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Results: 41
MRI visual rating scales in the diagnosis of dementia
Lorna Harper, Giorgio G Fumagalli, Frederik Barkhof, Philip Scheltens, John T O'Brien, Femke Bouwman, Emma J Burton, Jonathan D Rohrer, Nick C Fox, Gerard R Ridgway, Jonathan M Schott
Jan 29, 2016
Intracellular and Extracellular Roles of Granzyme K.
Annemieke C Bouwman, Kim R van Daalen, Sandra Crnko, Toine Ten Broeke, Niels Bovenschen
May 20, 2021
Granzymes are a family of serine proteases stored in granules inside cytotoxic cells of the immune system. Granzyme K (GrK) has been only limitedly characterized and knowledge on its molecular functions is emerging....
cytotoxic cells Cytotoxicity Disease granzyme K Inflammation Animals Bacterial Infections Cytokines Cytotoxicity Immunologic Endothelial Cells Extracellular Space Granzymes Humans Intracellular Space Lung Diseases Molecular Targeted Therapy Serine Proteinase Inhibitors Treatment Outcome Virus Diseases
Self-organising human gonads generated by a Matrigel-based gradient system.
Elizabeth Oliver, João Pedro Alves-Lopes, Femke Harteveld, Rod T Mitchell, Elisabet Åkesson, Olle Söder, Jan-Bernd Stukenborg
Nov 25, 2021
BACKGROUND: Advances in three-dimensional culture technologies have led to progression in systems used to model the gonadal microenvironment in vitro. Despite demonstrating basic functionality, tissue organisation is often...
Association of inflammation with depression and anxiety
Yuri Milaneschi, Nils Kappelmann, Zheng Ye, Femke Lamers, Sylvain Moser, Peter Jones, Stephen Burgess, Brenda WJH Penninx, Golam Khandaker
May 18, 2021
We examined whether inflammation is uniformly associated with all depressive and anxiety symptoms, and whether these associations are potentially causal. Data was from 147,478 individuals from the UK Biobank (UKB) and 2,905 from...
Mesoporous silica formation mechanisms probed using combined Spin-Echo Modulated Small Angle Neutron Scattering (SEMSANS) and Small Angle Neutron Scattering (SANS)
Julien Schmitt, Jan Joost Zeeuw, Jeroen Plomp, Wim G. Bouwman, Adam Washington, Robert Malcolm Dalgliesh, Chris Duif, Michel A. Thijs, Fankang Li, Roger Pynn, Steven R. Parnell, Karen J. Edler
Jun 24, 2020
The initial formation stages of surfactant-templated silica thin films which grow at the air-water interface were studied using combined spin-echo modulated small-angle neutron scattering (SEMSANS) and small-angle neutron...
Mesoporous silica formation mechanisms probed using combined Spin-Echo Modulated Small Angle Neutron Scattering (SEMSANS) and Small Angle Neutron Scattering (SANS)
Julien Schmitt, Jan Joost Zeeuw, Jeroen Plomp, Wim G. Bouwman, Adam Washington, Robert Malcolm Dalgliesh, Chris Duif, Michel A. Thijs, Fankang Li, Roger Pynn, Steven R. Parnell, Karen J. Edler
Jun 24, 2020
The initial formation stages of surfactant-templated silica thin films which grow at the air-water interface were studied using combined spin-echo modulated small-angle neutron scattering (SEMSANS) and small-angle neutron...
Proteomic evidence of dietary sources in ancient dental calculus.
Jessica Hendy, Christina Warinner, Abigail Bouwman, Matthew J Collins, Sarah Fiddyment, Roman Fischer, Richard Hagan, Courtney A Hofman, Malin Holst, Eros Chaves, Lauren Klaus, Greger Larson, Meaghan Mackie, Krista McGrath, Amy Z Mundorff, Anita Radini, Huiyun Rao, Christian Trachsel, Irina M Velsko, Camilla F Speller
Nov 22, 2018
Archaeological dental calculus has emerged as a rich source of ancient biomolecules, including proteins. Previous analyses of proteins extracted from ancient dental calculus revealed the presence of the dietary milk protein...
