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Personalized early detection and prevention of breast cancer
Nora Pashayan, Antonis C. Antoniou, Urska Ivanus, Laura J. Esserman, Douglas F. Easton, David French, Gaby Sroczynski, Per Hall, Jack Cuzick, D. Gareth Evans, Jacques Simard, Montserrat Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Giorgi Rossi, Jelle Wesseling, David Ritchie, Marc Tischkowitz, Mireille Broeders, Dan Reisel, Andres Metspalu, Thomas Callender, Harry de Koning, Peter Devilee, Suzette Delaloge, Marjanka K. Schmidt, Martin Widschwendter
Feb 16, 2021
Abstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early...
Personalized early detection and prevention of breast cancer
Nora Pashayan, Antonis C. Antoniou, Urska Ivanus, Laura J. Esserman, Douglas F. Easton, David French, Gaby Sroczynski, Per Hall, Jack Cuzick, D. Gareth Evans, Jacques Simard, Montserrat Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Giorgi Rossi, Jelle Wesseling, David Ritchie, Marc Tischkowitz, Mireille Broeders, Dan Reisel, Andres Metspalu, Thomas Callender, Harry de Koning, Peter Devilee, Suzette Delaloge, Marjanka K. Schmidt, Martin Widschwendter
Jun 18, 2021
Abstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early...
Personalized early detection and prevention of breast cancer
Nora Pashayan, Antonis C Antoniou, Urska Ivanus, Laura J Esserman, Douglas F Easton, David French, Gaby Sroczynski, Per Hall, Jack Cuzick, D Gareth Evans, Jacques Simard, Montserrat Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Giorgi Rossi, Jelle Wesseling, David Ritchie, Marc Tischkowitz, Mireille Broeders, Dan Reisel, Andres Metspalu, Thomas Callender, Harry de Koning, Peter Devilee, Suzette Delaloge, Marjanka K Schmidt, Martin Widschwendter
Mar 10, 2020
The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early detection and...
Archaerhodopsin Selectively and Reversibly Silences Synaptic Transmission through Altered pH.
Mohamady El-Gaby, Yu Zhang, Konstantin Wolf, Christof J Schwiening, Ole Paulsen, Olivia A Shipton
Sep 15, 2016
archaerhodopsin asymmetry Behavior Hippocampus Long-term memory optogenetics pH reversible Synapses synaptic silencing Adenoviridae Animals Archaeal Proteins Bacterial Proteins CA1 Region Hippocampal CA3 Region Hippocampal Gene Expression Genetic Vectors Hydrogen-Ion Concentration Injections Intraventricular Luminescent Proteins Male Memory Long-Term Mice Mice Inbred C57BL Neuronal Plasticity Optical Imaging optogenetics Presynaptic Terminals Recombinant Fusion Proteins Stereotaxic Techniques Synaptic Transmission
Personalized early detection and prevention of breast cancer
Nora Pashayan, Antonis C. Antoniou, Urska Ivanus, Laura J. Esserman, Douglas F. Easton, David French, Gaby Sroczynski, Per Hall, Jack Cuzick, D. Gareth Evans, Jacques Simard, Montserrat Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Giorgi Rossi, Jelle Wesseling, David Ritchie, Marc Tischkowitz, Mireille Broeders, Dan Reisel, Andres Metspalu, Thomas Callender, Harry de Koning, Peter Devilee, Suzette Delaloge, Marjanka K. Schmidt, Martin Widschwendter
Oct 17, 2020
Abstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early...
Left-right dissociation of hippocampal memory processes in mice.
Olivia A Shipton, Mohamady El-Gaby, John Apergis-Schoute, Karl Deisseroth, David M Bannerman, Ole Paulsen, Michael M Kohl
Sep 01, 2014
Adjusting for confounding by indication in observational studies
Maryse C Cnossen, Thomas A van Essen, Iris E Ceyisakar, Suzanne Polinder, Teuntje M Andriessen, Joukje van der Naalt, Iain Haitsma, Janneke Horn, Gaby Franschman, Pieter E Vos, Wilco C Peul, David K Menon, Andrew IR Maas, Ewout W Steyerberg, Hester F Lingsma
Sep 20, 2018
INTRODUCTION: Observational studies of interventions are at risk for confounding by indication. The objective of the current study was to define the circumstances for the validity of methods to adjust for confounding by...
Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages.
Yuning Lu, Gemma Basatemur, Ian C Scott, Davide Chiarugi, Marc Clement, James Harrison, Ravin Jugdaohsingh, Xian Yu, Stephen A Newland, Helen E Jolin, Xuan Li, Xiao Chen, Monika Szymanska, Guttorm Haraldsen, Gaby Palmer, Padraic G Fallon, E Suzanne Cohen, Andrew NJ McKenzie, Ziad Mallat
Mar 25, 2020
Splenic red pulp macrophages (RPMs) contribute to erythrocyte homeostasis and are required for iron recycling. Heme induces the expression of SPIC transcription factor in monocyte-derived macrophages and promotes their...
