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Results: 403
A Hybrid Hierarchical Heuristic-ACO With Local Search Applied to Travelling Salesman Problem, AS-FA-Ls
The combinatorial optimization problem is attracting research because they have a wide variety of applications ranging from route planning and supply chain optimization to industrial scheduling and the IoT. Solving such problems...
Published by: IGI Global Scientific Publishing
Fetal diffusion tensor quantification of brainstem pathology in Chiari II malformation.
Ramona Woitek, Daniela Prayer, Michael Weber, Gabriele Amann, Rainer Seidl, Dieter Bettelheim, Veronika Schöpf, Peter C Brugger, Julia Furtner, Ulrika Asenbaum, Gregor Kasprian
Aug 05, 2019
OBJECTIVES: This prenatal MRI study evaluated the potential of diffusion tensor imaging (DTI) metrics to identify changes in the midbrain of fetuses with Chiari II malformations compared to fetuses with mild ventriculomegaly...
The Association Between Food Addiction and Weight Status in School-Age Children and Adolescents.
Background: The association between food addiction (FA) and weight status in children and adolescents remains poorly understood. This study aimed to elucidate the association between FA and weight status using the validated...
Insights into Fanconi Anaemia from the structure of human FANCE
Fanconi Anaemia (FA) is a cancer predisposition disorder characterized by spontaneous chromosome breakage and high cellular sensitivity to genotoxic agents. In response to DNA damage, a multi-subunit assembly of FA proteins, the...
Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.
Martin Moder, Georgia Velimezi, Michel Owusu, Abdelghani Mazouzi, Marc Wiedner, Joana Ferreira da Silva, Lydia Robinson-Garcia, Fiorella Schischlik, Rastislav Slavkovsky, Robert Kralovics, Michael Schuster, Christoph Bock, Trey Ideker, Stephen P Jackson, Jörg Menche, Joanna I Loizou
Apr 18, 2018
Maintenance of genome integrity via repair of DNA damage is a key biological process required to suppress diseases, including Fanconi anemia (FA). We generated loss-of-function human haploid cells for FA complementation group C...
CRISPR-Cas Systems Cell Line DNA Damage DNA Helicases DNA Repair Fanconi Anemia Fanconi Anemia Complementation Group C Protein Fanconi Anemia Complementation Group D2 Protein Fanconi Anemia Complementation Group Proteins HEK293 Cells Haploidy Humans Mutagenesis Insertional NAD(P)H Dehydrogenase (Quinone) RecQ Helicases
Insights into Fanconi Anaemia from the structure of human FANCE
Fanconi Anaemia (FA) is a cancer predisposition disorder characterized by spontaneous chromosome breakage and high cellular sensitivity to genotoxic agents. In response to DNA damage, a multi-subunit assembly of FA proteins, the...
Molecular Characterization of Novel Mutations in Fanconi Anemia Patients
Kimberly Rickman
Jan 01, 0001
Fanconi anemia (FA) is a rare disorder that is characterized by bonemarrow failure in the first decade of life, developmental abnormalities, and predisposition to malignancies. The majority of patients have mutations in one of...
Published by: Rockefeller University
The Association Between Food Addiction and Weight Status in School-Age Children and Adolescents.
BACKGROUND: The association between food addiction (FA) and weight status in children and adolescents remains poorly understood. This study aimed to elucidate the association between FA and weight status using the validated...
Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
SP Jackson, Georgia Velimezi, Lydia Robinson-Garcia, Francisco Muñoz-Martínez, Wouter Wiegant, Joana Ferreira da Silva, Michel Owusu, Martin Moder, Marc Wiedner, Sara Rosenthal, Kathleen Fisch, Jason Moffat, Jörg Menche, Haico Van Attikum, Joanna Loizou
Sep 25, 2018
Defects in DNA repair can cause various genetic diseases with severe pathological phenotypes. Fanconi anemia (FA) is a rare disease characterized by bone marrow failure, developmental abnormalities and increased cancer risk that...
Converging evidence points towards a role of insulin signaling in regulating compulsive behavior.
