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Multivariate moment closure techniques for stochastic kinetic models.
Stochastic effects dominate many chemical and biochemical processes. Their analysis, however, can be computationally prohibitively expensive and a range of approximation schemes have been proposed to lighten the computational...
MEANS
Sisi Fan, Quentin Geissmann, Eszter Lakatos, Saulius Lukauskas, Angelique Ale, Ann C Babtie, Paul DW Kirk, Michael PH Stumpf
Jul 16, 2018
MOTIVATION: Many biochemical systems require stochastic descriptions. Unfortunately these can only be solved for the simplest cases and their direct simulation can become prohibitively expensive, precluding thorough analysis. As...
Let’s Not Talk About the Anthropocene
Jay Foster
Jan 07, 2019
The Hungarian philosopher of science Imre Lakatos once complained that Thomas Kuhn had reduced scientific research to “mob psychology." In The Structure of Scientific Revolutions (1962), Kuhn famously suggested that scientific...
Published by: Memorial University of Newfoundland
Let’s Not Talk About the Anthropocene
Jay Foster
Jan 07, 2019
The Hungarian philosopher of science Imre Lakatos once complained that Thomas Kuhn had reduced scientific research to “mob psychology." In The Structure of Scientific Revolutions (1962), Kuhn famously suggested that scientific...
Published by: Memorial University of Newfoundland
Celecoxib Prevents Doxorubicin-Induced Multidrug Resistance in Canine and Mouse Lymphoma Cell Lines
Edina Karai, Kornélia Szebényi, Tímea Windt, Sára Fehér, Eszter Szendi, Valéria Dékay, Péter Vajdovich, Gergely Szakács, András Füredi
Apr 30, 2020
Background: Treatment of malignancies is still a major challenge in human and canine cancer, mostly due to the emergence of multidrug resistance (MDR). One of the main contributors of MDR is the overexpression P-glycoprotein...
Associations between commute mode and cardiovascular disease, cancer, and all-cause mortality, and cancer incidence, using linked Census data over 25 years in England and Wales
Richard Patterson, Jenna Panter, Eszter P Vamos, Steven Cummins, Christopher Millett, Anthony A Laverty
Mar 31, 2020
Comparison of permutationally invariant polynomials, neural networks, and Gaussian approximation potentials in representing water interactions through many-body expansions.
Typology of how 'harmful commodity industries' interact with local governments in England
Sarah McKevitt, Martin White, Mark Petticrew, Carolyn Summerbell, Milica Vasiljevic, Emma Boyland, Steven Cummins, Anthony A Laverty, Cornelia Junghans, Christopher Millett, Frank De Vocht, Eva Hrobonova, Eszter P Vamos
Jan 25, 2023
The Impact of the Universal Infant Free School Meal Policy on Dietary Quality in English and Scottish Primary School Children
Jennie C Parnham, Kiara Chang, Christopher Millett, Anthony A Laverty, Stephanie von Hinke, Jonathan Pearson-Stuttard, Frank De Vocht, Martin White, Eszter P Vamos
May 24, 2022
Celecoxib Prevents Doxorubicin-Induced Multidrug Resistance in Canine and Mouse Lymphoma Cell Lines.
Edina Karai, Kornélia Szebényi, Tímea Windt, Sára Fehér, Eszter Szendi, Valéria Dékay, Péter Vajdovich, Gergely Szakács, András Füredi
Jul 17, 2020
BACKGROUND: Treatment of malignancies is still a major challenge in human and canine cancer, mostly due to the emergence of multidrug resistance (MDR). One of the main contributors of MDR is the overexpression P-glycoprotein...
Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology
Kornélia Szebényi, Léa M. D. Wenger, Yu Sun, Alexander W. E. Dunn, Colleen A. Limegrover, George M. Gibbons, Elena Conci, Ole Paulsen, Susanna B. Mierau, Gabriel Balmus, András Lakatos
Oct 29, 2021
Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology.
Kornélia Szebényi, Léa MD Wenger, Yu Sun, Alexander WE Dunn, Colleen A Limegrover, George M Gibbons, Elena Conci, Ole Paulsen, Susanna B Mierau, Gabriel Balmus, András Lakatos
Aug 25, 2021
Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology
Kornélia Szebényi, Léa M. D. Wenger, Yu Sun, Alexander W. E. Dunn, Colleen A. Limegrover, George M. Gibbons, Elena Conci, Ole Paulsen, Susanna B. Mierau, Gabriel Balmus, András Lakatos
Oct 28, 2021
Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.
