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Functional Divergence of the Arabidopsis Florigen-Interacting bZIP Transcription Factors FD and FDP.
Maida Romera-Branchat, Edouard Severing, Chloé Pocard, Hyonhwa Ohr, Coral Vincent, Guillaume Née, Rafael Martinez-Gallegos, Seonghoe Jang, Fernando Andrés Lalaguna, Pedro Madrigal, George Coupland
Jun 18, 2020
Flowering of many plant species depends on interactions between basic leucine zipper (bZIP) transcription factors and systemically transported florigen proteins. Members of the genus Arabidopsis contain two of these bZIPs, FD...
Early indicators of disease progression in Fabry disease that may indicate the need for disease-specific treatment initiation
Derralynn A Hughes, Patricio Aguiar, Patrick B Deegan, Fatih Ezgu, Andrea Frustaci, Olivier Lidove, Aleš Linhart, Jean-Claude Lubanda, James C Moon, Kathleen Nicholls, Dau-Ming Niu, Albina Nowak, Uma Ramaswami, Ricardo Reisin, Paula Rozenfeld, Raphael Schiffmann, Einar Svarstad, Mark Thomas, Roser Torra, Bojan Vujkovac, David G Warnock, Michael L West, Jack Johnson, Mark J Rolfe, Sandro Feriozzi
Oct 13, 2020
OBJECTIVES: The PRoposing Early Disease Indicators for Clinical Tracking in Fabry Disease (PREDICT-FD) initiative aimed to reach consensus among a panel of global experts on early indicators of disease progression that may...
A type III complement factor D deficiency
Christopher CT Sng, Sorcha O'Byrne, Daniil M Prigozhin, Matthias R Bauer, Jennifer C Harvey, Michelle Ruhle, Ben G Challis, Sara Lear, Lee D Roberts, Sarita Workman, Tobias Janowitz, Lukasz Magiera, Rainer Doffinger, Matthew S Buckland, Duncan J Jodrell, Robert K Semple, Timothy J Wilson, Yorgo Modis, James ED Thaventhiran
Mar 22, 2018
Abstract
Background: Complement factor D (FD) is the rate-limiting enzyme of the alternative complement pathway. Previous reports of FD deficiency featured absent plasma FD (type I deficiency) and susceptibility to...
A review of techniques to mitigate jamming in electromechanical actuators for safety critical applications
This paper presents a review of techniques to mitigate jamming in Electromechanical Actuators (EMA) for safety critical applications in aerospace. Published progress to date is evaluated, with the remaining challenges...
A review of techniques to mitigate jamming in electromechanical actuators for safety critical applications
This paper presents a review of techniques to mitigate jamming in Electromechanical Actuators (EMA) for safety critical applications in aerospace. Published progress to date is evaluated, with the remaining challenges...
Clinicopathological co-occurrence of Fahr’s disease and dementia with Lewy bodies
Melanie P Jensen, Olivera Spasic-Boskovic, James B Rowe, Clare Galton, Kieren SJ Allinson
Apr 15, 2020
We present the clinicopathological findings of a case of combined Fahr’s disease (FD) and dementia with Lewy bodies (DLB), associated with a novel pathogenic mutation. The patient presented with visual hallucinations...
A closer look at chemotherapy-induced flagellate dermatitis.
Background: Flagellate dermatitis (FD) is a rare skin rash, which may occur following the administration of antineoplastic agents. It has been reported following the administration of bleomycin, docetaxel, trastuzumab...
Investigating design
This paper contributes to the on-going focus on improving design research methods, by exploring and synthesising two key interrelated research approaches - manifest and latent. These approaches are widely used individually in...
A closer look at chemotherapy-induced flagellate dermatitis.
BACKGROUND: Flagellate dermatitis (FD) is a rare skin rash, which may occur following the administration of antineoplastic agents. It has been reported following the administration of bleomycin, docetaxel, trastuzumab...
Investigating design
This paper contributes to the on-going focus on improving design research methods, by exploring and synthesising two key interrelated research approaches - manifest and latent. These approaches are widely used individually in...
Analysing creative behaviour in the later stage design process
Creativity is widely seen as an important subject in the study of the engineering design process. This paper presents a framework and coding scheme for the analysis of creative designer behaviour within the later stage...
Managing complex engineering projects
The challenges of managing large complex engineering projects, such as those involving the design of infrastructure, aerospace and industrial systems; are widely acknowledged. While there exists a mature set of project...
The appearance of creative behaviour in later stage design processes
Creativity is widely seen as an important subject in the study of the engineering design process. Through analysis using a previously presented framework and coding scheme, this paper presents two studies on creative designer...
The appearance of creative behaviour in later stage design processes
Creativity is widely seen as an important subject in the study of the engineering design process. Through analysis using a previously presented framework and coding scheme, this paper presents two studies on creative designer...
Analysing creative behaviour in the later stage design process
Creativity is widely seen as an important subject in the study of the engineering design process. This paper presents a framework and coding scheme for the analysis of creative designer behaviour within the later stage...
Automatic generation of design structure matrices through the evolution of product models
Dealing with component interactions and dependencies remains a core and fundamental aspect of engineering, where conflicts and constraints are solved on an almost daily basis. Failure to consider these...
Dealing with component interactions and dependencies remains a core and fundamental aspect of engineering, where conflicts and constraints are solved on an almost daily basis. Failure to consider these...
Automatic generation of design structure matrices through the evolution of product models
Dealing with component interactions and dependencies remains a core and fundamental aspect of engineering, where conflicts and constraints are solved on an almost daily basis. Failure to consider these...
Dealing with component interactions and dependencies remains a core and fundamental aspect of engineering, where conflicts and constraints are solved on an almost daily basis. Failure to consider these...
Managing complex engineering projects
The challenges of managing large complex engineering projects, such as those involving the design of infrastructure, aerospace and industrial systems; are widely acknowledged. While there exists a mature set of project...
Investigation of associations between retinal microvascular parameters and albuminuria in UK Biobank
Euan N Paterson, Chris Cardwell, Thomas J MacGillivray, Emanuele Trucco, Alexander S Doney, Paul Foster, Alexander P Maxwell, Gareth J McKay, UK Biobank Eye and Vision Consortium
May 10, 2021
BACKGROUND: Associations between microvascular variation and chronic kidney disease (CKD) have been reported previously. Non-invasive retinal fundus imaging enables evaluation of the microvascular network and may offer insight...
Measurement of the Raman spectra and hygroscopicity of four pharmaceutical aerosols as they travel from pressurised metered dose inhalers (pMDI) to a model lung.
Particle inhalation is an effective and rapid delivery method for a variety of pharmaceuticals, particularly bronchodilation drugs used for treating asthma and COPD. Conditions of relative humidity and temperature inside the...
Sniff Invariant Odor Coding.
Sampling regulates stimulus intensity and temporal dynamics at the sense organ. Despite variations in sampling behavior, animals must make veridical perceptual judgments about external stimuli. In olfaction, odor sampling varies...
extracellular electrophysiology Olfactory Bulb Psychophysics Action Potentials Animals Body Weight Conditioning Psychological drinking Electrophysiology Male Mice Mice Inbred C57BL Mice Transgenic Models Neurological Odorants Olfactory Bulb Olfactory Pathways Rats Rats Long-Evans Reaction Time Reward Sensory Receptor Cells Smell
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