Search
Results: 32
DeepSynergy
Kristina Preuer, Richard PI Lewis, Sepp Hochreiter, Andreas Bender, Krishna C Bulusu, Günter Klambauer
Nov 05, 2018
MOTIVATION: While drug combination therapies are a well-established concept in cancer treatment, identifying novel synergistic combinations is challenging due to the size of combinatorial space. However, computational approaches...
Günter Blobel, 1981
The Rockefeller University
Jan 01, 0001
Günter Blobel. Regulation of intracellular protein traffic
Lecture delivered March 19, 1981
Posted with permission
Published by: Academic Press
Structural insights into the role of domain flexibility in human DNA ligase IV.
Takashi Ochi, Qian Wu, Dimitri Y Chirgadze, J Günter Grossmann, Victor M Bolanos-Garcia, Tom L Blundell
Mar 12, 2021
Knowledge of the architecture of DNA ligase IV (LigIV) and interactions with XRCC4 and XLF-Cernunnos is necessary for understanding its role in the ligation of double-strand breaks during nonhomologous end joining. Here we...
Catalytic Domain Chromatography Gel DNA DNA Breaks Double-Stranded DNA Ligase ATP DNA Ligases DNA Nucleotidyltransferases DNA Repair DNA Repair Enzymes DNA-Binding Proteins Escherichia coli Humans Models Molecular Protein Binding Protein Structure Secondary Protein Structure Tertiary Recombinant Proteins SCATTERING Small Angle X-Ray Diffraction
Quantitative atomic order characterization of a Mn2FeAl Heusler epitaxial thin film
Abstract
In this work, we investigate the effect of anti-site disorder on the half-metallic properties of a Mn2 FeAl Heusler alloy thin film. The film was grown...
Samer Kurdi, Yuya Sakuraba, Keisuke Masuda, Hiroo Tajiri, Bhaskaran Nair, Guillaume F Nataf, Mary E Vickers, Günter Reiss, Markus Meinert, Sarnjeet S Dhesi, Massimo Ghidini, Zoe Barber
Feb 10, 2022
“Ist die Schwarze Köchin da? Jajaja. . .”
RM Craig
Nov 30, 2016
Die Blechtrommel (1959) has inspired widely divergent readings, not least in respect of the aesthetic grounds that the novel offered for the social hope in the wake of Auschwitz. This article re-visits it against the backdrop of...
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.
Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Zukowska, Sebastian Lange, Thorsten Kaltenbacher, Björn Konukiewitz, Rupert Öllinger, Maximilian Zwiebel, Alex Strong, Hsi-Yu Yen, Ruby Banerjee, Sandra Louzada, Beiyuan Fu, Barbara Seidler, Juliana Götzfried, Kathleen Schuck, Zonera Hassan, Andreas Arbeiter, Nina Schönhuber, Sabine Klein, Christian Veltkamp, Mathias Friedrich, Lena Rad, Maxim Barenboim, Christoph Ziegenhain, Julia Hess, Oliver M Dovey, Stefan Eser, Swati Parekh, Fernando Constantino-Casas, Jorge de la Rosa, Marta I Sierra, Mario Fraga, Julia Mayerle, Günter Klöppel, Juan Cadiñanos, Pentao Liu, George Vassiliou, Wilko Weichert, Katja Steiger, Wolfgang Enard, Roland M Schmid, Fengtang Yang, Kristian Unger, Günter Schneider, Ignacio Varela, Allan Bradley, Dieter Saur, Roland Rad
Jun 25, 2018
Adaptor Proteins Signal Transducing Alleles Animals Carcinogenesis Carcinoma Pancreatic Ductal Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor p16 Disease Progression evolution Molecular Female Gene Dosage Genes myc Genes p53 Humans Male Mice Mutation NF-kappa B p52 Subunit Neoplasm Metastasis Nuclear Proteins Pancreatic Neoplasms Phenotype Phosphoproteins Proto-Oncogene Proteins p21(ras) Transcription Factors Transcriptome Transforming Growth Factor beta1 YAP-Signaling Proteins
Gain-of-function screen for genes that affect Drosophila muscle pattern formation.
