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Enrichment of human embryonic stem cell-derived V3 interneurons using an Nkx2-2 gene-specific reporter.
V3 spinal interneurons are a key element of the spinal circuits, which control motor function. However, to date, there are no effective ways of deriving a pure V3 population from human pluripotent stem cells. Here, we report a...
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Regularization of Inverse Problems
Variational regularization methods are commonly used to approximate solutions of inverse problems. In recent years, model-based variational regularization methods have often been replaced with data-driven ones such as the...
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Regularization of Inverse Problems
Variational regularization methods are commonly used to approximate solutions of inverse problems. In recent years, model-based variational regularization methods have often been replaced with data-driven ones such as the...
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Disruption of genomic neighbourhood at the imprinted IGF<sub>2</sub>-H<sub>19</sub> locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome
Hyper- and hypomethylation at the IGF2-H19 imprinting control region (ICR) result in reciprocal changes in IGF2-H19 expression and the two contrasting growth disorders, Beckwith–Wiedemann syndrome (BWS) and Silver–Russell...
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Antioxidant Therapy in Parkinson's Disease
Reactive oxygen species (ROS) play an important role as endogenous mediators in several cellular signalling pathways. However, at high concentrations they can also exert deleterious effects by reacting with many macromolecules...
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Disruption of genomic neighbourhood at the imprinted IGF<sub>2</sub>-H<sub>19</sub> locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome
Hyper- and hypomethylation at the IGF2-H19 imprinting control region (ICR) result in reciprocal changes in IGF2-H19 expression and the two contrasting growth disorders, Beckwith–Wiedemann syndrome (BWS) and Silver–Russell...
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Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome
Individuals with 22q11.2 microdeletion syndrome (22q11.2 DS) show cognitive and behavioral dysfunctions, developmental delays in childhood and risk of developing schizophrenia and autism. Despite extensive previous studies in...
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Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection
Abstract: Parental exposure to pathogens can prime offspring immunity in diverse organisms. The mechanisms by which this heritable priming occurs are largely unknown. Here we report that the soil bacteria Pseudomonas vranovensis...
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DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster.
Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several...
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Necessity 20 Years On
Investment tribunals have fleshed out the requirements of the defence of necessity in Article 25 of the Articles on State Responsibility. This article considers the impact of necessity in international investment law and in...
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Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection.
Parental exposure to pathogens can prime offspring immunity in diverse organisms. The mechanisms by which this heritable priming occurs are largely unknown. Here we report that the soil bacteria Pseudomonas vranovensis is a...
Published by: Nature Communications
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster.
Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several...
Published by:
Selectivity-permeability optimization of functionalised CNT-polymer membranes for water treatment

Polymer membranes incorporating carbon nanotubes (CNT) belong to two broad categories: Vertically aligned (VA-CNT) membranes, where the polymer acts solely as a matrix embedding an aligned forest of nanotubes, and thin film...

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Selectivity-permeability optimization of functionalised CNT-polymer membranes for water treatment

Polymer membranes incorporating carbon nanotubes (CNT) belong to two broad categories: Vertically aligned (VA-CNT) membranes, where the polymer acts solely as a matrix embedding an aligned forest of nanotubes, and thin film...

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Was Brexit triggered by the old and unhappy? Or by financial feelings?
On 23 June 2016, the United Kingdom voted in favour of ‘Brexit’. This paper is an attempt to understand why. It examines the micro-econometric predictors of anti-EU sentiment. The paper provides the first evidence for the idea...
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