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Results: 333
Somatic mutations and clonal dynamics in healthy and cirrhotic human liver.
Somatic mutant clones colonize the human esophagus with age.
Extended joint sparsity reconstruction for spatial and temporal ERT imaging
Electrical resistance tomography (ERT) is an imaging technique to recover the conductivity distribution with boundary measurements via attached electrodes. There are a wide range of applications using ERT for image...
The longitudinal dynamics and natural history of clonal haematopoiesis.
Margarete A Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, MS Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J Campbell, Eoin F McKinney, Francesco Cucca, Moritz Gerstung, George S Vassiliou
Jul 02, 2022
The longitudinal dynamics and natural history of clonal haematopoiesis.
Margarete A Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, MS Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J Campbell, Eoin F McKinney, Francesco Cucca, Moritz Gerstung, George Vassiliou
Jun 09, 2022
Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1-4. The understanding of how and when...
Planar array magnetic induction tomography further improvement
Purpose:
Magnetic induction tomography (MIT) is a tomographic imaging technique with a wide range of potential industrial applications. Planar array MIT is a convenient setup but unable to access freely from the entire...
Magnetic induction tomography (MIT) is a tomographic imaging technique with a wide range of potential industrial applications. Planar array MIT is a convenient setup but unable to access freely from the entire...
Automatic parameter selection of image reconstruction algorithms for planar array capacitive imaging
Landmines are often be made out of plastic with almost no metallic components which makes detection difficult. A plausible solution is to detect superficial buried plastic objects using planar array electrical capacitance...
Extended joint sparsity reconstruction for spatial and temporal ERT imaging
Electrical resistance tomography (ERT) is an imaging technique to recover the conductivity distribution with boundary measurements via attached electrodes. There are a wide range of applications using ERT for image...
Planar array magnetic induction tomography further improvement
Purpose:
Magnetic induction tomography (MIT) is a tomographic imaging technique with a wide range of potential industrial applications. Planar array MIT is a convenient setup but unable to access freely from the entire...
Magnetic induction tomography (MIT) is a tomographic imaging technique with a wide range of potential industrial applications. Planar array MIT is a convenient setup but unable to access freely from the entire...
Automatic parameter selection of image reconstruction algorithms for planar array capacitive imaging
Landmines are often be made out of plastic with almost no metallic components which makes detection difficult. A plausible solution is to detect superficial buried plastic objects using planar array electrical capacitance...
The longitudinal dynamics and natural history of clonal haematopoiesis.
Margarete A Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, MS Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J Campbell, Eoin F McKinney, Francesco Cucca, Moritz Gerstung, George Vassiliou
Jun 08, 2022
Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1-4. The understanding of how and when...
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
Philip S. Robinson, Tim H. H. Coorens, Claire Palles, Emily Mitchell, Federico Abascal, Sigurgeir Olafsson, Bernard C. H. Lee, Andrew R. J. Lawson, Henry Lee-Six, Luiza Moore, Mathijs A. Sanders, James Hewinson, Lynn Martin, Claudia M. A. Pinna, Sara Galavotti, Raheleh Rahbari, Peter J. Campbell, Iñigo Martincorena, Ian Tomlinson, Michael R. Stratton
Oct 06, 2021
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases.
Philip S Robinson, Tim HH Coorens, Claire Palles, Emily Mitchell, Federico Abascal, Sigurgeir Olafsson, Bernard CH Lee, Andrew RJ Lawson, Henry Lee-Six, Luiza Moore, Mathijs A Sanders, James Hewinson, Lynn Martin, Claudia MA Pinna, Sara Galavotti, Raheleh Rahbari, Peter J Campbell, Iñigo Martincorena, Ian Tomlinson, Michael R Stratton
Nov 01, 2021
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.
Philip S Robinson, Laura E Thomas, Federico Abascal, Hyunchul Jung, Luke MR Harvey, Hannah D West, Sigurgeir Olafsson, Bernard CH Lee, Tim HH Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A Sanders, Stefanie V Lensing, Simon JA Buczacki, Rogier Ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J Campbell, Iñigo Martincorena, Julian R Sampson, Michael R Stratton
Aug 08, 2022
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic MUTYH mutations cause predisposition to colorectal...
Clonal dynamics of haematopoiesis across the human lifespan.
Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J Dawson, Nicole Mende, Emily F Calderbank, Hyunchul Jung, Thomas Mitchell, Tim HH Coorens, David H Spencer, Heather Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A Fabre, Krishnaa Mahbubani, Federico Abascal, Alex Cagan, George S Vassiliou, Joanna Baxter, Inigo Martincorena, Michael R Stratton, David G Kent, Krishna Chatterjee, Kourosh Saeb Parsy, Anthony R Green, Jyoti Nangalia, Elisa Laurenti, Peter J Campbell
Jul 02, 2022
Clonal dynamics of haematopoiesis across the human lifespan.
Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J Dawson, Nicole Mende, Emily Calderbank, Hyunchul Jung, Thomas Mitchell, Tim HH Coorens, David H Spencer, Heather Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A Fabre, Krishnaa Mahbubani, Federico Abascal, Alex Cagan, George Vassiliou, Joanna Baxter, Inigo Martincorena, Michael R Stratton, David G Kent, Krishna Chatterjee, Kourosh Saeb Parsy, Tony Green, Jyoti Nangalia, Elisa Laurenti, Peter J Campbell
Jun 09, 2022
Age-related change in human haematopoiesis causes reduced regenerative capacity1, cytopenias2, immune dysfunction3 and increased risk of blood cancer4-6, but the reason for such abrupt functional decline after 70 years of age...
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