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Lotteries and Lindahl Prices in Public Good Provision
Jorg Franke
Dec 01, 2018
Lotteries are traditional instruments for fundraising in general. Morgan has shown that they can also be very effective in the provision of a public good. However, a fair lottery can only enhance provision but never result in...
Lotteries and Lindahl Prices in Public Good Provision
Jorg Franke
Dec 01, 2018
Lotteries are traditional instruments for fundraising in general. Morgan has shown that they can also be very effective in the provision of a public good. However, a fair lottery can only enhance provision but never result in...
Optimal Favoritism in All-Pay Auctions and Lottery Contests
We analyze the revenue-enhancing potential of favoring specific contestants in complete-information all-pay auctions and lottery contests with several heterogeneous contestants. Two instruments of favoritism are considered: head...
Large genome-wide association study identifies three novel risk variants for restless legs syndrome
Maria Didriksen, Muhammad Sulaman Nawaz, Joseph Dowsett, Steven Bell, Christian Erikstrup, Ole B. Pedersen, Erik Sørensen, Poul J. Jennum, Kristoffer S. Burgdorf, Brendan Burchell, Adam S. Butterworth, Nicole Soranzo, David B. Rye, Lynn Marie Trotti, Prabhjyot Saini, Lilja Stefansdottir, Sigurdur H. Magnusson, Gudmar Thorleifsson, Thordur Sigmundsson, Albert P. Sigurdsson, Katja van den Hurk, Franke Quee, Michael W. T. Tanck, Willem H. Ouwehand, David J. Roberts, Eric J. Earley, Michael P. Busch, Alan E. Mast, Grier P. Page, John Danesh, Emanuele Di Angelantonio, Hreinn Stefansson, Henrik Ullum, Kari Stefansson
Nov 25, 2020
Large genome-wide association study identifies three novel risk variants for restless legs syndrome.
Maria Didriksen, Muhammad Sulaman Nawaz, Joseph Dowsett, Steven Bell, Christian Erikstrup, Ole B Pedersen, Erik Sørensen, Poul J Jennum, Kristoffer S Burgdorf, Brendan Burchell, Adam S Butterworth, Nicole Soranzo, David B Rye, Lynn Marie Trotti, Prabhjyot Saini, Lilja Stefansdottir, Sigurdur H Magnusson, Gudmar Thorleifsson, Thordur Sigmundsson, Albert P Sigurdsson, Katja van den Hurk, Franke Quee, Michael WT Tanck, Willem H Ouwehand, David J Roberts, Eric J Earley, Michael P Busch, Alan E Mast, Grier P Page, John Danesh, Emanuele Di Angelantonio, Hreinn Stefansson, Henrik Ullum, Kari Stefansson
Oct 27, 2020
Optimal Favoritism in All-Pay Auctions and Lottery Contests
We analyze the revenue-enhancing potential of favoring specific contestants in complete-information all-pay auctions and lottery contests with several heterogeneous contestants. Two instruments of favoritism are considered: head...
Magnetic resonance imaging and positron emission tomography in anti-NMDA receptor encephalitis
Due to a variety of clinical manifestations anti-N-methyl-d-aspartate (NMDA) receptor encephalitis may be difficult to diagnose. Magnetic resonance imaging (MRI) may be used as a component of the workup for encephalopathy....
Bayesian test for colocalisation between pairs of genetic association studies using summary statistics.
Claudia Giambartolomei, Damjan Vukcevic, Eric E Schadt, Lude Franke, Aroon D Hingorani, Chris Wallace, Vincent Plagnol
Oct 03, 2018
Genetic association studies, in particular the genome-wide association study (GWAS) design, have provided a wealth of novel insights into the aetiology of a wide range of human diseases and traits, in particular cardiovascular...
Gut mucosa dissociation protocols influence cell type proportions and single-cell gene expression levels.
Werna TC Uniken Venema, Aarón D Ramírez-Sánchez, Emilia Bigaeva, Sebo Withoff, Iris Jonkers, Rebecca E McIntyre, Mennatallah Ghouraba, Tim Raine, Rinse K Weersma, Lude Franke, Eleonora AM Festen, Monique GP van der Wijst
Jun 15, 2022
Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of the cellular landscape of organs. Most single-cell protocols require fresh material, which limits sample size per experiment, and consequently, introduces...