erythrophagocytosis Interleukin-33 interleukin-33 receptor Interleukins iron metabolism red pulp macrophage Animals Erythrocytes Heme Homeostasis Interleukin-1 Receptor-Like 1 Protein Interleukin-33 Iron MACROPHAGES Mice Knockout Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Myeloid Differentiation Factor 88 Signal Transduction Spleen
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease
Eva Gonçalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M. Croft, Carsten Posovszky, Astor Rodrigues, Richard K. Russell, Farah Barakat, Marcus K. H. Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P. Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C. Matte, Kimberly C. Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A. Baeumler, Tudor A. Fulga, Mohammad Karaminejadranjbar, Ahmed Ahmed, Rachel Wilson, Jeffrey C. Barrett, Abdul Elkadri, Anne M. Griffiths, Scott B. Snapper, Neil Shah, Aleixo M. Muise, David C. Wilson, Holm H. Uhlig, Carl A. Anderson, Marlen Zurek, Caterina Strisciuglio, Mamoun Elawad, Bernice Lo, Carolina Arancibia-Carcamo, Adam Bailey, Ellie Barnes, Elizabeth Louise Bird-Lieberman, Oliver Brain, Barbara Braden, Jane Collier, James East, Lucy Howarth, Satish Keshav, Paul Klenerman, Simon Leedham, Rebecca Palmer, Fiona Powrie, Alison Simmons, Matthew Walker, Zoe Tolkien, Stephen Kaptoge, David Allen, Susan Mehenny, Jonathan Mant, Emanuele Di Angelantonio, Simon G. Thompson, Bahtiyar Yilmaz, Pascal Juillerat, Markus Geuking, Reiner Wiest, Andrew J. Macpherson, Francisco Damian Bravo, Lukas Brügger, Ove Carstens, Ulrike Graf Bigler, Benjamin Heimgartner, Monica Rusticeanu, Sybille Schmid (-Uebelhart), Bruno Strebel, Aurora Tatu, Radu Tutuian, Ove Øyås, Charlotte Ramon, Jörg Stelling, Yannick Franc, Nicolas Fournier, Valerie E. H. Pittet, Bernard Burnand, Mara Egger, Delphine Golay, Astrid Marot, Leilla Musso, Valérie Pittet, Jean-Benoît Rossel, Vivianne Seematter, Joachim Sommer, Rachel Vulliamy, Pierre Michetti, Michel H. Maillard, Céline Keller, Andreas Nydegger, Alain Schoepfe, Eva Archanioti, Jessica Ezri, Montserrat Fraga, Alain Schoepfer, Christoph Müller, Gerhard Rogler, Luc Biedermann, Mirjam Blattmann, Sabine Burk, Barbara Dora, Michael Fried, Benjamin Misselwitz, Beat Müllhaupt, Nicole Obialo, Daniel Pohl, Nadia Raschle, Michael Scharl, Stephan Vavricka, Roland Von Känel, Jonas Zeitz, Karim Abdelrahman, Gentiana Ademi, Jan Borovicka, Stephan Brand, Remus Frei, Johannes Haarer, Christina Knellwolf (-Grieger), Claudia Krieger(-Grübel), Patrizia Künzler, Christa Meyenberger, Pamela Meyer, Nina Röhrich, Mikael Sawatzki, Martin Schelling, Gian-Marco Semadeni, Michael Sulz, Dorothee Zimmermann, Patrick Aepli, Dominique H. Criblez, Cyrill Hess, Jean-Pierre Richterich, Johannes Spalinger, Dominic Staudenmann, Andreas Stulz, Stefanie Wöhrle, Amman Thomas, Claudia Anderegg, Henrik Köhler, Rachel Kusche, Anca-Teodora Antonino, Eviano Arrigoni, José M. Bengoa, Sophie Cunningham, Philippe de Saussure, Laurent Girard, Diana Bakker de Jong, Polat Bastürk, Simon Brunner, Lukas Degen, Petr Hruz, Carolina Khalid-de Bakker, Jan Niess, Bruno Balsiger, Janine Haldemann, Gaby Saner, Frank Seibold, Peter Bauerfeind, Andrea Becocci, Dominique Belli, Janek Binek, Peter Hengstler, Stephan Boehm, Tujana Boldanov, Patrick Bühr, Rebekka Koller, Vanessa Rueger, Arne Senning, Emanuel Burri, Sophie Buyse, Dahlia-Thao Cao, Fabrizia D’Angelo, Joakim Delarive, Christopher Doerig, Roxane Hessler, Claudia Preissler, Ronald Rentsch, Branislav Risti, Marc Alain Ritz, Michael Steuerwald, Jürg Vögtlin, Markus Sagmeister, Bernhard Sauter, Susanne Schibli, Christiane Sokollik, Hugo Schlauri, Jean-François Schnegg, Mariam Seirafi, Holger Spangenberger, Philippe Stadler, Peter Staub, Volker Stenz, Michela Tempia-Caliera, Joël Thorens, Kaspar Truninger, Patrick Urfer, Francesco Viani, Dominique Vouillamoz, Silvan Zander, Tina Wyli, L. Jostins, N. A. Kennedy, T. Ahmad, C. A. Lamb, C. Edwards, A. Hart, C. Hawkey, J. C. Mansfield, C. Mowat, W. G. Newman, A. Simmons, M. Tremelling, J. C. Lee, N. J. Prescott, C. G. Mathew, C. W. Lees, D. P. B. McGovern, S. R. Targan, G. Botwin, E. Mengesha, P. Fleshner, C. Landers, D. Li, J. D. Rioux, A. Bitton, J. Côté-Daigneault, M. J. Daly, R. Xavier, K. Morris, G. Boucher, J. H. Cho, C. Abraham, M. Merad, B. Sands, I. Peter, K. Hao, Y. Itan, R. H. Duerr, L. Konnikova, M. B. Schwartz, S. Proksell, E. Johnston, V. Miladinova, W. Chen, S. R. Brant, L. Datta, M. S. Silverberg, L. P. Schumm, S. Birch, M. Giri, K. Gettler, Y. Sharma, C. Stevens, M. Lazarev, T. Haritunians
Feb 20, 2021
Abstract: Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genotyping in 145...