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A Hybrid Hierarchical Heuristic-ACO With Local Search Applied to Travelling Salesman Problem, AS-FA-Ls
The combinatorial optimization problem is attracting research because they have a wide variety of applications ranging from route planning and supply chain optimization to industrial scheduling and the IoT. Solving such problems...
Published by: IGI Global Scientific Publishing
Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.
Martin Moder, Georgia Velimezi, Michel Owusu, Abdelghani Mazouzi, Marc Wiedner, Joana Ferreira da Silva, Lydia Robinson-Garcia, Fiorella Schischlik, Rastislav Slavkovsky, Robert Kralovics, Michael Schuster, Christoph Bock, Trey Ideker, Stephen P Jackson, Jörg Menche, Joanna I Loizou
Apr 18, 2018
Maintenance of genome integrity via repair of DNA damage is a key biological process required to suppress diseases, including Fanconi anemia (FA). We generated loss-of-function human haploid cells for FA complementation group C...
CRISPR-Cas Systems Cell Line DNA Damage DNA Helicases DNA Repair Fanconi Anemia Fanconi Anemia Complementation Group C Protein Fanconi Anemia Complementation Group D2 Protein Fanconi Anemia Complementation Group Proteins HEK293 Cells Haploidy Humans Mutagenesis Insertional NAD(P)H Dehydrogenase (Quinone) RecQ Helicases
Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
SP Jackson, Georgia Velimezi, Lydia Robinson-Garcia, Francisco Muñoz-Martínez, Wouter Wiegant, Joana Ferreira da Silva, Michel Owusu, Martin Moder, Marc Wiedner, Sara Rosenthal, Kathleen Fisch, Jason Moffat, Jörg Menche, Haico Van Attikum, Joanna Loizou
Sep 25, 2018
Defects in DNA repair can cause various genetic diseases with severe pathological phenotypes. Fanconi anemia (FA) is a rare disease characterized by bone marrow failure, developmental abnormalities and increased cancer risk that...
Micro-computed tomography (micro-CT) for the assessment of myocardial disarray, fibrosis and ventricular mass in a feline model of hypertrophic cardiomyopathy.
Jose Novo Matos, Patricia Garcia-Canadilla, Ian C Simcock, J Ciaran Hutchinson, Melanie Dobromylskyj, Anna Guy, Owen J Arthurs, Andrew C Cook, Virginia Luis Fuentes
Dec 14, 2020
Micro-computed tomography (micro-CT) is a high-resolution imaging modality that provides accurate tissue characterization. Hypertrophic cardiomyopathy (HCM) occurs as a spontaneous disease in cats, and is characterized by...
Exploring the perceptual inabilities of Eurasian jays (Garrulus glandarius) using magic effects.
In recent years, scientists have begun to use magic effects to investigate the blind spots in our attention and perception [G. Kuhn, Experiencing the Impossible: The Science of Magic (2019); S. Macknik, S. Martinez-Conde, S....
Fetal diffusion tensor quantification of brainstem pathology in Chiari II malformation.
Ramona Woitek, Daniela Prayer, Michael Weber, Gabriele Amann, Rainer Seidl, Dieter Bettelheim, Veronika Schöpf, Peter C Brugger, Julia Furtner, Ulrika Asenbaum, Gregor Kasprian
Aug 05, 2019
OBJECTIVES: This prenatal MRI study evaluated the potential of diffusion tensor imaging (DTI) metrics to identify changes in the midbrain of fetuses with Chiari II malformations compared to fetuses with mild ventriculomegaly...
The Association Between Food Addiction and Weight Status in School-Age Children and Adolescents.
Background: The association between food addiction (FA) and weight status in children and adolescents remains poorly understood. This study aimed to elucidate the association between FA and weight status using the validated...
Insights into Fanconi Anaemia from the structure of human FANCE
Fanconi Anaemia (FA) is a cancer predisposition disorder characterized by spontaneous chromosome breakage and high cellular sensitivity to genotoxic agents. In response to DNA damage, a multi-subunit assembly of FA proteins, the...
Micro-computed tomography (micro-CT) for the assessment of myocardial disarray, fibrosis and ventricular mass in a feline model of hypertrophic cardiomyopathy
Jose Novo Matos, Patricia Garcia-Canadilla, Ian C. Simcock, J. Ciaran Hutchinson, Melanie Dobromylskyj, Anna Guy, Owen J. Arthurs, Andrew C. Cook, Virginia Luis Fuentes
Nov 19, 2020
Abstract: Micro-computed tomography (micro-CT) is a high-resolution imaging modality that provides accurate tissue characterization. Hypertrophic cardiomyopathy (HCM) occurs as a spontaneous disease in cats, and is characterized...
Insights into Fanconi Anaemia from the structure of human FANCE
Fanconi Anaemia (FA) is a cancer predisposition disorder characterized by spontaneous chromosome breakage and high cellular sensitivity to genotoxic agents. In response to DNA damage, a multi-subunit assembly of FA proteins, the...
Molecular Characterization of Novel Mutations in Fanconi Anemia Patients
Kimberly Rickman
Jan 01, 0001
Fanconi anemia (FA) is a rare disorder that is characterized by bonemarrow failure in the first decade of life, developmental abnormalities, and predisposition to malignancies. The majority of patients have mutations in one of...
Published by: Rockefeller University
The Association Between Food Addiction and Weight Status in School-Age Children and Adolescents.