Blood Eosinophil Count and Metabolic, Cardiac and Pulmonary Outcomes
Marzyeh Amini, Judith M Vonk, Ali Abbasi, Bram P Prins, Marcel Bruinenberg, Lude Franke, Pim van der Harst, Gerjan Navis, Gerard H Koppelman, Bruce Hr Wolffenbuttel, H Marike Boezen, Harold Snieder, Daniel I Chasman, Behrooz Z Alizadeh
Jun 04, 2018
Blood eosinophil count is associated with a variety of common complex outcomes in epidemiological observation. The aim of this study was to explore the causal association between determined blood eosinophil count and 20 common...
Mendelian randomization Cardiovascular Diseases complex diseases eosinophil count genetic risk score instrumental variable Metabolic Diseases pulmonary diseases Asthma Blood Glucose blood pressure Body Mass Index Cohort Studies Diabetes mellitus Type 2 Female Forced Expiratory Volume Genome-Wide Association Study Glycated Hemoglobin Humans Leukocyte Count Lipids Male Mendelian Randomization Analysis Metabolic Syndrome Pulmonary Disease Chronic Obstructive Quantitative Trait Heritable
Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis.
Stage IV Colorectal Cancer Patients with High Risk Mutation Profiles Survived 16 Months Longer with Individualized Therapies.
Alexander Hendricks, Anu Amallraja, Tobias Meißner, Peter Forster, Philip Rosenstiel, Greta Burmeister, Clemens Schafmayer, Andre Franke, Sebastian Hinz, Michael Forster, Casey B Williams
Feb 09, 2020
Personalized treatment vs. standard of care is much debated, especially in clinical practice. Here we investigated whether overall survival differences in metastatic colorectal cancer patients are explained by tumor mutation...
Gut mucosa dissociation protocols influence cell type proportions and single-cell gene expression levels.
Werna TC Uniken Venema, Aarón D Ramírez-Sánchez, Emilia Bigaeva, Sebo Withoff, Iris Jonkers, Rebecca E McIntyre, Mennatallah Ghouraba, Tim Raine, Rinse K Weersma, Lude Franke, Eleonora AM Festen, Monique GP van der Wijst
Jul 15, 2022
Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of the cellular landscape of organs. Most single-cell protocols require fresh material, which limits sample size per experiment, and consequently, introduces...
A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease.
David González-Serna, Eguzkine Ochoa, Elena López-Isac, Antonio Julià, Frauke Degenhardt, Norberto Ortego-Centeno, Timothy RDJ Radstake, Andre Franke, Sara Marsal, Maureen D Mayes, Javier Martín, Ana Márquez, Scleroderma Genetic Consortium
Mar 09, 2020
Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn's disease (CD), some of which confer susceptibility to both diseases. In order to identify...
Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope
Cynthia SM Kramer, Marry EI Franke-van Dijk, Ashley J Priddey, Tamás Pongrácz, Elena Gnudi, Helena Car, Gonca E Karahan, Els van Beelen, Chalana CC Zilvold-van den Oever, Hendrik J Rademaker, Noortje de Haan, Manfred Wuhrer, Vasilis Kosmoliaptsis, Paul WHI Parren, Arend Mulder, Dave L Roelen, Frans HJ Claas, Sebastiaan Heidt
Oct 29, 2019
In the field of transplantation, the humoural immune response against mismatched HLA antigens of the donor is associated with inferior graft survival, but not in every patient. Donor-specific HLA antibodies (DSA) of different...
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01
Philippe Goyette, Gabrielle Boucher, Mallon Dermot, Eva Ellinghaus, Luke Jostins, Hailiang Huang, Stephan Ripke, Elena S Gusareva, Vito Annese, Stephen L Hauser, Jorge R Oksenberg, Ingo Thomsen, Stephen Leslie, Inflammatory Bowel Disease Genetics Consortium International, Mark J Daly, Steen Kristel van, Richard H Duerr, Jeffrey C Barrett, Dermot PB McGovern, L Philip Schumm, James Traherne, Mary N Carrington, Vasilis Kosmoliaptsis, Tom H Karlsen, Andre Franke, John D Rioux
Feb 12, 2015
The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner.
Frank Sleutels, Widia Soochit, Marek Bartkuhn, Helen Heath, Sven Dienstbach, Philipp Bergmaier, Vedran Franke, Manuel Rosa-Garrido, Suzanne van de Nobelen, Lisa Caesar, Michael van der Reijden, Jan Christian Bryne, Wilfred van Ijcken, J Anton Grootegoed, M Dolores Delgado, Boris Lenhard, Rainer Renkawitz, Frank Grosveld, Niels Galjart
Aug 13, 2012
Immune-related genetic enrichment in frontotemporal dementia
Iris Broce, Celeste M Karch, Natalie Wen, Chun C Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A Ross, Günter U Höglinger, Ulrich Muller, John Hardy, International FTD-Genomics Consortium, Parastoo Momeni, Christopher P Hess, William P Dillon, Zachary A Miller, Luke W Bonham, Gil D Rabinovici, Howard J Rosen, Gerard D Schellenberg, Andre Franke, Tom H Karlsen, Jan H Veldink, Raffaele Ferrari, Jennifer S Yokoyama, Bruce L Miller, Ole A Andreassen, Anders M Dale, Rahul S Desikan, Leo P Sugrue
Mar 16, 2018
BACKGROUND: Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are...
