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Breaching the Barrier
The double-membrane cell envelope of Gram-negative bacteria is a sophisticated barrier that facilitates the uptake of nutrients and protects the organism from toxic compounds. An antibiotic molecule must find its way through the...
antibiotic resistance efflux envelope permeability OUTER-MEMBRANE PROTEINS Porins Anti-Bacterial Agents Bacterial Outer Membrane Bacterial Outer Membrane Proteins Biological Transport Cell Membrane Permeability Electrophysiology Gram-Negative Bacteria Hydrophobic and Hydrophilic Interactions Lipopolysaccharides Liposomes Microscopy Models Molecular Permeability Porins
ImmUniverse Consortium
Stefania Vetrano, Gerben Bouma, Robert J Benschop, Thomas Birngruber, Antonio Costanzo, GRAM D'Haens, Loredana Frasca, Rainer Hillenbrand, Lars Iversen, Claus Johansen, Arthur Kaser, Hans JPM Koenen, Christa Noehammer, Laurent Peyrin-Biroulet, Jeroen Raes, Leonardo Ricotti, Philip Rosenstiel, Venkata P Satagopam, Stefan Schreiber, Severine Vermeire, Andreas Wollenberg, Stephan Weidinger, Daniel Ziemek, Silvio Danese, ImmUniverse Consortium
Jan 04, 2023
Immune mediated inflammatory diseases (IMIDs) are a heterogeneous group of debilitating, multifactorial and unrelated conditions featured by a dysregulated immune response leading to destructive chronic inflammation. The immune...
Vocalic Intrusions in Consonant Clusters in Child-Directed vs. Adult-Directed Speech.
Nina Gram Garmann, Pernille Hansen, Hanne Gram Simonsen, Elisabeth Holm, Eirik Tengesdal, Brechtje Post, Elinor Payne
Sep 05, 2021
In this paper, we investigate a prosodic-phonetic feature in child-directed speech within a dynamic, complex, interactive theoretical framework. We focus on vocalic intrusions, commonly occurring in Norwegian word initial...
Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria
SIGNR1, a member of a new family of mouse C-type lectins, is expressed at high levels in macrophages (M?) within the splenic marginal zone, lymph node medulla, and in some strains, in peritoneal cavity. We previously reported...
Published by: Rockefeller University
Vocalic Intrusions in Consonant Clusters in Child-Directed vs. Adult-Directed Speech
Nina Gram Garmann, Pernille Hansen, Hanne Gram Simonsen, Elisabeth Holm, Eirik Tengesdal, Brechtje Post, Elinor Payne
Aug 02, 2021
In this paper, we investigate a prosodic-phonetic feature in child-directed speech within a dynamic, complex, interactive theoretical framework. We focus on vocalic intrusions, commonly occurring in Norwegian word initial...
Multicountry Distribution and Characterization of Extended-spectrum β-Lactamase-associated Gram-negative Bacteria From Bloodstream Infections in Sub-Saharan Africa.
Trevor Toy, Gi Deok Pak, Trung Pham Duc, James I Campbell, Muna Ahmed El Tayeb, Vera von Kalckreuth, Justin Im, Ursula Panzner, Ligia Maria Cruz Espinoza, Daniel Eibach, Denise Myriam Dekker, Se Eun Park, Hyon Jin Jeon, Frank Konings, Ondari D Mogeni, Leonard Cosmas, Morten Bjerregaard-Andersen, Nagla Gasmelseed, Julian T Hertz, Anna Jaeger, Ralf Krumkamp, Benedikt Ley, Kamala Thriemer, Leon Parfait Kabore, Aissatou Niang, Tiana Mirana Raminosoa, Emmanuel Sampo, Nimako Sarpong, Abdramane Soura, Ellis Owusu-Dabo, Mekonnen Teferi, Biruk Yeshitela, Sven Poppert, Jürgen May, Jerome H Kim, Yun Chon, Jin Kyung Park, Abroaham Aseffa, Robert F Breiman, Heidi Schütt-Gerowitt, Peter Aaby, Yaw Adu-Sarkodie, John A Crump, Raphaël Rakotozandrindrainy, Christian G Meyer, Amy Gassama Sow, John D Clemens, Thomas F Wierzba, Stephen Baker, Florian Marks
Nov 26, 2019
BACKGROUND: Antimicrobial resistance (AMR) is a major global health concern, yet, there are noticeable gaps in AMR surveillance data in regions such as sub-Saharan Africa. We aimed to measure the prevalence of extended-spectrum...
