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Results: 246
Food based dietary patterns and chronic disease prevention.
Matthias B Schulze, Miguel A Martínez-González, Teresa T Fung, Alice H Lichtenstein, Nita G Forouhi
Sep 20, 2018
Matthias B Schulze and colleagues discuss current knowledge on the associations between dietary patterns and cancer, coronary heart disease, stroke, and type 2 diabetes, focusing on areas of uncertainty and future research...
A Dash of Pessimism? Ernst Bloch, Radical Disappointment and the Militant Excavation of Hope
Joe Davidson
Jul 19, 2021
Ernst Bloch is a philosopher of hope, of this there can be no doubt. It is the fidelity to the proposition that a better world is possible that undergirds Bloch’s work. Yet, the hopeful tenor of Bloch’s philosophy, as I argue...
Sensory studies, or when physics was psychophysics
Richard Staley
Jul 04, 2018
This paper highlights the significance of sensory studies and psychophysical investigations of the relations between psychic and physical phenomena for our understanding of the development of the physics discipline, by examining...
Constructing the bundle sheath towards enhanced photosynthesis.
This article comments on: van Rooijen R, Schulze S, Petzsch P, Westhoff P. 2020. Targeted misexpression of NAC052, acting in H3K4 demethylation, alters leaf morphological and anatomical traits in Arabidopsis thaliana. Journal of...
Equation of State of Fluid Methane from First Principles with Machine Learning Potentials.
Max Veit, Sandeep Kumar Jain, Satyanarayana Bonakala, Indranil Rudra, Detlef Hohl, Gábor Csányi
Feb 27, 2019
The predictive simulation of molecular liquids requires potential energy surface (PES) models that are not only accurate but also computationally efficient enough to handle the large systems and long time scales required for...
T cell stimulator cells, an efficient and versatile cellular system to assess the role of costimulatory ligands in the activation of human T cells.
Judith Leitner, Werner Kuschei, Katharina Grabmeier-Pfistershammer, Ramona Woitek, Ernst Kriehuber, Otto Majdic, Gerhard Zlabinger, Winfried F Pickl, Peter Steinberger
Jan 02, 2019
It is well established that full activation of T cells requires the interaction of the TCR complex with the peptide-MHC complex (Signal 1) and additional signals (Signal 2). These second signals are generated by the interaction...
Animals Antibodies Antigens CD Biological Assay Cell Line Tumor Humans Immunologic Factors Lymphocyte Activation Major Histocompatibility Complex Mice Peptides Receptor-CD3 Complex Antigen T-Cell Receptors Cell Surface Signaling Lymphocytic Activation Molecule Family Member 1 T-Lymphocytes Tumor Necrosis Factor Ligand Superfamily Member 15
The Verge of Renaissance: A Fantasy Novella
Samuel Ernst
Jan 01, 0001
The Verge of Renaissance is a four-part novella which reimagines the conflict between science and religion in our society as a conflict between science and magic in a fantasy world. It also draws inspiration from the late...
fantasy fiction Novella medieval religion Arts and Humanities English Language and Literature fiction
Published by: Ursinus College
Balancing glycolytic flux
The increased glucose metabolism in cancer cells is required to fulfill their high energetic and biosynthetic demands. Changes in the metabolic activity of cancer cells are caused by the activation of oncogenes or loss of tumor...
Bordetella parapertussis PagP mediates the addition of two palmitates to the lipopolysaccharide lipid A
Bordetella bronchiseptica PagP (PagPBB) is a lipid A palmitoyl transferase that is required for resistance to antibody-dependent complement-mediated killing in a murine model of infection. B. parapertussis contains...
The antecedents and consequences of affordable value innovations for emerging markets
Emerging markets offer tremendous growth opportunities for firms. While established multinational firms typically focus on premium segments in emerging markets, they often fail to leverage additional growth opportunities in...
The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis.
Male gametes are generated through a specialised differentiation pathway involving a series of developmental transitions that are poorly characterised at the molecular level. Here, we use droplet-based single-cell RNA-Sequencing...