Kevin Moreau, Ghita Ghislat, Warren Hochfeld, Maurizio Renna, Eszter Zavodszky, Gautam Runwal, Claudia Puri, Shirley Lee, Farah Siddiqi, Fiona M Menzies, Brinda Ravikumar, David C Rubinsztein
Jun 07, 2016
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A. Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G. Boutelle, Eszter Farkas, Jens P. Dreier, Martin Fabricius, C. William Shuttleworth, Andrew Carlson
Jul 22, 2020
Abstract: The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, “What should a clinician do when spreading...
Enabling transformative economic change in the post‐2020 biodiversity agenda
Esther Turnhout, Pamela McElwee, Mireille Chiroleu‐Assouline, Jennifer Clapp, Cindy Isenhour, Eszter Kelemen, Tim Jackson, Daniel C Miller, Graciela M Rusch, Joachim H Spangenberg, Anthony Waldron
May 03, 2021
Abstract: The COVID‐19 pandemic, its impact on the global economy, and current delays in the negotiation of the post‐2020 global biodiversity agenda of the Convention on Biological Diversity heighten the urgency to build back...
A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
GE Tyzack, CE Hall, CR Sibley, T Cymes, S Forostyak, G Carlino, IF Meyer, G Schiavo, S Zhang, GM Gibbons, J Newcombe, R Patani, A Lakatos
Jan 29, 2018
Amyotrophic Lateral Sclerosis Animals Anti-Inflammatory Agents Astrocytes Axons Cells Cultured Disease Models Animal Humans Inflammation Interleukin-6 Male Mice Mice Inbred C57BL Motor Neurons Neurons Neuroprotection Receptor EphB1 STAT3 Transcription Factor Sciatic Nerve Signal Transduction Transcriptome
Typology of how 'harmful commodity industries' interact with local governments in England
Sarah McKevitt, Martin White, Mark Petticrew, Carolyn Summerbell, Milica Vasiljevic, Emma Boyland, Steven Cummins, Anthony A Laverty, Cornelia Junghans, Christopher Millett, Frank De Vocht, Eva Hrobonova, Eszter P Vamos
Feb 23, 2023
A Compendium of Mutational Signatures of Environmental Agents.
Jill E Kucab, Xueqing Zou, Sandro Morganella, Madeleine Joel, A Scott Nanda, Eszter Nagy, Celine Gomez, Andrea Degasperi, Rebecca Harris, Stephen P Jackson, Volker M Arlt, David H Phillips, Serena Nik-Zainal
Mar 04, 2019
Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced pluripotent stem cells exposed to 79...
The Impact of the Universal Infant Free School Meal Policy on Dietary Quality in English and Scottish Primary School Children
The Universal Infant Free School Meal (UIFSM) policy was introduced in September 2014 in England and January 2015 in Scotland and offered all infant schoolchildren (ages 4–7 years) a free school lunch, regardless of...
Jennie C Parnham, Kiara Chang, Christopher Millett, Anthony A Laverty, Stephanie von Hinke, Jonathan Pearson-Stuttard, Frank De Vocht, Martin White, Eszter P Vamos
Apr 13, 2022
Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.
Giulia E Tyzack, Sergey Sitnikov, Daniel Barson, Kerala L Adams-Carr, Nike K Lau, Jessica C Kwok, Chao Zhao, Robin Jm Franklin, Ragnhildur T Karadottir, James W Fawcett, András Lakatos
Sep 05, 2014
Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output.
Stefano L Giandomenico, Susanna B Mierau, George M Gibbons, Lea MD Wenger, Laura Masullo, Timothy Sit, Magdalena Sutcliffe, Jerome Boulanger, Marco Tripodi, Emmanuel Derivery, Ole Paulsen, András Lakatos, Madeline A Lancaster
Dec 23, 2020
Neural organoids have the potential to improve our understanding of human brain development and neurological disorders. However, it remains to be seen whether these tissues can model circuit formation with functional neuronal...
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G Boutelle, Eszter Farkas, Jens P Dreier, Martin Fabricius, C William Shuttleworth, Andrew Carlson
Jul 29, 2019
The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, "What should a clinician do when spreading depolarizations are...
Cortical Spreading Depression Electroencephalography Intracerebral hemorrhage ischemic stroke outcome Subarachnoid Hemorrhage Traumatic brain injury Brain Injuries Traumatic Cortical Spreading Depression Electrocorticography Electroencephalography Excitatory Amino Acid Antagonists Humans Ketamine Outcome Assessment Health Care Precision Medicine stroke Subarachnoid Hemorrhage
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A. Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G. Boutelle, Eszter Farkas, Jens P. Dreier, Martin Fabricius, C. William Shuttleworth, Andrew Carlson
Jun 06, 2020
Abstract: The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, “What should a clinician do when spreading...
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