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Results: 37
Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse.
Tianye Jia, Chao Xie, Tobias Banaschewski, Gareth J Barker, Arun LW Bokde, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Trevor W Robbins, Jianfeng Feng, IMAGEN consortium
Mar 08, 2021
Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol...
Separate neural systems for behavioral change and for emotional responses to failure during behavioral inhibition.
Wanlu Deng, Edmund T Rolls, Xiaoxi Ji, Trevor W Robbins, Tobias Banaschewski, Arun LW Bokde, Uli Bromberg, Christian Buechel, Sylvane Desrivières, Patricia Conrod, Herta Flor, Vincent Frouin, Juergen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Herve Lemaitre, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jianfeng Feng
Apr 12, 2018
To analyze the involvement of different brain regions in behavioral inhibition and impulsiveness, differences in activation were investigated in fMRI data from a response inhibition task, the stop-signal task, in 1709...
Neural correlates of three types of negative life events during angry face processing in adolescents.
Fanny Gollier-Briant, Marie-Laure Paillère-Martinot, Hervé Lemaitre, Ruben Miranda, Hélène Vulser, Robert Goodman, Jani Penttilä, Maren Struve, Tahmine Fadai, Viola Kappel, Luise Poustka, Yvonne Grimmer, Uli Bromberg, Patricia Conrod, Tobias Banaschewski, Gareth J Barker, Arun LW Bokde, Christian Büchel, Herta Flor, Juergen Gallinat, Hugh Garavan, Andreas Heinz, Claire Lawrence, Karl Mann, Frauke Nees, Tomas Paus, Zdenka Pausova, Vincent Frouin, Marcella Rietschel, Trevor W Robbins, Michael N Smolka, Gunter Schumann, IMAGEN Consortium+, Jean-Luc Martinot, Eric Artiges
May 21, 2018
Negative life events (NLE) contribute to anxiety and depression disorders, but their relationship with brain functioning in adolescence has rarely been studied. We hypothesized that neural response to social threat would relate...
Trajectories of cortical structures associated with stress across adolescence
Tochukwu Nweze, Tobias Banaschewski, Cyracius Ajaelu, Chukwuemeka Okoye, Michael Ezenwa, Robert Whelan, Dimitri Papadopoulos Orfanos, Arun LW Bokde, Sylvane Desrivières, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Tomáš Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Gunter Schumann, Jamie L Hanson, IMAGEN consortium
Mar 29, 2023
Does domiciliary welfare rights advice improve health-related quality of life in independent-living, socio-economically disadvantaged people aged ≥60 years? Randomised controlled trial, economic and process evaluations in the North East of England.
Association between childhood trauma and risk for obesity
Qiang Luo, Lingli Zhang, Chu-Chung Huang, Yan Zheng, Jonathan W. Kanen, Qi Zhao, Ye Yao, Erin B. Quinlan, Tianye Jia, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Barbara J. Sahakian, Gunter Schumann, Fei Li, Jianfeng Feng, Sylvane Desrivières, Trevor W. Robbins
Oct 15, 2020
Association between childhood trauma and risk for obesity
Qiang Luo, Lingli Zhang, Chu-Chung Huang, Yan Zheng, Jonathan W. Kanen, Qi Zhao, Ye Yao, Erin B. Quinlan, Tianye Jia, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Barbara J. Sahakian, Gunter Schumann, Fei Li, Jianfeng Feng, Sylvane Desrivières, Trevor W. Robbins
Oct 18, 2021
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents.
Christian Büchel, Jan Peters, Tobias Banaschewski, Arun LW Bokde, Uli Bromberg, Patricia J Conrod, Herta Flor, Dimitri Papadopoulos, Hugh Garavan, Penny Gowland, Andreas Heinz, Henrik Walter, Bernd Ittermann, Karl Mann, Jean-Luc Martinot, Marie-Laure Paillère-Martinot, Frauke Nees, Tomas Paus, Zdenka Pausova, Luise Poustka, Marcella Rietschel, Trevor W Robbins, Michael N Smolka, Juergen Gallinat, Gunter Schumann, Brian Knutson, IMAGEN consortium
Mar 26, 2018
Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated...
Structural brain correlates of adolescent resilience.
