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Results: 56
Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system.
Miruna C Barbu, Floris Huider, Archie Campbell, Carmen Amador, Mark J Adams, Mary-Ellen Lynall, David M Howard, Rosie M Walker, Stewart W Morris, Jenny van Dongen, David J Porteous, Kathryn L Evans, Edward Bullmore, Gonneke Willemsen, Dorret I Boomsma, Heather C Whalley, Andrew M McIntosh
May 12, 2022
Imaging sex/gender and autism in the brain
The male preponderance in autism prevalence has brought together the disparate topics of sex/gender and autism research. Two directions of neuroimaging studies on the relationships between sex/gender and autism may inform...
Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses.
Nadeem Shaikh, Alice Mazzagatti, Simone De Angelis, Sarah C Johnson, Bjorn Bakker, Diana CJ Spierings, René Wardenaar, Eleni Maniati, Jun Wang, Michael A Boemo, Floris Foijer, Sarah E McClelland
Nov 20, 2022
BACKGROUND: A major driver of cancer chromosomal instability is replication stress, the slowing or stalling of DNA replication. How replication stress and genomic instability are connected is not known. Aphidicolin-induced...
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids.
Ary Marsee, Floris JM Roos, Monique MA Verstegen, HPB Organoid Consortium, Helmuth Gehart, Eelco de Koning, Frédéric Lemaigre, Stuart J Forbes, Weng Chuan Peng, Meritxell Huch, Takanori Takebe, Ludovic Vallier, Hans Clevers, Luc JW van der Laan, Bart Spee
May 26, 2021
Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also...
Atypically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay.
Dorothea L Floris, Meng-Chuan Lai, Tibor Auer, Michael V Lombardo, Christine Ecker, Bhismadev Chakrabarti, Sally J Wheelwright, Edward T Bullmore, Declan GM Murphy, Simon Baron-Cohen, John Suckling
Oct 16, 2015
autism cortical asymmetry language delay lateralization volumetric MRI Acoustic Stimulation Adolescent Adult Autistic Disorder Brain Mapping Cerebral Cortex Cognition Disorders Functional Laterality Humans Image Processing Computer-Assisted Language Development Disorders Magnetic Resonance Imaging Male Neuropsychological Tests Photic Stimulation Psychiatric Status Rating Scales Space Perception Statistics as Topic Young Adult
Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses.
Diffusional Kurtosis Imaging of White Matter Degeneration in Glaucoma.
Carlo Nucci, Francesco Garaci, Simone Altobelli, Francesco Di Ciò, Alessio Martucci, Francesco Aiello, Simona Lanzafame, Francesca Di Giuliano, Eliseo Picchi, Silvia Minosse, Massimo Cesareo, Maria Giovanna Guerrisi, Roberto Floris, Luca Passamonti, Nicola Toschi
Sep 24, 2020
Glaucoma is an optic neuropathy characterized by death of retinal ganglion cells and loss of their axons, progressively leading to blindness. Recently, glaucoma has been conceptualized as a more diffuse neurodegenerative...
Gray matter covariations and core symptoms of autism
Ting Mei, Alberto Llera, Dorothea L. Floris, Natalie J. Forde, Julian Tillmann, Sarah Durston, Carolin Moessnang, Tobias Banaschewski, Rosemary J. Holt, Simon Baron-Cohen, Annika Rausch, Eva Loth, Flavio Dell’Acqua, Tony Charman, Declan G. M. Murphy, Christine Ecker, Christian F. Beckmann, Jan K. Buitelaar
Oct 31, 2020
Reorganization of the structural connectome in Primary Open Angle Glaucoma
Francesco Di Cio', Francesco Garaci, Silvia Minosse, Luca Passamonti, Alessio Martucci, Simona Lanzafame, Francesca Di Giuliano, Eliseo Picchi, Massimo Cesareo, Maria Giovanna Guerrisi, Roberto Floris, Carlo Nucci, Nicola Toschi
Sep 14, 2020
Primary open angle Glaucoma (POAG) is one of the most common causes of permanent blindness in the world. Recent studies have suggested the hypothesis that POAG is also a central nervous system disorder which may result in...
The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism.
