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Interview with William Franklin Mitchell - VHP 011
William Franklin Mitchell
Jan 01, 0001
In his February 24, 2004 interview with Georgia Williamson, William Franklin Mitchell describes life as a volunteer chaplain for the army during WWII. Specifically, Mitchell shares the reason why he joined the service and what...
Published by: Winthrop University
Imaging Tau, Neuroinflammation, and Aβ in Dementia With Lewy Bodies
Elijah Mak, Ajenthan Surendranathan, Nicolas Nicastro, Franklin Aigbirhio, James Rowe, John O'Brien
Dec 20, 2018
Dementia with Lewy Bodies (DLB) is the second leading cause of degenerative dementia after Alzheimer's disease (AD).
Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man.
Rhiannon S Morris, P Simon Jones, Josef A Alawneh, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, Elizabeth A Warburton, Jean-Claude Baron
Nov 06, 2018
Modern ischaemic stroke management involves intravenous thrombolysis followed by mechanical thrombectomy, which allows markedly higher rates of recanalization and penumbral salvage than thrombolysis alone. However, <50% of...
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.
Elena Sanna, Margarida Rodrigues, Steven G Fagan, Timothy S Chisholm, Klara Kulenkampff, David Klenerman, Maria Grazia Spillantini, Franklin I Aigbirhio, Christopher A Hunter
May 21, 2021
Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am.
Flaviu Bulat, Friederike Hesse, Bala Attili, Chandra Solanki, Iosif A Mendichovszky, Franklin Aigbirhio, Finian J Leeper, Kevin M Brindle, André A Neves
Apr 11, 2023
There is an unmet clinical need for imaging agents capable of detecting early evidence of tumor cell death, since the timing, extent, and distribution of cell death in tumors following treatment can give an indication of...
Published by: Cancers
Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am
Flaviu Bulat, Friederike Hesse, Bala Attili, Chandra Solanki, Iosif A. Mendichovszky, Franklin Aigbirhio, Finian J. Leeper, Kevin M. Brindle, André A. Neves
Apr 05, 2023
article Cell Death Apoptosis tumor Imaging C2Am Trail-r2 Positron Emission Tomography (Pet) Gallium-68
Published by: MDPI
Para-chloro-2-[18F]fluoroethyl-etomidate
Isabella Silins, Anders Sundin, Patrik Nordeman, Mahabuba Jahan, Sergio Estrada, Azita Monazzam, Mark Lubberink, Franklin Aigbirhio, Per Hellman, Gunnar Antoni
May 21, 2021
Introduction: [11C]Metomidate ([11C]MTO), the methyl ester analogue of etomidate, was developed as a positron emission tomography (PET) radiotracer for adrenocortical tumours and has also been suggested for imaging in primary...
18F-CETO Adrenal masses Adrenal tracer positron emission tomography primary aldosteronism Adrenal Cortex Adrenal Cortex Neoplasms Animals Drug Evaluation Preclinical Etomidate Fluorine Radioisotopes Humans hyperaldosteronism Macaca fascicularis Mice Positron-Emission Tomography Radiopharmaceuticals Rats Tissue Distribution
18F-C2Am
Flaviu Bulat, Friederike Hesse, De-En Hu, Susana Ros, Connor Willminton-Holmes, Bangwen Xie, Bala Attili, Dmitry Soloviev, Franklin Aigbirhio, Finian J Leeper, Kevin M Brindle, André A Neves
Feb 03, 2021
INTRODUCTION: Trialing novel cancer therapies in the clinic would benefit from imaging agents that can detect early evidence of treatment response. The timing, extent and distribution of cell death in tumors following treatment...
A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein.
Yanyan Zhao, Ole Tietz, Wei-Li Kuan, Abdul K Haji-Dheere, Stephen Thompson, Benjamin Vallin, Elisabetta Ronchi, Gergely Tóth, David Klenerman, Franklin I Aigbirhio
Jul 28, 2021
Soluble forms of aggregated tau misfolded protein, generally termed oligomers, are considered to be the most toxic species of the different assembly states that are the pathological components of neurodegenerative disorders....
Published by: Chemical science
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.
Elena Sanna, Margarida Rodrigues, Steven G Fagan, Timothy S Chisholm, Klara Kulenkampff, David Klenerman, Maria Grazia Spillantini, Franklin I Aigbirhio, Christopher A Hunter
Aug 14, 2021
A key process in the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is the aggregation of proteins to produce fibrillary aggregates with a cross β-sheet structure, amyloid. The development...
Published by: Chemical science
Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain.
Joseph V Guadagno, P Simon Jones, Tim D Fryer, Olivier Barret, Franklin I Aigbirhio, T Adrian Carpenter, Christopher J Price, Jonathan H Gillard, Elizabeth A Warburton, Jean-Claude Baron
Apr 05, 2011
Aged 80 and over Body Water Brain Brain Ischemia Carotid Artery Internal Dissection Cerebrovascular Circulation Diffusion Diffusion Magnetic Resonance Imaging Energy Metabolism Female Humans Hypoxia Brain Intracranial Embolism Male Middle Aged Oxygen Consumption Positron-Emission Tomography Prospective Studies Time Factors Ultrasonography Doppler Transcranial
Microglial activation and tau burden predict cognitive decline in Alzheimer's disease.
