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Lack of detectable neoantigen depletion signals in the untreated cancer genome.
Somatic mutations can result in the formation of neoantigens, immunogenic peptides that are presented on the tumor cell surface by HLA molecules. These mutations are expected to be under negative selection pressure, but the...
Contrasting Instructional Technology Adoption in K-12 Education to Promote Digital Equity
This quantitative study examined the frequency of usage and teacher perception of educational technology by K - 12 public school teachers in three geographic settings: urban, rural, and suburban. The objective aimed to uncover...
Published by: IGI Global Scientific Publishing
Keeping Monks in Their Place?
T Larsson
Dec 16, 2015
In Search of Liberalism
TH Larsson
Jun 14, 2017
The history of political thought in Southeast Asia has overwhelmingly focused on nationalism and socialism/Marxism. Little has been written about the fate of liberalism in the region. This is in stark contrast with the...
Does Treating Vascular Risk Factors Prevent Dementia and Alzheimer's Disease? A Systematic Review and Meta-Analysis.
Alzheimer’s disease Dementia Meta-Analysis Prevention Prospective Studies Randomized controlled trials Risk Factors Systematic review Alzheimer Disease Dementia Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Insulin Prospective Studies PubMed Randomized Controlled Trials as Topic Risk Factors
Appraising the causal role of smoking in multiple diseases
BACKGROUND: The causal association between cigarette smoking and several diseases remains equivocal. The purpose of this study was to appraise the causal role of smoking in a wide range of diseases by summarizing the evidence...
Causal role of high body mass index in multiple chronic diseases
Homocysteine and small vessel stroke
OBJECTIVE: Trials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be...
Genetically proxied interleukin-6 receptor inhibition
Respiratory disease is a main feature of severe COVID-19, and the potential of IL-6 receptor blockade to increase risk of pneumonia warrants vigilance and caution in its application to treat COVID-19 https://bit.ly/34Y8Ner
Genetic liability to insomnia in relation to cardiovascular diseases
The present study aimed to determine the associations between insomnia and cardiovascular diseases (CVDs) using Mendelian randomisation (MR) analysis. As instrumental variables, we used 208 independent single-nucleotide...
IGF-1 and cardiometabolic diseases
Abstract: Aims/hypothesis: Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic...
Genetically predicted cortisol levels and risk of venous thromboembolism
Introduction
In observational studies, venous thromboembolism (VTE) has been associated with Cushing’s syndrome and with persistent mental stress, two conditions associated...
IGF-1 and cardiometabolic diseases
Abstract: Aims/hypothesis: Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic...
Circulating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes
Vitamin K plays a crucial role in blood coagulation, and hypercoagulability has been linked to atherosclerosis-related vascular disease. We used the Mendelian randomization study design to examine whether circulating vitamin K₁...
Smoking and stroke
We used the Mendelian randomization design to explore the potential causal association of smoking with ischemic stroke and intracerebral hemorrhage using summary statistics data for 34,217 ischemic stroke cases and 404,630...
Mendelian randomization in the bone field.
Identification of causative risk factors amenable for modification is essential for the prevention and treatment of osteoporosis. Observational studies have identified associations between several potentially modifiable risk...
Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank
AIMS: The causal role of adiposity for several cardiovascular diseases (CVDs) is unclear. Our primary aim was to apply the Mendelian randomization design to investigate the associations of body mass index (BMI) with 13 CVDs and...
Adiposity Body composition Body Mass Index cardiovascular disease Mendelian randomization obesity Adult Aged Biological Specimen Banks Body Mass Index Cardiovascular Diseases Female Genome-Wide Association Study Humans Incidence Male Mendelian Randomization Analysis Middle Aged obesity Polymorphism Single Nucleotide Risk Assessment Risk Factors United Kingdom
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