Florina Uzefovsky, Richard AI Bethlehem, Simone Shamay-Tsoory, Amber Ruigrok, Rosemary Holt, Michael Spencer, Lindsay Chura, Varun Warrier, Bhismadev Chakrabarti, Ed Bullmore, John Suckling, Dorothea Floris, Simon Baron-Cohen
May 01, 2019
BACKGROUND: Autism is a highly varied and heritable neurodevelopmental condition, and common variants explain approximately 50% of the genetic variance of autism. One of the genes implicated in autism is the oxytocin receptor...
Diffusional Kurtosis Imaging of White Matter Degeneration in Glaucoma
Carlo Nucci, Francesco Garaci, Simone Altobelli, Francesco Di Ciò, Alessio Martucci, Francesco Aiello, Simona Lanzafame, Francesca Di Giuliano, Eliseo Picchi, Silvia Minosse, Massimo Cesareo, Maria Giovanna Guerrisi, Roberto Floris, Luca Passamonti, Nicola Toschi
Sep 28, 2020
Glaucoma is an optic neuropathy characterized by death of retinal ganglion cells and loss of their axons, progressively leading to blindness. Recently, glaucoma has been conceptualized as a more diffuse neurodegenerative...
High-throughput total RNA sequencing in single cells using VASA-seq.
Fredrik Salmen, Joachim De Jonghe, Tomasz S Kaminski, Anna Alemany, Guillermo E Parada, Joe Verity-Legg, Ayaka Yanagida, Timo N Kohler, Nicholas Battich, Floris van den Brekel, Anna L Ellermann, Alfonso Martinez Arias, Jennifer Nichols, Martin Hemberg, Florian Hollfelder, Alexander van Oudenaarden
Dec 15, 2022
Most methods for single-cell transcriptome sequencing amplify the termini of polyadenylated transcripts, capturing only a small fraction of the total cellular transcriptome. This precludes the detection of many long non-coding...
Outcome prediction of head and neck squamous cell carcinoma by MRI radiomic signatures.
Steven W Mes, Floris HP van Velden, Boris Peltenburg, Carel FW Peeters, Dennis E Te Beest, Mark A van de Wiel, Joost Mekke, Doriene C Mulder, Roland M Martens, Jonas A Castelijns, Frank A Pameijer, Remco de Bree, Ronald Boellaard, C René Leemans, Ruud H Brakenhoff, Pim de Graaf
Jun 04, 2021
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) shows a remarkable heterogeneity between tumors, which may be captured by a variety of quantitative features extracted from diagnostic images, termed radiomics. The aim...
Factor Analysis Head and Neck Neoplasms Magnetic Resonance Imaging Prognosis Aged Area Under Curve Biomarkers Comorbidity Disease-Free Survival Factor Analysis Statistical Female Head and Neck Neoplasms Humans Kaplan-Meier Estimate Magnetic Resonance Imaging Male Middle Aged Neoplasm Recurrence Local Observer Variation Prognosis Radiometry Reproducibility of Results Retrospective Studies Squamous Cell Carcinoma of Head and Neck Treatment Outcome
Fractionating autism based on neuroanatomical normative modeling.
Mariam Zabihi, Dorothea L Floris, Seyed Mostafa Kia, Thomas Wolfers, Julian Tillmann, Alberto Llera Arenas, Carolin Moessnang, Tobias Banaschewski, Rosemary Holt, Simon Baron-Cohen, Eva Loth, Tony Charman, Thomas Bourgeron, Declan Murphy, Christine Ecker, Jan K Buitelaar, Christian F Beckmann, Andre Marquand, EU-AIMS LEAP group
Dec 07, 2020
Autism is a complex neurodevelopmental condition with substantial phenotypic, biological, and etiologic heterogeneity. It remains a challenge to identify biomarkers to stratify autism into replicable cognitive or biological...
Evaluation of data imputation strategies in complex, deeply-phenotyped data sets
A Llera, M Brammer, B Oakley, J Tillmann, M Zabihi, JS Amelink, T Mei, T Charman, C Ecker, F Dell'Acqua, T Banaschewski, C Moessnang, S Baron-Cohen, R Holt, S Durston, D Murphy, E Loth, JK Buitelaar, DL Floris, CF Beckmann
Aug 16, 2022
An increasing number of large-scale multi-modal research initiatives has been conducted in the typically developing population, e.g. Dev. Cogn. Neur. 32:43-54, 2018; PLoS Med. 12(3):e1001779, 2015; Elam and Van Essen, Enc. Comp....