Africa ESBL antibiotic resistance Antimicrobial resistance Extended-spectrum β-lactamase SURVEILLANCE Adolescent Adult Africa South of the Sahara Anti-Bacterial Agents Child Child Preschool Drug Resistance Multiple Bacterial Gram-Negative Bacteria Gram-Negative Bacterial Infections Humans Infant Infant Newborn Microbial Sensitivity Tests Middle Aged prevalence sentinel surveillance Young Adult beta-Lactamases
ImmUniverse Consortium
Stefania Vetrano, Gerben Bouma, Robert J Benschop, Thomas Birngruber, Antonio Costanzo, GRAM D'Haens, Loredana Frasca, Rainer Hillenbrand, Lars Iversen, Claus Johansen, Arthur Kaser, Hans JPM Koenen, Christa Noehammer, Laurent Peyrin-Biroulet, Jeroen Raes, Leonardo Ricotti, Philip Rosenstiel, Venkata P Satagopam, Stefan Schreiber, Severine Vermeire, Andreas Wollenberg, Stephan Weidinger, Daniel Ziemek, Silvio Danese, ImmUniverse Consortium
Nov 23, 2022
A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria.
Samuel H Light, Lin Su, Rafael Rivera-Lugo, Jose A Cornejo, Alexander Louie, Anthony T Iavarone, Caroline M Ajo-Franklin, Daniel A Portnoy
Jun 07, 2021
Extracellular electron transfer (EET) describes microbial bioelectrochemical processes in which electrons are transferred from the cytosol to the exterior of the cell1. Mineral-respiring bacteria use elaborate haem-based...
MQVC
Extensive research efforts in the area of Information Retrieval were concentrated on developing retrieval systems related to Arabic language for the different natural language and information retrieval methodologies. However...
Published by: Digital Commons @ Texas A&M University-San Antonio
Parental Report via a Mobile App in the Context of Early Language Trajectories
Karolina Mieszkowska, Grzegorz Krajewski, Krzysztof Sobota, Agnieszka Dynak, Joanna Kolak, Magdalena Krysztofiak, Barbara Łukomska, Magdalena Łuniewska, Nina Gram Garmann, Pernille Hansen, Anna Sara Hexeberg Romøren, Hanne Gram Simonsen, Katie Alcock, Napoleon Katsos, Ewa Haman
Apr 10, 2022
Social sciences researchers emphasize that new technologies can overcome the limitations of small and homogenous samples. In research on early language development, which often uses parental reports, taking the testing online...
MQVC
Extensive research efforts in the area of Information Retrieval were concentrated on developing retrieval systems related to Arabic language for the different natural language and information retrieval methodologies. However...
Published by: Digital Commons @ Texas A&M University-San Antonio
MQVC
Extensive research efforts in the area of Information Retrieval were concentrated on developing retrieval systems related to Arabic language for the different natural language and information retrieval methodologies. However...
Published by: Digital Commons @ Texas A&M University-San Antonio
Regulation of Surface Proteins Assembly on the Wall of Gram-Positive Bacteria
Assaf Raz
Jan 01, 0001
Cell wall peptidoglycan-anchored surface proteins are essential virulence factors in many Gram-positive bacteria. Attachment of these proteins to the peptidoglycan is achieved through a transpeptidation reaction, whereby sortase...
streptococcal disease Gram-Positive Bacteria surface proteins sortase localization protein anchoring sub-surface antigens LPXTGase Life Sciences
Published by: Rockefeller University
A high prevalence of multi-drug resistant Gram-negative bacilli in a Nepali tertiary care hospital and associated widespread distribution of Extended-Spectrum Beta-Lactamase (ESBL) and carbapenemase-encoding genes.
Sulochana Manandhar, Raphael M Zellweger, Nhukesh Maharjan, Sabina Dongol, Krishna G Prajapati, Guy Thwaites, Buddha Basnyat, Sameer Mani Dixit, Stephen Baker, Abhilasha Karkey
Jan 11, 2021
BACKGROUND: Multi-drug resistance (MDR) and extensive-drug resistance (XDR) associated with extended-spectrum beta-lactamases (ESBLs) and carbapenemases in Gram-negative bacteria are global public health concerns. Data on...
