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A guide to assessing cellular senescence in vitro and in vivo.
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly dynamic and regulated cellular state plays...
Ageing assessment Biomarkers Cellular Senescence detection aging Animals Animals Genetically Modified Biomarkers Cell Cycle Checkpoints Cell Cycle Proteins Cell Proliferation Cell Shape Cells Cultured Cellular Senescence Cytokines DNA Damage Genetic Loci Heterochromatin Humans Lamin Type B Lysosomes Mitochondria
Targeting senescent cells in translational medicine.
Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress...
Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1.
The TRAPP complexes are nucleotide exchange factors that play essential roles in membrane traffic and autophagy. TRAPPII activates Rab11, and TRAPPIII activates Rab1, with the two complexes sharing a core of small subunits that...
Anticholinergic burden in older adult inpatients
Maria Herrero-Zazo, Rachel Berry, Emma Bines, Debi Bhattacharya, Phyo K Myint, Victoria L Keevil
Jun 27, 2021
Background
Anticholinergic medications are associated with adverse outcomes in older adults and should be prescribed cautiously. We describe the Anticholinergic Risk Scale (ARS) scores of older inpatients and...
Published by: Therapeutic advances in drug safety
Codon Usage and Adenovirus Fitness
Judit Giménez-Roig, Estela Núñez-Manchón, Ramon Alemany, Eneko Villanueva, Cristina Fillat
Feb 24, 2021
Vaccination is the most effective method to date to prevent viral diseases. It intends to mimic a naturally occurring infection while avoiding the disease, exposing our bodies to viral antigens to trigger an immune response that...
Special Measures for Quality and Challenged Providers
Naomi Fulop, Estela Capelas Barbosa, Melissa Hill, Jean Ledger, Christopher Sherlaw-Johnson, Jonathan Spencer, Cecilia Vindrola-Padros, Steve Morris
Sep 11, 2020
BACKGROUND: Healthcare organisations in England rated as inadequate in terms of leadership and one other domain enter the Special Measures for Quality (SMQ) regime to receive increased support and oversight. There is also a...
Transgene codon usage drives viral fitness and therapeutic efficacy in oncolytic adenoviruses.
Estela Núñez-Manchón, Martí Farrera-Sal, Marc Otero-Mateo, Giancarlo Castellano, Rafael Moreno, David Medel, Ramon Alemany, Eneko Villanueva, Cristina Fillat
Aug 28, 2021
Arming oncolytic adenoviruses with therapeutic transgenes is a well-established strategy for multimodal tumour attack. However, this strategy sometimes leads to unexpected attenuated viral replication and a loss of oncolytic...
Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology.
Christopher Barrington, Dimitra Georgopoulou, Dubravka Pezic, Wazeer Varsally, Javier Herrero, Suzana Hadjur
Jul 01, 2020
Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute to cell-type specific genome structure is poorly understood. Here, we explore quantitative aspects of topologically associated...
Anticholinergic burden in older adult inpatients
Maria Herrero-Zazo, Rachel Berry, Emma Bines, Debi Bhattacharya, Phyo K. Myint, Victoria L. Keevil
May 10, 2021
Background:: Anticholinergic medications are associated with adverse outcomes in older adults and should be prescribed cautiously. We describe the Anticholinergic Risk Scale (ARS) scores of older inpatients and associations with...
Zasp52 strengthens whole embryo tissue integrity through supracellular actomyosin networks.
Dina J Ashour, Clinton H Durney, Vicente J Planelles-Herrero, Tim J Stevens, James J Feng, Katja Röper
Apr 03, 2023
Special Measures for Quality and Challenged Providers
Naomi Fulop, Estela Capelas Barbosa, Melissa Hill, Jean Ledger, Christopher Sherlaw-Johnson, Jonathan Spencer, Cecilia Vindrola-Padros, Steve Morris
May 26, 2020
BACKGROUND:Healthcare organisations in England rated as inadequate in terms of leadership and one other domain enter the Special Measures for Quality (SMQ) regime to receive increased support and oversight. There is also a...
Mixed Methods Research National Health Service (Nhs) Organisational Failure Special Measures For Quality
Published by: International journal of health policy and management
A Board Level Intervention to Develop Organisation-Wide Quality Improvement Strategies
Estela Capelas Barbosa, Lorelei Jones, Linda Pomeroy, Glenn Robert, Susan Burnett, Janet E Anderson, Steve Morris, Fulop Naomi
Aug 26, 2020
BACKGROUND: Hospital boards have statutory responsibility for upholding the quality of care in their organisations. International research on quality in hospitals resulted in a research-based guide to help senior hospital...
Using machine learning to model older adult inpatient trajectories from electronic health records data.
Maria Herrero-Zazo, Tomas Fitzgerald, Vince Taylor, Helen Street, Afzal N Chaudhry, John R Bradley, Ewan Birney, Victoria L Keevil
Feb 23, 2023
Sensitive and robust chemical detection using an olfactory brain-computer interface.
Erez Shor, Pedro Herrero-Vidal, Adam Dewan, Ilke Uguz, Vincenzo F Curto, George G Malliaras, Cristina Savin, Thomas Bozza, Dmitry Rinberg
Sep 27, 2021
When it comes to detecting volatile chemicals, biological olfactory systems far outperform all artificial chemical detection devices in their versatility, speed, and specificity. Consequently, the use of trained animals for...
Fratricide activity of MafB protein of N. meningitidis strain B16B6.
Jesús Arenas, Vincent de Maat, Laura Catón, Massis Krekorian, Juan Cruz Herrero, Flavio Ferrara, Jan Tommassen
May 11, 2020
BACKGROUND: Neisseria meningitidis is an inhabitant of the mucosal surfaces of the human nasopharynx. We recently demonstrated that the secreted meningococcal Two-partner secretion protein A (TpsA) is involved in interbacterial...
MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Variations in the magnetic properties of meteoritic cloudy zone
Claire IO Nichols, James FJ Bryson, Roberts Blukis, Julia Herrero‐Albillos, Florian Kronast, Rudolf Rüffer, Aleksandr I Chumakov, Richard J Harrison
Feb 03, 2020
Iron and stony‐iron meteorites form the Widmanstätten pattern during slow cooling. This pattern is composed of several microstructures whose length‐scale, composition and magnetic properties are dependent upon cooling rate. Here...
Lineage-specific gene radiations underlie the evolution of novel betalain pigmentation in Caryophyllales.
Samuel F Brockington, Ya Yang, Fernando Gandia-Herrero, Sarah Covshoff, Julian M Hibberd, Rowan F Sage, Gane KS Wong, Michael J Moore, Stephen A Smith
Jun 05, 2015
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