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Results: 290
Consensus-based technical recommendations for clinical translation of renal BOLD MRI
Octavia Bane, Iosif A. Mendichovszky, Bastien Milani, Ilona A. Dekkers, Jean-Francois Deux, Per Eckerbom, Nicolas Grenier, Michael E. Hall, Tsutomu Inoue, Christoffer Laustsen, Lilach O. Lerman, Chunlei Liu, Glen Morrell, Michael Pedersen, Menno Pruijm, Elizabeth A. Sadowski, Erdmann Seeliger, Kanishka Sharma, Harriet Thoeny, Peter Vermathen, Zhen J. Wang, Zbigniew Serafin, Jeff L. Zhang, Susan T. Francis, Steven Sourbron, Andreas Pohlmann, Sean B. Fain, Pottumarthi V. Prasad
Jun 06, 2020
Abstract: Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report...
Published by: Springer International Publishing
Consensus-based technical recommendations for clinical translation of renal BOLD MRI.
Octavia Bane, Iosif A Mendichovszky, Bastien Milani, Ilona A Dekkers, Jean-Francois Deux, Per Eckerbom, Nicolas Grenier, Michael E Hall, Tsutomu Inoue, Christoffer Laustsen, Lilach O Lerman, Chunlei Liu, Glen Morrell, Michael Pedersen, Menno Pruijm, Elizabeth A Sadowski, Erdmann Seeliger, Kanishka Sharma, Harriet Thoeny, Peter Vermathen, Zhen J Wang, Zbigniew Serafin, Jeff L Zhang, Susan T Francis, Steven Sourbron, Andreas Pohlmann, Sean B Fain, Pottumarthi V Prasad
Nov 24, 2020
Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the...
Compressed sensing electron tomography of needle-shaped biological specimens--Potential for improved reconstruction fidelity with reduced dose.
Zineb Saghi, Giorgio Divitini, Benjamin Winter, Rowan Leary, Erdmann Spiecker, Caterina Ducati, Paul A Midgley
Nov 05, 2015
Compressed sensing Electron tomography Isotropic resolution Life science Algorithms Animals Brain data compression Fourier Analysis Histocytological Preparation Techniques Image Processing Computer-Assisted Imaging Three-Dimensional Male Microscopy Electron Scanning Transmission Rats Rats Sprague-Dawley
Hematologic malignancies in South Africa 2000-2006
Sara J Schonfeld, Friederike Erdmann, Tracey Wiggill, Elvira Singh, Patricia Kellett, Chantal Babb, Joachim Schüz
Apr 16, 2018
Little is known about the incidence patterns of hematologic malignancies in Sub-Saharan Africa, including South Africa. We estimated incidence rates of pathology-confirmed adult cases of leukemia, myeloma and related diseases...
FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression.
Kia Joo Puan, Boris San Luis, Nurhashikin Yusof, Dilip Kumar, Anand Kumar Andiappan, Wendy Lee, Samanta Cajic, Dragana Vuckovic, Jing De Chan, Tobias Döllner, Han Wei Hou, Yunxuan Jiang, Chao Tian, 23andMe Research Team, Erdmann Rapp, Michael Poidinger, De Yun Wang, Nicole Soranzo, Bernett Lee, Olaf Rötzschke
Sep 01, 2021
Sialyl-Lewis x (sLex, CD15s) is a tetra-saccharide on the surface of leukocytes required for E-selectin-mediated rolling, a prerequisite for leukocytes to migrate out of the blood vessels. Here we show using flow cytometry that...
Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging.
Nicole Strittmatter, Panchali Kanvatirth, Paolo Inglese, Alan M Race, Anna Nilsson, Andreas Dannhorn, Hiromi Kudo, Robert D Goldin, Stephanie Ling, Edmond Wong, Frank Seeliger, Maria Paola Serra, Scott Hoffmann, Gareth Maglennon, Gregory Hamm, James Atkinson, Stewart Jones, Josephine Bunch, Per E Andrén, Zoltan Takats, Richard JA Goodwin, Pietro Mastroeni
Oct 20, 2021
Two-colour live-cell nanoscale imaging of intracellular targets.
Francesca Bottanelli, Emil B Kromann, Edward S Allgeyer, Roman S Erdmann, Stephanie Wood Baguley, George Sirinakis, Alanna Schepartz, David Baddeley, Derek K Toomre, James E Rothman, Joerg Bewersdorf
Jun 07, 2021
Stimulated emission depletion (STED) nanoscopy allows observations of subcellular dynamics at the nanoscale. Applications have, however, been severely limited by the lack of a versatile STED-compatible two-colour labelling...
