Jan 06, 2023
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD)...
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Krishna G Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N Wolford, Deepak S Atri, Elle M Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas A Marston, Frederick K Kamanu, Ida Surakka, Loreto Muñoz Venegas, Paul Sherliker, Satoshi Koyama, Kazuyoshi Ishigaki, Bjørn O Åsvold, Michael R Brown, Ben Brumpton, Paul S de Vries, Olga Giannakopoulou, Panagiota Giardoglou, Daniel F Gudbjartsson, Ulrich Güldener, Syed M Ijlal Haider, Anna Helgadottir, Maysson Ibrahim, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Tomasz Konopka, Ling Li, Lijiang Ma, Thomas Meitinger, Sören Mucha, Matthias Munz, Federico Murgia, Jonas B Nielsen, Markus M Nöthen, Shichao Pang, Tobias Reinberger, Gavin Schnitzler, Damian Smedley, Gudmar Thorleifsson, Moritz von Scheidt, Jacob C Ulirsch, John Danesh, David O Arnar, Noël P Burtt, Maria C Costanzo, Jason Flannick, Kaoru Ito, Dong-Keun Jang, Yoichiro Kamatani, Amit V Khera, Issei Komuro, Iftikhar J Kullo, Luca A Lotta, Christopher P Nelson, Robert Roberts, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Thomas R Webb, Aris Baras, Johan LM Björkegren, Eric Boerwinkle, George Dedoussis, Hilma Holm, Kristian Hveem, Olle Melander, Alanna C Morrison, Marju Orho-Melander, Loukianos S Rallidis, Arno Ruusalepp, Marc S Sabatine, Kari Stefansson, Pierre Zalloua, Patrick T Ellinor, Martin Farrall, John Danesh, Christian T Ruff, Hilary K Finucane, Jemma C Hopewell, Robert Clarke, Rajat M Gupta, Jeanette Erdmann, Nilesh J Samani, Heribert Schunkert, Hugh Watkins, Cristen J Willer, Panos Deloukas, Sekar Kathiresan, Adam S Butterworth, Paul S de Vries, Moritz von Scheidt
Dec 08, 2022
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
Bram P Prins, Timothy J Mead, Jennifer A Brody, Gardar Sveinbjornsson, Ioanna Ntalla, Nathan A Bihlmeyer, Marten van den Berg, Jette Bork-Jensen, Stefania Cappellani, Stefan Van Duijvenboden, Nikolai T Klena, George C Gabriel, Xiaoqin Liu, Cagri Gulec, Niels Grarup, Jeffrey Haessler, Leanne M Hall, Annamaria Iorio, Aaron Isaacs, Ruifang Li-Gao, Honghuang Lin, Ching-Ti Liu, Leo-Pekka Lyytikäinen, Jonathan Marten, Hao Mei, Martina Müller-Nurasyid, Michele Orini, Sandosh Padmanabhan, Farid Radmanesh, Julia Ramirez, Antonietta Robino, Molly Schwartz, Jessica van Setten, Albert V Smith, Niek Verweij, Helen R Warren, Stefan Weiss, Alvaro Alonso, David O Arnar, Michiel L Bots, Rudolf A de Boer, Anna F Dominiczak, Mark Eijgelsheim, Patrick T Ellinor, Xiuqing Guo, Stephan B Felix, Tamara B Harris, Caroline Hayward, Susan R Heckbert, Paul L Huang, JW Jukema, Mika Kähönen, Jan A Kors, Pier D Lambiase, Lenore J Launer, Man Li, Allan Linneberg, Christopher P Nelson, Oluf Pedersen, Marco Perez, Annette Peters, Ozren Polasek, Bruce M Psaty, Olli T Raitakari, Kenneth M Rice, Jerome I Rotter, Moritz F Sinner, Elsayed Z Soliman, Tim D Spector, Konstantin Strauch, Unnur Thorsteinsdottir, Andrew Tinker, Stella Trompet, André Uitterlinden, Ilonca Vaartjes, Peter van der Meer, Uwe Völker, Henry Völzke, Melanie Waldenberger, James G Wilson, Zhijun Xie, Folkert W Asselbergs, Marcus Dörr, Cornelia M van Duijn, Paolo Gasparini, Daniel F Gudbjartsson, Vilmundur Gudnason, Torben Hansen, Stefan Kääb, Jørgen K Kanters, Charles Kooperberg, Terho Lehtimäki, Henry J Lin, Steven A Lubitz, Dennis O Mook-Kanamori, Francesco J Conti, Christopher H Newton-Cheh, Jonathan Rosand, Igor Rudan, Nilesh J Samani, Gianfranco Sinagra, Blair H Smith, Hilma Holm, Bruno H Stricker, Sheila Ulivi, Nona Sotoodehnia, Suneel S Apte, Pim van der Harst, Kari Stefansson, Patricia B Munroe, Dan E Arking, Cecilia W Lo, Yalda Jamshidi