Is there evidence for bacterial transfer via the placenta and any role in the colonization of the infant gut? - a systematic review.
Angel Gil, Ricardo Rueda, Susan E Ozanne, Eline M van der Beek, Carolien van Loo-Bouwman, Marieke Schoemaker, Vittoria Marinello, Koen Venema, Catherine Stanton, Bettina Schelkle, Matthieu Flourakis, Christine A Edwards
Sep 28, 2020
With the important role of the gut microbiome in health and disease, it is crucial to understand key factors that establish the microbial community, including gut colonization during infancy. It has been suggested that the first...
Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis.
Markus Tschurtschenthaler, Priyadarshini Kachroo, Femke-Anouska Heinsen, Timon Erik Adolph, Malte Christoph Rühlemann, Johanna Klughammer, Felix Albert Offner, Ole Ammerpohl, Felix Krueger, Sébastien Smallwood, Silke Szymczak, Arthur Kaser, Andre Franke
Sep 13, 2016
Immunogenicity Testing of Lipidoids In Vitro and In Silico
Anne Marit de Groot, Kaushik Thanki, Monique Gangloff, Emily Falkenberg, Xianghui Zeng, Djai CJ van Bijnen, Willem van Eden, Henrik Franzyk, Hanne M Nielsen, Femke Broere, Nick J Gay, Camilla Foged, Alice JAM Sijts
Jun 04, 2018
Therapeutics based on small interfering RNA (siRNA) have promising potential as antiviral and anti-inflammatory agents. To deliver siRNA across cell membranes to reach the RNAi pathway in the cytosol of target cells, non-viral...
Analysing the attributes of Comprehensive Cancer Centres and Cancer Centres across Europe to identify key hallmarks.
Sebastian Kehrloesser, Simon Oberst, Willien Westerhuis, Astrid Wendler, Anke Wind, Harriët Blaauwgeers, Jean-Benoit Burrion, Péter Nagy, Gunnar Saeter, Eva Gustafsson, Paolo De Paoli, József Lovey, Claudio Lombardo, Thierry Philip, Dominique de Valeriola, Marjet Docter, Femke Boomsma, Mahasti Saghatchian, Marek Svoboda, Irene Philip, Francesco Monetti, Henk Hummel, Gordon McVie, Renée Otter, Wim van Harten
May 05, 2021
There is a persistent variation in cancer outcomes among and within European countries suggesting (among other causes) inequalities in access to or delivery of high-quality cancer care. European policy (EU Cancer Mission and...
accreditation Clinical Trials comprehensive cancer center multidisciplinarity quality standard Translational Research Academies and Institutes Biomedical Research Cancer Care Facilities Cohort Studies Europe Humans Medical Oncology Neoplasms Patient Care Team Patient-Centered Care Quality of Health Care Translational Research Biomedical
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation.
Arie B Brinkman, Serena Nik-Zainal, Femke Simmer, F Germán Rodríguez-González, Marcel Smid, Ludmil B Alexandrov, Adam Butler, Sancha Martin, Helen Davies, Dominik Glodzik, Xueqing Zou, Manasa Ramakrishna, Johan Staaf, Markus Ringnér, Anieta Sieuwerts, Anthony Ferrari, Sandro Morganella, Thomas Fleischer, Vessela Kristensen, Marta Gut, Marc J van de Vijver, Anne-Lise Børresen-Dale, Andrea L Richardson, GIlles Thomas, Ivo G Gut, John WM Martens, John A Foekens, Michael R Stratton, Hendrik G Stunnenberg
May 03, 2019
Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the...
Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk.
