The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.
Peter van Galen,
Antonija Kreso,
Nathan Mbong,
David G Kent,
Timothy Fitzmaurice,
Joseph E Chambers,
Stephanie Xie,
Elisa Laurenti,
Karin Hermans,
Kolja Eppert,
Stefan J Marciniak,
Jane C Goodall,
Anthony R Green,
Bradly G Wouters,
Erno Wienholds,
John E Dick
May 08, 2018
The blood system is sustained by a pool of haematopoietic stem cells (HSCs) that are long-lived due to their capacity for self-renewal. A consequence of longevity is exposure to stress stimuli including reactive oxygen species...