Ilse IGM van de Vondervoort, Houshang Amiri, Muriel MK Bruchhage, Charlotte A Oomen, Nitin Rustogi, Jason D Cooper, Jack JA van Asten, Arend Heerschap, Sabine Bahn, Steven Cr Williams, Jan K Buitelaar, Geert Poelmans, Jeffrey C Glennon
Sep 11, 2020
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with childhood onset, and is characterized by intrusive thoughts and fears (obsessions) that lead to repetitive behaviors (compulsions). Previously, we...
Animals Anxiety Blood Glucose Brain Brain-Derived Neurotrophic Factor Compulsive Behavior Diabetes mellitus Type 2 Diffusion tensor imaging Disease Models Animal Insulin Insulin-Like Growth Factor I KCNQ1 Potassium Channel Magnetic Resonance Spectroscopy Mice Proteomics Signal Transduction white matter
Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
A Saini, AR Norman, D Cunningham, I Chau, M Hill, D Tait, T Hickish, T Iveson, F Lofts, D Jodrell, PJ Ross, J Oates
Sep 02, 2020
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fluorouracil (5-FU) delivered by protracted intravenous infusion (PVI 5-FU) against the standard bolus regimen of 5-FU and folinic...
Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease
BACKGROUND AND PURPOSE: The relationship between type 2 diabetes mellitus (T2D) and cerebral small vessel disease (CSVD) is unclear. We aimed to examine the causal effect of T2D, fasting glucose levels, and higher insulin...
Mendelian Randomization Analysis cerebral small vessel disease Diabetes mellitus Type 2 Insulin Resistance stroke lacunar Aged Aged 80 and over cerebral hemorrhage cerebral small vessel diseases Diabetes mellitus Type 2 Female Genome-Wide Association Study Humans Magnetic Resonance Imaging Male Mendelian Randomization Analysis Middle Aged Risk Factors stroke lacunar
Mixed A-Cation Perovskites for Solar Cells
Hybrid lead halide perovskites containing a mixture of A-site cations such as the formamidinium (CH(NH2)2+, FA) and the smaller cesium (Cs+) cations have attracted considerable interest due to...
Mixed A-Cation Perovskites for Solar Cells
Hybrid lead halide perovskites containing a mixture of A-site cations such as the formamidinium (CH(NH2)2+, FA) and the smaller cesium (Cs+) cations have attracted considerable interest due to...
Effects of Multi-Shell Free Water Correction on Glioma Characterization.
Lea Starck, Fulvio Zaccagna, Ofer Pasternak, Ferdia Gallagher, Renate Grüner, Frank Riemer
Jan 05, 2022
Diffusion MRI is a useful tool to investigate the microstructure of brain tumors. However, the presence of fast diffusing isotropic signals originating from non-restricted edematous fluids, within and surrounding tumors, may...
Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.
Loes CA Rutten-Jacobs, Daniel J Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S Markus, Matthew Traylor
Sep 05, 2018
BACKGROUND AND PURPOSE: Structural integrity of the white matter is a marker of cerebral small vessel disease, which is the major cause of vascular dementia and a quarter of all strokes. Genetic studies provide a way to obtain...
cerebral small vessel diseases Diffusion tensor imaging Genetic Association Studies Humans white matter Adult Aged Biological Specimen Banks cerebral small vessel diseases Dementia Depression Depressive Disorder Major Diffusion Magnetic Resonance Imaging Female Genome-Wide Association Study Humans Male Middle Aged stroke United Kingdom white matter
Polycarboxylate / nanosilica modified quaternary cement formulations - enhancements and limitations
The effect of polycarboxylate/nanosilica (nS) particles in quaternary cement formulations comprising Portland cement (PC), limestone powder (LS) and fly ash (FA) was investigated for the first time. The reference formulation...
Phenotyping Genetic Diseases Using an Extension of ?-Scores for Multivariate Data
As the field of genomics matures, more complex genotypes and phenotypes are being studied. Fanconi anemia (FA), for example, is an inherited chromosome instability syndrome with a complex array of variable disease phenotypes...
