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Results: 44
Gut microbiota trajectory in early life may predict development of celiac disease.
Marta Olivares, Alan W Walker, Amalia Capilla, Alfonso Benítez-Páez, Francesc Palau, Julian Parkhill, Gemma Castillejo, Yolanda Sanz
Jul 31, 2018
BACKGROUND: To investigate whether alterations in the developing intestinal microbiota and immune markers precede celiac disease (CD) onset in infants at familial risk of developing the disease. METHODS: A nested case-control...
Celiac disease HLA genes Intestinal microbiology Bifidobacterium Case-Control Studies Celiac disease Child Preschool Enterococcus Feces Female Firmicutes Gastrointestinal Microbiome Gastrointestinal Tract High-Throughput Nucleotide Sequencing Humans Infant Infant Newborn Male Prospective Studies RNA Ribosomal 16S
Local Persistence of Novel MRSA Lineage after Hospital Ward Outbreak, Cambridge, UK, 2011–2013
Bacteria Cambridge MRSA Staphylococcus aureus United Kingdom infection control nosocomial staphylococci Cross Infection Disease Outbreaks Genome Bacterial History 21st Century Humans Methicillin-Resistant Staphylococcus aureus Phylogeny Polymorphism Single Nucleotide Staphylococcal Infections United Kingdom
Defining metrics for whole-genome sequence analysis of MRSA in clinical practice.
Kathy E Raven, Beth Blane, Narender Kumar, Danielle Leek, Eugene Bragin, Francesc Coll, Julian Parkhill, Sharon J Peacock
Feb 27, 2020
Bacterial sequencing will become increasingly adopted in routine microbiology laboratories. Here, we report the findings of a technical evaluation of almost 800 clinical methicillin-resistant Staphylococcus aureus (MRSA)...
MRSA quality metrics Translational whole-genome sequencing Bacterial Proteins Computational Biology High-Throughput Nucleotide Sequencing Humans Methicillin-Resistant Staphylococcus aureus Penicillin-Binding Proteins Polymorphism Single Nucleotide Staphylococcal Infections United Kingdom whole genome sequencing Workflow
Environmental and maternal factors shaping tonsillar microbiota development in piglets.
Simen Fredriksen, Xiaonan Guan, Jos Boekhorst, Francesc Molist, Peter van Baarlen, Jerry M Wells
Oct 28, 2022
BACKGROUND: The palatine tonsils are part of the mucosal immune system and stimulate immune responses through M cell uptake sampling of antigens and bacteria in the tonsillar crypts. Little is known about the development of the...
Environmental and maternal factors shaping tonsillar microbiota development in piglets.
Simen Fredriksen, Xiaonan Guan, Jos Boekhorst, Francesc Molist, Peter van Baarlen, Jerry M Wells
Sep 26, 2022
BACKGROUND: The palatine tonsils are part of the mucosal immune system and stimulate immune responses through M cell uptake sampling of antigens and bacteria in the tonsillar crypts. Little is known about the development of the...
Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure.
Louise Kime, Christopher P Randall, Frank I Banda, Francesc Coll, John Wright, Joseph Richardson, Joanna Empel, Julian Parkhill, Alex J O'Neill
Nov 13, 2019
Sporadic literature reports describe isolates of pathogenic bacteria that harbor an antibiotic resistance determinant but remain susceptible to the corresponding antibiotic as a consequence of a genetic defect. Such strains...
Effective therapeutic strategies in a preclinical mouse model of Charcot-Marie-Tooth disease.
Cristina Nuevo-Tapioles, Fulvio Santacatterina, Brenda Sánchez-Garrido, Cristina Núñez de Arenas, Adrián Robledo-Bérgamo, Paula Martínez-Valero, Lara Cantarero, Beatriz Pardo, Janet Hoenicka, Michael P Murphy, Jorgina Satrústegui, Francesc Palau, José M Cuezva
Aug 02, 2021
Charcot-Marie-Tooth (CMT) disease is a neuropathy that lacks effective therapy. CMT patients show degeneration of peripheral nerves, leading to muscle weakness and loss of proprioception. Loss of mitochondrial oxidative...