Adam Hulman, Rebecca K Simmons, Dorte Vistisen, Adam G Tabák, Jacqueline M Dekker, Marjan Alssema, Femke Rutters, Anitra DM Koopman, Thomas PJ Solomon, John P Kirwan, Torben Hansen, Anna Jonsson, Anette Prior Gjesing, Hans Eiberg, Arne Astrup, Oluf Pedersen, Thorkild IA Sørensen, Daniel R Witte, Kristine Færch
May 16, 2018
A horizon scan of global conservation issues for 2014.
William J Sutherland, Rosalind Aveling, Thomas M Brooks, Mick Clout, Lynn V Dicks, Liz Fellman, Erica Fleishman, David W Gibbons, Brandon Keim, Fiona Lickorish, Kathryn A Monk, Diana Mortimer, Lloyd S Peck, Jules Pretty, Johan Rockström, Jon Paul Rodríguez, Rebecca K Smith, Mark D Spalding, Femke H Tonneijck, Andrew R Watkinson
Oct 28, 2015
Direct evidence of milk consumption from ancient human dental calculus.
C Warinner, J Hendy, C Speller, E Cappellini, R Fischer, C Trachsel, J Arneborg, N Lynnerup, OE Craig, DM Swallow, A Fotakis, RJ Christensen, JV Olsen, A Liebert, N Montalva, S Fiddyment, S Charlton, M Mackie, A Canci, A Bouwman, F Rühli, MTP Gilbert, MJ Collins
Nov 22, 2018
Milk is a major food of global economic importance, and its consumption is regarded as a classic example of gene-culture evolution. Humans have exploited animal milk as a food resource for at least 8500 years, but the origins...
A 2021 Horizon Scan of Emerging Global Biological Conservation Issues.
William J Sutherland, Philip W Atkinson, Steven Broad, Sam Brown, Mick Clout, Maria P Dias, Lynn V Dicks, Helen Doran, Erica Fleishman, Elizabeth L Garratt, Kevin J Gaston, Alice C Hughes, Xavier le Roux, Fiona A Lickorish, Luke Maggs, James E Palardy, Lloyd S Peck, Nathalie Pettorelli, Jules Pretty, Mark D Spalding, Femke H Tonneijck, Matt Walpole, James EM Watson, Jonathan Wentworth, Ann Thornton
Dec 22, 2020
We present the results from our 12th annual horizon scan of issues likely to impact biological conservation in the future. From a list of 97 topics, our global panel of 25 scientists and practitioners identified the top 15...
A Horizon Scan of Emerging Global Biological Conservation Issues for 2020.
William J Sutherland, Maria P Dias, Lynn V Dicks, Helen Doran, Abigail C Entwistle, Erica Fleishman, David W Gibbons, Rosie Hails, Alice C Hughes, Jonathan Hughes, Ruth Kelman, Xavier le Roux, Becky LeAnstey, Fiona A Lickorish, Luke Maggs, James W Pearce-Higgins, Lloyd S Peck, Nathalie Pettorelli, Jules Pretty, Mark D Spalding, Femke H Tonneijck, Jonathan Wentworth, Ann Thornton
Dec 04, 2019
A 2018 Horizon Scan of Emerging Issues for Global Conservation and Biological Diversity.
William J Sutherland, Stuart HM Butchart, Ben Connor, Caroline Culshaw, Lynn V Dicks, Jason Dinsdale, Helen Doran, Abigail C Entwistle, Erica Fleishman, David W Gibbons, Zhigang Jiang, Brandon Keim, Xavier Le Roux, Fiona A Lickorish, Paul Markillie, Kathryn A Monk, Diana Mortimer, James W Pearce-Higgins, Lloyd S Peck, Jules Pretty, Colleen L Seymour, Mark D Spalding, Femke H Tonneijck, Rosalind A Gleave
Feb 23, 2018
This is our ninth annual horizon scan to identify emerging issues that we believe could affect global biological diversity, natural capital and ecosystem services, and conservation efforts. Our diverse and international team...
