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Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens.
MARKUS LIBRARY
The Rockefeller University
Jan 01, 0001
The Rita and Frits Markus Library is open in the newly renovated Welch Hall
Published by: The Rockefeller University
Similarities and differences in the determinants of trips outdoors performed by UK urban-and rural-living older adults
The frequency of trips outdoors is a strong indicator of older adults’ physical activity levels. This qualitative study compared and contrasted determinants of trips outdoors between rural- (n = 13) and urban-living (n = 15)...
Similarities and differences in the determinants of trips outdoors performed by UK urban-and rural-living older adults
The frequency of trips outdoors is a strong indicator of older adults’ physical activity levels. This qualitative study compared and contrasted determinants of trips outdoors between rural- (n = 13) and urban-living (n = 15)...
Predictors of loneliness and different types of social isolation of rural-living older adults in the UK
Loneliness and social isolation are recognised, conceptually distinct threats to health and wellbeing in older age but limited evidence is available on their predictors in rural populations. This study performed logistical...
Participant and public involvement in refining a peer-volunteering active aging intervention
Janet Withall, Janice L Thompson, Kenneth R Fox, Mark Davis, Selena Gray, Jolanthe De Koning, Liz Lloyd, Graham Parkhurst, Afroditi Stathi
Dec 06, 2016
Background: Evidence for the health benefits of a physically active lifestyle among older adults is strong, yet only a small proportion of older people meet physical activity recommendations. A synthesis of evidence identified...
Predictors of loneliness and different types of social isolation of rural-living older adults in the UK
Loneliness and social isolation are recognised, conceptually distinct threats to health and wellbeing in older age but limited evidence is available on their predictors in rural populations. This study performed logistical...
Objectively Measured Physical Activity and Body Fatness
Esther Winters-VAN Eekelen, Jeroen HPM VAN DER Velde, Sebastiaan C Boone, Kate Westgate, Søren Brage, Hildo J Lamb, Frits R Rosendaal, Renée de Mutsert
Jun 07, 2021
PURPOSE: It remains unclear to what extent habitual physical activity and sedentary time (ST) are associated with visceral fat and liver fat. We studied the substitution of ST with time spent physically active and total body fat...
Participant and public involvement in refining a peer-volunteering active aging intervention
Janet Withall, Janice L Thompson, Kenneth R Fox, Mark Davis, Selena Gray, Jolanthe De Koning, Liz Lloyd, Graham Parkhurst, Afroditi Stathi
Dec 06, 2016
Background: Evidence for the health benefits of a physically active lifestyle among older adults is strong, yet only a small proportion of older people meet physical activity recommendations. A synthesis of evidence identified...
Personalizing Breast Cancer Screening Based on Polygenic Risk and Family History.
Jeroen J van den Broek, Clyde B Schechter, Nicolien T van Ravesteyn, A Cecile JW Janssens, Michael C Wolfson, Amy Trentham-Dietz, Jacques Simard, Douglas F Easton, Jeanne S Mandelblatt, Peter Kraft, Harry J de Koning
Sep 23, 2020
BACKGROUND: We assessed the clinical utility of a first-degree breast cancer family history and polygenic risk score (PRS) to inform screening decisions among women aged 30-50 years. METHODS: Two established breast cancer models...
Whole tissue cervical mapping of HPV infection
Anne Hammer, Maurits Nc de Koning, Jan Blaakaer, Torben Steiniche, John Doorbar, Heather Griffin, Else Mejlgaard, Hans Svanholm, Wim Gv Quint, Patti E Gravitt
May 09, 2019
In this study, we aimed to provide molecular evidence of HPV latency in humans and discuss potential challenges of conducting studies on latency. We analyzed the entire cervix of two women who underwent hysterectomy unrelated to...
L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling.
Mari Lilith Lund, Giovanni Sorrentino, Kristoffer Lihme Egerod, Chantal Kroone, Brynjulf Mortensen, Filip Krag Knop, Frank Reimann, Fiona M Gribble, Daniel J Drucker, Eelco JP de Koning, Kristina Schoonjans, Fredrik Bäckhed, Thue W Schwartz, Natalia Petersen
Jan 29, 2020
ERS International Congress 2021
Thomas Gille, Pradeesh Sivapalan, Georgios Kaltsakas, Shailesh B Kolekar, Matthew Armstrong, Rachel Tuffnell, Rachael A Evans, Guido Vagheggini, Luiza Helena Degani-Costa, Cláudia Vicente, Nilakash Das, Vitalii Poberezhets, Camille Rolland-Debord, Sam Bayat, Ioannis Vogiatzis, Frits ME Franssen, Hilary Pinnock, Lowie EGW Vanfleteren
Jun 29, 2022
It is a challenge to keep abreast of all the clinical and scientific advances in the field of respiratory medicine. This article contains an overview of laboratory-based science, randomised controlled trials and qualitative...
