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Regioselective Transition-Metal-Catalyzed C–H Functionalization of Anilines
Anilines are a vital synthetic core of pharmaceuticals, agrochemicals, natural products and building blocks. Metal-catalyzed C–H functionalization has emerged as a powerful tool to derivatize biologically relevant molecules....
Regioselective Transition-Metal-Catalyzed C–H Functionalization of Anilines
Anilines are a vital synthetic core of pharmaceuticals, agrochemicals, natural products and building blocks. Metal-catalyzed C–H functionalization has emerged as a powerful tool to derivatize biologically relevant molecules....
Ruthenium(II)-Catalyzed C–H Functionalization Using the Oxazolidinone Heterocycle as a Weakly Coordinating Directing Group
Jamie A. Leitch, Philippe B. Wilson, Claire L. McMullin, Mary F. Mahon, Yunas Bhonoah, Ian H. Williams, Christopher G. Frost
Jul 27, 2016
Herein, we report the ruthenium-catalyzed ortho C–H alkenylation of a wide range of N-aryloxazolidinone scaffolds. Alkenylation was achieved with complete monoselectivity with a scope of 27 examples in 2-MeTHF. Yields ranged...
Ruthenium(II)-Catalyzed C–H Functionalization Using the Oxazolidinone Heterocycle as a Weakly Coordinating Directing Group
Jamie A. Leitch, Philippe B. Wilson, Claire L. McMullin, Mary F. Mahon, Yunas Bhonoah, Ian H. Williams, Christopher G. Frost
Jul 27, 2016
Herein, we report the ruthenium-catalyzed ortho C–H alkenylation of a wide range of N-aryloxazolidinone scaffolds. Alkenylation was achieved with complete monoselectivity with a scope of 27 examples in 2-MeTHF. Yields ranged...
Ruthenium-Catalyzed para-Selective C−H Alkylation of Aniline Derivatives
Jamie A. Leitch, Claire L. McMullin, Andrew J. Paterson, Mary F. Mahon, Yunas Bhonoah, Christopher G. Frost
Nov 20, 2017
The para-selective C−H alkylation of aniline derivatives furnished with a pyrimidine auxiliary is herein reported. This reaction is proposed to take place via an N−H-activated cyclometalate formed in situ. Experimental and DFT...
Ruthenium-Catalyzed para-Selective C−H Alkylation of Aniline Derivatives
Jamie A. Leitch, Claire L. McMullin, Andrew J. Paterson, Mary F. Mahon, Yunas Bhonoah, Christopher G. Frost
Nov 20, 2017
The para-selective C−H alkylation of aniline derivatives furnished with a pyrimidine auxiliary is herein reported. This reaction is proposed to take place via an N−H-activated cyclometalate formed in situ. Experimental and DFT...
John Panteleimon Manoussakis, ed. After God: Richard Kearney and the Religious Turn in Continental Philosophy. New York
Eric Severson
May 04, 2009
[Book Review] Eric Severson reviews John Panteleimon Manoussakis, ed. After God: Richard Kearney and the Religious Turn in Continental Philosophy. New York: Fordham University Press, 2005.
Published by: Memorial University of Newfoundland
Beyond C2 and C3
The indole scaffold will continue to play a vital part in the future of drug discovery and agrochemical development. Because of this, the necessity for elegant techniques to enable selective C–H functionalization is vast. Early...
Beyond C2 and C3
The indole scaffold will continue to play a vital part in the future of drug discovery and agrochemical development. Because of this, the necessity for elegant techniques to enable selective C–H functionalization is vast. Early...
Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation
Jamie A. Leitch, Callum J. Heron, Janette Mcknight, Gabriele Kociok-Köhn, Yunas Bhonoah, Christopher G. Frost
Dec 18, 2017
We report the C4-selective C–H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed r-activation methodology, whereby C–H activation at C1 enables the...
Catalytic meta-selective C–H functionalization to construct quaternary carbon centres
A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary...
Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation
Jamie A. Leitch, Callum J. Heron, Janette Mcknight, Gabriele Kociok-Köhn, Yunas Bhonoah, Christopher G. Frost
Dec 18, 2017
We report the C4-selective C–H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed r-activation methodology, whereby C–H activation at C1 enables the...
Catalytic meta-selective C–H functionalization to construct quaternary carbon centres
A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary...
Remote C6-Selective Ruthenium-Catalyzed C-H Alkylation of Indole Derivatives via σ-Activation
Jamie A. Leitch, Claire L. McMullin, Mary F. Mahon, Yunas Bhonoah, Christopher G. Frost
Apr 07, 2017
The site-selective functionalization of an indole template offers exciting possibilities for the derivatization of molecules with useful biological properties. Herein, we report the remote C6-selective C-H alkylation of...
Remote C6-Selective Ruthenium-Catalyzed C-H Alkylation of Indole Derivatives via σ-Activation
Jamie A. Leitch, Claire L. McMullin, Mary F. Mahon, Yunas Bhonoah, Christopher G. Frost
Apr 07, 2017
The site-selective functionalization of an indole template offers exciting possibilities for the derivatization of molecules with useful biological properties. Herein, we report the remote C6-selective C-H alkylation of...