Labeling Strategies Matter for Super-Resolution Microscopy
Roman S Erdmann, Stephanie Wood Baguley, Jennifer H Richens, Rebecca F Wissner, Zhiqun Xi, Edward S Allgeyer, Sheng Zhong, Alexander D Thompson, Nicholas Lowe, Richard Butler, Joerg Bewersdorf, James E Rothman, Daniel St Johnston, Alanna Schepartz, Derek Toomre
Jun 21, 2019
Genetically modulated educational attainment and coronary disease risk.
Lingyao Zeng, Ioanna Ntalla, Thorsten Kessler, Adnan Kastrati, Jeanette Erdmann, UK Biobank CardioMetabolic Consortium CHD working group, John Danesh, Hugh Watkins, Nilesh J Samani, Panos Deloukas, Heribert Schunkert
May 03, 2019
Atherosclerosis Coronary Artery Disease Genetics genome-wide association studies School education Coronary Disease Educational Status Female Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Humans Life Style Male Mendelian Randomization Analysis Polymorphism Single Nucleotide Risk Factors
Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk
Ingrid Brænne, Lingyao Zeng, Christina Willenborg, Vinicius Tragante, Thorsten Kessler, CARDIoGRAM consortium, CARDIoGRAMplusC4D Consortium, Cristen J Willer, Markku Laakso, Lars Wallentin, Paul W Franks, Veikko Salomaa, Abbas Dehghan, Thomas Meitinger, Nilesh J Samani, Folkert W Asselbergs, Jeanette Erdmann, Heribert Schunkert
Jan 25, 2018
Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease.
Gina M Peloso, Akihiro Nomura, Amit V Khera, Mark Chaffin, Hong-Hee Won, Diego Ardissino, John Danesh, Heribert Schunkert, James G Wilson, Nilesh Samani, Jeanette Erdmann, Ruth McPherson, Hugh Watkins, Danish Saleheen, Shane McCarthy, Tanya M Teslovich, Joseph B Leader, H Lester Kirchner, Jaume Marrugat, Atsushi Nohara, Masa-Aki Kawashiri, Hayato Tada, Frederick E Dewey, David J Carey, Aris Baras, Sekar Kathiresan
Apr 15, 2019
Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling.
Connor A Emdin, Amit V Khera, Derek Klarin, Pradeep Natarajan, Seyedeh M Zekavat, Akihiro Nomura, Mary Haas, Krishna Aragam, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Padhraig Gormley, Aarno Palotie, Nathan O Stitziel, Namrata Gupta, John Danesh, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Jan 19, 2018
BACKGROUND: Nitric oxide signaling plays a key role in the regulation of vascular tone and platelet activation. Here, we seek to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on risk for...
cardiovascular disease Genetics Nitric oxide nitric oxide synthase blood pressure Coronary Disease Genetic Association Studies Genetic Predisposition to Disease Humans Mutation Nitric oxide Nitric Oxide Synthase Type III Peripheral Arterial Disease Phenotype Polymorphism Single Nucleotide Protective factors Risk Factors Signal Transduction Soluble Guanylyl Cyclase stroke
Assessing the causal association of glycine with risk of cardio-metabolic diseases.
Laura BL Wittemans, Luca A Lotta, Clare Oliver-Williams, Isobel D Stewart, Praveen Surendran, Savita Karthikeyan, Felix R Day, Albert Koulman, Fumiaki Imamura, Lingyao Zeng, Jeanette Erdmann, Heribert Schunkert, Kay-Tee Khaw, Julian L Griffin, Nita G Forouhi, Robert A Scott, Angela M Wood, Stephen Burgess, Joanna MM Howson, John Danesh, Nicholas J Wareham, Adam S Butterworth, Claudia Langenberg
Feb 18, 2019
Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease.
