Abstract: Autophagy is an evolutionarily conserved process across eukaryotes that degrades cargoes like aggregate-prone proteins, pathogens, damaged organelles and macromolecules via delivery to lysosomes. The process involves...
Water resources development options are usually selected on a least-cost basis. While economic considerations are dominant in choosing projects, there are also a mix of other factors including social demands,
political...
The mechanistic target of rapamycin complex 2 (mTORC2) controls cell metabolism and survival in response to environmental inputs. Dysregulation of mTORC2 signaling has been linked to diverse human diseases, including cancer and...
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of cell growth and metabolism. Leucine (Leu) activates mTORC1 and many have tried to identify the mechanisms whereby cells sense Leu in this...
In his July 1984 interview with Michael Cooke, W. H. Winborne described his work with the Orangeburg Area Sickle Cell Anemia Foundation, the Family Health Center, and the outreach programs related to the foundation. Winborne...
The first example of enantioselective S‐H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95% ee) and yields (up to 97%) are achieved...
Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins...
The lysosomal degradation pathway of macroautophagy (herein referred to as autophagy) plays a crucial role in cellular physiology by regulating the removal of unwanted cargoes such as protein aggregates and damaged organelles....
The first example of enantioselective S‐H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95% ee) and yields (up to 97%) are achieved...
The neutral hydrogen (H I) content of dark matter haloes forms an intermediate state in the baryon cycle that connects the hot shock-heated gas and cold star-forming gas in haloes. Measurement of the relationship between H I...
Abstract: Searches for CP violation in the two-body decays Ds+→h+π0 and Ds+→h+η (where h+ denotes a π+ or K+ meson) are performed using pp collision data collected by the LHCb experiment corresponding to either 9 fb−1 or 6 fb−1...
Searches for $CP$ violation in the two-body decays $D_{(s)}^{+}\rightarrow
h^{+}\pi^{0}$ and $D_{(s)}^{+} \rightarrow h^{+}\eta$ (where $h^{+}$ denotes a
$\pi^{+}$ or $K^{+}$ meson) are performed using $pp$ collision data...
Herein, we report the ruthenium-catalyzed ortho C–H alkenylation of a wide range of N-aryloxazolidinone scaffolds. Alkenylation was achieved with complete monoselectivity with a scope of 27 examples in 2-MeTHF. Yields ranged...
Herein, we report the ruthenium-catalyzed ortho C–H alkenylation of a wide range of N-aryloxazolidinone scaffolds. Alkenylation was achieved with complete monoselectivity with a scope of 27 examples in 2-MeTHF. Yields ranged...