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Results: 57
Clinicians' opinions on recommending aspirin to prevent colorectal cancer to Australians aged 50-70 years
Shakira Milton, Jennifer McIntosh, Thivagar Yogaparan, Pavithran Alphonse, Sibel Saya, Napin Karnchanachari, Peter Nguyen, Phyllis Lau, Finlay Macrae, Jon Emery
Mar 04, 2021
OBJECTIVES: Australian guidelines recommend all adults aged 50-70 years old without existing contraindications consider taking low-dose aspirin (100-300 mg per day) for at least 2.5 years to reduce their risk of developing...
An RCT of a decision aid to support informed choices about taking aspirin to prevent colorectal cancer and other chronic diseases
Shakira Milton, Jennifer McIntosh, Finlay Macrae, Patty Chondros, Lyndal Trevena, Mark Jenkins, Fiona M Walter, Natalie Taylor, Lucy Boyd, Sibel Saya, Napin Karnchanachari, Kitty Novy, Carmody Forbes, Javiera Martinez Gutierrez, Kate Broun, Sara Whitburn, Sarah McGill, George Fishman, Julie Marker, Max Shub, Jon Emery
Sep 05, 2021
BACKGROUND: Australian guidelines recommend that all people aged 50-70 years old actively consider taking daily low-dose aspirin (100-300 mg per day) for 2.5 to 5 years to reduce their risk of colorectal cancer (CRC). Despite...
Aspirin bowel cancer cancer prevention Chemoprevention colorectal cancer decision aid General Practice Guideline implementation Informed decision making PREVENTIVE MEDICINE PRIMARY CARE Aged Aspirin Chronic Disease Colorectal Neoplasms Decision Support Techniques Humans Middle Aged Randomized Controlled Trials as Topic Victoria
An RCT of a decision aid to support informed choices about taking aspirin to prevent colorectal cancer and other chronic diseases
Shakira Milton, Jennifer McIntosh, Finlay Macrae, Patty Chondros, Lyndal Trevena, Mark Jenkins, Fiona M. Walter, Natalie Taylor, Lucy Boyd, Sibel Saya, Napin Karnchanachari, Kitty Novy, Carmody Forbes, Javiera Martinez Gutierrez, Kate Broun, Sara Whitburn, Sarah McGill, George Fishman, Julie Marker, Max Shub, Jon Emery
Jul 28, 2021
Abstract: Background: Australian guidelines recommend that all people aged 50–70 years old actively consider taking daily low-dose aspirin (100–300 mg per day) for 2.5 to 5 years to reduce their risk of colorectal cancer (CRC)....
An RCT of a decision aid to support informed choices about taking aspirin to prevent colorectal cancer and other chronic diseases
Shakira Milton, Jennifer McIntosh, Finlay Macrae, Patty Chondros, Lyndal Trevena, Mark Jenkins, Fiona M Walter, Natalie Taylor, Lucy Boyd, Sibel Saya, Napin Karnchanachari, Kitty Novy, Carmody Forbes, Javiera Martinez Gutierrez, Kate Broun, Sara Whitburn, Sarah McGill, George Fishman, Julie Marker, Max Shub, Jon Emery
Aug 16, 2021
Background
Australian guidelines recommend that all people aged 50-70 years old actively consider taking daily low-dose aspirin (100-300 mg per day) for 2.5 to 5 years to reduce their risk of colorectal cancer (CRC)....
Chemoprevention Aspirin colorectal cancer General Practice PREVENTIVE MEDICINE PRIMARY CARE bowel cancer cancer prevention Informed decision making Guideline implementation decision aid Humans Colorectal Neoplasms Chronic Disease Aspirin Decision Support Techniques Aged Middle Aged Victoria Randomized Controlled Trials as Topic
Published by: Trials
The Colorectal cancer RISk Prediction (CRISP) trial
Jon D Emery, Mark A Jenkins, Sibel Saya, Patty Chondros, Jasmeen Oberoi, Shakira Milton, Kitty Novy, Emily Habgood, Napin Karnchanachari, Marie Pirotta, Lyndal Trevena, Adrian Bickerstaffe, Richard De Abreu Lourenço, Anna Crothers, Driss Ait Ouakrim, Louisa Flander, James G Dowty, Fiona M Walter, Malcolm Clark, Sally Doncovio, Dariush Etemadmoghadam, George Fishman, Finlay Macrae, Ingrid Winship, Jennifer G McIntosh
Apr 17, 2023
BACKGROUND: A risk-stratified approach to colorectal cancer (CRC) screening could result in a more acceptable balance of benefits and harms, and be more cost-effective. AIM: To determine the effect of a consultation in general...
