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Highlights from ASCO-GI 2021 from EORTC Gastrointestinal tract cancer group.
Thibaud Koessler, Maria Alsina, Dirk Arnold, Irit Ben-Aharon, Manfred P Lutz, Radka Obermannova, Mark Peeters, Francesco Sclafani, Elizabeth Smyth, Juan W Valle, Anna Dorothea Wagner, Lucjan Wyrwicz, Elisa Fontana, Markus Moehler
Sep 28, 2021
Last year the field of immunotherapy was finally introduced to GI oncology, with several changes in clinical practice such as advanced hepatocellular carcinoma or metastatic colorectal MSI-H. At the virtual ASCO-GI symposium...
Highlights from ASCO-GI 2021 from EORTC Gastrointestinal tract cancer group.
Thibaud Koessler, Maria Alsina, Dirk Arnold, Irit Ben-Aharon, Manfred P Lutz, Radka Obermannova, Mark Peeters, Francesco Sclafani, Elizabeth Smyth, Juan W Valle, Anna Dorothea Wagner, Lucjan Wyrwicz, Elisa Fontana, Markus Moehler
Sep 24, 2021
Last year the field of immunotherapy was finally introduced to GI oncology, with several changes in clinical practice such as advanced hepatocellular carcinoma or metastatic colorectal MSI-H. At the virtual ASCO-GI symposium...
Published by: British journal of cancer
THE DICTIONARY OF NEWFOUNDLAND ENGLISH
Jeff A. Webb
Jan 09, 2014
IN THE FALL OF 1982 the Dictionary of Newfoundland English (DNE) arrived in bookshops. It was the culmination of about 30 years of effort on the part of George Story, William Kirwin and John Widdowson, and was the greatest...
Published by: Memorial University of Newfoundland
THE DICTIONARY OF NEWFOUNDLAND ENGLISH
Jeff A. Webb
Jan 09, 2014
IN THE FALL OF 1982 the Dictionary of Newfoundland English (DNE) arrived in bookshops. It was the culmination of about 30 years of effort on the part of George Story, William Kirwin and John Widdowson, and was the greatest...
Published by: Memorial University of Newfoundland
Broad external validation of a multivariable risk prediction model for gastrointestinal malignancy in iron deficiency anaemia.
Orouba Almilaji, Gwilym Webb, Alec Maynard, Thomas P Chapman, Brian SF Shine, Antony J Ellis, John Hebden, Sharon Docherty, Elizabeth J Williams, Jonathon Snook
Jan 28, 2022
BACKGROUND: Using two large datasets from Dorset, we previously reported an internally validated multivariable risk model for predicting the risk of GI malignancy in IDA-the IDIOM score. The aim of this retrospective...
Broad external validation of a multivariable risk prediction model for gastrointestinal malignancy in iron deficiency anaemia.
Orouba Almilaji, Gwilym Webb, Alec Maynard, Thomas P Chapman, Brian SF Shine, Antony J Ellis, John Hebden, Sharon Docherty, Elizabeth J Williams, Jonathon Snook
Jan 05, 2022
BACKGROUND: Using two large datasets from Dorset, we previously reported an internally validated multivariable risk model for predicting the risk of GI malignancy in IDA-the IDIOM score. The aim of this retrospective...
The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors.
Lucy Thorne, Angela Nalwoga, Alexander J Mentzer, Alexis de Rougemont, Myra Hosmillo, Emily Webb, Margaret Nampiija, Allan Muhwezi, Tommy Carstensen, Deepti Gurdasani, Adrian V Hill, Manj S Sandhu, Alison Elliott, Ian Goodfellow
Jul 25, 2018
BACKGROUND: Human noroviruses (HuNoVs) are a prominent cause of gastroenteritis, yet fundamental questions remain regarding epidemiology, diversity, and immunity in sub-Saharan African children. We investigated HuNoV...
Antibodies Viral Blood Group Antigens Caliciviridae Infections Child Preschool Cross-Sectional Studies Demography Disease Susceptibility Enzyme-Linked Immunosorbent Assay Female Fucosyltransferases Gastroenteritis genetic variation Genotype Humans Infant Infant Newborn Longitudinal Studies Male Norovirus Polymorphism Single Nucleotide Pregnancy Risk Factors Seroepidemiologic Studies Socioeconomic Factors Uganda
Genomic Mutation Profile of Primary Gastrointestinal Diffuse Large B-Cell Lymphoma.