Nicole Staudt, Andreas Molitor, Kalman Somogyi, Juan Mata, Silvia Curado, Karsten Eulenberg, Martin Meise, Thomas Siegmund, Thomas Häder, Andres Hilfiker, Günter Brönner, Anne Ephrussi, Pernille Rørth, Stephen M Cohen, Sonja Fellert, Ho-Ryun Chung, Olaf Piepenburg, Ulrich Schäfer, Herbert Jäckle, Gerd Vorbrüggen
Aug 08, 2017
This article reports the production of an EP-element insertion library with more than 3,700 unique target sites within the Drosophila melanogaster genome and its use to systematically identify genes that affect embryonic muscle...
Lipocalin 2 Protects from Inflammation and Tumorigenesis Associated with Gut Microbiota Alterations.
Validation of the movement disorder society criteria for the diagnosis of 4-repeat tauopathies.
Gesine Respondek, Max-Joseph Grimm, Ines Piot, Thomas Arzberger, Yaroslau Compta, Elisabet Englund, Leslie W Ferguson, Ellen Gelpi, Sigrun Roeber, Armin Giese, Murray Grossman, David J Irwin, Wassilios G Meissner, Christer Nilsson, Alexander Pantelyat, Alex Rajput, John C van Swieten, Claire Troakes, Günter U Höglinger, Movement Disorder Society-Endorsed Progressive Supranuclear Palsy Study Group
Oct 31, 2019
BACKGROUND: The Movement Disorder Society criteria for progressive supranuclear palsy introduced the category "probable 4-repeat (4R)-tauopathy" for joint clinical diagnosis of progressive supranuclear palsy and corticobasal...
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.
Roland Rad, Juan Cadiñanos, Lena Rad, Ignacio Varela, Alexander Strong, Lydia Kriegl, Fernando Constantino-Casas, Stefan Eser, Maren Hieber, Barbara Seidler, Stacey Price, Mario F Fraga, Vincenzo Calvanese, Gary Hoffman, Hannes Ponstingl, Günter Schneider, Kosuke Yusa, Carolyn Grove, Roland M Schmid, Wei Wang, George Vassiliou, Thomas Kirchner, Ultan McDermott, Pentao Liu, Dieter Saur, Allan Bradley
Oct 14, 2020
We show that BRAF(V600E) initiates an alternative pathway to colorectal cancer (CRC), which progresses through a hyperplasia/adenoma/carcinoma sequence. This pathway underlies significant subsets of CRCs with distinctive...
Animals Cell Transformation Neoplastic Colorectal Neoplasms Cyclin-Dependent Kinase Inhibitor p16 Drug Screening Assays Antitumor MAP Kinase Signaling System Mice Microsatellite Instability Mutation Neoplasm Invasiveness Neoplasm Proteins Phosphoinositide-3 Kinase Inhibitors Proto-Oncogene Proteins B-raf Tumor Suppressor Protein p53 Wnt Signaling Pathway
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
Lisa Mayr, Felix Grabherr, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai T. R. Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R. Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A. Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R. Moschen, Günter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E. Adolph
Apr 14, 2021
Abstract: The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by...
Clinical Conditions "Suggestive of Progressive Supranuclear Palsy"-Diagnostic Performance.
Max-Joseph Grimm, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Leslie Ferguson, Ellen Gelpi, Armin Giese, Murray Grossman, David J Irwin, Alexander Pantelyat, Alex Rajput, Sigrun Roeber, John C van Swieten, Claire Troakes, Wassilios G Meissner, Christer Nilsson, Ines Piot, Yaroslau Compta, James B Rowe, Günter U Höglinger, Movement Disorder Society-endorsed PSP Study Group
Sep 10, 2020
BACKGROUND: The Movement Disorder Society diagnostic criteria for progressive supranuclear palsy introduced the diagnostic certainty level "suggestive of progressive supranuclear palsy" for clinical conditions with subtle signs...