Akihiro Nomura, Connor A Emdin, Hong Hee Won, Gina M Peloso, Pradeep Natarajan, Diego Ardissino, John Danesh, Heribert Schunkert, Adolfo Correa, Matthew J Bown, Nilesh J Samani, Jeanette Erdmann, Ruth McPherson, Hugh Watkins, Danish Saleheen, Roberto Elosua, Masa-Aki Kawashiri, Hayato Tada, Namrata Gupta, Svati H Shah, Daniel J Rader, Stacey Gabriel, Amit V Khera, Sekar Kathiresan
Dec 17, 2020
Coronary Artery Disease Lipids Odds Ratio Pedigree prevalence ATP Binding Cassette Transporter Subfamily G Member 5 ATP Binding Cassette Transporter Subfamily G Member 8 Adult Case-Control Studies Cholesterol LDL Coronary Artery Disease Female Heterozygote Humans Hypercholesterolemia Intestinal Diseases Lipid Metabolism Inborn Errors Lipoproteins Loss of Function Mutation Male Middle Aged Odds Ratio Phytosterols Risk Factors Sitosterols
Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis
Alessandra Bettiol, Maria Letizia Urban, Lorenzo Dagna, Vincent Cottin, Franco Franceschini, Stefano Del Giacco, Franco Schiavon, Thomas Neumann, Giuseppe Lopalco, Pavel Novikov, Chiara Baldini, Carlo Lombardi, Alvise Berti, Federico Alberici, Marco Folci, Simone Negrini, Renato Alberto Sinico, Luca Quartuccio, Claudio Lunardi, Paola Parronchi, Frank Moosig, Georgina Espígol-Frigolé, Jan Schroeder, Anna Luise Kernder, Sara Monti, Ettore Silvagni, Claudia Crimi, Francesco Cinetto, Paolo Fraticelli, Dario Roccatello, Angelo Vacca, Aladdin J Mohammad, Bernhard Hellmich, Maxime Samson, Elena Bargagli, Jan Willem Cohen Tervaert, Camillo Ribi, Davide Fiori, Federica Bello, Filippo Fagni, Luca Moroni, Giuseppe Alvise Ramirez, Mouhamad Nasser, Chiara Marvisi, Paola Toniati, Davide Firinu, Roberto Padoan, Allyson Egan, Benjamin Seeliger, Florenzo Iannone, Carlo Salvarani, David Jayne, Domenico Prisco, Augusto Vaglio, Giacomo Emmi, European EGPA Study Group
Jan 07, 2022
OBJECTIVE: Mepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis with polyangiitis (EGPA) at a dose of 300 mg every 4 weeks in the randomized, controlled MIRRA trial. In a few recently reported...
Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis
Alessandra Bettiol, Maria Letizia Urban, Lorenzo Dagna, Vincent Cottin, Franco Franceschini, Stefano Del Giacco, Franco Schiavon, Thomas Neumann, Giuseppe Lopalco, Pavel Novikov, Chiara Baldini, Carlo Lombardi, Alvise Berti, Federico Alberici, Marco Folci, Simone Negrini, Renato Alberto Sinico, Luca Quartuccio, Claudio Lunardi, Paola Parronchi, Frank Moosig, Georgina Espígol-Frigolé, Jan Schroeder, Anna Luise Kernder, Sara Monti, Ettore Silvagni, Claudia Crimi, Francesco Cinetto, Paolo Fraticelli, Dario Roccatello, Angelo Vacca, Aladdin J Mohammad, Bernhard Hellmich, Maxime Samson, Elena Bargagli, Jan Willem Cohen Tervaert, Camillo Ribi, Davide Fiori, Federica Bello, Filippo Fagni, Luca Moroni, Giuseppe Alvise Ramirez, Mouhamad Nasser, Chiara Marvisi, Paola Toniati, Davide Firinu, Roberto Padoan, Allyson Egan, Benjamin Seeliger, Florenzo Iannone, Carlo Salvarani, David Jayne, Domenico Prisco, Augusto Vaglio, Giacomo Emmi, European EGPA Study Group
Nov 15, 2021
OBJECTIVE: Mepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis with polyangiitis (EGPA) at a dose of 300 mg every 4 weeks in the randomized, controlled MIRRA trial. In a few recently reported...
ANGPTL3 Deficiency and Protection Against Coronary Artery Disease
NO Stitziel, AV Khera, X Wang, AJ Bierhals, AC Vourakis, AE Sperry, P Natarajan, D Klarin, CA Emdin, SM Zekavat, A Nomura, J Erdmann, H Schunkert, NJ Samani, WE Kraus, SH Shah, B Yu, E Boerwinkle, DJ Rader, N Gupta, PM Frossard, A Rasheed, J Danesh, ES Lander, S Gabriel, D Saleheen, K Musunuru, S Kathiresan, PROMIS and Myocardial Infarction Genetics Consortium Investigators
Oct 30, 2017
Background
Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether...
Genetically determined height and coronary artery disease.
Christopher P Nelson, Stephen E Hamby, Danish Saleheen, Jenna C Hopewell, Lingyao Zeng, Themistocles L Assimes, Stavroula Kanoni, Christina Willenborg, Stephen Burgess, Phillipe Amouyel, Sonia Anand, Stefan Blankenberg, Bernhard O Boehm, Robert J Clarke, Rory Collins, George Dedoussis, Martin Farrall, Paul W Franks, Leif Groop, Alistair S Hall, Anders Hamsten, Christian Hengstenberg, G Kees Hovingh, Erik Ingelsson, Sekar Kathiresan, Frank Kee, Inke R König, Jaspal Kooner, Terho Lehtimäki, Winifred März, Ruth McPherson, Andres Metspalu, Markku S Nieminen, Christopher J O'Donnell, Colin NA Palmer, Annette Peters, Markus Perola, Muredach P Reilly, Samuli Ripatti, Robert Roberts, Veikko Salomaa, Svati H Shah, Stefan Schreiber, Agneta Siegbahn, Unnur Thorsteinsdottir, Giovani Veronesi, Nicholas Wareham, Cristen J Willer, Pierre A Zalloua, Jeanette Erdmann, Panos Deloukas, Hugh Watkins, Heribert Schunkert, John Danesh, John R Thompson, Nilesh J Samani, CARDIoGRAM+C4D Consortium
Jun 03, 2015
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease.