Peifeng Li, Jia Chai, Zi Chen, Yang Liu, Jie Wei, Yixiong Liu, Danhui Zhao, Jing Ma, Kaijing Wang, Xia Li, Yang Shao, Li Gong, Wei Zhang, Shuangping Guo, Qingguo Yan, Mingyang Li, Linni Fan, Zhe Wang
Mar 19, 2021
Primary gastrointestinal diffuse large B-cell lymphoma (GI-DLBCL) is the most common gastrointestinal lymphoma, but its genetic features are poorly understood. We performed whole-exome sequencing of 25 primary tumor samples from...
Impact of Gastrointestinal Disease States on Oral Drug Absorption – implications for formulation design – a PEARRL review
Objectives: Drug product performance in patients with gastrointestinal (GI) diseases can be altered compared to healthy subjects due to pathophysiological changes. In this review, relevant differences in patients with...
Methyl-orvinol—Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome
Marta Zielińska, Agata Jarmuż, Andrzej Wasilewski, Gerta Cami-Kobeci, Stephen Husbands, Jakub Fichna
Apr 01, 2017
Background Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional disorder of the gastrointestinal (GI) tract. The major IBS-D symptoms include diarrhea, abdominal pain and discomfort. High density of opioid...
Design, development, and validation of a strand-specific RT-qPCR assay for GI and GII human Noroviruses.
Katja Marie Kjara König, Aminu S Jahun, Komal Nayak, Lydia N Drumright, Matthias Zibauer, Ian Goodfellow, Myra Hosmillo
Jan 06, 2022
Human noroviruses (HuNoV) are the major cause of viral gastroenteritis worldwide. Similar to other positive-sense single-stranded RNA viruses, norovirus RNA replication requires the formation of a negative strand RNA...
Dysbiosis associated with acute helminth infections in herbivorous youngstock - observations and implications.
Laura E Peachey, Cecilia Castro, Rebecca A Molena, Timothy P Jenkins, Julian L Griffin, Cinzia Cantacessi
Jul 16, 2019
A plethora of data points towards a role of the gastrointestinal (GI) microbiota of neonatal and young vertebrates in supporting the development and regulation of the host immune system. However, knowledge of the impact that...
Dysbiosis associated with acute helminth infections in herbivorous youngstock – observations and implications
Laura E. Peachey, Cecilia Castro, Rebecca A. Molena, Timothy P. Jenkins, Julian L. Griffin, Cinzia Cantacessi
Jul 30, 2020
Abstract: A plethora of data points towards a role of the gastrointestinal (GI) microbiota of neonatal and young vertebrates in supporting the development and regulation of the host immune system. However, knowledge of the...
Impact of Gastrointestinal Disease States on Oral Drug Absorption – implications for formulation design – a PEARRL review
Objectives: Drug product performance in patients with gastrointestinal (GI) diseases can be altered compared to healthy subjects due to pathophysiological changes. In this review, relevant differences in patients with...
Charlotte's Society for Human Resource Management Awards Four Winthrop Students Scholarships
Winthrop University
Jan 01, 0001
The student winners are Rachel Farr, Marissa Nichols, Anthony Jablonecki '14 and Shelby Webb '14.
Published by: Winthrop University
Design, development, and validation of a strand-specific RT-qPCR assay for GI and GII human Noroviruses.
Katja Marie Kjara König, Aminu Jahun, Komal Nayak, Lydia N Drumright, Matthias Zibauer, Ian Goodfellow, Myra Hosmillo
Nov 03, 2021
Human noroviruses (HuNoV) are the major cause of viral gastroenteritis worldwide. Similar to other positive-sense single-stranded RNA viruses, norovirus RNA replication requires the formation of a negative strand RNA...
Methyl-orvinol—Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome
Marta Zielińska, Agata Jarmuż, Andrzej Wasilewski, Gerta Cami-Kobeci, Stephen Husbands, Jakub Fichna
Apr 01, 2017
Background Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional disorder of the gastrointestinal (GI) tract. The major IBS-D symptoms include diarrhea, abdominal pain and discomfort. High density of opioid...
Helminth-microbiota cross-talk - A journey through the vertebrate digestive system.
The gastrointestinal (GI) tract of vertebrates is inhabited by a vast array of organisms, i.e., the microbiota and macrobiota. The former is composed largely of commensal microorganisms, which play vital roles in host nutrition...
Bacterial 16S rRNA sequencing Gastrointestinal Tract Helminth-microbiota interactions Lactobacilli Microbial diversity microbial richness Prevotella Ancylostomatoidea Animals Ascaris Gastrointestinal Tract Helminths host-parasite interactions Humans Immunity mucosal Intestinal Mucosa Intestine Large Intestine Small Lactobacillus Microbiota Nematoda Platyhelminths Schistosoma Stomach strongyloides stercoralis Trematoda Trichuris
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