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Interview with William Franklin Mitchell - VHP 011
William Franklin Mitchell
Jan 01, 0001
In his February 24, 2004 interview with Georgia Williamson, William Franklin Mitchell describes life as a volunteer chaplain for the army during WWII. Specifically, Mitchell shares the reason why he joined the service and what...
Published by: Winthrop University
A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein.
Yanyan Zhao, Ole Tietz, Wei-Li Kuan, Abdul K Haji-Dheere, Stephen Thompson, Benjamin Vallin, Elisabetta Ronchi, Gergely Tóth, David Klenerman, Franklin I Aigbirhio
Jul 28, 2021
Soluble forms of aggregated tau misfolded protein, generally termed oligomers, are considered to be the most toxic species of the different assembly states that are the pathological components of neurodegenerative disorders....
Published by: Chemical science
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.
Elena Sanna, Margarida Rodrigues, Steven G Fagan, Timothy S Chisholm, Klara Kulenkampff, David Klenerman, Maria Grazia Spillantini, Franklin I Aigbirhio, Christopher A Hunter
Aug 14, 2021
A key process in the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is the aggregation of proteins to produce fibrillary aggregates with a cross β-sheet structure, amyloid. The development...
Published by: Chemical science
Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man.
Rhiannon S Morris, P Simon Jones, Josef A Alawneh, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, Elizabeth A Warburton, Jean-Claude Baron
Nov 06, 2018
Modern ischaemic stroke management involves intravenous thrombolysis followed by mechanical thrombectomy, which allows markedly higher rates of recanalization and penumbral salvage than thrombolysis alone. However, <50% of...
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.
Elena Sanna, Margarida Rodrigues, Steven G Fagan, Timothy S Chisholm, Klara Kulenkampff, David Klenerman, Maria Grazia Spillantini, Franklin I Aigbirhio, Christopher A Hunter
May 21, 2021
Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.
Thomas Geeraerts, Jonathan P Coles, Franklin I Aigbirhio, John D Pickard, David K Menon, Tim D Fryer, Young T Hong
Jun 18, 2018
OBJECTIVE: [(11)C]Flumazenil ([(11)C]FMZ) positron emission tomography (PET) can be used as a measure of neuronal loss. The purpose of this study was to validate reference tissue kinetic modelling of [(11)C]FMZ PET within a...
Imaging Tau, Neuroinflammation, and Aβ in Dementia With Lewy Bodies
Elijah Mak, Ajenthan Surendranathan, Nicolas Nicastro, Franklin Aigbirhio, James Rowe, John O'Brien
Dec 20, 2018
Dementia with Lewy Bodies (DLB) is the second leading cause of degenerative dementia after Alzheimer's disease (AD).
Do Regions of Increased Inflammation Progress to New White Matter Hyperintensities?
Daniel J Tozer, Robin B Brown, Jessica Walsh, Young T Hong, Guy B Williams, John T O'Brien, Franklin I Aigbirhio, Tim D Fryer, Hugh S Markus
Feb 09, 2023
BACKGROUND: Recent studies have demonstrated increased microglial activation using 11C-PK11195 positron emission tomography imaging, indicating central nervous system inflammation, in cerebral small vessel disease. However...
CADASIL cerebral small vessel disease Magnetic Resonance Imaging positron emission tomography white matter Humans Diffusion tensor imaging CADASIL white matter Neuroinflammatory Diseases Magnetic Resonance Imaging Cerebral Infarction leukoencephalopathies Positron-Emission Tomography Inflammation Brain
Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.
Andrea M Santangelo, Steve J Sawiak, Tim Fryer, Young Hong, Yoshiro Shiba, Hannah F Clarke, Patrick J Riss, Valentina Ferrari, Roger Tait, John Suckling, Franklin I Aigbirhio, Angela C Roberts
Jun 20, 2019
Genetic variation in the serotonin transporter gene (SLC6A4) is associated with vulnerability to affective disorders and pharmacotherapy efficacy. We recently identified sequence polymorphisms in the common marmoset SLC6A4...
Anxiety insula cortex serotonin 2A receptor serotonin transporter polymorphism Animals Anxiety Behavior Animal Callithrix Cerebral Cortex Female Fluorobenzenes Genotype Humans Injections Intramuscular Male Models Animal Piperidines Polymorphism Genetic Promoter Regions Genetic RNA Receptor Serotonin 5-HT2A Serotonin 5-HT2 Receptor Antagonists Serotonin Plasma Membrane Transport Proteins Stress Psychological
A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein.
Yanyan Zhao, Ole Tietz, Wei-Li Kuan, Abdul K Haji-Dheere, Stephen Thompson, Benjamin Vallin, Elisabetta Ronchi, Gergely Tóth, David Klenerman, Franklin I Aigbirhio
Apr 22, 2020
Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain.
