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Cover Image for The FUSION protein crystallization screen. View Article
The FUSION protein crystallization screen.
Fabrice Gorrec, Dom Bellini
Mar 11, 2022
The success and speed of atomic structure determination of biological macromolecules by X-ray crystallography depends critically on the availability of diffraction-quality crystals. However, the process of screening...
X-ray crystallography crystallization screens macromolecular crystallization protein crystals
Cover Image for Environmental performance of miscanthus-lime lightweight concrete using life cycle assessment View Article
Environmental performance of miscanthus-lime lightweight concrete using life cycle assessment
Fabrice Ntimugura, Raffaele Vinai, Anna B. Harper, Pete Walker
Jul 01, 2021

In the UK context, miscanthus is a potential alternative perennial crop for the development of bio-based building materials. This paper presents the environmental benefits of using miscanthus shives in lightweight blocks and...

Bio-based building materials Carbon capture Environmental impact Miscanthus Thermal insulation
Cover Image for High-Throughput Steady-State Enzyme Kinetics Measured in a Parallel Droplet Generation and Absorbance Detection Platform. View Article
High-Throughput Steady-State Enzyme Kinetics Measured in a Parallel Droplet Generation and Absorbance Detection Platform.
Stefanie Neun, Liisa van Vliet, Florian Hollfelder, Fabrice Gielen
Dec 23, 2022
Emulsions Microfluidics Kinetics Biological Assay Hydrolysis Microfluidic Analytical Techniques
Cover Image for Platelet α-granules modulate the inflammatory response under systemic lipopolysaccharide injection in mice. View Article
Platelet α-granules modulate the inflammatory response under systemic lipopolysaccharide injection in mice.
Sofiane Tariket, Jose A Guerrero, Olivier Garraud, Cedric Ghevaert, Fabrice Cognasse
Jan 30, 2019
Animals Blood Proteins CD40 Ligand Disease Models Animal Gray Platelet Syndrome Immunoassay Inflammation Lipopolysaccharides Male Mice Mice Inbred C57BL Mice Knockout Mutation
Cover Image for Alpha rhythm collapse predicts iso-electric suppressions during anesthesia. View Article
Alpha rhythm collapse predicts iso-electric suppressions during anesthesia.
Jérôme Cartailler, Pierre Parutto, Cyril Touchard, Fabrice Vallée, David Holcman
Sep 01, 2020
Could an overly deep sedation be anticipated from ElectroEncephaloGram (EEG) patterns? We report here motifs hidden in the EEG signal that predict the appearance of Iso-Electric Suppressions (IES), observed during epileptic...
Learning algorithms Risk Factors Translational Research Alpha Rhythm Anesthesia General Electroencephalography Female Humans Male Middle Aged Propofol Signal Processing Computer-Assisted
Cover Image for 2D constraint modifies packing behaviour View Article
2D constraint modifies packing behaviour
Jonathan A Davidson, Stephen J Jenkins, Fabrice Gorrec, Stuart M Clarke
Jan 10, 2022
Using a combination of X-ray diffraction and simulation techniques, we are able to identify a crystalline monolayer of 1,3,5-triiodotrifluorobenzene formed on graphite. The monolayer is found to exhibit an incommensurate...
DFT monolayer diffraction halogen bonding physisorption triiodotrifluorobenzene
Cover Image for Epilepsy and Ecstatic Experiences View Article
Epilepsy and Ecstatic Experiences
Fabienne Picard, Peter Bossaerts, Fabrice Bartolomei
Jan 07, 2022
Ecstatic epilepsy is a rare form of focal epilepsy in which the aura (beginning of the seizures) consists of a blissful state of mental clarity/feeling of certainty. Such a state has also been described as a "religious" or...
active inference anterior insula certainty ecstatic aura ecstatic epilepsy Interoception mental clarity predictive coding
Cover Image for High-Throughput Steady-State Enzyme Kinetics Measured in a Parallel Droplet Generation and Absorbance Detection Platform. View Article
High-Throughput Steady-State Enzyme Kinetics Measured in a Parallel Droplet Generation and Absorbance Detection Platform.
Stefanie Neun, Liisa van Vliet, Florian Hollfelder, Fabrice Gielen
Dec 08, 2022
Microfluidic water-in-oil emulsion droplets are becoming a mainstay of experimental biology, where they replace the classical test tube. In most applications, such as ultrahigh-throughput directed evolution, the droplet content...
article
Cover Image for Environmental performance of miscanthus-lime lightweight concrete using life cycle assessment View Article
Environmental performance of miscanthus-lime lightweight concrete using life cycle assessment
Fabrice Ntimugura, Raffaele Vinai, Anna B. Harper, Pete Walker
Jul 01, 2021

In the UK context, miscanthus is a potential alternative perennial crop for the development of bio-based building materials. This paper presents the environmental benefits of using miscanthus shives in lightweight blocks and...