Published by: http://hdl.handle.net/10209/490
Phase Behavior and Substitution Limit of Mixed Cesium-Formamidinium Lead TriIodide Perovskites
Bethan Charles, Mark T. Weller, Sebastian Rieger, Lauren Hatcher, Paul F. Henry, Jochen Feldmann, Daniel Wolverson, Chick Wilson
Mar 24, 2020
The mixed cation lead iodide perovskite photovoltaics show improved stability following site substitution of cesium ions (Cs +) onto the formamidinium cation sites (FA +) of (CH(NH 2)...
BenchML
Abstract
We introduce a machine-learning (ML) framework for high-throughput benchmarking of diverse representations of chemical systems against datasets of materials and molecules....
Two truncating variants in FANCC and breast cancer risk
Thilo Dörk, Paolo Peterlongo, Arto Mannermaa, Manjeet K. Bolla, Qin Wang, Joe Dennis, Thomas Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Laura E. Beane Freeman, Matthias W. Beckmann, Alicia Beeghly-Fadiel, Sabine Behrens, Marina Bermisheva, Carl Blomqvist, Natalia V. Bogdanova, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Federico Canzian, Tsun L. Chan, Jenny Chang-Claude, Stephen J. Chanock, Ji-Yeob Choi, Hans Christiansen, Christine L. Clarke, Fergus J. Couch, Kamila Czene, Mary B. Daly, Isabel dos-Santos-Silva, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Chi Gao, Susan M. Gapstur, Montserrat García-Closas, José A. García-Sáenz, Mia M. Gaudet, Graham G. Giles, Mark S. Goldberg, David E. Goldgar, Pascal Guénel, Lothar Haeberle, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Mikael Hartman, Jan Hauke, Alexander Hein, Peter Hillemanns, Frans B. L. Hogervorst, Maartje J. Hooning, John L. Hopper, Tony Howell, Dezheng Huo, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M. John, Audrey Jung, Rudolf Kaaks, Daehee Kang, Pooja Middha Kapoor, Elza Khusnutdinova, Sung-Won Kim, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Ava Kwong, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Sara Lindström, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Jan Lubiński, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Elena Martinez, Keitaro Matsuo, Dimitris Mavroudis, Alfons Meindl, Usha Menon, Roger L. Milne, Nur Aishah Mohd Taib, Kenneth Muir, Anna Marie Mulligan, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, William G. Newman, Kenneth Offit, Olufunmilayo I. Olopade, Andrew F. Olshan, Janet E. Olson, Håkan Olsson, Sue K. Park, Tjoung-Won Park-Simon, Julian Peto, Dijana Plaseska-Karanfilska, Esther Pohl-Rescigno, Nadege Presneau, Brigitte Rack, Paolo Radice, Muhammad U. Rashid, Gad Rennert, Hedy S. Rennert, Atocha Romero, Matthias Ruebner, Emmanouil Saloustros, Marjanka K. Schmidt, Rita K. Schmutzler, Michael O. Schneider, Minouk J. Schoemaker, Christopher Scott, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Susan Slager, Snezhana Smichkoska, Melissa C. Southey, John J. Spinelli, Jennifer Stone, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Soo H. Teo, Mary Beth Terry, Amanda E. Toland, Rob A. E. M. Tollenaar, Diana Torres, Gabriela Torres-Mejía, Melissa A. Troester, Thérèse Truong, Shoichiro Tsugane, Michael Untch, Celine M. Vachon, Ans M. W. van den Ouweland, Elke M. van Veen, Joseph Vijai, Camilla Wendt, Alicja Wolk, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, Alison M. Dunning, Paul D. P. Pharoah, Detlev Schindler, Peter Devilee, Douglas F. Easton, Rosemary Balleine, Robert Baxter, Stephen Braye, Jane Carpenter, Jane Dahlstrom, John Forbes, C. Soon Lee, Deborah Marsh, Adrienne Morey, Nirmala Pathmanathan, Rodney Scott, Peter Simpson, Allan Spigelman, Nicholas Wilcken, Desmond Yip, Nikolajs Zeps, Anne-Lise Børresen-Dale, Grethe I. Grenaker Alnæs, Kristine K. Sahlberg, Lars Ottestad, Rolf Kåresen, Ellen Schlichting, Marit Muri Holmen, Toril Sauer, Vilde Haakensen, Olav Engebråten, Bjørn Naume, Alexander Fosså, Cecile E. Kiserud, Kristin V. Reinertsen, Åslaug Helland, Margit Riis, Jürgen Geisler
Aug 28, 2020
Abstract: Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the...
