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Model free audit methodology for bias evaluation of tumour progression in oncology

Many oncology studies incorporate a blinded independent central review (BICR) to make an assessment of the integrity of the primary endpoint, progression free survival. Recently, it has been suggested that, in order to assess...

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Model free audit methodology for bias evaluation of tumour progression in oncology

Many oncology studies incorporate a blinded independent central review (BICR) to make an assessment of the integrity of the primary endpoint, progression free survival. Recently, it has been suggested that, in order to assess...

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Cosmological distances with general-relativistic ray tracing
Hayley J Macpherson
Mar 07, 2023
Abstract In this work we present the first results from a new ray-tracing tool to calculate cosmological distances in the context of fully nonlinear general relativity. We use...
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Sharp bounds on Helmholtz impedance-to-impedance maps and application to overlapping domain decomposition

We prove sharp bounds on certain impedance-to-impedance maps (and their compositions) for the Helmholtz equation with large wavenumber (i.e., at high frequency) using semiclassical defect measures. Gong et al. (Numer. Math....

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A new transform method I
Euan A Spence, A S Fokas
Jan 01, 0001
A new method for solving boundary-value problems (BVPs) for linear and certain nonlinear PDEs was introduced by one of the authors in the late 1990s. For linear PDEs, this method constructs novel integral representations (IRs)...
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Analysis of a Helmholtz preconditioning problem motivated by uncertainty quantification
This paper analyses the following question: let Aj, j = 1,2, be the Galerkin matrices corresponding to finite-element discretisations of the exterior Dirichlet problem for the heterogeneous Helmholtz equations ∇⋅ (Aj∇uj) +...
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Scattering by finely-layered obstacles

We consider the scalar Helmholtz equation with variable, discontinuous coefficients, modeling transmission of acoustic waves through an anisotropic penetrable obstacle. We first prove a well-posedness result and a...

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High-frequency bounds for the Helmholtz equation under parabolic trapping and applications in numerical analysis
This paper is concerned with resolvent estimates on the real axis for the Helmholtz equation posed in the exterior of a bounded obstacle with Dirichlet boundary conditions when the obstacle is trapping. There are two resolvent...
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Spurious Quasi-Resonances in Boundary Integral Equations for the Helmholtz Transmission Problem
We consider the Helmholtz transmission problem with piecewise-constant material coefficients, and the standard associated direct boundary integral equations. For certain coefficients and geometries, the norms of the inverses of...
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Arylboronic Acid Catalyzed C-Alkylation and Allylation Reactions Using Benzylic Alcohols
The arylboronic acid catalyzed dehydrative C-alkylation of 1,3-diketones and 1,3-ketoesters using secondary benzylic alcohols as the electrophile is reported, forming new C–C bonds (19 examples, up to 98% yield) with the release...
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Numerical estimation of coercivity constants for boundary integral operators in acoustic scattering
Timo Betcke, Euan A Spence
Jan 01, 0001
Coercivity is an important concept for proving existence and uniqueness of solutions to variational problems in Hilbert spaces. But while coercivity estimates are well known for many variational problems arising from partial...
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Domain decomposition preconditioning for high-frequency Helmholtz problems with absorption
In this paper we give new results on domain decomposition preconditioners for GMRES when computing piecewise-linear finite-element approximations} of the Helmholtz equation $-\Delta u - (k^2+ \ri \eps)u = f$, with absorption...
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Numerical estimation of coercivity constants for boundary integral operators in acoustic scattering
Timo Betcke, Euan A Spence
Jan 01, 0001
Coercivity is an important concept for proving existence and uniqueness of solutions to variational problems in Hilbert spaces. But while coercivity estimates are well known for many variational problems arising from partial...
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Scattering by finely-layered obstacles

We consider the scalar Helmholtz equation with variable, discontinuous coefficients, modeling transmission of acoustic waves through an anisotropic penetrable obstacle. We first prove a well-posedness result and a...

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Acoustic transmission problems
Andrea Moiola, Euan Spence
Feb 28, 2019

We consider the Helmholtz transmission problem with one penetrable star-shaped Lipschitz obstacle. Under a natural assumption about the ratio of the wavenumbers, we prove bounds on the solution in terms of the data, with...

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Acoustic transmission problems
Andrea Moiola, Euan Spence
Feb 28, 2019

We consider the Helmholtz transmission problem with one penetrable star-shaped Lipschitz obstacle. Under a natural assumption about the ratio of the wavenumbers, we prove bounds on the solution in terms of the data, with...

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A new transform method II
Euan A Spence, A S Fokas
Jan 01, 0001
A new method for solving boundary-value problems (BVPs) for linear and certain nonlinear PDEs was introduced by one of the authors in the late 1990s. For linear PDEs, this method constructs novel integral representations (IRs)...
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