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Transcriptomic and Proteomic Studies of Intercellular Communication Between Melanocytes and Keratinocytes in Human Skin
Gabriella Stephanne Spitz-Becker
Jan 01, 0001
The epidermis is a stratified epithelium composed of multiple cell types. Keratinocytes are the most prevalent cells in the epidermis and provide the barrier function of the skin. Interspersed amongst the keratinocytes in the...
Published by: Rockefeller University
Chronic Migraine: Role of CGRP antagonists and Botox
Gabriella Hassan
Jan 01, 0001
Chronic migraine (CM) is characterized by the International Headache Society classification (ICHD-3) as headache that occurs for greater than or equal to 15 days a month, lasting 4 or more hours. For chronic migraine patients...
Chronic migraine Medication CGRP CGRP-antagonists OnabotulinumtoxinA Analytical, Diagnostic and Therapeutic Techniques and Equipment Chemicals and Drugs health information technology
Published by: Harrisburg University of Science and Technology
Myocardial Fibrosis in Heart Failure
All heart muscle diseases that cause chronic heart failure finally converge into one dreaded pathological process that is myocardial fibrosis. Myocardial fibrosis predicts major adverse cardiovascular events and death, yet we...
Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins.
Over the past decade, there has been a growing interest in investigating whether disordered proteins can be targeted for clinical purposes using small molecules [1-8]. While small-molecule binding to disordered proteins can be...
Determination of Thermal Niche for a Ground Beetle Predator (Bembidion spp.) in Barley Fields
Gabriella R Altmire
Jan 01, 0001
The activity density of Bembidion spp. was studied in barley fields in relation to temperature to determine its thermal optimum and thermal niche breadth, and to evaluate whether its thermal niche is complementary or redundant...
Published by: Ursinus College
Effect of Plant Biodiversity on Insect Pests in a Forage Agroecosystem
Gabriella R Altmire
Jan 01, 0001
Agroecosystems are species-poor in comparison to natural ecosystems and this may lead to an increased susceptibility to pest outbreaks. Pesticides prevent pest outbreaks; however, they threaten human, non-human, and...
agriculture Biodiversity insect herbivore plant monoculture agriculture Biology Ecology and Evolutionary Biology entomology Life Sciences
Published by: Ursinus College
Inclusive Education and UDL Professional Development for Teachers in Sweden and India
In education, the factors involved in a successful inclusive education classroom are diverse and multidimensional, with a growing research base. Universal design for learning (UDL) can help educators address the varied needs of...
Gender & Diversity Education Curriculum Development and Instructional Design Social Sciences and Humanities Library and Information Science
Published by: IGI Global Scientific Publishing
RNA-dependent RNA polymerase 1 in potato (Solanum tuberosum) and its relationship to other plant RNA-dependent RNA polymerases.
Lydia JR Hunter, Samuel F Brockington, Alex M Murphy, Adrienne E Pate, Kristina Gruden, Stuart A MacFarlane, Peter Palukaitis, John P Carr
Feb 26, 2016
Gene Expression Regulation Enzymologic Gene Expression Regulation Plant Host-Pathogen Interactions Plant Diseases Plant Proteins Plants Genetically Modified Potexvirus Potyvirus RNA Interference RNA-Dependent RNA Polymerase Reverse Transcriptase Polymerase Chain Reaction Salicylic Acid Solanum tuberosum Tobacco Mosaic Virus
Signalling adjustments to direct and indirect environmental effects on signal perception in meerkats.
The efficiency of communication between animals is determined by the perception range of signals. With changes in the environment, signal transmission between a sender and a receiver can be influenced both directly, where the...
Myocardial Fibrosis in Heart Failure
Abstract: All heart muscle diseases that cause chronic heart failure finally converge into one dreaded pathological process that is myocardial fibrosis. Myocardial fibrosis predicts major adverse cardiovascular events and death...
Stalagmite evidence of Last Glacial Maximum to early Holocene climate variability in southwestern Iran
Mojgan Soleimani, Alireza Nadimi, Gabriella Koltai, Yuri Dublyansky, Stacy Carolin, Christoph Spotl
Oct 29, 2022
Glacial periods and their terminations are useful for assessing the full scale of natural climate variability in the diverse climate regions of West Asia (i.e. deserts, mountains, alluvial plains, coastal zones). In this study...
A Small Molecule Stabilizes the Disordered Native State of the Alzheimer's Aβ Peptide.
The stabilization of native states of proteins is a powerful drug discovery strategy. It is still unclear, however, whether this approach can be applied to intrinsically disordered proteins. Here, we report a small molecule that...
Financial Stress Interacts With CLOCK Gene to Affect Migraine.
Daniel Baksa, Xenia Gonda, Nora Eszlari, Peter Petschner, Veronika Acs, Lajos Kalmar, JF William Deakin, Gyorgy Bagdy, Gabriella Juhasz
Feb 17, 2020
Previous studies suggested that both maladaptive stress response and circadian dysregulation might have a role in the background of migraine. However, effects of circadian genes on migraine have not been tested yet. In the...
Measuring the mechanical properties of plant cells by combining micro-indentation with osmotic treatments.
Alain Weber, Siobhan Braybrook, Michal Huflejt, Gabriella Mosca, Anne-Lise Routier-Kierzkowska, Richard S Smith
Jun 02, 2015
Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle.
John A Halsall, Simon Andrews, Felix Krueger, Charlotte E Rutledge, Gabriella Ficz, Wolf Reik, Bryan M Turner
Apr 12, 2021
Chromatin configuration influences gene expression in eukaryotes at multiple levels, from individual nucleosomes to chromatin domains several Mb long. Post-translational modifications (PTM) of core histones seem to be involved...
