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Results: 267
Interrogation and Manipulation of the IGG FC Glycan
Aaron Keshav Gupta
Jan 01, 0001
Antibody signaling is a cardinal feature of successful adaptive immune responses. The magnitude and direction of this signaling is determined by the structure of a given antibody's fragment crystallizable (Fc) domain, which...
Published by: Rockefeller University
Selective blockade of the inhibitory Fc? receptor (Fc?RIIB) in human dendritic cells and monocytes induces a type I interferon response program
The ability of dendritic cells (DCs) to activate immunity is linked to their maturation status. In prior studies, we have shown that selective antibody-mediated blockade of inhibitory Fc?RIIB receptor on human DCs in the...
Published by: Rockefeller University
Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments.
Julia Moreno-Vicente, Jane E Willoughby, Martin C Taylor, Steven G Booth, Vikki L English, Emily L Williams, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Jinny Kim, HT Claude Chan, Mark S Cragg, Juliet C Gray, Stephen A Beers
Jan 28, 2022
BACKGROUND: Despite extensive clinical use, the mechanisms that lead to therapeutic resistance to anti-programmed cell-death (PD)-1 monoclonal antibodies (mAbs) remain elusive. Here, we sought to determine how interactions...
Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis
Macrophage receptors for the Fc domain of immunoglobulin G (IgG) can mediate the efficient binding and phagocytosis of IgG-coated particles. After internalization, phagocytic vacuoles fuse with lysosomes, initiating the...
Published by: Rockefeller University
Selective blockade of inhibitory Fc? receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
he final differentiation or maturation of dendritic cells (DCs) in response to environmental stimuli influences their ability to both initiate immunity and determine the quality of the response to antigens. Circulating immune...
Published by: Rockefeller University
Introducing Fog Computing (FC) Technology to Internet of Things (IoT) Cloud-Based Anti-Theft Vehicles Solutions
Eissa Alreshidi
Aug 02, 2022
Securing vehicles, especially against theft, has become a significant concern. Smart antitheft solutions have emerged to provide better protection. However, most existing smart vehicle antitheft solutions use (GSM) and (GPS)...
Published by: IGI Global Scientific Publishing
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Frederick Arce Vargas, Andrew JS Furness, Kevin Litchfield, Kroopa Joshi, Rachel Rosenthal, Ehsan Ghorani, Isabelle Solomon, Marta H Lesko, Nora Ruef, Claire Roddie, Jake Y Henry, Lavinia Spain, Assma Ben Aissa, Andrew Georgiou, Yien Ning Sophia Wong, Myles Smith, Dirk Strauss, Andrew Hayes, David Nicol, Tim O'Brien, Linda Mårtensson, Anne Ljungars, Ingrid Teige, Björn Frendéus, TRACERx Melanoma, TRACERx Renal, TRACERx Lung consortia, Martin Pule, Teresa Marafioti, Martin Gore, James Larkin, Samra Turajlic, Charles Swanton, Karl S Peggs, Sergio A Quezada
Jun 29, 2018
With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo...
CTLA-4 Fc-gamma receptors IgG subclass antibody-dependent cell-mediated cytotoxicity immune checkpoints immune regulatory antibodies ipilimumab regulatory T cell depletion tremelimumab tumor immunotherapy Animals Antibodies Monoclonal Antibodies Monoclonal Humanized Antineoplastic Agents Immunological CTLA-4 Antigen Cell Line Tumor Female Humans Ipilimumab Melanoma Mice Polymorphism Single Nucleotide Receptors IgG T-Lymphocytes Regulatory Treatment Outcome Xenograft Model Antitumor Assays
Monographs of the RIMR. Vol. 4, 1912
The Rockefeller University
Jan 01, 0001
A Clinical Study of Acute Poliomyelitis by Francis W. Peabody, George Draper, and A. R. Dochez
Published by: The Rockefeller Institute for Medical Research
Antibody-Effector Functions in Antiviral Response
Kevin Shuolong Kao
Jan 01, 0001
Antibodies are a fundamental component of the adaptive arm of the immune system. Interactions of the antibody's fragment crystallizable (Fc) domain with Fc receptors (FcR) on effector leukocytes is essential for proper...
Published by: Rockefeller University
Discordant attributes of structural and functional brain connectivity in a two-layer multiplex network.
Several studies have suggested that functional connectivity (FC) is constrained by the underlying structural connectivity (SC) and mutually correlated. However, not many studies have focused on differences in the network...
Early Effects of Passive Leg-Raising Test, Fluid Challenge, and Norepinephrine on Cerebral Autoregulation and Oxygenation in COVID-19 Critically Ill Patients
Chiara Robba, Antonio Messina, Denise Battaglini, Lorenzo Ball, Iole Brunetti, Matteo Bassetti, Daniele R. Giacobbe, Antonio Vena, Nicolo' Patroniti, Maurizio Cecconi, Basil F. Matta, Xiuyun Liu, Patricia R. M. Rocco, Marek Czosnyka, Paolo Pelosi
Jun 30, 2021
Background: Coronavirus disease 2019 (COVID-19) patients are at high risk of neurological complications consequent to several factors including persistent hypotension. There is a paucity of data on the effects of therapeutic...
Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.
Belinda M Kumpel, Radka Saldova, Carolien AM Koeleman, Jodie L Abrahams, Agnes Hipgrave Ederveen, Kathryn L Armour, Natalia I Olovnikova, Gestur Vidarsson, Rick Kapur, Pauline M Rudd, Manfred Wuhrer
Jan 29, 2021
Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays...
“The thing is, kids don’t grow the same”
The prevalence of overweight and obesity is high among preschool age (3–5 years) children in South Africa, and children in urban low-income settings are particularly at risk. A better understanding of how parents or caregivers...
The Grizzly, January 24, 2013
Jessica Orbon, Sara Sherr, Rosemary Clark, Olivia Z. Schultz, Matthew Johnston, Courtney Scott, John Robinson, Samantha Salomon, Larissa Coyne, Eilish Bennett, Sara Hourwitz, Allen Weaver, Alyse Reid, Jordan Demcher
Jan 01, 0001
Distinguished Retirees Leave Ursinus New Deans Take Office Plans for Library's Future Resident Adviser Recruitment Continues UC Welcomes New RD Intervarsity Christian Fellowship Strives for Change Students Create Their Own...
Ursinus College Collegeville Pennsylvania newspaper Myrin Library Terry Winegar Meredith Goldsmith Rebecca Kohn Frances Novack James Sidie Ellen Matthews Annette Lucas Robert Davidson Love Wallace resident advisers InterVarsity Christian Fellowship Wismer dining hall Ben Abitz Football Amber Yacenda Basketball Malik Draper cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
"The thing is, kids don't grow the same"
The prevalence of overweight and obesity is high among preschool age (3-5 years) children in South Africa, and children in urban low-income settings are particularly at risk. A better understanding of how parents or caregivers...
Published by: PLOS ONE
Early Effects of Passive Leg-Raising Test, Fluid Challenge, and Norepinephrine on Cerebral Autoregulation and Oxygenation in COVID-19 Critically Ill Patients.
Chiara Robba, Antonio Messina, Denise Battaglini, Lorenzo Ball, Iole Brunetti, Matteo Bassetti, Daniele R Giacobbe, Antonio Vena, Nicolo' Patroniti, Maurizio Cecconi, Basil F Matta, Xiuyun Liu, Patricia RM Rocco, Marek Czosnyka, Paolo Pelosi
Aug 11, 2021
Background: Coronavirus disease 2019 (COVID-19) patients are at high risk of neurological complications consequent to several factors including persistent hypotension. There is a paucity of data on the effects of therapeutic...
Highly Water-Soluble Orotic Acid Nanocrystals Produced by High-Energy Milling
Jéssica de Cássia Zaghi Compri, Veni Maria Andres Felli, Felipe Rebello Lourenço, Takayuki Takatsuka, Nikoletta Fotaki, Raimar Löbenberg, Nádia Araci Bou-Chacra, Gabriel Lima Barros de Araujo
May 01, 2019
Orotic acid (OA), a heterocyclic compound also known as vitamin B13, has shown potent antimalarial and cardiac protection activities; however, its limited water solubility has posed a barrier to its use in therapeutic...
Attachment representations and socio-emotional difficulties in alternative care
Attachment has been assessed in children living in alternative care (AC) settings, such as Residential Homes (RC) and Foster Care (FC). However, no study has been conducted to compare attachment styles in residential, foster and...
Long-range intramolecular electronic communication in bis(ferrocenylethynyl) complexes incorporating conjugated heterocyclic spacers
H.H. Shah, R.A. Al-Balushi, M.K. Al-Suti, M.S. Khan, Christopher H Woodall, K.C. Molloy, P.R. Raithby, T.P. Robinson, S.E.C. Dale, F. Marken
May 06, 2013
A new series of bis(ferrocenylethynyl) complexes, 3–7, and a mono(ferrocenylethynyl) complex, 8, have been synthesized incorporating conjugated heterocyclic spacer groups, with the ethynyl group facilitating an effective...
Retrospective evaluation of hyperproteinorrachia without pleocytosis (albuminocytologic dissociation) and survival in dogs.
BACKGROUND: Hyperproteinorrachia (raised cerebrospinal fluid total protein [CSF-TP]) without pleocytosis (HP) (also known as albuminocytologic dissociation) is identified in dogs with different neurologic diseases. However, the...
Conservative and disruptive modes of adolescent change in human brain functional connectivity.
František Váša, Rafael Romero-Garcia, Manfred G Kitzbichler, Jakob Seidlitz, Kirstie J Whitaker, Matilde M Vaghi, Prantik Kundu, Ameera X Patel, Peter Fonagy, Raymond J Dolan, Peter B Jones, Ian M Goodyer, Petra E Vértes, Edward T Bullmore
Feb 29, 2020
Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change in functional connectivity (FC) of resting-state oscillations between pairs of...
Can public sector community health workers deliver a nurturing care intervention in South Africa? The Amagugu Asakhula feasibility study.
BACKGROUND: Nurturing care interventions have the potential to promote health and development in early childhood. Amagugu Asakhula was designed to promote developmentally important dietary and movement behaviours among children...
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