Frameworks for supporting patient and public involvement in research
Trisha Greenhalgh, Lisa Hinton, Teresa Finlay, Alastair Macfarlane, Nick Fahy, Ben Clyde, Alan Chant
Mar 09, 2020
BACKGROUND: Numerous frameworks for supporting, evaluating and reporting patient and public involvement in research exist. The literature is diverse and theoretically heterogeneous. OBJECTIVES: To identify and synthesize...
The use of a risk assessment and decision support tool (CRISP) compared with usual care in general practice to increase risk-stratified colorectal cancer screening
Jennifer G Walker, Finlay Macrae, Ingrid Winship, Jasmeen Oberoi, Sibel Saya, Shakira Milton, Adrian Bickerstaffe, James G Dowty, Richard De Abreu Lourenço, Malcolm Clark, Louise Galloway, George Fishman, Fiona M Walter, Louisa Flander, Patty Chondros, Driss Ait Ouakrim, Marie Pirotta, Lyndal Trevena, Mark A Jenkins, Jon D Emery
Sep 05, 2018
BACKGROUND: Australia and New Zealand have the highest incidence rates of colorectal cancer worldwide. In Australia there is significant unwarranted variation in colorectal cancer screening due to low uptake of the...
colorectal cancer screening Decision support Faecal occult blood test General Practice Precision Medicine Precision screening PRIMARY CARE Risk assessment tool risk-stratified screening Aged Clinical Trials Phase II as Topic Colorectal Neoplasms Decision Support Techniques Early Detection of Cancer Female General Practice Humans Male Middle Aged Multicenter Studies as Topic Predictive Value of Tests Primary Health Care Prognosis Randomized Controlled Trials as Topic Risk Assessment Risk Factors Time Factors Victoria
Self-prioritization and perceptual matching
Marius Golubickis, Johanna K. Falben, Arash Sahraie, Aleksandar Visokomogilski, William A. Cunningham, Jie Sui, C. Neil Macrae
Oct 01, 2017
Recent research has revealed that self-referential processing enhances perceptual judgments — the so-called self-prioritization effect. The extent and origin of this effect remains unknown, however. Noting the multifaceted...
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells.
David K Finlay, Ella Rosenzweig, Linda V Sinclair, Carmen Feijoo-Carnero, Jens L Hukelmann, Julia Rolf, Andrey A Panteleyev, Klaus Okkenhaug, Doreen A Cantrell
Jun 28, 2018
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8+ cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the control...
3-Phosphoinositide-Dependent Protein Kinases Animals Aryl Hydrocarbon Receptor Nuclear Translocator CD8-Positive T-Lymphocytes Cell Differentiation Cell Movement Chemokines Gene Expression Regulation Glucose Glycolysis Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1 alpha Subunit Interleukin-2 Mechanistic Target of Rapamycin Complex 1 Mice Mice Inbred C57BL Mice Mutant Strains Mice Transgenic Multiprotein Complexes Phosphatidylinositol 3-Kinases Protein Serine-Threonine Kinases Proteins Proto-Oncogene Proteins c-akt Receptors Antigen T-Cell Receptors Chemokine TOR Serine-Threonine Kinases
Biological maturation, relative age and self-regulation in male professional academy soccer players
Sean Cumming, Christopher Searle, Janie Hemsley, Finlay Haswell, Hannah Edwards, Des Ryan, Sam Scott, Alex Gross, Jeff Lewis, Paul White, Siobhan Mitchell, Robert M Malina
Nov 01, 2018
Objectives
The main and interactive effects of biological maturity status and relative age upon self-regulation in male academy soccer players are considered. Consistent with the ‘underdog’ hypothesis, whereby relatively...
The main and interactive effects of biological maturity status and relative age upon self-regulation in male academy soccer players are considered. Consistent with the ‘underdog’ hypothesis, whereby relatively...
The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation.
Mariagnese Barbera, Massimiliano di Pietro, Elaine Walker, Charlotte Brierley, Shona MacRae, Benjamin D Simons, Phil H Jones, John Stingl, Rebecca C Fitzgerald
Feb 13, 2020
OBJECTIVE: Knowledge of the cellular mechanisms involved in homeostasis of human squamous oesophagus in the steady state and following chronic injury is limited. We aimed to better understand these mechanisms by using a...
Self-prioritization and perceptual matching
Marius Golubickis, Johanna K. Falben, Arash Sahraie, Aleksandar Visokomogilski, William A. Cunningham, Jie Sui, C. Neil Macrae
Oct 01, 2017
Recent research has revealed that self-referential processing enhances perceptual judgments — the so-called self-prioritization effect. The extent and origin of this effect remains unknown, however. Noting the multifaceted...