Tumor Necrosis Factor α Influences Phenotypic Plasticity and Promotes Epigenetic Changes in Human Basal Forebrain Cholinergic Neuroblasts.
Giulia Guarnieri, Erica Sarchielli, Paolo Comeglio, Erika Herrera-Puerta, Irene Piaceri, Benedetta Nacmias, Matteo Benelli, Gavin Kelsey, Mario Maggi, Pasquale Gallina, Gabriella Barbara Vannelli, Annamaria Morelli
Nov 09, 2020
TNFα is the main proinflammatory cytokine implicated in the pathogenesis of neurodegenerative disorders, but it also modulates physiological functions in both the developing and adult brain. In this study, we investigated a...
Alzheimer’s disease DNA Methylation NGF TNFα receptors ciliogenesis human fetal neurons Neurogenesis Neuroinflammation Nucleus basalis of Meynert Basal Forebrain basal nucleus of Meynert Cell Line Cholinergic Neurons DNA Methylation Epigenesis Genetic Humans Microtubule-Associated Proteins Nerve Tissue Proteins Neuronal Plasticity Receptors Nerve Growth Factor Receptors Tumor Necrosis Factor Type II Tumor Necrosis Factor-alpha whole genome sequencing
Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages
Milos Gojkovic, Pedro P Cunha, Gabriella S Darmasaputra, Laura Barbieri, Helene Rundqvist, Pedro Veliça, Randall S Johnson
Jun 10, 2021
Myeloid cell interactions with cells of the adaptive immune system are an essential aspect of immunity. A key aspect of that interrelationship is its modulation by the microenvironment. Oxygen is known to influence...
HIF Nitric oxide prolyl hydroxylase inhibitors Hypoxia immunosuppression Myeloid Cells von Hippel-Lindau. Adaptive Immunity Animals CD8-Positive T-Lymphocytes Cell Hypoxia Cell Line Tumor Cell Proliferation Coculture Techniques Glycine Humans Hypoxia-Inducible Factor 1 alpha Subunit Isoquinolines MACROPHAGES Mice Mice Transgenic Oxygen Von Hippel-Lindau Tumor Suppressor Protein
Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation.
Hemalvi Patani, Michael D Rushton, Jonathan Higham, Saul A Teijeiro, David Oxley, Pedro Cutillas, Duncan Sproul, Gabriella Ficz
Sep 09, 2020
Epigenetic reprogramming is a cancer hallmark, but how it unfolds during early neoplastic events and its role in carcinogenesis and cancer progression is not fully understood. Here we show that resetting from primed to naïve...
Animals Cell Line Cell Transformation Neoplastic Cellular Reprogramming Coculture Techniques CpG Islands DNA (Cytosine-5-)-Methyltransferases DNA Methylation DNA Methyltransferase 3A Epigenesis Genetic FIBROBLASTS Gene Expression Regulation Neoplastic Gene Knockdown Techniques HEK293 Cells Histones Human Embryonic Stem Cells Humans Mice Mixed Function Oxygenases Neoplasms Promoter Regions Genetic Proto-Oncogene Proteins RNA Small Interfering
Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages
Milos Gojkovic, Pedro P. Cunha, Gabriella S. Darmasaputra, Laura Barbieri, Helene Rundqvist, Pedro Veliça, Randall S. Johnson
May 26, 2021
Myeloid cell interactions with cells of the adaptive immune system are an essential aspect of immunity. A key aspect of that interrelationship is its modulation by the microenvironment. Oxygen is known to influence...
The Differential Diagnosis of Discrepant Thyroid Function Tests
Irene Campi, Danila Covelli, Carla Moran, Laura Fugazzola, Chiara Cacciatore, Fabio Orlandi, Gabriella Gallone, Krishna Chatterjee, Paolo Beck-Peccoz, Luca Persani
Jul 21, 2020
Background: Discrepant thyroid function tests (TFTs) are typical of inappropriate secretion of TSH (IST), a rare entity encompassing TSH-secreting adenomas (TSHoma) and Resistance to Thyroid Hormone (RTHβ) due to THRB mutations....
hyperthyroidism immuno-assay pituitary adenoma resistance to thyroid hormone thyroid hormone thyrotropin (TSH) Adolescent Adult Aged Case-Control Studies Delayed Diagnosis Diagnosis Differential Female Follow-Up Studies Humans hyperthyroidism Male Middle Aged Mutation Prognosis Retrospective Studies Thyroid Function Tests Thyroid Hormone Receptors beta Thyroid Hormones Thyroid Neoplasms Young Adult
Tumor Necrosis Factor α Influences Phenotypic Plasticity and Promotes Epigenetic Changes in Human Basal Forebrain Cholinergic Neuroblasts
Giulia Guarnieri, Erica Sarchielli, Paolo Comeglio, Erika Herrera-Puerta, Irene Piaceri, Benedetta Nacmias, Matteo Benelli, Gavin Kelsey, Mario Maggi, Pasquale Gallina, Gabriella Barbara Vannelli, Annamaria Morelli
Aug 26, 2020
TNFα is the main proinflammatory cytokine implicated in the pathogenesis of neurodegenerative disorders, but it also modulates physiological functions in both the developing and adult brain. In this study, we investigated a...
Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae.
Acute, but not longer-term, exposure to environmental enrichment attenuates Pavlovian cue-evoked conditioned approach and Fos expression in the prefrontal cortex in mice.
Gabriella Margetts-Smith, Anastasia I Macnaghten, Leonie S Brebner, Joseph J Ziminski, Meike C Sieburg, Jeffrey W Grimm, Hans S Crombag, Eisuke Koya
Apr 27, 2021
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