Radiological biomarkers for diagnosis in PSP
Jennifer L Whitwell, Günter U Höglinger, Angelo Antonini, Yvette Bordelon, Adam L Boxer, Carlo Colosimo, Thilo van Eimeren, Lawrence I Golbe, Jan Kassubek, Carolin Kurz, Irene Litvan, Alexander Pantelyat, Gil Rabinovici, Gesine Respondek, Axel Rominger, James B Rowe, Maria Stamelou, Keith A Josephs, Movement Disorder Society-endorsed PSP Study Group
Nov 23, 2017
PSP is a pathologically defined neurodegenerative tauopathy with a variety of clinical presentations including typical Richardson's syndrome and other variant PSP syndromes. A large body of neuroimaging research has been...
Genetic determinants of survival in progressive supranuclear palsy
Edwin Jabbari, Shunsuke Koga, Rebecca R Valentino, Regina H Reynolds, Raffaele Ferrari, Manuela MX Tan, James B Rowe, Clifton L Dalgard, Sonja W Scholz, Dennis W Dickson, Thomas T Warner, Tamas Revesz, Günter U Höglinger, Owen A Ross, Mina Ryten, John Hardy, Maryam Shoai, Huw R Morris, PSP Genetics Group
Jan 21, 2021
BACKGROUND: The genetic basis of variation in the progression of primary tauopathies has not been determined. We aimed to identify genetic determinants of survival in progressive supranuclear palsy (PSP). METHODS: In stage one...
Adult Age of Onset Aged Chromosomes Human Pair 12 Databases Genetic Female Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Humans Kaplan-Meier Estimate Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Linkage Disequilibrium Male Middle Aged Polymorphism Single Nucleotide RNA Long Noncoding Supranuclear Palsy Progressive Survival Analysis White People
Potential of Non-Coding RNA as Biomarkers for Progressive Supranuclear Palsy.
Fabio A Simoes, Greig Joilin, Oliver Peters, Luisa-Sophie Schneider, Josef Priller, Eike Jakob Spruth, Ina Vogt, Okka Kimmich, Annika Spottke, Daniel C Hoffmann, Björn Falkenburger, Moritz Brandt, Johannes Prudlo, Kathrin Brockmann, Franca Laura Fries, James B Rowe, Alistair Church, Gesine Respondek, Sarah F Newbury, P Nigel Leigh, Huw R Morris, Günter U Höglinger, Majid Hafezparast
Jan 10, 2023
Objective markers for the neurodegenerative disorder progressive supranuclear palsy (PSP) are needed to provide a timely diagnosis with greater certainty. Non-coding RNA (ncRNA), including microRNA, piwi-interacting RNA, and...
Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders
Thilo van Eimeren, Angelo Antonini, Daniela Berg, Nico Bohnen, Roberto Ceravolo, Alexander Drzezga, Günter U Höglinger, Makoto Higuchi, Stephane Lehericy, Simon Lewis, Oury Monchi, Peter Nestor, Matej Ondrus, Nicola Pavese, María Cecilia Peralta, Paola Piccini, José Ángel Pineda-Pardo, Irena Rektorová, María Rodríguez-Oroz, Axel Rominger, Klaus Seppi, A Jon Stoessl, Alessandro Tessitore, Stephane Thobois, Valtteri Kaasinen, Gregor Wenning, Hartwig R Siebner, Antonio P Strafella, James B Rowe
May 30, 2019
INTRODUCTION: Therapeutic strategies targeting protein aggregations are ready for clinical trials in atypical parkinsonian disorders. Therefore, there is an urgent need for neuroimaging biomarkers to help with the early...
In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution.