Keith B Burt, Robert Whelan, Patricia J Conrod, Tobias Banaschewski, Gareth J Barker, Arun LW Bokde, Uli Bromberg, Christian Büchel, Mira Fauth-Bühler, Herta Flor, André Galinowski, Juergen Gallinat, Penny Gowland, Andreas Heinz, Bernd Ittermann, Karl Mann, Frauke Nees, Dimitri Papadopoulos-Orfanos, Tomas Paus, Zdenka Pausova, Luise Poustka, Marcella Rietschel, Trevor W Robbins, Michael N Smolka, Andreas Ströhle, Gunter Schumann, Hugh Garavan, IMAGEN consortium
Apr 11, 2018
BACKGROUND: Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim...
Differential predictors for alcohol use in adolescents as a function of familial risk.
Mira Tschorn, Robert C Lorenz, Paul F O'Reilly, Abraham Reichenberg, Tobias Banaschewski, Arun LW Bokde, Erin B Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Bernd Ittermann, Jean-Luc Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sabina Millenet, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Andreas Heinz, Michael A Rapp, IMAGEN consortium
Apr 19, 2021
Traditional models of future alcohol use in adolescents have used variable-centered approaches, predicting alcohol use from a set of variables across entire samples or populations. Following the proposition that predictive...
Association between childhood trauma and risk for obesity
Qiang Luo, Lingli Zhang, Chu-Chung Huang, Yan Zheng, Jonathan W Kanen, Qi Zhao, Ye Yao, Erin B Quinlan, Tianye Jia, Tobias Banaschewski, Arun LW Bokde, Uli Bromberg, Christian Büchel, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Barbara J Sahakian, Gunter Schumann, Fei Li, Jianfeng Feng, Sylvane Desrivières, Trevor W Robbins, IMAGEN consortium
Nov 09, 2020
BACKGROUND: Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined. METHODS: Participants from three population-based neuroimaging cohorts...
Plasticity of an ultrafast interaction between nucleoporins and nuclear transport receptors.
ROBO3s
Marcel Werner, Anna Dyas, Iwan Parfentev, Geske E Schmidt, Iga K Mieczkowska, Lukas C Müller-Kirschbaum, Claudia Müller, Stefan Kalkhof, Oliver Reinhardt, Henning Urlaub, Frauke Alves, Julia Gallwas, Evangelos Prokakis, Florian Wegwitz
Oct 04, 2022
Basal-like breast cancer (BLBC) is a highly aggressive breast cancer subtype frequently associated with poor prognosis. Due to the scarcity of targeted treatment options, conventional cytotoxic chemotherapies frequently remain...
A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease.
David González-Serna, Eguzkine Ochoa, Elena López-Isac, Antonio Julià, Frauke Degenhardt, Norberto Ortego-Centeno, Timothy RDJ Radstake, Andre Franke, Sara Marsal, Maureen D Mayes, Javier Martín, Ana Márquez, Scleroderma Genetic Consortium
Mar 09, 2020
Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn's disease (CD), some of which confer susceptibility to both diseases. In order to identify...
Identification of platelet function defects by multi-parameter assessment of thrombus formation.
Susanne M de Witt, Frauke Swieringa, Rachel Cavill, Moniek ME Lamers, Roger van Kruchten, Tom Mastenbroek, Constance Baaten, Susan Coort, Nicholas Pugh, Ansgar Schulz, Inge Scharrer, Kerstin Jurk, Barbara Zieger, Kenneth J Clemetson, Richard W Farndale, Johan WM Heemskerk, Judith MEM Cosemans
Jul 10, 2014
Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions.
ROBO3s
Marcel Werner, Anna Dyas, Iwan Parfentev, Geske E Schmidt, Iga K Mieczkowska, Lukas C Müller-Kirschbaum, Claudia Müller, Stefan Kalkhof, Oliver Reinhardt, Henning Urlaub, Frauke Alves, Julia Gallwas, Evangelos Prokakis, Florian Wegwitz
Sep 03, 2022
Basal-like breast cancer (BLBC) is a highly aggressive breast cancer subtype frequently associated with poor prognosis. Due to the scarcity of targeted treatment options, conventional cytotoxic chemotherapies frequently remain...
Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation.