Two truncating variants in FANCC and breast cancer risk.
Thilo Dörk, Paolo Peterlongo, Arto Mannermaa, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas Ahearn, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Laura E Beane Freeman, Matthias W Beckmann, Alicia Beeghly-Fadiel, Sabine Behrens, Marina Bermisheva, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Federico Canzian, Tsun L Chan, Jenny Chang-Claude, Stephen J Chanock, Ji-Yeob Choi, Hans Christiansen, Christine L Clarke, Fergus J Couch, Kamila Czene, Mary B Daly, Isabel dos-Santos-Silva, Miriam Dwek, Diana M Eccles, Arif B Ekici, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Chi Gao, Susan M Gapstur, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Mark S Goldberg, David E Goldgar, Pascal Guénel, Lothar Haeberle, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Mikael Hartman, Jan Hauke, Alexander Hein, Peter Hillemanns, Frans BL Hogervorst, Maartje J Hooning, John L Hopper, Tony Howell, Dezheng Huo, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M John, Audrey Jung, Rudolf Kaaks, Daehee Kang, Pooja Middha Kapoor, Elza Khusnutdinova, Sung-Won Kim, Cari M Kitahara, Stella Koutros, Peter Kraft, Vessela N Kristensen, Ava Kwong, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Sara Lindström, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Jan Lubiński, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Elena Martinez, Keitaro Matsuo, Dimitris Mavroudis, Alfons Meindl, Usha Menon, Roger L Milne, Nur Aishah Mohd Taib, Kenneth Muir, Anna Marie Mulligan, Susan L Neuhausen, Heli Nevanlinna, Patrick Neven, William G Newman, Kenneth Offit, Olufunmilayo I Olopade, Andrew F Olshan, Janet E Olson, Håkan Olsson, Sue K Park, Tjoung-Won Park-Simon, Julian Peto, Dijana Plaseska-Karanfilska, Esther Pohl-Rescigno, Nadege Presneau, Brigitte Rack, Paolo Radice, Muhammad U Rashid, Gad Rennert, Hedy S Rennert, Atocha Romero, Matthias Ruebner, Emmanouil Saloustros, Marjanka K Schmidt, Rita K Schmutzler, Michael O Schneider, Minouk J Schoemaker, Christopher Scott, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Susan Slager, Snezhana Smichkoska, Melissa C Southey, John J Spinelli, Jennifer Stone, Harald Surowy, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Soo H Teo, Mary Beth Terry, Amanda E Toland, Rob AEM Tollenaar, Diana Torres, Gabriela Torres-Mejía, Melissa A Troester, Thérèse Truong, Shoichiro Tsugane, Michael Untch, Celine M Vachon, Ans MW van den Ouweland, Elke M van Veen, Joseph Vijai, Camilla Wendt, Alicja Wolk, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, ABCTB Investigators, NBCS Collaborators, Alison M Dunning, Paul DP Pharoah, Detlev Schindler, Peter Devilee, Douglas F Easton
Sep 09, 2019
Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk...
Translational control during developmental transitions
The many steps of gene expression, from the transcription of a gene to the production of its protein product, are well understood. Yet, transcriptional regulation has been the focal point for the study of gene expression during...
Distribution dependent SDEs driven by additive fractional Brownian motion
Abstract We study distribution dependent stochastic differential equations with irregular, possibly distributional drift, driven by an additive fractional Brownian motion of Hurst parameter...
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