Synchronous vegetation response to the last glacial-interglacial transition in northwest Europe
Abstract The North Atlantic region experienced abrupt high-amplitude cooling at the onset of the Younger Dryas stadial. However, due to chronological uncertainties in the available terrestrial...
S Engels, CS Lane, A Haliuc, WZ Hoek, F Muschitiello, I Baneschi, A Bouwman, C Bronk Ramsey, J Collins, R De Bruijn, O Heiri, K Hubay, G Jones, A Laug, J Merkt, M Müller, T Peters, F Peterse, RA Staff, ATM ter Schure, F Turner, V van den Bos, F Wagner-Cremer
Jun 09, 2022
Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.
Cindy JM Loomans, Nerys Williams Giuliani, Jeetindra Balak, Femke Ringnalda, Léon van Gurp, Meritxell Huch, Sylvia F Boj, Toshiro Sato, Lennart Kester, Susana M Chuva de Sousa Lopes, Matthias S Roost, Susan Bonner-Weir, Marten A Engelse, Ton J Rabelink, Harry Heimberg, Robert GJ Vries, Alexander van Oudenaarden, Françoise Carlotti, Hans Clevers, Eelco JP de Koning
Oct 03, 2018
Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. Here, we describe a 3D culture system that supports the expansion of adult human pancreatic...
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes
Robert W. Koivula, Naeimeh Atabaki-Pasdar, Giuseppe N. Giordano, Tom White, Jerzy Adamski, Jimmy D. Bell, Joline Beulens, Søren Brage, Søren Brunak, Federico De Masi, Emmanouil T. Dermitzakis, Ian M. Forgie, Gary Frost, Torben Hansen, Tue H. Hansen, Andrew Hattersley, Tarja Kokkola, Azra Kurbasic, Markku Laakso, Andrea Mari, Timothy J. McDonald, Oluf Pedersen, Femke Rutters, Jochen M. Schwenk, Harriet J. A. Teare, E. Louise Thomas, Ana Vinuela, Anubha Mahajan, Mark I. McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Imre Pavo, Paul W. Franks
Jun 06, 2020
Abstract: Aims/hypothesis: It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed...
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes
Robert W Koivula, Naeimeh Atabaki-Pasdar, Giuseppe N Giordano, Tom White, Jerzy Adamski, Jimmy D Bell, Joline Beulens, Søren Brage, Søren Brunak, Federico De Masi, Emmanouil T Dermitzakis, Ian M Forgie, Gary Frost, Torben Hansen, Tue H Hansen, Andrew Hattersley, Tarja Kokkola, Azra Kurbasic, Markku Laakso, Andrea Mari, Timothy J McDonald, Oluf Pedersen, Femke Rutters, Jochen M Schwenk, Harriet JA Teare, E Louise Thomas, Ana Vinuela, Anubha Mahajan, Mark I McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Imre Pavo, Paul W Franks, IMI DIRECT Consortium
Jan 29, 2021
Beta cell function ectopic fat glycaemic control insulin sensitivity physical activity Prediabetes structural equation modelling Type 2 diabetes Aged Blood Glucose Cohort Studies Cross-Sectional Studies Denmark Diabetes mellitus Type 2 Energy Metabolism Exercise Female Finland Glucose Tolerance Test glycemic control Homeostasis Humans Insulin Resistance Male Middle Aged Netherlands Sweden
A horizon scan of global biological conservation issues for 2022
William J Sutherland, Philip W Atkinson, Stuart HM Butchart, Marcela Capaja, Lynn V Dicks, Erica Fleishman, Kevin J Gaston, Rosemary S Hails, Alice C Hughes, Becky Le Anstey, Xavier le Roux, Fiona A Lickorish, Luke Maggs, Noor Noor, Thomasina EE Oldfield, James E Palardy, Lloyd S Peck, Nathalie Pettorelli, Jules Pretty, Mark D Spalding, Femke H Tonneijck, Gemma Truelove, James EM Watson, Jonathan Wentworth, Jeremy D Wilson, Ann Thornton
Nov 25, 2021
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