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Results: 61
Genetics and genomics of pulmonary arterial hypertension.
Nicholas W Morrell, Micheala A Aldred, Wendy K Chung, C Gregory Elliott, William C Nichols, Florent Soubrier, Richard C Trembath, James E Loyd
May 20, 2019
Since 2000 there have been major advances in our understanding of the genetic and genomics of pulmonary arterial hypertension (PAH), although there remains much to discover. Based on existing knowledge, around 25-30% of patients...
Media Coverage of 3D Visual Tools Used in Urban Participatory Planning
The opportunities provided by adopting digitally-generated visual tools in urban participatory planning are compelling. These visual tools can promote interactions between authorities and citizens and among citizens. However...
Published by: IGI Global Scientific Publishing
Sparse Cyclic Excitations Explain the Low Ionic Conductivity of Stoichiometric Li<sub>7</sub>La<sub>3</sub>Zr<sub>2</sub>O<sub>12</sub>
We have performed long time-scale molecular dynamics simulations of the cubic and tetragonal phases of the solid lithium-ion-electrolyte Li7La3Zr2O12 (LLZO), using a first-principles...
Cell-free DNA technologies for the analysis of brain cancer.
Survival for glioma patients has shown minimal improvement over the past 20 years. The ability to detect and monitor gliomas relies primarily upon imaging technologies that lack sensitivity and specificity, especially during the...
Sparse Cyclic Excitations Explain the Low Ionic Conductivity of Stoichiometric Li<sub>7</sub>La<sub>3</sub>Zr<sub>2</sub>O<sub>12</sub>
We have performed long time-scale molecular dynamics simulations of the cubic and tetragonal phases of the solid lithium-ion-electrolyte Li7La3Zr2O12 (LLZO), using a first-principles...
BMPR2 mutations and survival in pulmonary arterial hypertension
Jonathan DW Evans, Barbara Girerd, David Montani, Xiao-Jian Wang, Nazzareno Galiè, Eric D Austin, Greg Elliott, Koichiro Asano, Ekkehard Grünig, Yi Yan, Zhi-Cheng Jing, Alessandra Manes, Massimiliano Palazzini, Lisa A Wheeler, Ikue Nakayama, Toru Satoh, Christina Eichstaedt, Katrin Hinderhofer, Matthias Wolf, Erika B Rosenzweig, Wendy K Chung, Florent Soubrier, Gérald Simonneau, Olivier Sitbon, Stefan Gräf, Stephen Kaptoge, Emanuele Di Angelantonio, Marc Humbert, Nicholas W Morrell
Jan 13, 2016
Refined characterization of circulating tumor DNA through biological feature integration
Abstract Circulating tumor DNA (ctDNA) in blood plasma is present at very low concentrations compared to cell-free DNA (cfDNA) of non-tumor origin. To enhance ctDNA detection, recent studies have...
Havell Markus, Dineika Chandrananda, Elizabeth Moore, Florent Mouliere, James Morris, James D Brenton, Christopher G Smith, Nitzan Rosenfeld
Feb 04, 2022
Valorisation of sawdust through the combined microwave-assisted hydrothermal pre-treatment and fermentation using an oleaginous yeast
Luca Longanesi, Florent P. Bouxin, Jiajun Fan, Hadiza Auta, Richard Gammons, Vitaily L. Budarin, Aikaterini Vriza, James H. Clark, Christopher J. Chuck
Jul 31, 2022
Oleaginous yeast, cultured on second-generation lignocellulosic resources, has the potential to be a key part of the future energy sector. However, the multiple unit operations necessary to produce concentrated hydrolysates...
Fermentation Metschnikowia pulcherrima Microbial lipids Microwave-assisted pretreatment Sawdust /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9.
Mathilde Mathieu, Nathalie Névo, Mabel Jouve, José Ignacio Valenzuela, Mathieu Maurin, Frederik J Verweij, Roberta Palmulli, Danielle Lankar, Florent Dingli, Damarys Loew, Eric Rubinstein, Gaëlle Boncompain, Franck Perez, Clotilde Théry
Sep 05, 2021
Despite their roles in intercellular communications, the different populations of extracellular vesicles (EVs) and their secretion mechanisms are not fully characterized: how and to what extent EVs form as intraluminal vesicles...
Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients.
Florent Mouliere, Richard Mair, Dineika Chandrananda, Francesco Marass, Christopher G Smith, Jing Su, James Morris, Colin Watts, Kevin M Brindle, Nitzan Rosenfeld
Dec 06, 2018
Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell-free tumor DNA (cftDNA) in cerebrospinal fluid (CSF) has been proposed as an alternative to detection in plasma. We used...
Laboratory investigation of the Bruun Rule and beach response to sea level rise
Alexander L. Atkinson, Tom E. Baldock, Florent Birrien, David P. Callaghan, Peter Nielsen, Tomas Beuzen, Ian L. Turner, Chris E. Blenkinsopp, Roshanka Ranasinghe
Jun 01, 2018
Rising sea levels are expected to cause widespread coastal recession over the course of the next century. In this work, new insight into the response of sandy beaches to sea level rise is obtained through a series of...