Sep 17, 2018
ADAMTS6 Conduction exome chip Meta-Analysis ADAMTS Proteins Animals Black People Connexin 43 Electrocardiography Exome Female Gene Expression Gene Expression Profiling Genetic Loci Genome-Wide Association Study Heart Conduction System Humans Male Mice Middle Aged Myocardium Open Reading Frames Polymorphism Single Nucleotide White People Exome Sequencing
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K Hedman, Jemma B Wilk, Michael P Morley, Mark D Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, Krishna G Aragam, Johan Ärnlöv, Joshua D Backman, Mary L Biggs, Heather L Bloom, Jeffrey Brandimarto, Michael R Brown, Leonard Buckbinder, David J Carey, Daniel I Chasman, Xing Chen, Xu Chen, Jonathan Chung, William Chutkow, James P Cook, Graciela E Delgado, Spiros Denaxas, Alexander S Doney, Marcus Dörr, Samuel C Dudley, Michael E Dunn, Gunnar Engström, Tõnu Esko, Stephan B Felix, Chris Finan, Ian Ford, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S Gottdiener, Stefan Gross, Daníel F Guðbjartsson, Rebecca Gutmann, Christopher M Haggerty, Pim van der Harst, Craig L Hyde, Erik Ingelsson, J Wouter Jukema, Maryam Kavousi, Kay-Tee Khaw, Marcus E Kleber, Lars Køber, Andrea Koekemoer, Claudia Langenberg, Lars Lind, Cecilia M Lindgren, Barry London, Luca A Lotta, Ruth C Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Kenneth B Margulies, Winfried März, Olle Melander, Ify R Mordi, Thomas Morgan, Andrew D Morris, Andrew P Morris, Alanna C Morrison, Michael W Nagle, Christopher P Nelson, Alexander Niessner, Teemu Niiranen, Michelle L O'Donoghue, Anjali T Owens, Colin NA Palmer, Helen M Parry, Markus Perola, Eliana Portilla-Fernandez, Bruce M Psaty, Regeneron Genetics Center, Kenneth M Rice, Paul M Ridker, Simon PR Romaine, Jerome I Rotter, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa A Shalaby, Diane T Smelser, Nicholas L Smith, Steen Stender, David J Stott, Per Svensson, Mari-Liis Tammesoo, Kent D Taylor, Maris Teder-Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Benoit Tyl, Andre G Uitterlinden, Abirami Veluchamy, Uwe Völker, Adriaan A Voors, Xiaosong Wang, Nicholas J Wareham, Dawn Waterworth, Peter E Weeke, Raul Weiss, Kerri L Wiggins, Heming Xing, Laura M Yerges-Armstrong, Bing Yu, Faiez Zannad, Jing Hua Zhao, Harry Hemingway, Nilesh J Samani, John JV McMurray, Jian Yang, Peter M Visscher, Christopher Newton-Cheh, Anders Malarstig, Hilma Holm, Steven A Lubitz, Naveed Sattar, Michael V Holmes, Thomas P Cappola, Folkert W Asselbergs, Aroon D Hingorani, Karoline Kuchenbaecker, Patrick T Ellinor, Chim C Lang, Kari Stefansson, J Gustav Smith, Ramachandran S Vasan, Daniel I Swerdlow, R Thomas Lumbers
Jan 29, 2020
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only...
Adaptor Proteins Signal Transducing Apoptosis Regulatory Proteins Atrial fibrillation Cardiomyopathies Carrier Proteins Case-Control Studies Coronary Artery Disease Cyclin-Dependent Kinase Inhibitor p21 Genome-Wide Association Study Heart Failure Humans Mendelian Randomization Analysis Microfilament Proteins Muscle Proteins Risk Factors Ventricular Function Left
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