Animals Cell Separation Chromatin Chromosome Mapping Chromosomes Human Pair 21 Epigenesis Genetic Female Flow Cytometry Gene Expression Profiling Gene Expression Regulation Developmental Histones Humans Male Meiotic Prophase I Mice Mice Inbred C57BL Mice Transgenic Sequence Analysis RNA Single-Cell Analysis Spermatocytes Spermatogenesis Testis Transcription Genetic X Chromosome
Bordetella parapertussis PagP mediates the addition of two palmitates to the lipopolysaccharide lipid A
Bordetella bronchiseptica PagP (PagPBB) is a lipid A palmitoyl transferase that is required for resistance to antibody-dependent complement-mediated killing in a murine model of infection. B. parapertussis contains...
Proteomic systems evaluation of the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology.
David A Cox, Michael G Gottschalk, Hendrik Wesseling, Agnes Ernst, Jason D Cooper, Sabine Bahn
Jul 07, 2016
chronic phencyclidine (PCP) rat model Molecular validity Proteomics Psychosis models Schizophrenia Systems Biology Animals Chromatography Liquid Disease Models Animal Humans Ketamine Machine Learning Male Mice Transgenic Phencyclidine Prefrontal Cortex Protein Interaction Maps Proteomics Psychotic Disorders Rats Receptors N-Methyl-D-Aspartate Schizophrenia Tandem Mass Spectrometry
Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42.
Dissociable hormonal profiles for psychopathology and stress in anorexia and bulimia nervosa.
Margaret L Westwater, Flavia Mancini, Jane Shapleske, Jaco Serfontein, Monique Ernst, Hisham Ziauddeen, Paul C Fletcher
May 07, 2020
Shedding light on AT1G29480 of
<scp>
<i>Arabidopsis thaliana</i>
</scp>
—An enigmatic locus restricted to Brassicacean genomes
Kumari Billakurthi, Stefanie Schulze, Eva Lena Marie Schulz, Tammy L Sage, Tina B Schreier, Julian M Hibberd, Martha Ludwig, Peter Westhoff
Oct 17, 2022
Abstract: A key feature of C4 Kranz anatomy is the presence of an enlarged, photosynthetically highly active bundle sheath whose cells contain large numbers of chloroplasts. With the aim to identify novel candidate regulators of...
Gitelman syndrome: consensus and guidance from a Kidney Disease
Anne Blanchard, Detlef Bockenhauer, Davide Bolignano, Lorenzo A Calò, Etienne Cosyns, Olivier Devuyst, David H Ellison, Fiona E Karet Frankl, Nine VAM Knoers, Martin Konrad, Shih-Hua Lin, Rosa Vargas-Poussou
Feb 12, 2019
Gitelman syndrome (GS) is a rare, salt-losing tubulopathy characterized by hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria. The disease is recessively inherited, caused by inactivating mutations in the...
SLC12A3 hypokalemic metabolic alkalosis hypomagnesemia salt-losing tubulopathy thiazide-sensitive sodium-chloride cotransporter Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors Anti-Inflammatory Agents Non-Steroidal Bartter Syndrome Calcium Chloride Channels Chondrocalcinosis Consensus Development Conferences as Topic Diagnosis Differential Dietary Supplements Genetic Testing Gitelman syndrome Humans Hypokalemia Magnesium Mutation Phenotype Potassium Practice Guidelines as Topic Quality of life Rare Diseases Sodium Chloride Dietary Solute Carrier Family 12 Member 3 Ultrasonography
Automatic Segmentation of Drosophila Neural Compartments Using GAL4 Expression Data Reveals Novel Visual Pathways.
Karin Panser, Laszlo Tirian, Florian Schulze, Santiago Villalba, Gregory SXE Jefferis, Katja Bühler, Andrew D Straw
Mar 28, 2019
Identifying distinct anatomical structures within the brain and developing genetic tools to target them are fundamental steps for understanding brain function. We hypothesize that enhancer expression patterns can be used to...
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