BACKGROUND: The association between food addiction (FA) and weight status in children and adolescents remains poorly understood. This study aimed to elucidate the association between FA and weight status using the validated...
Converging evidence points towards a role of insulin signaling in regulating compulsive behavior.
Ilse IGM van de Vondervoort, Houshang Amiri, Muriel MK Bruchhage, Charlotte A Oomen, Nitin Rustogi, Jason D Cooper, Jack JA van Asten, Arend Heerschap, Sabine Bahn, Steven Cr Williams, Jan K Buitelaar, Geert Poelmans, Jeffrey C Glennon
Sep 11, 2020
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with childhood onset, and is characterized by intrusive thoughts and fears (obsessions) that lead to repetitive behaviors (compulsions). Previously, we...
Animals Anxiety Blood Glucose Brain Brain-Derived Neurotrophic Factor Compulsive Behavior Diabetes mellitus Type 2 Diffusion tensor imaging Disease Models Animal Insulin Insulin-Like Growth Factor I KCNQ1 Potassium Channel Magnetic Resonance Spectroscopy Mice Proteomics Signal Transduction white matter
Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
A Saini, AR Norman, D Cunningham, I Chau, M Hill, D Tait, T Hickish, T Iveson, F Lofts, D Jodrell, PJ Ross, J Oates
Sep 02, 2020
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fluorouracil (5-FU) delivered by protracted intravenous infusion (PVI 5-FU) against the standard bolus regimen of 5-FU and folinic...
Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease
BACKGROUND AND PURPOSE: The relationship between type 2 diabetes mellitus (T2D) and cerebral small vessel disease (CSVD) is unclear. We aimed to examine the causal effect of T2D, fasting glucose levels, and higher insulin...
Mendelian Randomization Analysis cerebral small vessel disease Diabetes mellitus Type 2 Insulin Resistance stroke lacunar Aged Aged 80 and over cerebral hemorrhage cerebral small vessel diseases Diabetes mellitus Type 2 Female Genome-Wide Association Study Humans Magnetic Resonance Imaging Male Mendelian Randomization Analysis Middle Aged Risk Factors stroke lacunar
Mixed A-Cation Perovskites for Solar Cells
Hybrid lead halide perovskites containing a mixture of A-site cations such as the formamidinium (CH(NH2)2+, FA) and the smaller cesium (Cs+) cations have attracted considerable interest due to...
Mixed A-Cation Perovskites for Solar Cells
Hybrid lead halide perovskites containing a mixture of A-site cations such as the formamidinium (CH(NH2)2+, FA) and the smaller cesium (Cs+) cations have attracted considerable interest due to...
Effects of Multi-Shell Free Water Correction on Glioma Characterization.
Lea Starck, Fulvio Zaccagna, Ofer Pasternak, Ferdia Gallagher, Renate Grüner, Frank Riemer
Jan 05, 2022
Diffusion MRI is a useful tool to investigate the microstructure of brain tumors. However, the presence of fast diffusing isotropic signals originating from non-restricted edematous fluids, within and surrounding tumors, may...
Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.
Loes CA Rutten-Jacobs, Daniel J Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S Markus, Matthew Traylor
Sep 05, 2018
BACKGROUND AND PURPOSE: Structural integrity of the white matter is a marker of cerebral small vessel disease, which is the major cause of vascular dementia and a quarter of all strokes. Genetic studies provide a way to obtain...
cerebral small vessel diseases Diffusion tensor imaging Genetic Association Studies Humans white matter Adult Aged Biological Specimen Banks cerebral small vessel diseases Dementia Depression Depressive Disorder Major Diffusion Magnetic Resonance Imaging Female Genome-Wide Association Study Humans Male Middle Aged stroke United Kingdom white matter
Polycarboxylate / nanosilica modified quaternary cement formulations - enhancements and limitations
The effect of polycarboxylate/nanosilica (nS) particles in quaternary cement formulations comprising Portland cement (PC), limestone powder (LS) and fly ash (FA) was investigated for the first time. The reference formulation...
Phenotyping Genetic Diseases Using an Extension of ?-Scores for Multivariate Data
As the field of genomics matures, more complex genotypes and phenotypes are being studied. Fanconi anemia (FA), for example, is an inherited chromosome instability syndrome with a complex array of variable disease phenotypes...
Published by: http://hdl.handle.net/10209/490
Phase Behavior and Substitution Limit of Mixed Cesium-Formamidinium Lead TriIodide Perovskites
Bethan Charles, Mark T. Weller, Sebastian Rieger, Lauren Hatcher, Paul F. Henry, Jochen Feldmann, Daniel Wolverson, Chick Wilson
Mar 24, 2020
The mixed cation lead iodide perovskite photovoltaics show improved stability following site substitution of cesium ions (Cs +) onto the formamidinium cation sites (FA +) of (CH(NH 2)...
A participatory approach to the evaluation of participatory museum research projects
In this paper we will describe, justify and critique a participatory approach that we have developed in order to evaluate the success of a participatory research project that was exploring ways of making museum learning...
Emergent analysis and dissemination within participatory research
Authentic participation involving jointly undertaken analysis of data and dissemination of findings is rarely evident in participatory research involving disabled people. This paper examines analysis and dissemination which...
BenchML
Abstract
We introduce a machine-learning (ML) framework for high-throughput benchmarking of diverse representations of chemical systems against datasets of materials and molecules....
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