Sanne LN Brouns, Johanna P van Geffen, Elena Campello, Frauke Swieringa, Luca Spiezia, René van Oerle, Isabella Provenzale, Remco Verdoold, Richard W Farndale, Kenneth J Clemetson, Henri MH Spronk, Paola EJ van der Meijden, Rachel Cavill, Marijke JE Kuijpers, Elisabetta Castoldi, Paolo Simioni, Johan WM Heemskerk
Sep 09, 2020
In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion, platelet...
Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome.
Johanna P van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian ME Tullemans, Fiorella A Solari, Bing Peng, Kenneth J Clemetson, Richard W Farndale, Ludwig J Dubois, Albert Sickmann, René P Zahedi, Robert Ahrends, Erik AL Biessen, Judith C Sluimer, Johan WM Heemskerk, Marijke JE Kuijpers
Feb 12, 2021
Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Millions of people worldwide display mildly elevated levels of plasma lipids and cholesterol linked to diet and life-style. While the prothrombotic...
High-throughput elucidation of thrombus formation reveals sources of platelet function variability.
Johanna P van Geffen, Sanne LN Brouns, Joana Batista, Harriet McKinney, Carly Kempster, Magdolna Nagy, Suthesh Sivapalaratnam, Constance CFMJ Baaten, Nikki Bourry, Mattia Frontini, Kerstin Jurk, Manuela Krause, Daniele Pillitteri, Frauke Swieringa, Remco Verdoold, Rachel Cavill, Marijke JE Kuijpers, Willem H Ouwehand, Kate Downes, Johan WM Heemskerk
Oct 31, 2019
In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation. Based on assessment of the inter- and intra-subject variability in...
Behavioural intervention for weight loss maintenance versus standard weight advice in adults with obesity
Falko F Sniehotta, Elizabeth H Evans, Kirby Sainsbury, Ashley Adamson, Alan Batterham, Frauke Becker, Heather Brown, Stephan U Dombrowski, Dan Jackson, Denise Howell, Karim Ladha, Elaine McColl, Patrick Olivier, Alexander J Rothman, Alison Steel, Luke Vale, Rute Vieira, Martin White, Peter Wright, Vera Araújo-Soares
May 15, 2019
BACKGROUND: Scalable weight loss maintenance (WLM) interventions for adults with obesity are lacking but vital for the health and economic benefits of weight loss to be fully realised. We examined the effectiveness and...
Adult Behavior Therapy Body Mass Index Cost-Benefit Analysis Diet Healthy Exercise Feeding Behavior Female Health Care Costs Health Knowledge Attitudes practice Healthy lifestyle Humans Male Middle Aged obesity Patient Education as Topic Risk Reduction Behavior Time Factors Treatment Outcome United Kingdom Weight Gain Weight Loss
Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome
Johanna P. van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian M. E. Tullemans, Fiorella A. Solari, Bing Peng, Kenneth J. Clemetson, Richard W. Farndale, Ludwig J. Dubois, Albert Sickmann, René P. Zahedi, Robert Ahrends, Erik A. L. Biessen, Judith C. Sluimer, Johan W. M. Heemskerk, Marijke J. E. Kuijpers
Dec 08, 2020
Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation
Sanne L. N. Brouns, Johanna P. van Geffen, Elena Campello, Frauke Swieringa, Luca Spiezia, René van Oerle, Isabella Provenzale, Remco Verdoold, Richard W. Farndale, Kenneth J. Clemetson, Henri M. H. Spronk, Paola E. J. van der Meijden, Rachel Cavill, Marijke J. E. Kuijpers, Elisabetta Castoldi, Paolo Simioni, Johan W. M. Heemskerk
Jul 28, 2021
Abstract: In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion...
Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation
Sanne L. N. Brouns, Johanna P. van Geffen, Elena Campello, Frauke Swieringa, Luca Spiezia, René van Oerle, Isabella Provenzale, Remco Verdoold, Richard W. Farndale, Kenneth J. Clemetson, Henri M. H. Spronk, Paola E. J. van der Meijden, Rachel Cavill, Marijke J. E. Kuijpers, Elisabetta Castoldi, Paolo Simioni, Johan W. M. Heemskerk
Jul 17, 2020
Abstract: In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion...
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