Joseph V Guadagno, P Simon Jones, Tim D Fryer, Olivier Barret, Franklin I Aigbirhio, T Adrian Carpenter, Christopher J Price, Jonathan H Gillard, Elizabeth A Warburton, Jean-Claude Baron
Apr 05, 2011
Aged 80 and over Body Water Brain Brain Ischemia Carotid Artery Internal Dissection Cerebrovascular Circulation Diffusion Diffusion Magnetic Resonance Imaging Energy Metabolism Female Humans Hypoxia Brain Intracranial Embolism Male Middle Aged Oxygen Consumption Positron-Emission Tomography Prospective Studies Time Factors Ultrasonography Doppler Transcranial
Assessing the Effects of Cytoprotectants on Selective Neuronal Loss, Sensorimotor Deficit and Microglial Activation after Temporary Middle Cerebral Occlusion.
Julius V Emmrich, Sohail Ejaz, David J Williamson, Young T Hong, Sergey Sitnikov, Tim D Fryer, Franklin I Aigbirhio, Heike Wulff, Jean-Claude Baron
Jan 09, 2020
Although early reperfusion after stroke salvages the still-viable ischemic tissue, peri-infarct selective neuronal loss (SNL) can cause sensorimotor deficits (SMD). We designed a longitudinal protocol to assess the effects of...
Synthesis, radiolabelling and in vitro imaging of multifunctional nanoceramics
Marina Lledos, Vincenzo Mirabello, Sophia Sarpaki, Haobo Ge, Hubert Jakub Smugowski, Laurence Carroll, Eric O. Aboagye, Franklin I. Aigbirhio, Stanley W Botchway, Jonathan R Dilworth, David Gonzalez Calatayud, Pawel Plucinski, Gareth Price, Sofia Pascu
Apr 01, 2018
Molecular imaging has become a powerful technique in preclinical and clinical research aiming towards the diagnosis of many diseases. In this work, we address the synthetic challenges in achieving lab-scale, batch-to-batch...
cellular bioimaging core-shell nanoparticles Hypoxia Radiochemistry Self-assembly /dk/atira/pure/subjectarea/asjc/2500/2502 name=Biomaterials /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson's disease.
MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.
Robin B Brown, Daniel J Tozer, Laurence Loubière, Young T Hong, Tim D Fryer, Guy B Williams, Martin J Graves, Franklin I Aigbirhio, John T O'Brien, Hugh S Markus
Sep 03, 2022
Background: Cerebral small vessel disease (SVD) is a common cause of stroke and cognitive impairment. Recent data has implicated neuroinflammation and increased blood-brain barrier (BBB) permeability in its pathogenesis, but...
18F-AV1451 PET imaging and multimodal MRI changes in progressive supranuclear palsy.
Nicolas Nicastro, Patricia Vazquez Rodriguez, Maura Malpetti, William Richard Bevan-Jones, P Simon Jones, Luca Passamonti, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Oct 04, 2019
Diffusion tensor imaging MRI PET progressive supranuclear palsy Tau Aged Aged 80 and over Carbolines Cross-Sectional Studies Diffusion tensor imaging Female Gray Matter Humans Magnetic Resonance Imaging Male Middle Aged Multimodal Imaging Positron-Emission Tomography Supranuclear Palsy Progressive white matter tau Proteins
Radiosynthesis of (R,S)-[18 F]GE387
Luxi Qiao, Emily Fisher, Lindsay McMurray, Selena Milicevic Sephton, Matthew Hird, Nisha Kuzhuppilly-Ramakrishnan, David J Williamson, Xiouyun Zhou, Eryn Werry, Michael Kassiou, Saijinder Luthra, William Trigg, Franklin I Aigbirhio
Apr 01, 2019
Preclinical evaluation of (S)-[18F]GE387, a novel 18-kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971.
Nisha K Ramakrishnan, Matthew Hird, Stephen Thompson, David J Williamson, Luxi Qiao, David R Owen, Allen F Brooks, Peter JH Scott, Sergio Bacallado, John T O'Brien, Franklin I Aigbirhio
Jan 07, 2022
In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.
W Richard Bevan-Jones, Thomas E Cope, P Simon Jones, Luca Passamonti, Young T Hong, Tim Fryer, Robert Arnold, Jonathan P Coles, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Jan 28, 2019
Neuroinflammation occurs in frontotemporal dementia, however its timing relative to protein aggregation and neuronal loss is unknown. Using positron emission tomography and magnetic resonance imaging to quantify these processes...
Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum.
Daniele Caprioli, Bianca Jupp, Young T Hong, Stephen J Sawiak, Valentina Ferrari, Laura Wharton, David J Williamson, Carolyn McNabb, David Berry, Franklin I Aigbirhio, Trevor W Robbins, Tim D Fryer, Jeffrey W Dalley
Mar 26, 2015
Addiction attention-deficit hyperactivity disorder Dopamine methylphenidate Nucleus Accumbens positron emission tomography Animals Central Nervous System Stimulants Corpus Striatum Dopamine Uptake Inhibitors Impulsive Behavior Male Methylphenidate Positron-Emission Tomography Rats Receptors Dopamine D2 Receptors Dopamine D3
11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies.
Nicolas Nicastro, Negin Holland, George Savulich, Stephen F Carter, Elijah Mak, Young T Hong, Selena Milicevic Sephton, Tim D Fryer, Franklin I Aigbirhio, James B Rowe, John T O'Brien
Nov 10, 2020
OBJECTIVE: Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer's disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in...
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