Connor A Emdin, Amit V Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam, Mary Haas, Alexander Bick, Seyedeh M Zekavat, Akihiro Nomura, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Daniel Chasman, Paul Ridker, Joshua Denny, Lisa Bastarache, Judith H Lichtman, Gail D'Onofrio, Jennifer Mattera, John A Spertus, Wayne H-H Sheu, Kent D Taylor, Bruce M Psaty, Stephen S Rich, Wendy Post, Jerome I Rotter, Yii-Der Ida Chen, Harlan Krumholz, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Jun 13, 2018
Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted...
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.
Connor A Emdin, Mary E Haas, Amit V Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
May 16, 2020
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection...
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Connor A. Emdin, Mary E. Haas, Amit V. Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G. Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J. Bown, Nilesh J. Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
May 05, 2020
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection...
Liver resection and ablation for squamous cell carcinoma liver metastases.
J Engstrand, LF Abreu de Carvalho, D Aghayan, A Balakrishnan, A Belli, B Björnsson, BVM Dasari, O Detry, M Di Martino, B Edwin, J Erdmann, R Fristedt, G Fusai, T Gimenez-Maurel, O Hemmingsson, C Hidalgo Salinas, B Isaksson, A Ivanecz, F Izzo, WT Knoefel, P Kron, N Lehwald-Tywuschik, M Lesurtel, JPA Lodge, N Machairas, MV Marino, V Martin, A Paterson, J Rystedt, P Sandström, A Serrablo, AK Siriwardena, H Taflin, TM van Gulik, S Yaqub, I Özden, JM Ramia, C Sturesson, E-AHPBA Scientific and Research Committee
Sep 24, 2021
Association analyses based on false discovery rate implicate new loci for coronary artery disease
CP Nelson, A Goel, AS Butterworth, S Kanoni, TR Webb, E Marouli, L Zeng, I Ntalla, FY Lai, JC Hopewell, O Giannakopoulou, T Jiang, SE Hamby, E Di Angelantonio, TL Assimes, EP Bottinger, JC Chambers, R Clarke, CNA Palmer, RM Cubbon, P Ellinor, R Ermel, E Evangelou, PW Franks, C Grace, D Gu, AD Hingorani, JMM Howson, E Ingelsson, A Kastrati, T Kessler, T Kyriakou, T Lehtimäki, X Lu, Y Lu, W März, R McPherson, A Metspalu, M Pujades-Rodriguez, A Ruusalepp, EE Schadt, AF Schmidt, MJ Sweeting, PA Zalloua, K AlGhalayini, BD Keavney, JS Kooner, RJF Loos, RS Patel, MK Rutter, M Tomaszewski, I Tzoulaki, E Zeggini, J Erdmann, G Dedoussis, JLM Björkegren, EPIC-CVD Consortium, CARDIoGRAMplusC4D, UK Biobank CardioMetabolic Consortium CHD working group, H Schunkert, M Farrall, J Danesh, NJ Samani, H Watkins, P Deloukas
Aug 21, 2017
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
JMM Howson, W Zhao, DR Barnes, W-K Ho, R Young, DS Paul, LL Waite, DF Freitag, EB Fauman, EL Salfati, BB Sun, JD Eicher, AD Johnson, WHH Sheu, SF Nielsen, W-Y Lin, P Surendran, A Malarstig, JB Wilk, A Tybjaerg-Hansen, KL Rasmussen, PR Kamstrup, P Deloukas, J Erdmann, S Kathiresan, NJ Samani, H Schunkert, H Watkins, CARDIoGRAMplusC4D, R Do, DJ Rader, JA Johnson, SL Hazen, AA Quyyumi, JA Spertus, CJ Pepine, N Franceschini, A Justice, AP Reiner, S Buyske, LA Hindorff, CL Carty, KE North, C Kooperberg, E Boerwinkle, K Young, M Graff, U Peters, D Absher, CA Hsiung, W-J Lee, KD Taylor, Y-H Chen, I-T Lee, X Guo, R-H Chung, Y-J Hung, JI Rotter, J-MJ Juang, T Quertermous, T-D Wang, A Rasheed, P Frossard, DS Alam, AAS Majumder, E Di Angelantonio, R Chowdhury, EPIC-CVD, Y-DI Chen, BG Nordestgaard, TL Assimes, J Danesh, AS Butterworth, D Saleheen
Aug 25, 2017
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