Performance of HPV E4 and p16INK4a biomarkers in predicting regression of cervical intraepithelial neoplasia grade 2 (CIN2)
Rikke Kamp Damgaard, David Jenkins, Maurits Nc de Koning, Wim Gv Quint, Mark H Stoler, John Doorbar, Johnny Kahlert, Patti E Gravitt, Torben Steiniche, Lone Kjeld Petersen, Anne Hammer
Aug 06, 2022
Performance of HPV E4 and p16INK4a biomarkers in predicting regression of cervical intraepithelial neoplasia grade 2 (CIN2)
Rikke Kamp Damgaard, David Jenkins, Maurits Nc de Koning, Wim Gv Quint, Mark H Stoler, John Doorbar, Johnny Kahlert, Patti E Gravitt, Torben Steiniche, Lone Kjeld Petersen, Anne Hammer
Jul 08, 2022
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids.
Ary Marsee, Floris JM Roos, Monique MA Verstegen, HPB Organoid Consortium, Helmuth Gehart, Eelco de Koning, Frédéric Lemaigre, Stuart J Forbes, Weng Chuan Peng, Meritxell Huch, Takanori Takebe, Ludovic Vallier, Hans Clevers, Luc JW van der Laan, Bart Spee
May 26, 2021
Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also...
The tribulations of trials
J Withall, Colin J. Greaves, Janice L Thompson, Jolanthe De Koning, Jessica C. bollen, Sarah Moorlock, Ken R. Fox, Max Western, Tristan Snowsill, Antonieta Medina-Lara, Rosina Cross, Peter Ladlow, Gordon Taylor, Vasiliki Zisi, James Clynes, Selena Gray, Sandra Agyapong-Badu, Jack Guralnik, Jack Rejeski, Afroditi Stathi
Mar 09, 2020
Background: Challenges of recruitment to randomised controlled trials (RCTs) and successful strategies to overcome them should be clearly reported to improve recruitment into future trials. REtirement in ACTion (REACT) is a...
The tribulations of trials
J Withall, Colin J. Greaves, Janice L Thompson, Jolanthe De Koning, Jessica C. bollen, Sarah Moorlock, Ken R. Fox, Max Western, Tristan Snowsill, Antonieta Medina-Lara, Rosina Cross, Peter Ladlow, Gordon Taylor, Vasiliki Zisi, James Clynes, Selena Gray, Sandra Agyapong-Badu, Jack Guralnik, Jack Rejeski, Afroditi Stathi
Mar 09, 2020
Background: Challenges of recruitment to randomised controlled trials (RCTs) and successful strategies to overcome them should be clearly reported to improve recruitment into future trials. REtirement in ACTion (REACT) is a...
Hosting an Educational Careers Day Within the Virtual Paradigm
George E Richardson, Conor S Gillespie, Soham Bandyopadhyay, Emma J Norton, Jigi M Joshi, Orla Mantle, Catinca Ciuculete, Armin Nazari, John Ong, Ajitesh Anand, Jay Park, Rosaline De Koning, Setthasorn Zhi Yang Ooi, Joshua Erhabor, Harmani K Daler, Bailint Borbas, Zeluleko Sibanda, Illectra Lerou, Alvaro Y Touzet, Phil Mcelnay, Suzanne Murray, Peter J Hutchinson, Alistair Jenkins
Mar 18, 2022
INTRODUCTION: To explore our experience of hosting the 10th Annual Neurology and Neurosurgery Interest Group-Society of British Neurological Surgeons (NANSIG-SBNS) Neurosurgery Careers Day, held virtually for the first time....
Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.
Cindy JM Loomans, Nerys Williams Giuliani, Jeetindra Balak, Femke Ringnalda, Léon van Gurp, Meritxell Huch, Sylvia F Boj, Toshiro Sato, Lennart Kester, Susana M Chuva de Sousa Lopes, Matthias S Roost, Susan Bonner-Weir, Marten A Engelse, Ton J Rabelink, Harry Heimberg, Robert GJ Vries, Alexander van Oudenaarden, Françoise Carlotti, Hans Clevers, Eelco JP de Koning
Oct 03, 2018
Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. Here, we describe a 3D culture system that supports the expansion of adult human pancreatic...