Fractionating autism based on neuroanatomical normative modeling
Mariam Zabihi, Dorothea L. Floris, Seyed Mostafa Kia, Thomas Wolfers, Julian Tillmann, Alberto Llera Arenas, Carolin Moessnang, Tobias Banaschewski, Rosemary Holt, Simon Baron-Cohen, Eva Loth, Tony Charman, Thomas Bourgeron, Declan Murphy, Christine Ecker, Jan K. Buitelaar, Christian F. Beckmann, Andre Marquand
Nov 09, 2020
Towards robust and replicable sex differences in the intrinsic brain function of autism.
Dorothea L Floris, José OA Filho, Meng-Chuan Lai, Steve Giavasis, Marianne Oldehinkel, Maarten Mennes, Tony Charman, Julian Tillmann, Guillaume Dumas, Christine Ecker, Flavio Dell'Acqua, Tobias Banaschewski, Carolin Moessnang, Simon Baron-Cohen, Sarah Durston, Eva Loth, Declan GM Murphy, Jan K Buitelaar, Christian F Beckmann, Michael P Milham, Adriana Di Martino
Apr 12, 2021
BACKGROUND: Marked sex differences in autism prevalence accentuate the need to understand the role of biological sex-related factors in autism. Efforts to unravel sex differences in the brain organization of autism have...
Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.
Floris Foijer, Lee A Albacker, Bjorn Bakker, Diana C Spierings, Ying Yue, Stephanie Z Xie, Stephanie Davis, Annegret Lutum-Jehle, Darin Takemoto, Brian Hare, Brinley Furey, Roderick T Bronson, Peter M Lansdorp, Allan Bradley, Peter K Sorger
Oct 14, 2020
Chromosome instability (CIN) is deleterious to normal cells because of the burden of aneuploidy. However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a...
Mad2 Aneuploidy cancer biology chromosomal instability Chromosomes Genes human karyotype heterogeneity MOUSE spindle checkpoint Animals Carcinoma Hepatocellular Cell Survival chromosomal instability Disease Models Animal Hepatocytes Lymphoma T-Cell M Phase Cell Cycle Checkpoints Mad2 Proteins Mice Sequence Deletion T-Lymphocytes
Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies.
Bjorn Bakker, Aaron Taudt, Mirjam E Belderbos, David Porubsky, Diana CJ Spierings, Tristan V de Jong, Nancy Halsema, Hinke G Kazemier, Karina Hoekstra-Wakker, Allan Bradley, Eveline SJM de Bont, Anke van den Berg, Victor Guryev, Peter M Lansdorp, Maria Colomé-Tatché, Floris Foijer
Oct 14, 2020
BACKGROUND: Chromosome instability leads to aneuploidy, a state in which cells have abnormal numbers of chromosomes, and is found in two out of three cancers. In a chromosomal instable p53 deficient mouse model with accelerated...
Aneuploidy Copy number detection karyotype heterogeneity leukaemia Lymphoma Single-cell sequencing Aneuploidy Animals chromosomal instability Chromosome Aberrations Comparative Genomic Hybridization Computational Biology DNA Copy Number Variations Genetic Heterogeneity Humans Karyotype Mice Mice Knockout Neoplasms Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Single-Cell Analysis Software
Gray matter covariations and core symptoms of autism
Ting Mei, Alberto Llera, Dorothea L Floris, Natalie J Forde, Julian Tillmann, Sarah Durston, Carolin Moessnang, Tobias Banaschewski, Rosemary J Holt, Simon Baron-Cohen, Annika Rausch, Eva Loth, Flavio Dell'Acqua, Tony Charman, Declan GM Murphy, Christine Ecker, Christian F Beckmann, Jan K Buitelaar, EU-AIMS LEAP group
Dec 07, 2020
BACKGROUND: Voxel-based morphometry (VBM) studies in autism spectrum disorder (autism) have yielded diverging results. This might partly be attributed to structural alterations being associating with the combined influence of...
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