Maura Malpetti, Rogier A Kievit, Luca Passamonti, P Simon Jones, Kamen A Tsvetanov, Timothy Rittman, Elijah Mak, Nicolas Nicastro, W Richard Bevan-Jones, Li Su, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Rowe
May 18, 2020
Tau pathology, neuroinflammation, and neurodegeneration are key aspects of Alzheimer's disease. Understanding whether these features predict cognitive decline, alone or in combination, is crucial to develop new prognostic...
Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.
Thomas Geeraerts, Jonathan P Coles, Franklin I Aigbirhio, John D Pickard, David K Menon, Tim D Fryer, Young T Hong
Jun 18, 2018
OBJECTIVE: [(11)C]Flumazenil ([(11)C]FMZ) positron emission tomography (PET) can be used as a measure of neuronal loss. The purpose of this study was to validate reference tissue kinetic modelling of [(11)C]FMZ PET within a...
Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson's disease.
A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein.
Yanyan Zhao, Ole Tietz, Wei-Li Kuan, Abdul K Haji-Dheere, Stephen Thompson, Benjamin Vallin, Elisabetta Ronchi, Gergely Tóth, David Klenerman, Franklin I Aigbirhio
Apr 22, 2020
Radiosynthesis of [18F]-Labelled Pro-Nucleotides (ProTides).
Alessandra Cavaliere, Katrin C Probst, Stephen J Paisey, Christopher Marshall, Abdul KH Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D Westwell
Apr 24, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success....
Do Regions of Increased Inflammation Progress to New White Matter Hyperintensities?
Daniel J Tozer, Robin B Brown, Jessica Walsh, Young T Hong, Guy B Williams, John T O'Brien, Franklin I Aigbirhio, Tim D Fryer, Hugh S Markus
Feb 09, 2023
BACKGROUND: Recent studies have demonstrated increased microglial activation using 11C-PK11195 positron emission tomography imaging, indicating central nervous system inflammation, in cerebral small vessel disease. However...
CADASIL cerebral small vessel disease Magnetic Resonance Imaging positron emission tomography white matter Humans Diffusion tensor imaging CADASIL white matter Neuroinflammatory Diseases Magnetic Resonance Imaging Cerebral Infarction leukoencephalopathies Positron-Emission Tomography Inflammation Brain
18 F-C2Am
Flaviu Bulat, Friederike Hesse, De-En Hu, Susana Ros, Connor Willminton-Holmes, Bangwen Xie, Bala Attili, Dmitry Soloviev, Franklin Aigbirhio, Finian. J. Leeper, Kevin M. Brindle, André A. Neves
Dec 09, 2020
Abstract: Introduction: Trialing novel cancer therapies in the clinic would benefit from imaging agents that can detect early evidence of treatment response. The timing, extent and distribution of cell death in tumors following...
First-in-human evaluation of [18F]CETO
Isabella Silins, Anders Sundin, Mark Lubberink, Lleah O'Sullivan, Mark Gurnell, Franklin Aigbirhio, Morris Brown, Anders Wall, Tobias Åkerström, Sara Roslin, Per Hellman, Gunnar Antoni
Jan 05, 2023
In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.
W Richard Bevan-Jones, Thomas E Cope, P Simon Jones, Luca Passamonti, Young T Hong, Tim Fryer, Robert Arnold, Jonathan P Coles, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Jan 28, 2019
Neuroinflammation occurs in frontotemporal dementia, however its timing relative to protein aggregation and neuronal loss is unknown. Using positron emission tomography and magnetic resonance imaging to quantify these processes...
The Ursinus Weekly, May 16, 1932
"Passing of the Third Floor Back" presented by the Curtain Club Criticism of 1932 Ruby made by Prof. Sheeder Annual coronation of May queen featured in gay spring pageant "Y" doggie roast Franklin and Marshall wins track...
Ursinus College Collegeville Pennsylvania newspaper track team baseball May Day pageant Charles Macfarland Russell C. Johnson tennis Webster Stover YMCA YWCA student government cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.
Richard W Bevan-Jones, Thomas E Cope, Simon P Jones, Luca Passamonti, Young T Hong, Tim Fryer, Robert Arnold, Jonathan P Coles, Franklin A Aigbirhio, Karalyn Patterson, John T O'Brien, James B Rowe
Nov 29, 2018
The PET ligand [18F]AV-1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly associated with TDP-43...
Rare Diseases Brain Disorders Dementia Acquired Cognitive Impairment aging Neurodegenerative Neurosciences Alzheimer's Disease Alzheimer's Disease Related Dementias (ADRD) Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) frontotemporal dementia (FTD) 2 Aetiology 2.1 Biological and endogenous factors Neurological
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