PowerBacGWAS
Francesc Coll, Theodore Gouliouris, Sebastian Bruchmann, Jody Phelan, Kathy E Raven, Taane G Clark, Julian Parkhill, Sharon Peacock
Mar 31, 2022
Genome-wide association studies (GWAS) are increasingly being applied to investigate the genetic basis of bacterial traits. However, approaches to perform power calculations for bacterial GWAS are limited. Here we implemented...
Transmission of methicillin-resistant $\textit{Staphylococcus aureus}$ in long-term care facilities and their related healthcare networks
Ewan Harrison, Catherine Ludden, Hayley J Brodrick, Beth Blane, Gráinne Brennan, Dearbháile Morris, Francesc Coll, Sandra Reuter, Nicholas M Brown, Mark Holmes, Brian O’Connell, Julian Parkhill, M Estee Török, Martin Cormican, Sharon Peacock
Oct 28, 2016
Prospective genomic surveillance of methicillin-resistant Staphylococcus aureus (MRSA) associated with bloodstream infection, England, 1 October 2012 to 30 September 2013.
Michelle S Toleman, Sandra Reuter, Dorota Jamrozy, Hayley J Wilson, Beth Blane, Ewan M Harrison, Francesc Coll, Russell J Hope, Angela Kearns, Julian Parkhill, Sharon J Peacock, M Estée Török
Feb 14, 2019
MRSA Methicillin-Resistant Staphylococcus aureus WGS bacteraemia EPIDEMIOLOGY Public Health SURVEILLANCE whole-genome sequencing Adolescent Adult Aged Aged 80 and over Bacteremia Child Child Preschool Cohort Studies Cross Infection Disease Outbreaks England Epidemiological Monitoring Feasibility Studies Female Genome Bacterial Humans Infant Infant Newborn Male Methicillin-Resistant Staphylococcus aureus Middle Aged molecular epidemiology Phylogeny Prospective Studies Public Health Public Health Surveillance Sequence Analysis DNA Staphylococcal Infections whole genome sequencing
Localization of Autonomous Robot in an Urban Area Based on SURF Feature Extraction of Images
Md. Haque, Anowar Hossain, Abu Yasin, Md. Adnan, Sonia Rahnuma, Kallol Naha, Mohammod Kabir, Francesc Serratosa
Oct 01, 2020
An autonomous robot is now an internationally discussed topic to ease the life of humans. Localization and movement are two rudimentary necessities of the autonomous robots before accomplishing any job. So, many researchers have...
Published by: IGI Global Scientific Publishing
Detection of vancomycin-resistant Enterococcus faecium hospital-adapted lineages in municipal wastewater treatment plants indicates widespread distribution and release into the environment.
Theodore Gouliouris, Kathy E Raven, Danesh Moradigaravand, Catherine Ludden, Francesc Coll, Beth Blane, Plamena Naydenova, Carolyne Horner, Nicholas M Brown, Jukka Corander, Direk Limmathurotsakul, Julian Parkhill, Sharon J Peacock
Jan 06, 2020
Vancomycin-resistant Enterococcus faecium (VREfm) is a leading cause of healthcare-associated infection. Reservoirs of VREfm are largely assumed to be nosocomial although there is a paucity of data on alternative sources. Here...
Automated detection of archaeological mounds using machine-learning classification of multisensor and multitemporal satellite data.
Hector A Orengo, Francesc C Conesa, Arnau Garcia-Molsosa, Agustín Lobo, Adam S Green, Marco Madella, Cameron A Petrie
Jul 06, 2020
Systematic Surveillance Detects Multiple Silent Introductions and Household Transmission of Methicillin-Resistant Staphylococcus aureus USA300 in the East of England.
Michelle S Toleman, Sandra Reuter, Francesc Coll, Ewan M Harrison, Beth Blane, Nicholas M Brown, M Estée Török, Julian Parkhill, Sharon J Peacock
Apr 29, 2016
MRSA Staphylococcus aureus USA300 molecular epidemiology whole-genome sequencing Adolescent Adult Aged Aged 80 and over Child Child Preschool Disease Transmission Infectious England Epidemiological Monitoring Family Characteristics Family Health Female Genotype Humans Male Methicillin-Resistant Staphylococcus aureus Middle Aged molecular epidemiology Prospective Studies Sequence Analysis DNA Staphylococcal Infections Young Adult
Investigation of a Cluster of Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Transmission in a Community Setting.