Personalized early detection and prevention of breast cancer
Nora Pashayan, Antonis C. Antoniou, Urska Ivanus, Laura J. Esserman, Douglas F. Easton, David French, Gaby Sroczynski, Per Hall, Jack Cuzick, D. Gareth Evans, Jacques Simard, Montserrat Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Giorgi Rossi, Jelle Wesseling, David Ritchie, Marc Tischkowitz, Mireille Broeders, Dan Reisel, Andres Metspalu, Thomas Callender, Harry de Koning, Peter Devilee, Suzette Delaloge, Marjanka K. Schmidt, Martin Widschwendter
Jun 18, 2021
Abstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early...
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei.
Ali H Alghamdi, Jane C Munday, Gustavo Daniel Campagnaro, Dominik Gurvic, Fredrik Svensson, Chinyere E Okpara, Arvind Kumar, Juan Quintana, Maria Esther Martin Abril, Patrik Milić, Laura Watson, Daniel Paape, Luca Settimo, Anna Dimitriou, Joanna Wielinska, Graeme Smart, Laura F Anderson, Christopher M Woodley, Siu Pui Ying Kelly, Hasan MS Ibrahim, Fabian Hulpia, Mohammed I Al-Salabi, Anthonius A Eze, Teresa Sprenger, Ibrahim A Teka, Simon Gudin, Simone Weyand, Mark Field, Christophe Dardonville, Richard R Tidwell, Mark Carrington, Paul O'Neill, David W Boykin, Ulrich Zachariae, Harry P De Koning
Nov 02, 2020
Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor...
Personalized early detection and prevention of breast cancer
Nora Pashayan, Antonis C. Antoniou, Urska Ivanus, Laura J. Esserman, Douglas F. Easton, David French, Gaby Sroczynski, Per Hall, Jack Cuzick, D. Gareth Evans, Jacques Simard, Montserrat Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Giorgi Rossi, Jelle Wesseling, David Ritchie, Marc Tischkowitz, Mireille Broeders, Dan Reisel, Andres Metspalu, Thomas Callender, Harry de Koning, Peter Devilee, Suzette Delaloge, Marjanka K. Schmidt, Martin Widschwendter
Oct 17, 2020
Abstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early...
Personalized early detection and prevention of breast cancer
Nora Pashayan, Antonis C. Antoniou, Urska Ivanus, Laura J. Esserman, Douglas F. Easton, David French, Gaby Sroczynski, Per Hall, Jack Cuzick, D. Gareth Evans, Jacques Simard, Montserrat Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Giorgi Rossi, Jelle Wesseling, David Ritchie, Marc Tischkowitz, Mireille Broeders, Dan Reisel, Andres Metspalu, Thomas Callender, Harry de Koning, Peter Devilee, Suzette Delaloge, Marjanka K. Schmidt, Martin Widschwendter
Feb 16, 2021
Abstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early...
Global population structure and evolution of Bordetella pertussis and their relationship with vaccination.
Marieke J Bart, Simon R Harris, Abdolreza Advani, Yoshichika Arakawa, Daniela Bottero, Valérie Bouchez, Pamela K Cassiday, Chuen-Sheue Chiang, Tine Dalby, Norman K Fry, María Emilia Gaillard, Marjolein van Gent, Nicole Guiso, Hans O Hallander, Eric T Harvill, Qiushui He, Han GJ van der Heide, Kees Heuvelman, Daniela F Hozbor, Kazunari Kamachi, Gennady I Karataev, Ruiting Lan, Anna Lutyńska, Ram P Maharjan, Jussi Mertsola, Tatsuo Miyamura, Sophie Octavia, Andrew Preston, Michael A Quail, Vitali Sintchenko, Paola Stefanelli, M Lucia Tondella, Raymond SW Tsang, Yinghua Xu, Shu-Man Yao, Shumin Zhang, Julian Parkhill, Frits R Mooi
Jun 25, 2019
Bordetella pertussis causes pertussis, a respiratory disease that is most severe for infants. Vaccination was introduced in the 1950s, and in recent years, a resurgence of disease was observed worldwide, with significant...
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