John Panteleimon Manoussakis, ed. After God: Richard Kearney and the Religious Turn in Continental Philosophy. New York
Eric Severson
May 04, 2009
[Book Review] Eric Severson reviews John Panteleimon Manoussakis, ed. After God: Richard Kearney and the Religious Turn in Continental Philosophy. New York: Fordham University Press, 2005.
Published by: Memorial University of Newfoundland
Peter Gratton and John Panteleimon Manoussakis, eds. Traversing the Imaginary: Richard Kearney and the Postmodern Challenge. Evanston, Ill.
Eric Severson
May 04, 2009
Book Review. Eric Severson reviews Peter Gratton and John Panteleimon Manoussakis, eds. Traversing the Imaginary: Richard Kearney and the Postmodern Challenge. Evanston, Ill.: Northwestern University Press, 2007.
Published by: Memorial University of Newfoundland
Peter Gratton and John Panteleimon Manoussakis, eds. Traversing the Imaginary: Richard Kearney and the Postmodern Challenge. Evanston, Ill.
Eric Severson
May 04, 2009
Book Review. Eric Severson reviews Peter Gratton and John Panteleimon Manoussakis, eds. Traversing the Imaginary: Richard Kearney and the Postmodern Challenge. Evanston, Ill.: Northwestern University Press, 2007.
Published by: Memorial University of Newfoundland
ERIC-PCR Analysis of the Clinical and Environmental strains of V. cholerae during 2013 Epidemic in Nigeria
Smith Stella, Nwaokorie Francisca, Awoderu Oluwatoyin, Bamidele Tajudeen, Akinsinde Kehinde, Ochoga Michael, Oladele David, Bamidele Moses, Fesobi Toun, Afocha Eberechukwu, Amoo Samuel, Ajayi Morakinyo, Atat Prince, Ogbonna Francisca, Nduaga Samuel, Idika Nneoma, Oparaugo Chinedu, Musa Adesola, Adeneye Adeniyi, Ijeh Margaret, Ujah Innocent
Nov 21, 2015
Background: Molecular markers are important tools in the monitoring of toxigenic strains of Vibrio cholerae in environmental and clinical samples.
Objectives: The study was aimed at determining the clinical and environmental...
Published by: IJHS Medical Association
Using Knowledge Management to Improve the Effectiveness of Data Fusion Centers
Data fusion centers have been around since the 9/11 terrorist attacks but have been shackled with an underperforming label. Products from fusion centers often do not support the mission of the organizations supporting the...
Published by: IGI Global Scientific Publishing
Interview with W. H. Winborne
W. H. Winborne
Jan 01, 0001
In his July 1984 interview with Michael Cooke, W. H. Winborne described his work with the Orangeburg Area Sickle Cell Anemia Foundation, the Family Health Center, and the outreach programs related to the foundation. Winborne...
sickle cell anemia Orangeburg Area Sickle Cell Anemia Foundation Family Health Center (previously Orangeburg County Consumer Health Council) Seventh Day Adventist DHEC (Department of Health and Environmental Control) outreach programs Oral History
Published by: Winthrop University
ERIC-PCR Analysis of the Clinical and Environmental strains of V. cholerae during 2013 Epidemic in Nigeria
Smith Stella, Nwaokorie Francisca, Awoderu Oluwatoyin, Bamidele Tajudeen, Akinsinde Kehinde, Ochoga Michael, Oladele David, Bamidele Moses, Fesobi Toun, Afocha Eberechukwu, Amoo Samuel, Ajayi Morakinyo, Atat Prince, Ogbonna Francisca, Nduaga Samuel, Idika Nneoma, Oparaugo Chinedu, Musa Adesola, Adeneye Adeniyi, Ijeh Margaret, Ujah Innocent
Nov 21, 2015
Background: Molecular markers are important tools in the monitoring of toxigenic strains of Vibrio cholerae in environmental and clinical samples.
Objectives: The study was aimed at determining the clinical and environmental...
Published by: IJHS Medical Association
Enantioselective S‐H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
Patrícia B. Momo, Alexandria N. Leveille, Elliot H. E. Farrar, Matthew N. Grayson, Anita E. Mattson, Antonio Carlos Bender Burtoloso
Sep 01, 2020
The first example of enantioselective S‐H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95% ee) and yields (up to 97%) are achieved...
Enantioselective S‐H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
Patrícia B. Momo, Alexandria N. Leveille, Elliot H. E. Farrar, Matthew N. Grayson, Anita E. Mattson, Antonio Carlos Bender Burtoloso
Sep 01, 2020
The first example of enantioselective S‐H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95% ee) and yields (up to 97%) are achieved...
Constraints on the evolution of the relationship between H i mass and halo mass in the last 12 Gyr
The neutral hydrogen (H I) content of dark matter haloes forms an intermediate state in the baryon cycle that connects the hot shock-heated gas and cold star-forming gas in haloes. Measurement of the relationship between H I...
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