Michelle S Toleman, Emmeline R Watkins, Tom Williams, Beth Blane, Belinda Sadler, Ewan M Harrison, Francesc Coll, Julian Parkhill, Bernadette Nazareth, Nicholas M Brown, Sharon J Peacock
Sep 02, 2019
BACKGROUND: Whole-genome sequencing (WGS) has typically been used to confirm or refute hospital/ward outbreaks of methicillin-resistant Staphylococcus aureus (MRSA) identified through routine practice. However, appropriately...
MRSA community EPIDEMIOLOGY General Practice genome sequencing Adolescent Adult Aged Aged 80 and over Bacteremia Child Cross Infection DNA Bacterial Disease Outbreaks Female General Practice Genome Bacterial Humans Male Methicillin-Resistant Staphylococcus aureus Middle Aged Phylogeny Prospective Studies Public Health Sequence Analysis DNA Staphylococcal Infections United Kingdom whole genome sequencing Young Adult
Complex Routes of Nosocomial Vancomycin-Resistant Enterococcus faecium Transmission Revealed by Genome Sequencing.
Kathy E Raven, Theodore Gouliouris, Hayley Brodrick, Francesc Coll, Nicholas M Brown, Rosy Reynolds, Sandra Reuter, M Estée Török, Julian Parkhill, Sharon J Peacock
Mar 09, 2017
Enterococcus faecium genome sequencing. infection control transmission vancomycin resistant Cross Infection Enterococcus faecium Genome Bacterial Gram-Positive Bacterial Infections Humans Phylogeny Polymorphism Single Nucleotide Retrospective Studies Vancomycin-Resistant Enterococci whole genome sequencing
Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data.
Oliver Stirrup, Joseph Hughes, Matthew Parker, David G Partridge, James G Shepherd, James Blackstone, Francesc Coll, Alexander Keeley, Benjamin B Lindsey, Aleksandra Marek, Christine Peters, Joshua B Singer, COVID-19 Genomics UK (COG-UK) Consortium, Asif Tamuri, Thushan I de Silva, Emma C Thomson, Judith Breuer
Jul 29, 2021
covid-19 SARS-CoV-2 EPIDEMIOLOGY Global Health healthcare associated human infectious disease microbiology nosocomial outbreak whole genome sequencing covid-19 Cross Infection Disease Outbreaks Genome Viral Hospitals Humans Population Surveillance Probability Retrospective Studies SARS-CoV-2 United Kingdom whole genome sequencing
Quantifying acquisition and transmission of Enterococcus faecium using genomic surveillance.
Theodore Gouliouris, Francesc Coll, Catherine Ludden, Beth Blane, Kathy E Raven, Plamena Naydenova, Charles Crawley, Mili Estée Török, David A Enoch, Nicholas M Brown, Ewan M Harrison, Julian Parkhill, Sharon J Peacock
Aug 14, 2020
Nosocomial acquisition and transmission of vancomycin-resistant Enterococcus faecium (VREfm) is the driver for E. faecium carriage in hospitalized patients, which, in turn, is a risk factor for invasive infection in...
Adult Aged Aged 80 and over Alcohols Anti-Bacterial Agents Chlorhexidine Cross Infection Disease Outbreaks Disinfectants Enterococcus faecium Genome Bacterial Gram-Positive Bacterial Infections Humans infection control Microbial Sensitivity Tests Middle Aged Prospective Studies vancomycin Vancomycin-Resistant Enterococci whole genome sequencing Young Adult
One Health Genomic Surveillance of Escherichia coli Demonstrates Distinct Lineages and Mobile Genetic Elements in Isolates from Humans versus Livestock.
Catherine Ludden, Kathy E Raven, Dorota Jamrozy, Theodore Gouliouris, Beth Blane, Francesc Coll, Marcus de Goffau, Plamena Naydenova, Carolyne Horner, Juan Hernandez-Garcia, Paul Wood, Nazreen Hadjirin, Milorad Radakovic, Nicholas M Brown, Mark Holmes, Julian Parkhill, Sharon J Peacock
Feb 07, 2019
Livestock have been proposed as a reservoir for drug-resistant Escherichia coli that infect humans. We isolated and sequenced 431 E. coli isolates (including 155 extended-spectrum β-lactamase [ESBL]-producing isolates) from...
