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Results: 177
Session report
GS Phani Madabhushi
Apr 02, 2015
Performance of vertical drains in liquefaction mitigation under structures
Abstract: Several techniques have been developed in order to mitigate damage to buildings during and after liquefaction events. Benefits of using vertical drains have been verified by analysing their performance in the soil and...
The combination of cardiorespiratory fitness and muscle strength, and mortality risk.
Youngwon Kim, Tom White, Katrien Wijndaele, Kate Westgate, Stephen J Sharp, Jørn W Helge, Nick J Wareham, Soren Brage
May 03, 2018
Little is known about the combined associations of cardiorespiratory fitness (CRF) and hand grip strength (GS) with mortality in general adult populations. The purpose of this study was to compare the relative risk of mortality...
Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor.
Andras S Solt, Mark J Bostock, Binesh Shrestha, Prashant Kumar, Tony Warne, Christopher G Tate, Daniel Nietlispach
Jun 08, 2018
A complex conformational energy landscape determines G-protein-coupled receptor (GPCR) signalling via intracellular binding partners (IBPs), e.g., Gs and β-arrestin. Using 13C methyl methionine NMR for the β1-adrenergic...
Numerical modelling of structures adjacent to retaining walls subjected to earthquake loading
In an urban environment, it is often necessary to locate structures close to existing retaining walls due to congestion in space. When such structures are in seismically active zones, the dynamic loading attracted by the...
LEAP-GWU-2015
As part of the LEAP-GWU-2015 exercise, a dynamic centrifuge test was conducted at the University of Cambridge on a 5° slope of medium dense Ottawa F-65 sand. The model preparation and saturation details are presented in this...
Gitelman syndrome: consensus and guidance from a Kidney Disease
Anne Blanchard, Detlef Bockenhauer, Davide Bolignano, Lorenzo A Calò, Etienne Cosyns, Olivier Devuyst, David H Ellison, Fiona E Karet Frankl, Nine VAM Knoers, Martin Konrad, Shih-Hua Lin, Rosa Vargas-Poussou
Feb 12, 2019
Gitelman syndrome (GS) is a rare, salt-losing tubulopathy characterized by hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria. The disease is recessively inherited, caused by inactivating mutations in the...
SLC12A3 hypokalemic metabolic alkalosis hypomagnesemia salt-losing tubulopathy thiazide-sensitive sodium-chloride cotransporter Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors Anti-Inflammatory Agents Non-Steroidal Bartter Syndrome Calcium Chloride Channels Chondrocalcinosis Consensus Development Conferences as Topic Diagnosis Differential Dietary Supplements Genetic Testing Gitelman syndrome Humans Hypokalemia Magnesium Mutation Phenotype Potassium Practice Guidelines as Topic Quality of life Rare Diseases Sodium Chloride Dietary Solute Carrier Family 12 Member 3 Ultrasonography
Independent and joint associations of grip strength and adiposity with all-cause and cardiovascular disease mortality in 403,199 adults
Youngwon Kim, Katrien Wijndaele, Duck-Chul Lee, Stephen J Sharp, Nick Wareham, Soren Brage
Jul 28, 2017
Background: Higher grip strength (GS) is associated with lower mortality risk. However, whether this association is independent of adiposity is uncertain.Objective: The purpose of this study was to examine the associations...
Making urinary extracellular vesicles a clinically tractable source of biomarkers for inherited tubulopathies using a small volume precipitation method
Biomarkers of inherited tubulopathies would be useful for clarifying diagnoses in patients where genetic screening is not readily available or where disease-attributable mutations are not found. Urinary extracellular vesicles...
Novel insights into PORCN mutations, associated phenotypes and pathophysiological aspects.
Annabelle Arlt, Nicolai Kohlschmidt, Andreas Hentschel, Enrika Bartels, Claudia Gross, Ana Töpf, Pınar Edem, Nora Szabo, Albert Sickmann, Nancy Meyer, Ulrike Schara-Schmidt, Jarred Lau, Hanns Lochmüller, Rita Horvath, Yavuz Oktay, Andreas Roos, Semra Hiz
Mar 05, 2022
BACKGROUND: Goltz syndrome (GS) is a X-linked disorder defined by defects of mesodermal- and ectodermal-derived structures and caused by PORCN mutations. Features include striated skin-pigmentation, ocular and skeletal...
Griscelli Syndrome Type 2 Sine Albinism
Yuta Ohishi, Sandra Ammann, Vahid Ziaee, Katharina Strege, Miriam Groß, Carla Vazquez Amos, Mohammad Shahrooei, Parisa Ashournia, Anahita Razaghian, Gillian M Griffiths, Stephan Ehl, Mitsunori Fukuda, Nima Parvaneh
Jan 18, 2021
Griscelli syndrome type 2 (GS-2) is an inborn error of immunity characterized by partial albinism and episodes of hemophagocytic lymphohistiocytosis (HLH). It is caused by RAB27A mutations that encode RAB27A, a member of the Rab...
Leukocytes Mononuclear Cell Line COS Cells Animals Humans Albinism Piebaldism rab GTP-Binding Proteins Adaptor Proteins Signal Transducing Membrane Proteins Binding Sites Mutation Missense Adolescent Child Child Preschool Infant Infant Newborn Female Male Lymphohistiocytosis Hemophagocytic rab27 GTP-Binding Proteins Primary Immunodeficiency Diseases Chlorocebus aethiops
Modelling water use efficiency in a dynamic environment
S Vialet-Chabrand, JSA Matthews, O Brendel, MR Blatt, Y Wang, A Hills, H Griffiths, S Rogers, T Lawson
May 14, 2018
Intrinsic water use efficiency (Wi), the ratio of net CO2 assimilation (A) over stomatal conductance to water vapour (gs), is a complex trait used to assess plant performance. Improving Wi could lead in theory to higher...
Incidence of surrogacy in the USA and Israel and implications on women's health
PURPOSE: Gestational surrogacy (GS) has been researched in multiple qualitative studies. In contrast, quantitative aspects of the practice are conspicuously understudied. The present article assesses and compares the incidence...
Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase.
The catalytic activities of enzymes can be described using Gene Ontology (GO) terms and Enzyme Commission (EC) numbers. These annotations are available from numerous biological databases and are routinely accessed by researchers...
Assessment of bridge natural frequency as an indicator of scour using centrifuge modelling
Kasun D. Kariyawasam, Campbell R. Middleton, Gopal Madabhushi, Stuart K. Haigh, James P. Talbot
Sep 30, 2020
Effector gene birth in plant parasitic nematodes
Catherine J Lilley, Abbas Maqbool, Duqing Wu, Hazijah B Yusup, Laura M Jones, Paul RJ Birch, Mark J Banfield, Peter E Urwin, Sebastian Eves-van den Akker
Oct 10, 2018
Plant pathogens and parasites are a major threat to global food security. Plant parasitism has arisen four times independently within the phylum Nematoda, resulting in at least one parasite of every major food crop in the world....
Griscelli Syndrome Type 2 Sine Albinism
Yuta Ohishi, Sandra Ammann, Vahid Ziaee, Katharina Strege, Miriam Groß, Carla Vazquez Amos, Mohammad Shahrooei, Parisa Ashournia, Anahita Razaghian, Gillian M. Griffiths, Stephan Ehl, Mitsunori Fukuda, Nima Parvaneh
Dec 24, 2020
Griscelli syndrome type 2 (GS-2) is an inborn error of immunity characterized by partial albinism and episodes of hemophagocytic lymphohistiocytosis (HLH). It is caused by RAB27A mutations that encode RAB27A, a member of the Rab...
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