The Implication of Early Chromatin Changes in X Chromosome Inactivation.
Jan Jakub Żylicz, Aurélie Bousard, Kristina Žumer, Francois Dossin, Eusra Mohammad, Simão Teixeira da Rocha, Björn Schwalb, Laurène Syx, Florent Dingli, Damarys Loew, Patrick Cramer, Edith Heard
Jan 08, 2019
During development, the precise relationships between transcription and chromatin modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm to explore the implication of chromatin changes in gene...
PRC1 PRC2 polycomb X Chromosome Inactivation XIST Embryonic Stem Cells epigenetics histone acetylation Histone deacetylase Acetylation Animals Chromatin Embryonic Stem Cells Epigenomics Female Gene Silencing Histone Deacetylases Histones Mice Polycomb-Group Proteins Protein Processing Post-Translational RNA Long Noncoding Transcription Genetic Ubiquitination X Chromosome X Chromosome Inactivation
High fragmentation characterizes tumour-derived circulating DNA.
Florent Mouliere, Bruno Robert, Erika Arnau Peyrotte, Maguy Del Rio, Marc Ychou, Franck Molina, Celine Gongora, Alain R Thierry
May 01, 2019
BACKGROUND: Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cancers including colorectal cancer, especially when considering the detection of mutations. Certainly due to lack of normalization...
TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells.
Maria Papadopoulou, Paola Tieppo, Naomi McGovern, Françoise Gosselin, Jerry KY Chan, Glenn Goetgeluk, Nicolas Dauby, Alexandra Cogan, Catherine Donner, Florent Ginhoux, Bart Vandekerckhove, David Vermijlen
Oct 28, 2019
Phosphoantigen-reactive Vγ9Vδ2 T cells represent the main innate human γδ T cell subset and dominate the fetal and adult peripheral blood γδ T cell repertoire. It has been hypothesized that adult blood Vγ9Vδ2 T cells find their...
Valorisation of sawdust through the combined microwave-assisted hydrothermal pre-treatment and fermentation using an oleaginous yeast
Luca Longanesi, Florent P. Bouxin, Jiajun Fan, Hadiza Auta, Richard Gammons, Vitaily L. Budarin, Aikaterini Vriza, James H. Clark, Christopher J. Chuck
Jul 31, 2022
Oleaginous yeast, cultured on second-generation lignocellulosic resources, has the potential to be a key part of the future energy sector. However, the multiple unit operations necessary to produce concentrated hydrolysates...
Fermentation Metschnikowia pulcherrima Microbial lipids Microwave-assisted pretreatment Sawdust /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Measurement of Plasma Cell-Free Mitochondrial Tumor DNA Improves Detection of Glioblastoma in Patient-Derived Orthotopic Xenograft Models.
Richard Mair, Florent Mouliere, Christopher G Smith, Dineika Chandrananda, Davina Gale, Francesco Marass, Dana WY Tsui, Charles E Massie, Alan J Wright, Colin Watts, Nitzan Rosenfeld, Kevin M Brindle
Dec 06, 2018
Multimodal Microscale Imaging of Textured Perovskite-Silicon Tandem Solar Cells.
Elizabeth M Tennyson, Kyle Frohna, William K Drake, Florent Sahli, Terry Chien-Jen Yang, Fan Fu, Jérémie Werner, Cullen Chosy, Alan R Bowman, Tiarnan A S Doherty, Quentin Jeangros, Christophe Ballif, Samuel D Stranks
Aug 26, 2021
Halide perovskite/crystalline silicon (c-Si) tandem solar cells promise power conversion efficiencies beyond the limits of single-junction cells. However, the local light-matter interactions of the perovskite material embedded...
Published by: ACS energy letters
A three-dimensional atlas of human dermal leukocytes, lymphatics, and blood vessels.
Xiao-Nong Wang, Naomi McGovern, Merry Gunawan, Connor Richardson, Martin Windebank, Tee-Wei Siah, Hwee-Ying Lim, Katja Fink, Jackson L Yao Li, Lai G Ng, Florent Ginhoux, Veronique Angeli, Matthew Collin, Muzlifah Haniffa
Jun 29, 2018
Dendritic cells (DCs), macrophages (Mφ), and T cells are major components of the skin immune system, but their interstitial spatial organization is poorly characterized. Using four-channel whole-mount immunofluorescence staining...
Adolescent Adult Aged ANISOTROPY CD11c Antigen Carrier Proteins Cell Movement Dermis Female Flow Cytometry Humans Langerhans Cells Leukocytes Lymphatic System Lymphatic Vessels Lymphocytes Lymphoma T-Cell Cutaneous MACROPHAGES Microfilament Proteins Middle Aged Phenotype Platelet Endothelial Cell Adhesion Molecule-1 Skin Young Adult
Multimodal Microscale Imaging of Textured Perovskite-Silicon Tandem Solar Cells.