Anja Fischer, Robert Lersch, Niklas de Andrade Krätzig, Alexander Strong, Mathias J Friedrich, Julia Weber, Thomas Engleitner, Rupert Öllinger, Hsi-Yu Yen, Ursula Kohlhofer, Irene Gonzalez-Menendez, David Sailer, Liz Kogan, Mari Lahnalampi, Saara Laukkanen, Thorsten Kaltenbacher, Christine Klement, Majdaddin Rezaei, Tim Ammon, Juan J Montero, Günter Schneider, Julia Mayerle, Mathias Heikenwälder, Marc Schmidt-Supprian, Leticia Quintanilla-Martinez, Katja Steiger, Pentao Liu, Juan Cadiñanos, George S Vassiliou, Dieter Saur, Olli Lohi, Merja Heinäniemi, Nathalie Conte, Allan Bradley, Lena Rad, Roland Rad
Apr 17, 2023
In contrast to mono- or biallelic loss of tumor-suppressor function, effects of discrete gene dysregulations, as caused by non-coding (epi)genome alterations, are poorly understood. Here, by perturbing the regulatory genome in...
Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.
Roman Maresch, Sebastian Mueller, Christian Veltkamp, Rupert Öllinger, Mathias Friedrich, Irina Heid, Katja Steiger, Julia Weber, Thomas Engleitner, Maxim Barenboim, Sabine Klein, Sandra Louzada, Ruby Banerjee, Alexander Strong, Teresa Stauber, Nina Gross, Ulf Geumann, Sebastian Lange, Marc Ringelhan, Ignacio Varela, Kristian Unger, Fengtang Yang, Roland M Schmid, George S Vassiliou, Rickmer Braren, Günter Schneider, Mathias Heikenwalder, Allan Bradley, Dieter Saur, Roland Rad
Oct 14, 2020
Mouse transgenesis has provided fundamental insights into pancreatic cancer, but is limited by the long duration of allele/model generation. Here we show transfection-based multiplexed delivery of CRISPR/Cas9 to the pancreas of...
Animals BRCA2 Protein CRISPR-Cas Systems Carcinogenesis Chromosome Deletion Electroporation Genetic Engineering Genome High-Throughput Nucleotide Sequencing Immunohistochemistry Magnetic Resonance Imaging Mice Mutation Neoplasms Experimental Pancreas Pancreatic Neoplasms Phylogeny Polymerase Chain Reaction Proto-Oncogene Proteins p21(ras) Sequence Analysis DNA Transfection Translocation Genetic
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Lisa Mayr, Felix Grabherr, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai T R Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R Moschen, Günter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E Adolph
May 16, 2020
The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by enrichment with...
Published by: Nature Communications
Potential of Non-Coding RNA as Biomarkers for Progressive Supranuclear Palsy.
Fabio A Simoes, Greig Joilin, Oliver Peters, Luisa-Sophie Schneider, Josef Priller, Eike Jakob Spruth, Ina Vogt, Okka Kimmich, Annika Spottke, Daniel C Hoffmann, Björn Falkenburger, Moritz Brandt, Johannes Prudlo, Kathrin Brockmann, Franca Laura Fries, James B Rowe, Alistair Church, Gesine Respondek, Sarah F Newbury, P Nigel Leigh, Huw R Morris, Günter U Höglinger, Majid Hafezparast
Dec 08, 2022
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Lisa Mayr, Felix Grabherr, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai TR Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R Moschen, Günter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E Adolph
Apr 08, 2020
The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by enrichment with...
Immune-related genetic enrichment in frontotemporal dementia
Iris Broce, Celeste M Karch, Natalie Wen, Chun C Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A Ross, Günter U Höglinger, Ulrich Muller, John Hardy, International FTD-Genomics Consortium, Parastoo Momeni, Christopher P Hess, William P Dillon, Zachary A Miller, Luke W Bonham, Gil D Rabinovici, Howard J Rosen, Gerard D Schellenberg, Andre Franke, Tom H Karlsen, Jan H Veldink, Raffaele Ferrari, Jennifer S Yokoyama, Bruce L Miller, Ole A Andreassen, Anders M Dale, Rahul S Desikan, Leo P Sugrue
Mar 16, 2018
BACKGROUND: Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are...
PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice.
Julia Weber, Jorge de la Rosa, Carolyn S Grove, Markus Schick, Lena Rad, Olga Baranov, Alexander Strong, Anja Pfaus, Mathias J Friedrich, Thomas Engleitner, Robert Lersch, Rupert Öllinger, Michael Grau, Irene Gonzalez Menendez, Manuela Martella, Ursula Kohlhofer, Ruby Banerjee, Maria A Turchaninova, Anna Scherger, Gary J Hoffman, Julia Hess, Laura B Kuhn, Tim Ammon, Johnny Kim, Günter Schneider, Kristian Unger, Ursula Zimber-Strobl, Mathias Heikenwälder, Marc Schmidt-Supprian, Fengtang Yang, Dieter Saur, Pentao Liu, Katja Steiger, Dmitriy M Chudakov, Georg Lenz, Leticia Quintanilla-Martinez, Ulrich Keller, George S Vassiliou, Juan Cadiñanos, Allan Bradley, Roland Rad
May 07, 2019
B-cell lymphoma (BCL) is the most common hematologic malignancy. While sequencing studies gave insights into BCL genetics, identification of non-mutated cancer genes remains challenging. Here, we describe PiggyBac transposon...
Animals CRISPR-Cas Systems Clone Cells DNA Transposable Elements Gene Dosage Gene Expression Regulation Neoplastic Genes Neoplasm Genes Tumor Suppressor Genetic Association Studies Genetic Testing Humans Loss of Heterozygosity Lymphoma B-Cell Mice Inbred C57BL Mice Transgenic Receptors Antigen B-Cell Reproducibility of Results
Clinical diagnosis of progressive supranuclear palsy
Günter U Höglinger, Gesine Respondek, Maria Stamelou, Carolin Kurz, Keith A Josephs, Anthony E Lang, Brit Mollenhauer, Ulrich Müller, Christer Nilsson, Jennifer L Whitwell, Thomas Arzberger, Elisabet Englund, Ellen Gelpi, Armin Giese, David J Irwin, Wassilios G Meissner, Alexander Pantelyat, Alex Rajput, John C van Swieten, Claire Troakes, Angelo Antonini, Kailash P Bhatia, Yvette Bordelon, Yaroslau Compta, Jean-Christophe Corvol, Carlo Colosimo, Dennis W Dickson, Richard Dodel, Leslie Ferguson, Murray Grossman, Jan Kassubek, Florian Krismer, Johannes Levin, Stefan Lorenzl, Huw R Morris, Peter Nestor, Wolfgang H Oertel, Werner Poewe, Gil Rabinovici, James B Rowe, Gerard D Schellenberg, Klaus Seppi, Thilo van Eimeren, Gregor K Wenning, Adam L Boxer, Lawrence I Golbe, Irene Litvan, Movement Disorder Society-endorsed PSP Study Group
Jun 05, 2017
A Modified Progressive Supranuclear Palsy Rating Scale.
Marie-Therese Grötsch, Gesine Respondek, Carlo Colosimo, Yaroslau Compta, Jean Christophe Corvol, Joaquim Ferreira, Meret Koroni Huber, Martin Klietz, Lea FM Krey, Johannes Levin, Milica Jecmenica-Lukic, Daniel Macías-García, Wassilios G Meissner, Pablo Mir, Huw Morris, Christer Nilsson, James B Rowe, Klaus Seppi, Maria Stamelou, John C van Swieten, Gregor Wenning, Teodoro del Ser, Lawrence I Golbe, Günter U Höglinger, the ProPSP Study Group, and the Movement Disorder Society-Endorsed PSP Study Group Describe PSP Study Group
Jan 26, 2021
BACKGROUND: The Progressive Supranuclear Palsy Rating Scale is a prospectively validated physician-rated measure of disease severity for progressive supranuclear palsy. We hypothesized that, according to experts' opinion...
|
|< |
< |
1 |