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Results: 35
A practical guide for mutational signature analysis in hematological malignancies
Francesco Maura, Andrea Degasperi, Ferran Nadeu, Daniel Leongamornlert, Helen Davies, Luiza Moore, Romina Royo, Bachisio Ziccheddu, Xose S. Puente, Herve Avet-Loiseau, Peter J. Campbell, Serena Nik-Zainal, Elias Campo, Nikhil Munshi, Niccolò Bolli
Jul 04, 2020
Abstract: Analysis of mutational signatures is becoming routine in cancer genomics, with implications for pathogenesis, classification, prognosis, and even treatment decisions. However, the field lacks a consensus on analysis...
Revisiting Legal Capital
Eilís Ferran
Sep 02, 2020
Abstract: This paper argues for the UK to revisit the legal capital (maintenance of capital) doctrine. Leaving the EU could present an opportunity but to reform legal capital just because Brexit may make it possible to do so...
The Existential Search of the European Banking Authority
Eilís Ferran
Mar 30, 2016
The European Banking Authority (EBA), an EU agency that works to
ensure effective and consistent prudential regulation and supervision across the European banking sector as a whole, was established several years before the...
Corporate Mobility and Company Law
Eilís Ferran
Jun 23, 2016
Globalisation has given commercial parties more freedom to choose the company law system that best suits their private needs. The growing range of techniques to facilitate choice between systems of company law reshapes the...
A practical guide for mutational signature analysis in hematological malignancies.
Francesco Maura, Andrea Degasperi, Ferran Nadeu, Daniel Leongamornlert, Helen Davies, Luiza Moore, Romina Royo, Bachisio Ziccheddu, Xose S Puente, Herve Avet-Loiseau, Peter J Cambell, Serena Nik-Zainal, Elias Campo, Nikhil Munshi, Niccolò Bolli
Jul 15, 2019
The UK as a Third Country Actor in EU Financial Services Regulation
E Ferran
Mar 10, 2017
Unless it remains in the single market via membership of the European Economic Area or is able otherwise to negotiate special access terms, after Brexit the UK will have to fall back on the third country provisions of EU...
Shareholder Engagement and Custody Chains
Abstract Shareholder engagement has come to be seen to be pivotal to good corporate governance. It is therefore more important than ever for the mechanisms of shareholder engagement to be up to...
Eilís Ferran
Sep 08, 2022
Long-Term Sustained Effect of Liver-Targeted Adeno-Associated Virus Gene Therapy for Mitochondrial Neurogastrointestinal Encephalomyopathy.
Javier Torres-Torronteras, Raquel Cabrera-Pérez, Ferran Vila-Julià, Carlo Viscomi, Yolanda Cámara, Michio Hirano, Massimo Zeviani, Ramon Martí
Jul 04, 2018
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is caused by mutations in TYMP, the gene encoding the enzyme thymidine phosphorylase (TP). TP dysfunction results in systemic accumulation of the noxious TP...
AAV MNGIE liver/metabolic Mitochondria thymidine phosphorylase Animals Carcinogenesis Deoxyuridine Dependovirus Female Gene Dosage Genetic Therapy Genetic Vectors Intestinal Pseudo-Obstruction Kaplan-Meier Estimate Liver Male Mice Mitochondria Liver Muscular Dystrophy Oculopharyngeal Ophthalmoplegia Thymidine Thymidine Phosphorylase Time Factors Transgenes
The strangest proton?
Abstract: We present an improved determination of the strange quark and antiquark parton distribution functions of the proton by means of a global QCD analysis that takes into account a comprehensive set of strangeness-sensitive...
Designed beta-hairpins inhibit LDH5 oligomerization and enzymatic activity
Lactate dehydrogenase 5 (LDH5) is overexpressed in aggressive and metastatic tumors and is an attractive target for anticancer therapy. Small molecule drugs have been developed to target the substrate and/or the cofactor sites...
The strangest proton?
Abstract: We present an improved determination of the strange quark and antiquark parton distribution functions of the proton by means of a global QCD analysis that takes into account a comprehensive set of strangeness-sensitive...
The strangest proton?
Abstract: We present an improved determination of the strange quark and antiquark parton distribution functions of the proton by means of a global QCD analysis that takes into account a comprehensive set of strangeness-sensitive...
Dancing sprites
Serge Soula, Janusz Mlynarczyk, Martin Füllekrug, Nicolau Pineda, Jean François Georgis, Oscar van der Velde, Joan Montanyà, Ferran Fabró
Mar 16, 2017
On 29-30 October 2013, a low-light video camera installed at Pic du Midi (2877m), recorded transient luminous events above a very active storm over the Mediterranean Sea. The minimum cloud top temperature reached -73°C, while...
Dancing sprites
Serge Soula, Janusz Mlynarczyk, Martin Füllekrug, Nicolau Pineda, Jean François Georgis, Oscar van der Velde, Joan Montanyà, Ferran Fabró
Mar 16, 2017
On 29-30 October 2013, a low-light video camera installed at Pic du Midi (2877m), recorded transient luminous events above a very active storm over the Mediterranean Sea. The minimum cloud top temperature reached -73°C, while...
Genomes reveal marked differences in the adaptive evolution between orangutan species.