Elizabeth M Tennyson, Kyle Frohna, William K Drake, Florent Sahli, Terry Chien-Jen Yang, Fan Fu, Jérémie Werner, Cullen Chosy, Alan R Bowman, Tiarnan AS Doherty, Quentin Jeangros, Christophe Ballif, Samuel D Stranks
May 18, 2021
Halide perovskite/crystalline silicon (c-Si) tandem solar cells promise power conversion efficiencies beyond the limits of single-junction cells. However, the local light-matter interactions of the perovskite material embedded...
Laboratory investigation of the Bruun Rule and beach response to sea level rise
Alexander L. Atkinson, Tom E. Baldock, Florent Birrien, David P. Callaghan, Peter Nielsen, Tomas Beuzen, Ian L. Turner, Chris E. Blenkinsopp, Roshanka Ranasinghe
Jun 01, 2018
Rising sea levels are expected to cause widespread coastal recession over the course of the next century. In this work, new insight into the response of sandy beaches to sea level rise is obtained through a series of...
The value of cell-free DNA for molecular pathology.
Caitlin M Stewart, Prachi D Kothari, Florent Mouliere, Richard Mair, Saira Somnay, Ryma Benayed, Ahmet Zehir, Britta Weigelt, Sarah-Jane Dawson, Maria E Arcila, Michael F Berger, Dana WY Tsui
Sep 17, 2018
Retrospective methods to estimate radiation dose at the site of breast cancer development after Hodgkin lymphoma radiotherapy.
Nicola S Russell, Inge M Krul, Anna M van Eggermond, Berthe MP Aleman, Rosie Cooke, Susanne Kuiper, Steven D Allen, Matthew G Wallis, Damien Llanas, Ibrahima Diallo, Florent de Vathaire, Susan A Smith, Michael Hauptmann, Annegien Broeks, Anthony J Swerdlow, Flora E van Leeuwen
Feb 23, 2018
BACKGROUND: An increased risk of breast cancer following radiotherapy for Hodgkin lymphoma (HL) has now been robustly established. In order to estimate the dose-response relationship more accurately, and to aid clinical decision...
Fragmentation patterns and personalized sequencing of cell-free DNA in urine and plasma of glioma patients.
Florent Mouliere, Christopher G Smith, Katrin Heider, Jing Su, Ymke van der Pol, Mareike Thompson, James Morris, Jonathan CM Wan, Dineika Chandrananda, James Hadfield, Marta Grzelak, Irena Hudecova, Dominique-Laurent Couturier, Wendy Cooper, Hui Zhao, Davina Gale, Matthew Eldridge, Colin Watts, Kevin Brindle, Nitzan Rosenfeld, Richard Mair
Sep 05, 2021
Glioma-derived cell-free DNA (cfDNA) is challenging to detect using liquid biopsy because quantities in body fluids are low. We determined the glioma-derived DNA fraction in cerebrospinal fluid (CSF), plasma, and urine samples...
Bayesian Inference Associates Rare KDR Variants with Specific Phenotypes in Pulmonary Arterial Hypertension.
Emilia M Swietlik, Daniel Greene, Na Zhu, Karyn Megy, Marcella Cogliano, Smitha Rajaram, Divya Pandya, Tobias Tilly, Katie A Lutz, Carrie CL Welch, Michael W Pauciulo, Laura Southgate, Jennifer M Martin, Carmen M Treacy, Christopher J Penkett, Jonathan C Stephens, Harm J Bogaard, Colin Church, Gerry Coghlan, Anna W Coleman, Robin Condliffe, Christina A Eichstaedt, Mélanie Eyries, Henning Gall, Stefano Ghio, Barbara Girerd, Ekkehard Grünig, Simon Holden, Luke Howard, Marc Humbert, David G Kiely, Gabor Kovacs, Jim Lordan, Rajiv D Machado, Robert V MacKenzie Ross, Colm McCabe, Shahin Moledina, David Montani, Horst Olschewski, Joanna Pepke-Zaba, Laura Price, Christopher J Rhodes, Werner Seeger, Florent Soubrier, Jay Suntharalingam, Mark R Toshner, Anton Vonk Noordegraaf, John Wharton, James M Wild, Stephen John Wort, Allan Lawrie, Martin R Wilkins, Richard C Trembath, Yufeng Shen, Wendy K Chung, Andrew J Swift, William C Nichols, Nicholas W Morrell, Stefan Gräf
Dec 15, 2020
Background - Approximately 25% of patients with pulmonary arterial hypertension (PAH) have been found to harbor rare mutations in disease-causing genes. To identify missing heritability in PAH we integrated deep phenotyping with...
Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients
Florent Mouliere, Christopher G Smith, Katrin Heider, Jing Su, Ymke van der Pol, Mareike Thompson, James Morris, Jonathan C M Wan, Dineika Chandrananda, James Hadfield, Marta Grzelak, Irena Hudecova, Dominique‐Laurent Couturier, Wendy Cooper, Hui Zhao, Davina Gale, Matthew Eldridge, Colin Watts, Kevin Brindle, Nitzan Rosenfeld, Richard Mair
Jul 28, 2021
EMBO02 EMBO03 article ARTICLES cell‐free DNA Circulating Tumor DNA fragmentomics gliomas Liquid biopsy
Published by: EMBO molecular medicine
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