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.
Chris Eijsbouts, Tenghao Zheng, Nicholas A Kennedy, Ferdinando Bonfiglio, Carl A Anderson, Loukas Moutsianas, Joanne Holliday, Jingchunzi Shi, Suyash Shringarpure, 23andMe Research Team, Alexandru-Ioan Voda, Bellygenes Initiative, Gianrico Farrugia, Andre Franke, Matthias Hübenthal, Gonçalo Abecasis, Matthew Zawistowski, Anne Heidi Skogholt, Eivind Ness-Jensen, Kristian Hveem, Tõnu Esko, Maris Teder-Laving, Alexandra Zhernakova, Michael Camilleri, Guy Boeckxstaens, Peter J Whorwell, Robin Spiller, Gil McVean, Mauro D'Amato, Luke Jostins, Miles Parkes
Jan 05, 2022
Irritable bowel syndrome (IBS) results from disordered brain-gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK...
Aged Anxiety Disorders CD56 Antigen Cell Adhesion Molecules Cytoskeletal Proteins Female Genetic Predisposition to Disease Genome-Wide Association Study Guanine Nucleotide Exchange Factors Homeodomain Proteins Humans Irritable Bowel Syndrome Male Middle Aged Molecular Chaperones Mood Disorders Polymorphism Single Nucleotide United Kingdom
Cell-type specialization is encoded by specific chromatin topologies.
Warren Winick-Ng, Alexander Kukalev, Izabela Harabula, Luna Zea-Redondo, Dominik Szabó, Mandy Meijer, Leonid Serebreni, Yingnan Zhang, Simona Bianco, Andrea M Chiariello, Ibai Irastorza-Azcarate, Christoph J Thieme, Thomas M Sparks, Sílvia Carvalho, Luca Fiorillo, Francesco Musella, Ehsan Irani, Elena Torlai Triglia, Aleksandra A Kolodziejczyk, Andreas Abentung, Galina Apostolova, Eleanor J Paul, Vedran Franke, Rieke Kempfer, Altuna Akalin, Sarah A Teichmann, Georg Dechant, Mark A Ungless, Mario Nicodemi, Lonnie Welch, Gonçalo Castelo-Branco, Ana Pombo
Jan 07, 2022
The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function1-3. Methods based on chromatin conformation capture have mapped chromatin structures in neuronal systems such...
Cell-type specialization is encoded by specific chromatin topologies.
Warren Winick-Ng, Alexander Kukalev, Izabela Harabula, Luna Zea-Redondo, Dominik Szabó, Mandy Meijer, Leonid Serebreni, Yingnan Zhang, Simona Bianco, Andrea M Chiariello, Ibai Irastorza-Azcarate, Christoph J Thieme, Thomas M Sparks, Sílvia Carvalho, Luca Fiorillo, Francesco Musella, Ehsan Irani, Elena Torlai Triglia, Aleksandra A Kolodziejczyk, Andreas Abentung, Galina Apostolova, Eleanor J Paul, Vedran Franke, Rieke Kempfer, Altuna Akalin, Sarah Teichmann, Georg Dechant, Mark A Ungless, Mario Nicodemi, Lonnie Welch, Gonçalo Castelo-Branco, Ana Pombo
Nov 24, 2021
The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function1-3. Methods based on chromatin conformation capture have mapped chromatin structures in neuronal systems such...
Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders.
MD Hettwer, S Larivière, BY Park, OA van den Heuvel, L Schmaal, OA Andreassen, CRK Ching, M Hoogman, J Buitelaar, D van Rooij, DJ Veltman, DJ Stein, B Franke, TGM van Erp, ENIGMA ADHD Working Group, ENIGMA Autism Working Group, ENIGMA Bipolar Disorder Working Group, ENIGMA Major Depression Working Group, ENIGMA OCD Working Group, ENIGMA Schizophrenia Working Group, N Jahanshad, PM Thompson, SI Thomopoulos, RAI Bethlehem, BC Bernhardt, SB Eickhoff, SL Valk
Nov 15, 2022
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