ESBL Escherichia coli Antimicrobial resistance Genomics Livestock Animals Computational Biology Cross-Sectional Studies Drug Resistance Bacterial England Epidemiological Monitoring Escherichia coli Escherichia coli Infections Genes Bacterial genetic variation Genomics Humans Interspersed Repetitive Sequences Livestock Meat One Health prevalence Sequence Analysis DNA whole genome sequencing
Characteristics of Staphylococcus aureus Isolated from Patients in Busia County Referral Hospital, Kenya.
Characteristics of Staphylococcus aureus Isolated from Patients in Busia County Referral Hospital, Kenya.
Benear Apollo Obanda, Elizabeth AJ Cook, Eric M Fèvre, Lilly Bebora, William Ogara, Shu-Hua Wang, Wondwossen Gebreyes, Ronald Ngetich, Dolphine Wandede, Johnstone Muyodi, Beth Blane, Francesc Coll, Ewan M Harrison, Sharon J Peacock, George C Gitao
Jan 26, 2023
Staphylococcus aureus is an important pathogen associated with hospital, community, and livestock-acquired infections, with the ability to develop resistance to antibiotics. Nasal carriage by hospital inpatients is a risk for...
The Obemat2.0 Study
Veronica Luque, Albert Feliu, Joaquín Escribano, Natalia Ferré, Gemma Flores, Raquel Monné, Desirée Gutiérrez-Marín, Núria Guillen, Judit Muñoz-Hernando, Marta Zaragoza-Jordana, Mariona Gispert-Llauradó, Carme Rubio-Torrents, Mercè Núñez-Roig, Mireia Alcázar, Raimon Ferré, Josep M Basora, Pablo Hsu, Clara Alegret-Basora, Francesc Arasa, Michelle Venables, Priya Singh, Ricardo Closa-Monasterolo
Oct 14, 2019
The primary aim of the Obemat2.0 trial was to evaluate the efficacy of a multicomponent motivational program for the treatment of childhood obesity, coordinated between primary care and hospital specialized services, compared to...
Childhood obesity motivational interview obesity treatment PRIMARY CARE Adolescent Body Mass Index Child Cluster Analysis Diet Exercise Female Humans Male Motivational interviewing Patient Education as Topic Pediatric Obesity Psychotherapy Group Spain Telemedicine Treatment Adherence and Compliance Treatment Outcome Waist Circumference
Multi-Drug Resistant Staphylococcus aureus Carriage in Abattoir Workers in Busia, Kenya.
Benear Apollo Obanda, Cheryl L Gibbons, Eric M Fèvre, Lilly Bebora, George Gitao, William Ogara, Shu-Hua Wang, Wondwossen Gebreyes, Ronald Ngetich, Beth Blane, Francesc Coll, Ewan M Harrison, Samuel Kariuki, Sharon J Peacock, Elizabeth AJ Cook
Jan 24, 2023
Abattoir workers have been identified as high-risk for livestock-associated Staphylococcus aureus carriage. This study investigated S. aureus carriage in abattoir workers in Western Kenya. Nasal swabs were collected once from...
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses.
Javier Rodríguez-Ubreva, Anna Arutyunyan, Marc Jan Bonder, Lucía Del Pino-Molina, Stephen J Clark, Carlos de la Calle-Fabregat, Luz Garcia-Alonso, Louis-François Handfield, Laura Ciudad, Eduardo Andrés-León, Felix Krueger, Francesc Català-Moll, Virginia C Rodríguez-Cortez, Krzysztof Polanski, Lira Mamanova, Stijn van Dongen, Vladimir Yu Kiselev, María T Martínez-Saavedra, Holger Heyn, Javier Martín, Klaus Warnatz, Eduardo López-Granados, Carlos Rodríguez-Gallego, Oliver Stegle, Gavin Kelsey, Roser Vento-Tormo, Esteban Ballestar
Apr 01, 2022
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