Bio-based building materials Carbon capture Environmental impact Miscanthus Thermal insulation
Cover Image for Small-Angle Neutron Scattering Reveals the Structural Details of Thermosensitive Polymer-Grafted Cellulose Nanocrystal Suspensions. View Article
Small-Angle Neutron Scattering Reveals the Structural Details of Thermosensitive Polymer-Grafted Cellulose Nanocrystal Suspensions.
Firas Azzam, Bruno Frka-Petesic, Enrico F Semeraro, Fabrice Cousin, Bruno Jean
Jul 15, 2020
Cover Image for Using Redox-Active πbridging Ligand as a Control Switch of Intramolecular Magnetic Interactions View Article
Using Redox-Active πbridging Ligand as a Control Switch of Intramolecular Magnetic Interactions
Xiaozhou Ma, Elizaveta A. Suturina, Mathieu Rouzières, Mikhail Platunov, Fabrice Wilhelm, Andrei Rogalev, Rodolphe Clérac, Pierre Dechambenoit
May 15, 2019

Intramolecular magnetic interactions in the dinuclear complexes [(tpy)Ni(tphz)Ni(tpy)]n+ (n = 4, 3, and 2; tpy, terpyridine; tphz, tetrapyridophenazine) were tailored by changing the oxidation state of the...

Cover Image for Epilepsy and Ecstatic Experiences View Article
Epilepsy and Ecstatic Experiences
Fabienne Picard, Peter Bossaerts, Fabrice Bartolomei
Oct 23, 2021
Ecstatic epilepsy is a rare form of focal epilepsy in which the aura (beginning of the seizures) consists of a blissful state of mental clarity/feeling of certainty. Such a state has also been described as a "religious" or...
ecstatic epilepsy ecstatic aura anterior insula mental clarity certainty predictive coding active inference Interoception
Cover Image for Deep learning guided image-based droplet sorting for on-demand selection and analysis of single cells and 3D cell cultures. View Article
Deep learning guided image-based droplet sorting for on-demand selection and analysis of single cells and 3D cell cultures.
Vasileios Anagnostidis, Benjamin Sherlock, Jeremy Metz, Philip Mair, Florian Hollfelder, Fabrice Gielen
Jan 21, 2021
Uncovering the heterogeneity of cellular populations and multicellular constructs is a long-standing goal in fields ranging from antimicrobial resistance to cancer research. Emerging technology platforms such as droplet...
Animals Cell Culture Techniques Cell Movement Deep learning Microfluidics Spheroids Cellular
Cover Image for Inverse Opal CuCrO2 Photocathodes for H2 Production Using Organic Dyes and a Molecular Ni Catalyst. View Article
Inverse Opal CuCrO2 Photocathodes for H2 Production Using Organic Dyes and a Molecular Ni Catalyst.
Charles E Creissen, Julien Warnan, Daniel Antón-García, Yoann Farré, Fabrice Odobel, Erwin Reisner
Mar 25, 2020
Dye-sensitized photoelectrochemical (DSPEC) cells are an emerging approach to producing solar fuels. The recent development of delafossite CuCrO2 as a p-type semiconductor has enabled H2 generation through the coassembly of...
Published by: ACS catalysis
Cover Image for Solar electricity and fuel production with perylene monoimide dye-sensitised TiO2 in water. View Article
Solar electricity and fuel production with perylene monoimide dye-sensitised TiO2 in water.
Julien Warnan, Janina Willkomm, Yoann Farré, Yann Pellegrin, Mohammed Boujtita, Fabrice Odobel, Erwin Reisner
Feb 04, 2019
7 Affordable and Clean Energy
Cover Image for Inverse Opal CuCrO2 Photocathodes for H2 Production Using Organic Dyes and a Molecular Ni Catalyst. View Article
Inverse Opal CuCrO2 Photocathodes for H2 Production Using Organic Dyes and a Molecular Ni Catalyst.
Charles E Creissen, Julien Warnan, Daniel Antón-García, Yoann Farré, Fabrice Odobel, Erwin Reisner
Sep 13, 2019
dye-sensitized molecular catalyst photocatalysis solar fuels p-type semiconductor delafossite
Cover Image for Halogen Bonding in Bicomponent Monolayers View Article
Halogen Bonding in Bicomponent Monolayers
Jonathan A Davidson, Marco Sacchi, Fabrice Gorrec, Stuart M Clarke, Stephen J Jenkins
Jan 18, 2021
A homologous series of halogen bonding monolayers based on terminally iodinated perfluoroalkanes and 4,4'-bipyridine have been observed on a graphitic surface and noninvasively probed using powder X-ray diffraction. An excellent...
Cover Image for Using Redox-Active πbridging Ligand as a Control Switch of Intramolecular Magnetic Interactions View Article
Using Redox-Active πbridging Ligand as a Control Switch of Intramolecular Magnetic Interactions
Xiaozhou Ma, Elizaveta A. Suturina, Mathieu Rouzières, Mikhail Platunov, Fabrice Wilhelm, Andrei Rogalev, Rodolphe Clérac, Pierre Dechambenoit
May 15, 2019

Intramolecular magnetic interactions in the dinuclear complexes [(tpy)Ni(tphz)Ni(tpy)]n+ (n = 4, 3, and 2; tpy, terpyridine; tphz, tetrapyridophenazine) were tailored by changing the oxidation state of the...

