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G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Biodegradable Polycarbonate Iongels for Electrophysiology Measurements.
Alexander Y Yuen, Luca Porcarelli, Robert H Aguirresarobe, Ana Sanchez-Sanchez, Isabel Del Agua, Usein Ismailov, George G Malliaras, David Mecerreyes, Esma Ismailova, Haritz Sardon
Nov 15, 2018
In recent years, gels based on ionic liquids incorporated into polymer matrices, namely iongels, have emerged as long-term contact media for cutaneous electrophysiology. Iongels possess high ionic conductivity and negligible...
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
Molecular weight cut-off determination of organic solvent nanofiltration membranes using poly(propylene glycol)
A new method for determining the molecular weight cut-off (MWCO) of an organic solvent nanofiltration (OSN) membrane has been developed utilising poly(propylene) glycol (PPG) oligomers. This new MWCO method overcomes the...
Molecular weight cut-off (MWCO) Organic solvent nanofiltration (OSN) ) Solvent Resistant Nanofiltration (SRNF) Poly(propylene) glycol (PPG) Poly(propylene) oxide (PPO) ) reverse phase high-performance liquid chromatography (HPLC) evaporative light scattering detection (ELSD) Membranes /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/1500/1506 name=Filtration and Separation /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/1500/1507 name=Fluid Flow and Transfer Processes
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019
A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019
A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...
Molecular weight cut-off determination of organic solvent nanofiltration membranes using poly(propylene glycol)
A new method for determining the molecular weight cut-off (MWCO) of an organic solvent nanofiltration (OSN) membrane has been developed utilising poly(propylene) glycol (PPG) oligomers. This new MWCO method overcomes the...
Molecular weight cut-off (MWCO) Organic solvent nanofiltration (OSN) ) Solvent Resistant Nanofiltration (SRNF) Poly(propylene) glycol (PPG) Poly(propylene) oxide (PPO) ) reverse phase high-performance liquid chromatography (HPLC) evaporative light scattering detection (ELSD) Membranes /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/1500/1506 name=Filtration and Separation /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/1500/1507 name=Fluid Flow and Transfer Processes
Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds to G-Quadruplex DNA and RNA
In the early-diverging protozoan parasite Plasmodium , few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of...
James Edwards-Smallbone, Anders L Jensen, Lydia E Roberts, Francis Isidore G Totañes, Sarah R Hart, Catherine J Merrick
Mar 08, 2022
Fungal G-protein-coupled receptors:
G-protein signalling pathways are involved in sensing the environment, enabling fungi to coordinate cell function, metabolism and development with their surroundings, thereby promoting their survival, propagation and virulence....
/dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/2400/2403 name=Immunology /dk/atira/pure/subjectarea/asjc/2400/2402 name=Applied Microbiology and Biotechnology /dk/atira/pure/subjectarea/asjc/1300/1311 name=Genetics /dk/atira/pure/subjectarea/asjc/2700/2726 name=Microbiology (medical) /dk/atira/pure/subjectarea/asjc/1300/1307 name=Cell Biology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Fungal G-protein-coupled receptors:
G-protein signalling pathways are involved in sensing the environment, enabling fungi to coordinate cell function, metabolism and development with their surroundings, thereby promoting their survival, propagation and virulence....
/dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/2400/2403 name=Immunology /dk/atira/pure/subjectarea/asjc/2400/2402 name=Applied Microbiology and Biotechnology /dk/atira/pure/subjectarea/asjc/1300/1311 name=Genetics /dk/atira/pure/subjectarea/asjc/2700/2726 name=Microbiology (medical) /dk/atira/pure/subjectarea/asjc/1300/1307 name=Cell Biology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Krylov Methods for Low-Rank Regularization
This paper introduces new solvers for the computation of low-rank approximate solutions to large-scale linear problems, with a particular focus on the regularization of linear inverse problems. Although Krylov methods...
Krylov Methods for Low-Rank Regularization
This paper introduces new solvers for the computation of low-rank approximate solutions to large-scale linear problems, with a particular focus on the regularization of linear inverse problems. Although Krylov methods...
A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase
Sam Groom, Nina K Blum, Alexandra E Conibear, Alexander Disney, Rob Hill, Stephen M Husbands, Yangmei Li, Lawrence Toll, Andrea Kliewer, Stefan Schulz, Graeme Henderson, Eamonn Kelly, Chris P Bailey
Apr 30, 2023
Background and Purpose: G protein-biased μ opioid receptor agonists have the potential to induce less receptor desensitisation and tolerance than balanced opioids. Here, we investigated if the cyclic endomorphin analogue...
Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure.
James H Felce, Sarah L Latty, Rachel G Knox, Susan R Mattick, Yuan Lui, Steven F Lee, David Klenerman, Simon J Davis
May 10, 2018
The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of mostly individual receptors....
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