Maja P Mattle-Greminger, Tugce Bilgin Sonay, Alexander Nater, Marc Pybus, Tariq Desai, Guillem de Valles, Ferran Casals, Aylwyn Scally, Jaume Bertranpetit, Tomas Marques-Bonet, Carel P van Schaik, Maria Anisimova, Michael Krützen
Apr 12, 2019
BACKGROUND: Integrating demography and adaptive evolution is pivotal to understanding the evolutionary history and conservation of great apes. However, little is known about the adaptive evolution of our closest relatives, in...
Designed beta-hairpins inhibit LDH5 oligomerization and enzymatic activity
Lactate dehydrogenase 5 (LDH5) is overexpressed in aggressive and metastatic tumors and is an attractive target for anticancer therapy. Small molecule drugs have been developed to target the substrate and/or the cofactor sites...
Pancrustacean Evolution Illuminated by Taxon-Rich Genomic-Scale Data Sets with an Expanded Remipede Sampling
Jesus Lozano-Fernandez, Mattia Giacomelli, James F. Fleming, Albert Chen, Jakob Vinther, Philip Francis Thomsen, Henrik Glenner, Ferran Palero, David A. Legg, Thomas M. Iliffe, Davide Pisani, Jørgen Olesen
Aug 01, 2019
The relationships of crustaceans and hexapods (Pancrustacea) have been much discussed and partially elucidated following the emergence of phylogenomic data sets. However, major uncertainties still remain regarding the...
Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis.
Arman Eshaghi, Rogier A Kievit, Ferran Prados, Carole H Sudre, Jennifer Nicholas, M Jorge Cardoso, Dennis Chan, Richard Nicholas, Sebastien Ourselin, John Greenwood, Alan J Thompson, Daniel C Alexander, Frederik Barkhof, Jeremy Chataway, Olga Ciccarelli
May 03, 2019
Cortical grey matter sodium accumulation is associated with disability and secondary progressive disease course in relapse-onset multiple sclerosis.
Wallace J Brownlee, Bhavana Solanky, Ferran Prados, Marios Yiannakas, Patricia Da Mota, Frank Riemer, Manuel Jorge Cardoso, Sebastian Ourselin, Xavier Golay, Claudia Gandini Wheeler-Kingshott, Olga Ciccarelli
Sep 10, 2019
Challenges and Perspectives of Quantitative Functional Sodium Imaging (fNaI).
Claudia AM Gandini Wheeler-Kingshott, Frank Riemer, Fulvia Palesi, Antonio Ricciardi, Gloria Castellazzi, Xavier Golay, Ferran Prados, Bhavana Solanky, Egidio U D'Angelo
Dec 17, 2018
Brain function has been investigated via the blood oxygenation level dependent (BOLD) effect using magnetic resonance imaging (MRI) for the past decades. Advances in sodium imaging offer the unique chance to access signal...
Pancrustacean Evolution Illuminated by Taxon-Rich Genomic-Scale Data Sets with an Expanded Remipede Sampling
Jesus Lozano-Fernandez, Mattia Giacomelli, James F. Fleming, Albert Chen, Jakob Vinther, Philip Francis Thomsen, Henrik Glenner, Ferran Palero, David A. Legg, Thomas M. Iliffe, Davide Pisani, Jørgen Olesen
Aug 01, 2019
The relationships of crustaceans and hexapods (Pancrustacea) have been much discussed and partially elucidated following the emergence of phylogenomic data sets. However, major uncertainties still remain regarding the...
Periventricular magnetisation transfer ratio abnormalities in multiple sclerosis improve after alemtuzumab.
J William L Brown, Ferran Prados Carrasco, Arman Eshaghi, Carole H Sudre, Tom Button, Matteo Pardini, Rebecca S Samson, Sebastien Ourselin, Claudia Am Gandini Wheeler-Kingshott, Joanne L Jones, Alasdair J Coles, Declan T Chard
May 10, 2019
BACKGROUND: In multiple sclerosis (MS), disease effects on magnetisation transfer ratio (MTR) increase towards the ventricles. This periventricular gradient is evident shortly after first symptoms and is independent of white...
Remyelination varies between and within lesions in multiple sclerosis following bexarotene.
J William L Brown, Ferran Prados, Daniel R Altmann, Baris Kanber, Jonathan Stutters, Nick G Cunniffe, Joanne L Jones, Zoya G Georgieva, Edward J Needham, Cyrus Daruwalla, Claudia Gandini Wheeler-Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard
Sep 18, 2022
Remyelination varies between and within lesions in multiple sclerosis following bexarotene.
J William L Brown, Ferran Prados, Daniel R Altmann, Baris Kanber, Jonathan Stutters, Nick G Cunniffe, Joanne L Jones, Zoya G Georgieva, Edward J Needham, Cyrus Daruwalla, Claudia Gandini Wheeler-Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard
Oct 24, 2022
Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One)
J William L Brown, Nick G Cunniffe, Ferran Prados, Baris Kanber, Joanne L Jones, Edward Needham, Zoya Georgieva, David Rog, Owen R Pearson, James Overell, David MacManus, Rebecca S Samson, Jonathan Stutters, Charles ffrench-Constant, Claudia AM Gandini Wheeler-Kingshott, Carla Moran, Paul D Flynn, Andrew W Michell, Robin Jm Franklin, Siddharthan Chandran, Daniel R Altmann, Declan T Chard, Peter Connick, Alasdair J Coles
May 31, 2021
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