Search

Background Problems of quality and safety persist in health systems worldwide. We conducted a large research programme to examine culture and behaviour in the English National Health Service (NHS). Methods Mixed-methods study...

Background Problems of quality and safety persist in health systems worldwide. We conducted a large research programme to examine culture and behaviour in the English National Health Service (NHS). Methods Mixed-methods study...

BACKGROUND: Experimental proof of gene function assignments in plants is based on mutant analyses. T-DNA insertion lines provided an invaluable resource of mutants and enabled systematic reverse genetics-based investigation of...

Chromosomal rearrangements chromosome fusions GABI-Kat genome assembly Long read sequencing Reverse Genetics Structural variants Translocations Arabidopsis DNA Bacterial Genomics Mutagenesis Insertional

BACKGROUND: Inflammation occurs as an immediate protective response of the immune system to a harmful stimulus, whether locally confined or systemic. In contrast, a persisting, i.e., chronic, inflammatory state, even at a...

C-Reactive Protein Fibrinogen Inflammation Mass Spectrometry Metabolomics nuclear magnetic resonance spectroscopy White blood cell count Adult Atherosclerosis Biomarkers C-Reactive Protein Cardiovascular Diseases Female Humans Inflammation Inflammation Mediators Male Mass Spectrometry Metabolomics Middle Aged Nuclear Magnetic Resonance Biomolecular Risk Factors

Aged Cohort Studies Female Humans Male Metabolome Middle Aged multimorbidity Noncommunicable Diseases Plasma

Background: In numerous studies based predominantly on rodent models, administration of 3,5-diiodo-L-thyronine (3,5-T2), a metabolite of the thyroid hormones (TH) thyroxine (T4) and triiodo-L-thyronine (T3), was reported to...

3 5-diiodothyronine caffeine metabolism Metabolomics Thyroid thyrotoxicosis Adult caffeine Coffee DNA Fingerprinting Diiodothyronines Female Healthy Volunteers Humans Magnetic Resonance Spectroscopy Male Mass Spectrometry Metabolomics Middle Aged Reference Values Thyroid Function Tests Thyroid Hormones Thyrotoxicosis Thyrotropin Thyroxine

article /631/208 /692/53 /45 /45/61 /82/80 article

article /631/208 /692/53 /45 /45/61 /82/80 article

aging Alternative Splicing Blood Proteins covid-19 Connective Tissue Diseases Disease Drug development Female Gallstones Genetic Association Studies genetic variation Genome Human Genome-Wide Association Study Genomics Humans Internet Male Phenotype Proteins Proteome Quantitative Trait Loci Sex Characteristics

Saliva, as a biofluid, is inexpensive and non-invasive to obtain, and provides a vital tool to investigate oral health and its interaction with systemic health conditions. There is growing interest in salivary biomarkers for...

Biomarkers Cohort Studies Computational Biology Female Genetic Loci Genome-Wide Association Study Humans Male Metabolic Networks and Pathways Metabolome Middle Aged Polymorphism Single Nucleotide Saliva

In cross-platform analyses of 174 metabolites, we identify 499 associations (P < 4.9 × 10-10) characterized by pleiotropy, allelic heterogeneity, large and nonlinear effects and enrichment for nonsynonymous variation. We...

Diabetes mellitus Type 2 Eye Diseases Gene Frequency Genetic Loci Genetic Pleiotropy Genome Human Glucagon-Like Peptide-2 Receptor Glycine HEALTH Humans Linear Models Mendelian Randomization Analysis metabolism metabolism Inborn Errors Metabolome Mutation Missense Phenotype Polymorphism Single Nucleotide Retinal Telangiectasis Sample Size Serine

Garrod's concept of 'chemical individuality' has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at...

Humans Metabolome Metabolomics Plasma Phenotype metabolism Inborn Errors Membrane Proteins 3-Oxo-5-alpha-Steroid 4-Dehydrogenase

Garrod's concept of 'chemical individuality' has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at...

article /631/208/480 /631/208/457 article