Enterohemorrhagic Escherichia coli responds to gut microbiota metabolites by altering metabolism and activating stress responses.
Stefanie L Vogt, Antonio Serapio-Palacios, Sarah E Woodward, Andrew S Santos, Stefan PW de Vries, Michelle C Daigneault, Lisa V Brandmeier, Andrew J Grant, Duncan J Maskell, Emma Allen-Vercoe, B Brett Finlay
Apr 17, 2023
Enterohemorrhagic Escherichia coli (EHEC) is a major cause of severe bloody diarrhea, with potentially lethal complications, such as hemolytic uremic syndrome. In humans, EHEC colonizes the colon, which is also home to a diverse...
Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites.
Biological maturation, relative age and self-regulation in male professional academy soccer players
Sean Cumming, Christopher Searle, Janie Hemsley, Finlay Haswell, Hannah Edwards, Des Ryan, Sam Scott, Alex Gross, Jeff Lewis, Paul White, Siobhan Mitchell, Robert M Malina
Nov 01, 2018
Objectives
The main and interactive effects of biological maturity status and relative age upon self-regulation in male academy soccer players are considered. Consistent with the ‘underdog’ hypothesis, whereby relatively...
The main and interactive effects of biological maturity status and relative age upon self-regulation in male academy soccer players are considered. Consistent with the ‘underdog’ hypothesis, whereby relatively...
Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection.
Thomas L Williams, Maria T Colzani, Robyn G C Macrae, Emma L Robinson, Stuart Bloor, Edward J D Greenwood, Jun Ru Zhan, Gregory Strachan, Rhoda E Kuc, Duuamene Nyimanu, Janet J Maguire, Paul J Lehner, Sanjay Sinha, Anthony P Davenport
Aug 30, 2021
Patients with cardiovascular comorbidities are more susceptible to severe infection with SARS-CoV-2, known to directly cause pathological damage to cardiovascular tissue. We outline a screening platform using human embryonic...
Myocytes Cardiac Humans Benztropine Peptides Antiviral Agents Drug Evaluation Preclinical Human Embryonic Stem Cells SARS-CoV-2
Published by: Communications biology
Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection.
Endosymbiosis undone by stepwise elimination of the plastid in a parasitic dinoflagellate.
Sebastian G Gornik, Febrimarsa, Andrew M Cassin, James I MacRae, Abhinay Ramaprasad, Zineb Rchiad, Malcolm J McConville, Antony Bacic, Geoffrey I McFadden, Arnab Pain, Ross F Waller
May 29, 2015
diaminopimelate aminotransferase endosymbiosis organelle loss plastid loss plastid metabolism Adenosine Triphosphate Amino Acid Oxidoreductases Animals Cell Nucleus Crustacea Cytosol Dinoflagellida Fatty Acid Synthases Fatty Acids Mitochondria Molecular Sequence Data Parasites Photosynthesis Phylogeny Plasmodium Plastids RNA Symbiosis Transcriptome
Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection
Selection and Application of Tissue microRNAs for Nonendoscopic Diagnosis of Barrett's Esophagus.
Xiaodun Li, Sam Kleeman, Sally B Coburn, Carlo Fumagalli, Juliane Perner, Sriganesh Jammula, Ruth M Pfeiffer, Linda Orzolek, Haiping Hao, Philip R Taylor, Ahmad Miremadi, Núria Galeano-Dalmau, Pierre Lao-Sirieix, Maria Tennyson, Shona MacRae, Michael B Cook, Rebecca C Fitzgerald
Sep 27, 2018
BACKGROUND & AIMS: MicroRNA (miRNA) is highly stable in biospecimens and provides tissue-specific profiles, making it a useful biomarker of carcinogenesis. We aimed to discover a set of miRNAs that could accurately discriminate...
DNA methylation signature is prognostic of choroid plexus tumor aggressiveness
Malgorzata Pienkowska, Sanaa Choufani, Andrei L. Turinsky, Tanya Guha, Diana M. Merino, Ana Novokmet, Michael Brudno, Rosanna Weksberg, Adam Shlien, Cynthia Hawkins, Eric Bouffet, Uri Tabori, Richard J. Gilbertson, Jonathan L. Finlay, Nada Jabado, Christian Thomas, Martin Sill, David Capper, Martin Hasselblatt, David Malkin
Aug 12, 2020
Abstract: Background: Histological grading of choroid plexus tumors (CPTs) remains the best prognostic tool to distinguish between aggressive choroid plexus carcinoma (CPC) and the more benign choroid plexus papilloma (CPP) or...
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