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Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America.
“But not laughing”
Hero Chalmers
Dec 10, 2018
This article examines William Cavendish’s two treatises on horsemanship printed in 1658 and 1667, respectively. It argues that a close reading of these works in their discursive and iconographic contexts reveals their engagement...
Transjugular intrahepatic portosystemic stent-shunts
These guidelines on transjugular intrahepatic portosystemic stent-shunt (TIPSS) in the management of portal hypertension have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British...
N Chalmers
Mar 02, 2020
Continuous endocytic recycling of tight junction proteins
Tight junctions consist of many proteins, including transmembrane and associated cytoplasmic proteins, which act to provide a barrier regulating transport across epithelial and endothelial tissues. These junctions are dynamic...
The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells
Tight junctions mediate the intercellular diffusion barrier found in epithelial tissues but they are not static complexes; instead there is rapid movement of individual proteins within the junctions. In addition some tight...
A comparison of current analytical methods for predicting soil-structure interaction due to tunnelling
Current procedures for the assessment of buildings response to tunnelling take into account the effect of soil-structure interaction through the definition of the building stiffness relative to the soil stiffness. Limitations...
The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells
Tight junctions mediate the intercellular diffusion barrier found in epithelial tissues but they are not static complexes; instead there is rapid movement of individual proteins within the junctions. In addition some tight...
The N-terminal RASSF family
The RASSF (Ras-association domain family) has recently gained several new members and now contains ten proteins (RASSF1–10), several of which are potential tumour suppressors. The family can be split into two groups, the...
The F1000Research Antibody Validation Article Collection
Well validated antibodies are crucial to progress in a wide range of life science disciplines, but validating an antibody is a complex and ongoing process. Antibody validation is often carried out as preliminary work to a...
A comparison of current analytical methods for predicting soil-structure interaction due to tunnelling
Current procedures for the assessment of buildings response to tunnelling take into account the effect of soil-structure interaction through the definition of the building stiffness relative to the soil stiffness. Limitations...
The N-terminal RASSF family
The RASSF (Ras-association domain family) has recently gained several new members and now contains ten proteins (RASSF1–10), several of which are potential tumour suppressors. The family can be split into two groups, the...
The MDCK variety pack
The MDCK cell line provides a tractable model for studying protein trafficking, polarity and junctions (tight, adherens, desmosome and gap) in epithelial cells. However, there are many different strains of MDCK cells available...
Reporting research antibody use
Research antibodies are used in a wide range of bioscience disciplines, yet it is common to hear dissatisfaction amongst researchers with respect to their quality. Although blame is often attributed to the manufacturers...
Continuous endocytic recycling of tight junction proteins
Tight junctions consist of many proteins, including transmembrane and associated cytoplasmic proteins, which act to provide a barrier regulating transport across epithelial and endothelial tissues. These junctions are dynamic...
Reporting research antibody use
Research antibodies are used in a wide range of bioscience disciplines, yet it is common to hear dissatisfaction amongst researchers with respect to their quality. Although blame is often attributed to the manufacturers...
The MDCK variety pack
The MDCK cell line provides a tractable model for studying protein trafficking, polarity and junctions (tight, adherens, desmosome and gap) in epithelial cells. However, there are many different strains of MDCK cells available...
The F1000Research Antibody Validation Article Collection
Well validated antibodies are crucial to progress in a wide range of life science disciplines, but validating an antibody is a complex and ongoing process. Antibody validation is often carried out as preliminary work to a...
Searching for prostate cancer stem cells
The cancer stem cell hypothesis postulates that a single stem-like cancer cell is able to produce all cancer cell types found in a tumor. These cells are also thought to be the causative agents of relapse following therapy. In...
Grainyhead-like 3, a transcription factor identified in a microarray screen, promotes the specification of the superficial layer of the embryonic epidermis
Andrew Chalmers, Kim Lachani, Yongchol Shin, Victoria Sherwood, Ken Cho, Nancy Papalopulu
Sep 01, 2006
The Xenopus ectoderm consists of two populations of cells, superficial polarised epithelial cells and deep, non-epithelial cells. These two cell types differ in their developmental fate. In the neural ectoderm, primary neurons...
Impact of the Crossrail tunnelling project on masonry buildings with shallow foundations
Matthew J. DeJong, Giorgia Giardina, Benjamin Chalmers, Deborah Lazarus, David Ashworth, Robert J. Mair
Oct 01, 2019
Building monitoring and protection are important components of underground projects in urban areas. Typically the procedures applied for the assessment of settlement-induced damage to buildings are based on simplified...
Photopolymerization of polydiacetylene in hybrid liposomes
Liposomes containing lipids and polydiacetylene (PDA) are hybrid systems encompassing both a fluid phospholipid membrane and a polymer scaffold (PDA). However, the biophysical role of PDA in such liposomes is not well...
Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family.
Iain W Chalmers, Andrew J McArdle, Richard Mr Coulson, Marissa A Wagner, Ralf Schmid, Hirohisa Hirai, Karl F Hoffmann
Jun 16, 2011
Allergens Alternative Splicing Amino Acid Sequence Animals Cloning Molecular DNA Complementary evolution Molecular Exons Gene Expression Regulation Developmental Genes Helminth Helminth Proteins Introns Multigene Family Phylogeny Schistosoma mansoni Sequence Analysis Protein Sequence Homology Amino Acid Species Specificity Venoms
Grainyhead-like 3, a transcription factor identified in a microarray screen, promotes the specification of the superficial layer of the embryonic epidermis
Andrew Chalmers, Kim Lachani, Yongchol Shin, Victoria Sherwood, Ken Cho, Nancy Papalopulu
Sep 01, 2006
The Xenopus ectoderm consists of two populations of cells, superficial polarised epithelial cells and deep, non-epithelial cells. These two cell types differ in their developmental fate. In the neural ectoderm, primary neurons...
Truncated RASSF7 promotes centrosomal defects and cell death
Tulay Gulsen, Irene Hadjicosti, Yueshi Li, Xinyun Zhang, Paul R. Whitley, Andrew D. Chalmers
Jan 15, 2016
RASSF7 protein localises to the centrosome and plays a key role in mitosis. Its expression is also increased in a range of tumour types. However, little is known about the molecular basis of RASSF7's function and it is not...
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