Antimicrobial resistance Carbapenemase ESBL ESKAPE Gram-negative bacilli multi-drug resistance Nepal Acinetobacter Anti-Bacterial Agents Bacterial Proteins Drug Resistance Multiple Bacterial Enterobacter Escherichia coli Gram-Negative Bacteria Gram-Negative Bacterial Infections Humans Klebsiella Microbial Sensitivity Tests Nepal prevalence Retrospective Studies Tertiary Care Centers beta-Lactamases
The Antibiotic resistance profiles of bacterial strains isolated from inpatients and outpatients from five hospitals in Egypt
Lamees galal1, Mosaad sayed Mohamed2, Riham Shawky3, Neveen AbdelAziz4*and Ramadan Eldomany3
Mar 11, 2015
Background:Multidrug resistance (MDR) of pathogens has become a serious threat for modern human health care. The strategy for the control of antimicrobial resistance lies mainly in the implementation of effective infection...
Published by: IJHS Medical Association
A high prevalence of multi-drug resistant Gram-negative bacilli in a Nepali tertiary care hospital and associated widespread distribution of Extended-Spectrum Beta-Lactamase (ESBL) and carbapenemase-encoding genes
Sulochana Manandhar, Raphael M. Zellweger, Nhukesh Maharjan, Sabina Dongol, Krishna G. Prajapati, Guy Thwaites, Buddha Basnyat, Sameer Mani Dixit, Stephen Baker, Abhilasha Karkey
Oct 21, 2020
Abstract: Background: Multi-drug resistance (MDR) and extensive-drug resistance (XDR) associated with extended-spectrum beta-lactamases (ESBLs) and carbapenemases in Gram-negative bacteria are global public health concerns. Data...
Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation.
Lasse Reimer, Hjalte Gram, Nanna Møller Jensen, Cristine Betzer, Li Yang, Lorrain Jin, Min Shi, Driss Boudeffa, Giuliana Fusco, Alfonso De Simone, Deniz Kirik, Hilal A Lashuel, Jing Zhang, Poul Henning Jensen
Mar 02, 2023
Aggregated α-synuclein (α-syn) accumulates in the neuronal Lewy body (LB) inclusions in Parkinson's disease (PD) and LB dementia. Yet, under nonpathological conditions, monomeric α-syn is hypothesized to exist in an equilibrium...
Analysis of microbial keratitis incidence, isolates and in-vitro antimicrobial susceptibility in the East of England
Malik Moledina, Harry W Roberts, Achyut Mukherjee, David Spokes, Dimitris Pimenides, Christopher Stephenson, Ramy Bassily, Madhavan S Rajan, James Myerscough
Feb 28, 2023
BACKGROUND/OBJECTIVES: To report the incidence, microbiological profile and in-vitro antimicrobial susceptibilities of microbial keratitis (MK) in the East of England (EoE) over a 6-year period. SUBJECTS/METHODS: A retrospective...
ARIBA
Martin Hunt, Alison E Mather, Leonor Sánchez-Busó, Andrew J Page, Julian Parkhill, Jacqueline A Keane, Simon R Harris
May 25, 2018
Antimicrobial resistance (AMR) is one of the major threats to human and animal health worldwide, yet few high-throughput tools exist to analyse and predict the resistance of a bacterial isolate from sequencing data. Here we...
Antimicrobial activity of ruthenium-based intercalators
Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating...
A high prevalence of multi-drug resistant Gram-negative bacilli in a Nepali tertiary care hospital and associated widespread distribution of Extended-Spectrum Beta-Lactamase (ESBL) and carbapenemase-encoding genes
Sulochana Manandhar, Raphael M. Zellweger, Nhukesh Maharjan, Sabina Dongol, Krishna G. Prajapati, Guy Thwaites, Buddha Basnyat, Sameer Mani Dixit, Stephen Baker, Abhilasha Karkey
Oct 21, 2021
Abstract: Background: Multi-drug resistance (MDR) and extensive-drug resistance (XDR) associated with extended-spectrum beta-lactamases (ESBLs) and carbapenemases in Gram-negative bacteria are global public health concerns. Data...
Asymptomatic bacteriuria among pregnant women attending antenatal care at Mbale Hospital, Eastern Uganda.
Julius Nteziyaremye, Stanley Jacob Iramiot, Rebecca Nekaka, Milton W Musaba, Julius Wandabwa, Enoch Kisegerwa, Paul Kiondo
Mar 25, 2020
BACKGROUND: Asymptomatic bacteriuria in pregnancy (ASBP) is associated with adverse pregnancy outcomes such as pyelonephritis, preterm or low birth weight delivery if untreated. The aim of this study was to determine the...
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