Cover Image for A heteroleptic diradical Cr(iii) complex with extended spin delocalization and large intramolecular magnetic exchange View Article
A heteroleptic diradical Cr(iii) complex with extended spin delocalization and large intramolecular magnetic exchange
Xiaozhou Ma, Elizaveta A. Suturina, Mathieu Rouzières, Fabrice Wilhelm, Andrei Rogalev, Rodolphe Clérac, Pierre Dechambenoit
May 04, 2020

Successive chemical reductions of the heteroleptic complex [(tpy)Cr III(tphz)] 3+(tpy = terpyridine; tphz = tetrapyridophenazine) give rise to the mono- and di-radical redox isomers, [(tpy)Cr...

Cover Image for A heteroleptic diradical Cr(iii) complex with extended spin delocalization and large intramolecular magnetic exchange View Article
A heteroleptic diradical Cr(iii) complex with extended spin delocalization and large intramolecular magnetic exchange
Xiaozhou Ma, Elizaveta A. Suturina, Mathieu Rouzières, Fabrice Wilhelm, Andrei Rogalev, Rodolphe Clérac, Pierre Dechambenoit
May 04, 2020

Successive chemical reductions of the heteroleptic complex [(tpy)Cr III(tphz)] 3+(tpy = terpyridine; tphz = tetrapyridophenazine) give rise to the mono- and di-radical redox isomers, [(tpy)Cr...

Cover Image for A fully unsupervised compartment-on-demand platform for precise nanoliter assays of time-dependent steady-state enzyme kinetics and inhibition. View Article
A fully unsupervised compartment-on-demand platform for precise nanoliter assays of time-dependent steady-state enzyme kinetics and inhibition.
Fabrice Gielen, Liisa van Vliet, Bartosz T Koprowski, Sean RA Devenish, Martin Fischlechner, Joshua B Edel, Xize Niu, Andrew J deMello, Florian Hollfelder
Jun 05, 2020
The ability to miniaturize biochemical assays in water-in-oil emulsion droplets allows a massive scale-down of reaction volumes, so that high-throughput experimentation can be performed more economically and more efficiently....
Kinetics Nanotechnology Particle Size Prunus Time Factors beta-Glucosidase
Cover Image for PI3K inhibitors are finally coming of age. View Article
PI3K inhibitors are finally coming of age.
Bart Vanhaesebroeck, Matthew WD Perry, Jennifer R Brown, Fabrice André, Klaus Okkenhaug
Jun 17, 2021
Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has been hampered by issues such as poor drug tolerance and...
Animals Humans Immune System Diseases Immunotherapy Neoplasms Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors
Cover Image for An atypical epigenetic mechanism affects uniparental expression of Pol IV-dependent siRNAs. View Article
An atypical epigenetic mechanism affects uniparental expression of Pol IV-dependent siRNAs.
Rebecca A Mosher, Ek Han Tan, Juhyun Shin, Robert L Fischer, Craig S Pikaard, David C Baulcombe
May 22, 2018
BACKGROUND: Small RNAs generated by RNA polymerase IV (Pol IV) are the most abundant class of small RNAs in flowering plants. In Arabidopsis thaliana Pol IV-dependent short interfering (p4-si)RNAs are imprinted and accumulate...
Arabidopsis Chromatin Chromosomes Plant DNA Glycosylases DNA Methylation DNA-Directed RNA Polymerases Endosperm Epigenesis Genetic Gene Expression Regulation Plant Genetic Loci Histones Lysine RNA Small Interfering
Cover Image for Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats. View Article
Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats.
Laurens H Lindenburg, Teodors Pantelejevs, Fabrice Gielen, Pedro Zuazua-Villar, Maren Butz, Eric Rees, Clemens F Kaminski, Jessica A Downs, Marko Hyvönen, Florian Hollfelder
Aug 18, 2021
BRC repeats RAD51 modular protein engineering protein evolution synthetic biology Amino Acid Sequence BRCA2 Protein Cell Line Tumor Humans Protein Binding Rad51 Recombinase
Cover Image for A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH. View Article
A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH.
Nicolas Wicker, Annaïck Carles, Ian G Mills, Maija Wolf, Abhi Veerakumarasivam, Henrik Edgren, Fabrice Boileau, Bohdan Wasylyk, Jack A Schalken, David E Neal, Olli Kallioniemi, Olivier Poch
Jun 16, 2011
Chromosomes Artificial Bacterial Gene Dosage Humans Male Models Statistical Nucleic Acid Hybridization Oligonucleotides Prostatic Neoplasms

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