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Results: 14329
Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App NL-G-F Mice.
Melissa Huang, Jennifer Macdonald, Isabelle Lavenir, Renren Chen, Molly Craxton, Elizabeth Slavik-Smith, Stephen W Davies, Michel Goedert
Feb 12, 2023
Alzheimer's Disease (AD) is characterized by the pathologic assembly of amyloid β (Aβ) peptide, which deposits into extracellular plaques, and tau, which accumulates in intraneuronal inclusions. To investigate the link between...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
f-scLVM
Florian Buettner, Naruemon Pratanwanich, Davis J McCarthy, John C Marioni, Oliver Stegle
Mar 26, 2018
Single-cell RNA-sequencing (scRNA-seq) allows studying heterogeneity in gene expression in large cell populations. Such heterogeneity can arise due to technical or biological factors, making decomposing sources of variation...
Gene set annotations Single-cell RNA-seq Sparse factor analysis Animals Computer Simulation Databases as Topic Factor Analysis Statistical Gene Expression Regulation Mice Models Theoretical Mouse embryonic stem cells Neurons Reproducibility of Results Sequence Analysis RNA Single-Cell Analysis Software
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Synthesis and characterization of fluorinated β-ketoiminate zinc precursors and their utility in the AP-MOCVD growth of ZnO
Andrew L. Johnson, Samuel D. Cosham, Gabriele Kociok-Kohn, Jeff A. Hamilton, Michael S. Hill, Kieran C. Molloy, Remi Castaing
Sep 01, 2015
A novel family of zinc bis beta-ketoiminate complexes 2b-2h have been synthesized by reaction of the isolated free ligands (1a-h) with dimethylzinc. The isolated zinc complexes were characterized by elemental analysis, NMR...
Synthesis and characterization of fluorinated β-ketoiminate zinc precursors and their utility in the AP-MOCVD growth of ZnO
Andrew L. Johnson, Samuel D. Cosham, Gabriele Kociok-Kohn, Jeff A. Hamilton, Michael S. Hill, Kieran C. Molloy, Remi Castaing
Sep 01, 2015
A novel family of zinc bis beta-ketoiminate complexes 2b-2h have been synthesized by reaction of the isolated free ligands (1a-h) with dimethylzinc. The isolated zinc complexes were characterized by elemental analysis, NMR...
The First Near-infrared Transmission Spectrum of HIP 41378 f, A Low-mass Temperate Jovian World in a Multiplanet System
Munazza K. Alam, James Kirk, Courtney D. Dressing, Mercedes López-Morales, Kazumasa Ohno, Peter Gao, Babatunde Akinsanmi, Alexandre Santerne, Salomé Grouffal, Vardan Adibekyan, Susana C. C. Barros, Lars A. Buchhave, Ian J. M. Crossfield, Fei Dai, Magali Deleuil, Steven Giacalone, Jorge Lillo-Box, Mark Marley, Andrew W. Mayo, Annelies Mortier, Nuno C. Santos, Sérgio G. Sousa, Emma V. Turtelboom, Peter J. Wheatley, Andrew M. Vanderburg
Mar 01, 2022
Abstract: We present a near-infrared transmission spectrum of the long-period (P = 542 days), temperate (T eq = 294 K) giant planet HIP 41378 f obtained with the Wide-Field Camera 3 instrument aboard the Hubble Space Telescope...
G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
3D printed customised external cranial plate in a patient with syndrome of trephined
Mee H., Greasley S., Whiting G., Harkin C., Oliver G., Marsden D., Andrews R., Sireau S., Price RD., Anwar F., Timofeev IS., Hutchinson PJ., White PA., Helmy A.
Nov 22, 2021
Abstract: Background: Syndrome of the trephined is a well-recognised phenomenon that occurs in patients following a craniectomy. It is associated with several symptoms, including headaches, motor impairments, cognitive disorders...
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure.
James H Felce, Sarah L Latty, Rachel G Knox, Susan R Mattick, Yuan Lui, Steven F Lee, David Klenerman, Simon J Davis
May 10, 2018
The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of mostly individual receptors....
Homer F. Swift, 1920
The Rockefeller University
Jan 01, 0001
Homer F. Swift, M.D. Trench Fever
Lecture delivered January 10th, 1920
Published by: J.B. Lippincott Company
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
Assembly of the peripheral stalk of ATP synthase in human mitochondria.
Jiuya He, Joe Carroll, ShuJing Ding, Ian M Fearnley, Martin G Montgomery, John E Walker
Oct 19, 2020
The adenosine triphosphate (ATP) synthase in human mitochondria is a membrane bound assembly of 29 proteins of 18 kinds organized into F1-catalytic, peripheral stalk (PS), and c8-rotor ring modules. All but two membrane...
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
When Bio Meets Technology
Amy E Rochford, Alejandro Carnicer-Lombarte, Vincenzo F Curto, George G Malliaras, Damiano G Barone
Aug 29, 2019
Systematics of the α′ expansion in F-theory
Abstract: Extracting reliable low-energy information from string compactifications notoriously requires a detailed understanding of the UV sensitivity of the corresponding effective field theories. Despite past efforts in...
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators
Dec 12, 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective...
C-F Bond Activation of P(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> By Ruthenium Dihydride Complexes
The major product of the reaction between Ru(IMe4)2(PPh3)2H2 (1; IMe4 = 1,3,4,5-tetramethylimidazol-2-ylidene) and P(C6F5)3 (PCF)...
C-F Bond Activation of P(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> By Ruthenium Dihydride Complexes
The major product of the reaction between Ru(IMe4)2(PPh3)2H2 (1; IMe4 = 1,3,4,5-tetramethylimidazol-2-ylidene) and P(C6F5)3 (PCF)...
Experimental and computational studies of the copper borate complexes [(NHC)Cu(HBEt<sub>3</sub>)] and [(NHC)Cu(HB(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>)]
Lee R. Collins, Nasir A. Rajabi, Stuart A. Macgregor, Mary F. Mahon, Michael K. Whittlesey
Dec 05, 2016
The synthesis of the Cu-borate complexes [(6Mes)Cu(HBR3)] featuring the unusual [HBEt3]− (5) and [HB(C6F5)3]− (6) ligands is described. Experimental...
Systematics of the α′ expansion in F-theory
Extracting reliable low-energy information from string compactifications
notoriously requires a detailed understanding of the UV sensitivity of the
corresponding effective field theories. Despite past efforts in...
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